Effect of Enzymatically Modified Isoquercitrin, a Flavonoid, on Symptoms of Japanese Cedar Pollinosis: A Randomized Double-Blind Placebo-Controlled Trial

• Published in: International archives of allergy and immunology Vol. 149; no. 4; pp. 359 - 368
• Main Authors: Kawai, Mari, Hirano, Toru, Arimitsu, Junsuke, Higa, Shinji, Kuwahara, Yusuke, Hagihara, Keisuke, Shima, Yoshihito, Narazaki, Masashi, Ogata, Atsushi, Koyanagi, Mihoko, Kai, Tomoko, Shimizu, Ryosuke, Moriwaki, Masamitsu, Suzuki, Yukio, Ogino, Satoshi, Kawase, Ichiro, Tanaka, Toshio
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.01.2009; S. Karger AG
• Subjects: Adult; Allergies; Biological and medical sciences; Biomarkers - blood; Clinical outcomes; Cryptomeria - immunology; Cryptomeria japonica; Cytokines - blood; Double-Blind Method; Female; Flavonoids - administration & dosage; Flavonoids - chemistry; Flavonoids - therapeutic use; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Immunopathology; Male; Medical sciences; Middle Aged; Original Paper; Phytochemicals; Pollen; Pollen - immunology; Quercetin - administration & dosage; Quercetin - analogs & derivatives; Quercetin - chemistry; Quercetin - therapeutic use; Rhinitis, Allergic, Seasonal - drug therapy; Rhinitis, Allergic, Seasonal - immunology; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Trees; Asia; Japan; Pollinosis; Flavonoid; Quercetin; Immunopathology; Symptomatology; Polyphenol; Immunology; Phenols; Double blind study; Randomized controlled trial

Background: Flavonoids exert antiallergic and antioxidant effects. We investigated the efficacy of enzymatically modified isoquercitrin (EMIQ), a flavonoid, to relieve symptoms of pollinosis. Methods: In a parallel-group, double-blind placebo-controlled study design, 20 subjects with Japanese cedar...