Effect of coordinated ligands on antiproliferative activity and DNA cleavage property of three mononuclear Cu(II)-terpyridine complexes
Three mononuclear copper(II) complexes, [Cu(tpy)Cl2] 1, [Cu(tpy)(NO3)2(H2O)] 2 and [Cu(Ptpy)Cl2]·H2O·HCl 3 have been synthesised and characterized by various spectroscopic techniques and single crystal X-ray diffraction. Complexes 1 and 3 have five coordinate geometry in solid state, whereas complex...
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Published in | European journal of medicinal chemistry Vol. 57; pp. 449 - 458 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Kidlington
Elsevier Masson SAS
01.11.2012
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Three mononuclear copper(II) complexes, [Cu(tpy)Cl2] 1, [Cu(tpy)(NO3)2(H2O)] 2 and [Cu(Ptpy)Cl2]·H2O·HCl 3 have been synthesised and characterized by various spectroscopic techniques and single crystal X-ray diffraction. Complexes 1 and 3 have five coordinate geometry in solid state, whereas complex 2 has six coordinate geometry. Mass spectral and EPR evidence suggest that in solution all the three complexes exist predominantly as a four coordinate species. Molecular modelling and DNA cleavage studies indicate that complexes 1 and 2 are DNA minor groove binders, whereas 3 is an intercalator. All the three complexes show nuclease activity in the presence of hydrogen peroxide. The three complexes have been found to be cytotoxic towards A549 lung adenocarcinoma cells.
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► Three new mononuclear Cu (II) terpyridine complexes have been synthesised and crystallographically characterised. ► These complexes have been found to be cytotoxic to cancerous cell line. ► The observed cytotoxicity of the complexes has been found to be due to their ability to bring about apoptotic cell death. ► These compounds may have potential application in chemotherapy. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0223-5234 1768-3254 |
DOI: | 10.1016/j.ejmech.2012.06.039 |