An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia

• Published in: Blood Vol. 135; no. 26; pp. 2337 - 2353
• Main Authors: Ko, Tun Kiat, Javed, Asif, Lee, Kian Leong, Pathiraja, Thushangi N., Liu, Xingliang, Malik, Simeen, Soh, Sheila Xinxuan, Heng, Xiu Ting, Takahashi, Naoto, Tan, Joanna H.J., Bhatia, Ravi, Khng, Alexis J., Chng, Wee-Joo, Sia, Yee Yen, Fruman, David A., Ng, King Pan, Chan, Zhu En, Xie, Kim Jiajing, Hoi, Qiangze, Chan, Cheryl Xueli, Teo, Audrey S.M., Velazquez Camacho, Oscar, Meah, Wee Yang, Khor, Chiea Chuen, Ong, Chin Thing J., Soon, Wei Jia W., Tan, Patrick, Ng, Pauline C., Chuah, Charles, Hillmer, Axel M., Ong, S. Tiong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 25.06.2020
• Subjects: Blast Crisis - genetics; Cell Differentiation; Chromatin Immunoprecipitation; Datasets as Topic; DNA Methylation; Enhancer of Zeste Homolog 2 Protein - physiology; Gene Dosage; Gene Expression Regulation, Leukemic - genetics; Gene Ontology; High-Throughput Nucleotide Sequencing; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology; Mutation; Polycomb Repressive Complex 1 - genetics; Polycomb Repressive Complex 1 - physiology; Polycomb Repressive Complex 2 - genetics; Polycomb Repressive Complex 2 - physiology; Transcriptome; Whole Exome Sequencing; Whole Genome Sequencing

Targeted therapies against the BCR-ABL1 kinase have revolutionized treatment of chronic phase (CP) chronic myeloid leukemia (CML). In contrast, management of blast crisis (BC) CML remains challenging because BC cells acquire complex molecular alterations that confer stemness features to progenitor p...