Specificity and Redundancy of Profilin 1 and 2 Function in Brain Development and Neuronal Structure

• Published in: Cells (Basel, Switzerland) Vol. 10; no. 9; p. 2310
• Main Authors: Di Domenico, Marina, Jokwitz, Melanie, Witke, Walter, Pilo Boyl, Pietro
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 03.09.2021; MDPI
• Subjects: Actin; Antibodies; brain development; Cell division; Dendritic branching; Embryogenesis; Genotype & phenotype; Informatics; Isoforms; Mammals; Morphogenesis; Nervous system; Neural stem cells; neuronal branching; neuronal precursor cells; Neurons; Phenotypes; Physiology; Profilin; Stem cells; United States > US

Profilin functions have been discussed in numerous cellular processes, including actin polymerization. One puzzling aspect is the concomitant expression of more than one profilin isoform in most tissues. In neuronal precursors and in neurons, profilin 1 and profilin 2 are co-expressed, but their spe...