Replacement of current opioid drugs focusing on MOR-related strategies - Busserolles, Jérôme; Lolignier, Stéphane; Kerckhove, Nicolas; Bertin, Célian; Authier, Nicolas; Eschalier, Alain (Pharmacology & therapeutics (Oxford), 2020)
Keywords: Analgesia; Analgesics - adverse effects; Analgesics - therapeutic use; Analgesics, Opioid; Analgesics, Opioid - adverse effects; Animals; Central Nervous System; Central Nervous System - drug effects; Central Nervous System - metabolism; Central Nervous System - physiopathology; Drug Discovery; Humans; Innovative targets; Life Sciences; Ligands; Molecular Targeted Therapy; Mu opioid receptors (MORs); Opioid abuse and misuse; Opioid adverse side effects; Opioid Epidemic; Opioid Peptides; Opioid Peptides - adverse effects; Opioid Peptides - metabolism; Opioid Peptides - therapeutic use; Opioid receptor signaling; Opioid-Related Disorders; Opioid-Related Disorders - diagnosis; Opioid-Related Disorders - epidemiology; Opioid-Related Disorders - prevention & control; Pain; Pain - drug therapy; Pain - metabolism; Pain - physiopathology; Pain Threshold; Pain Threshold - drug effects; Receptors, Opioid, mu; Receptors, Opioid, mu - agonists; Receptors, Opioid, mu - metabolism; Signal Transduction; Opioid abuse and misuse; OR; KO; DOR; CNCP; PKA; TRPV1; Mu opioid receptors (MORs); KOR; Analgesia; MOR; Innovative targets; DENKI; Opioid adverse side effects; NEP; Oprm1; Opioid receptor signaling; GPCR; GIRK; VDCCs; TRPM3; APN