Stable and dynamic cortical electrophysiology of induction and emergence with propofol anesthesia

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 49; pp. 21170 - 21175
• Main Authors: Breshears, Jonathan D., Roland, Jarod L., Sharma, Mohit, Gaona, Charles M., Freudenburg, Zachary V., Tempelhoff, Rene, Avidan, Michael S., Leuthardt, Eric C., Raichle, Marcus E.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 07.12.2010; National Acad Sciences
• Subjects: Anesthesia; Anesthesia - methods; Anesthetics; Architecture; Biological Sciences; Brain; Cerebral Cortex - drug effects; Cerebral Cortex - physiology; consciousness; Consciousness - drug effects; Correlation coefficients; Correlations; cortex; Covariance; Electrodes; Electroencephalography - methods; Electrophysiological Phenomena; Electrophysiology; Evoked Potentials, Somatosensory - drug effects; Human subjects; Humans; image analysis; Metabolism; Propofol - pharmacology; Statistical variance; Studies; Thalamus - drug effects; Thalamus - physiology; Unconsciousness; variance

The mechanism(s) by which anesthetics reversibly suppress consciousness are incompletely understood. Previous functional imaging studies demonstrated dynamic changes in thalamic and cortical metabolic activity, as well as the maintained presence of metabolically defined functional networks despite t...