Association between vitamin D deficiency and tuberculosis in a Korean population
BACKGROUND: Several in vitro studies have been conducted regarding the immunomodulatory and mycobactericidal roles of vitamin D in tuberculous infection. However, discrepancies exist among epidemiological studies. We compared vitamin D deficiency between patients with tuberculosis (TB) and healthy c...
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Published in | The international journal of tuberculosis and lung disease Vol. 18; no. 1; pp. 73 - 78 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Paris, France
International Union Against Tuberculosis and Lung Disease
01.01.2014
International Union against Tuberculosis and Lung Disease |
Subjects | |
Online Access | Get full text |
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Summary: | BACKGROUND: Several in vitro studies have been conducted regarding the immunomodulatory and mycobactericidal roles of vitamin D in tuberculous infection. However, discrepancies exist among epidemiological studies. We compared vitamin D deficiency between patients with tuberculosis (TB)
and healthy control subjects and identified risk factors for vitamin D deficiency.METHOD: This was an age- and sex-matched case-control analysis of 94 TB cohort and 282 Korean national survey participants.RESULTS: The median baseline 25-hydroxyvitamin D (25[OH]D) level in the TB group
(9.86 ng/ml, IQR 7.19-14.15) was lower than in controls (16.03 ng/ml, IQR 12.38-20.30, P < 0.001). The prevalence of severe vitamin D deficiency was higher in patients with TB (51.1%) than in controls (8.2%, P = 0.001). The median 25(OH)D level increased from 11.40
ng/ml (IQR 7.85-15.73) to 13.18 ng/ml (IQR 10.60-19.71) after treatment completion (P = 0.037). On multivariate analysis, presence of TB and history of TB were independently associated with severe vitamin D deficiency.CONCLUSION: Patients with TB had a higher prevalence
of vitamin D deficiency than control subjects in a Korean population. The median 25(OH)D level increased after TB treatment. Further studies are needed to establish a causal relationship. |
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Bibliography: | (R) Medicine - General 1027-3719(20140101)18:1L.73;1- ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1027-3719 1815-7920 |
DOI: | 10.5588/ijtld.13.0536 |