Somatostatin and its receptors: Functional regulation in the development of mice Sertoli cells

• Published in: The Journal of steroid biochemistry and molecular biology Vol. 138; pp. 257 - 266
• Main Authors: Riaz, Hasan, Liang, Aixin, Khan, Muhammad Kasib, Dong, Ping, Han, Li, Shahzad, Muhammad, Chong, Zhenlu, Ahmad, Sibtain, Hua, Guohua, Yang, Liguo
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2013
• Subjects: Animals; Apoptosis; Apoptosis - drug effects; Blotting, Western; cAMP; Cell cycle; Cell Cycle - drug effects; Cells, Cultured; dose response; forskolin; gene expression; genes; Immunohistochemistry; interphase; Male; messenger RNA; Mice; quantitative polymerase chain reaction; Real-Time Polymerase Chain Reaction; Receptors, Somatostatin - genetics; Receptors, Somatostatin - metabolism; Sertoli cells; Sertoli Cells - drug effects; Sertoli Cells - metabolism; Somatostatin; Somatostatin - analogs & derivatives; Somatostatin - genetics; Somatostatin - metabolism; Somatostatin - pharmacology; somatostatin receptors; spermatogenesis; Western blotting; Somatostatin; cAMP; Sertoli cells; Cell cycle; Apoptosis

•Mice Sertoli cells expressed all somatostatin receptors.•Somatostatin receptor subtype 2 and 5 are important during Sertoli cell developmental period.•SRIF14 treatment elicited a dose dependent increase in apoptosis and cellular arrest. Recently, Sertoli cells have been ascertained as the target fo...