MEI4, a yeast gene required for meiotic recombination
Mutants at the MEI4 locus were detected in a search for mutants defective in meiotic gene conversion. mei4 mutants exhibit decreased sporulation and produce inviable spores. The spore inviability phenotype is rescued by a spo13 mutation, which causes cells to bypass the meiosis I division. The ME14...
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| Published in | Genetics (Austin) Vol. 123; no. 4; pp. 675 - 682 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.12.1989
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Mutants at the MEI4 locus were detected in a search for mutants defective in meiotic gene conversion. mei4 mutants exhibit decreased sporulation and produce inviable spores. The spore inviability phenotype is rescued by a spo13 mutation, which causes cells to bypass the meiosis I division. The ME14 gene has been cloned from a yeast genomic library by complementation of the recombination defect and has been mapped to chromosome V near gln3. Strains carrying a deletion/insertion mutation of the MEI4 gene display no meiotically induced gene conversion but normal mitotic conversion frequencies. Both meiotic interchromosomal and intrachromosomal crossing over are completely abolished in mei4 strains. The mei4 mutation is able to rescue the spore-inviability phenotype of spo13 rad52 strains (i.e., mei4 spo13 rad52 mutants produce viable spores), indicating that MEI4 acts before RAD52 in the meiotic recombination pathway |
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| AbstractList | Mutants at the MEI4 locus were detected in a search for mutants defective in meiotic gene conversion. mei4 mutants exhibit decreased sporulation and produce inviable spores. The spore inviability phenotype is rescued by a spo13 mutation, which causes cells to bypass the meiosis I division. The MEI4 gene has been cloned from a yeast genomic library by complementation of the recombination defect and has been mapped to chromosome V near gln3. Strains carrying a deletion/insertion mutation of the MEI4 gene display no meiotically induced gene conversion but normal mitotic conversion frequencies. Both meiotic interchromosomal and intrachromosomal crossing over are completely abolished in mei4 strains. The mei4 mutation is able to rescue the spore-inviability phenotype of spo13 and 52 strains (i.e., mei4 spo13 rad52 mutants produce viable spores), indicating that MEI4 acts before RAD52 in the meiotic recombination pathway. Mutants at the MEI4 locus were detected in a search for mutants defective in meiotic gene conversion, mei4 mutants exhibit decreased sporulation and produce inviable spores. The spore inviability phenotype is rescued by a spo13 mutation, which causes cells to bypass the meiosis I division. The MEI4 gene has been cloned from a yeast genomic library by complementation of the recombination defect and has been mapped to chromosome V near gln3. Strains carrying a deletion/insertion mutation of the MEI4 gene display no meiotically induced gene conversion but normal mitotic conversion frequencies. Both meiotic interchromosomal and intrachromosomal crossing over are completely abolished in mei4 strains. Mutants at the MEI4 locus were detected in a search for mutants defective in meiotic gene conversion. mei4 mutants exhibit decreased sporulation and produce inviable spores. The spore inviability phenotype is rescued by a spo13 mutation, which causes cells to bypass the meiosis I division. The ME14 gene has been cloned from a yeast genomic library by complementation of the recombination defect and has been mapped to chromosome V near gln3. Strains carrying a deletion/insertion mutation of the MEI4 gene display no meiotically induced gene conversion but normal mitotic conversion frequencies. Both meiotic interchromosomal and intrachromosomal crossing over are completely abolished in mei4 strains. The mei4 mutation is able to rescue the spore-inviability phenotype of spo13 rad52 strains (i.e., mei4 spo13 rad52 mutants produce viable spores), indicating that MEI4 acts before RAD52 in the meiotic recombination pathway Abstract Mutants at the MEI4 locus were detected in a search for mutants defective in meiotic gene conversion. mei4 mutants exhibit decreased sporulation and produce inviable spores. The spore inviability phenotype is rescued by a spo13 mutation, which causes cells to bypass the meiosis I division. The MEI4 gene has been cloned from a yeast genomic library by complementation of the recombination defect and has been mapped to chromosome V near gln3. Strains carrying a deletion/insertion mutation of the MEI4 gene display no meiotically induced gene conversion but normal mitotic conversion frequencies. Both meiotic interchromosomal and intrachromosomal crossing over are completely abolished in mei4 strains. The mei4 mutation is able to rescue the spore-inviability phenotype of spo13 and 52 strains (i.e., mei4 spo13 rad52 mutants produce viable spores), indicating that MEI4 acts before RAD52 in the meiotic recombination pathway. |
| Author | Menees, T.M. (Yale University, New Haven, CT) Roeder, G.S |
| Author_xml | – sequence: 1 fullname: Menees, T.M. (Yale University, New Haven, CT) – sequence: 2 fullname: Roeder, G.S |
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| References | 3413075 - Proc Natl Acad Sci U S A. 1988 Aug;85(16):6057-61 797314 - Annu Rev Genet. 1976;10:53-134 2653960 - Genetics. 1989 Mar;121(3):445-62 3549449 - Genetics. 1987 Feb;115(2):233-46 17247336 - Genetics. 1949 Sep;34(5):607-26 3538420 - Science. 1986 Dec 19;234(4783):1582-5 3015718 - Genetics. 1986 Jul;113(3):551-67 17248996 - Genetics. 1980 Jan;94(1):51-68 4603162 - Genetics. 1974 Jun;77(2):231-44 5802566 - Genetics. 1969 Jan;61(1):79-89 17176533 - Genetics. 1978 Apr;88(4 Pt 1):651-71 7021312 - Genetics. 1980 Nov;96(3):589-611 3606589 - Bioessays. 1987 May;6(5):232-6 3916863 - Yeast. 1985 Dec;1(2):83-138 4550514 - Radiat Res. 1972 Jan;49(1):133-47 3280137 - Cell. 1988 Mar 25;52(6):863-73 6310324 - Methods Enzymol. 1983;101:202-11 6241453 - Annu Rev Genet. 1984;18:331-413 3539696 - Genetics. 1986 Nov;114(3):731-52 3003748 - Proc Natl Acad Sci U S A. 1986 Feb;83(3):735-9 4599956 - Genetics. 1974 Apr;76(4):745-53 6336730 - J Bacteriol. 1983 Jan;153(1):163-8 359409 - Genetics. 1978 Sep;90(1):49-68 3299047 - Mol Cell Biol. 1987 Apr;7(4):1425-35 |
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| Snippet | Mutants at the MEI4 locus were detected in a search for mutants defective in meiotic gene conversion. mei4 mutants exhibit decreased sporulation and produce... Abstract Mutants at the MEI4 locus were detected in a search for mutants defective in meiotic gene conversion. mei4 mutants exhibit decreased sporulation and... Mutants at the MEI4 locus were detected in a search for mutants defective in meiotic gene conversion, mei4 mutants exhibit decreased sporulation and produce... |
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| SubjectTerms | Chromosome Mapping Cloning, Molecular DESCENDANCE DNA Mutational Analysis DNA, Fungal - genetics Epistasis, Genetic Genes, Fungal Genetic Complementation Test LEVADURA LEVURE MEIOSE MEIOSIS MUTANT MUTANTES PROGENIE RECOMBINACION RECOMBINAISON Recombination, Genetic Restriction Mapping Saccharomyces cerevisiae - genetics |
| Title | MEI4, a yeast gene required for meiotic recombination |
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