An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia
Targeted therapies against the BCR-ABL1 kinase have revolutionized treatment of chronic phase (CP) chronic myeloid leukemia (CML). In contrast, management of blast crisis (BC) CML remains challenging because BC cells acquire complex molecular alterations that confer stemness features to progenitor p...
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Published in | Blood Vol. 135; no. 26; pp. 2337 - 2353 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
Elsevier Inc
25.06.2020
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Abstract | Targeted therapies against the BCR-ABL1 kinase have revolutionized treatment of chronic phase (CP) chronic myeloid leukemia (CML). In contrast, management of blast crisis (BC) CML remains challenging because BC cells acquire complex molecular alterations that confer stemness features to progenitor populations and resistance to BCR-ABL1 tyrosine kinase inhibitors. Comprehensive models of BC transformation have proved elusive because of the rarity and genetic heterogeneity of BC, but are important for developing biomarkers predicting BC progression and effective therapies. To better understand BC, we performed an integrated multiomics analysis of 74 CP and BC samples using whole-genome and exome sequencing, transcriptome and methylome profiling, and chromatin immunoprecipitation followed by high-throughput sequencing. Employing pathway-based analysis, we found the BC genome was significantly enriched for mutations affecting components of the polycomb repressive complex (PRC) pathway. While transcriptomically, BC progenitors were enriched and depleted for PRC1- and PRC2-related gene sets respectively. By integrating our data sets, we determined that BC progenitors undergo PRC-driven epigenetic reprogramming toward a convergent transcriptomic state. Specifically, PRC2 directs BC DNA hypermethylation, which in turn silences key genes involved in myeloid differentiation and tumor suppressor function via so-called epigenetic switching, whereas PRC1 represses an overlapping and distinct set of genes, including novel BC tumor suppressors. On the basis of these observations, we developed an integrated model of BC that facilitated the identification of combinatorial therapies capable of reversing BC reprogramming (decitabine+PRC1 inhibitors), novel PRC-silenced tumor suppressor genes (NR4A2), and gene expression signatures predictive of disease progression and drug resistance in CP.
•Genetically heterogeneous BC progenitors demonstrate molecular convergence on PRC1- and PRC2-regulated pathways.•A model of PRC-driven reprogramming identifies novel BC combination therapies, tumor suppressor genes, and biomarkers for transformation.
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AbstractList | Targeted therapies against the BCR-ABL1 kinase have revolutionized treatment of chronic phase (CP) chronic myeloid leukemia (CML). In contrast, management of blast crisis (BC) CML remains challenging because BC cells acquire complex molecular alterations that confer stemness features to progenitor populations and resistance to BCR-ABL1 tyrosine kinase inhibitors. Comprehensive models of BC transformation have proved elusive because of the rarity and genetic heterogeneity of BC, but are important for developing biomarkers predicting BC progression and effective therapies. To better understand BC, we performed an integrated multiomics analysis of 74 CP and BC samples using whole-genome and exome sequencing, transcriptome and methylome profiling, and chromatin immunoprecipitation followed by high-throughput sequencing. Employing pathway-based analysis, we found the BC genome was significantly enriched for mutations affecting components of the polycomb repressive complex (PRC) pathway. While transcriptomically, BC progenitors were enriched and depleted for PRC1- and PRC2-related gene sets respectively. By integrating our data sets, we determined that BC progenitors undergo PRC-driven epigenetic reprogramming toward a convergent transcriptomic state. Specifically, PRC2 directs BC DNA hypermethylation, which in turn silences key genes involved in myeloid differentiation and tumor suppressor function via so-called epigenetic switching, whereas PRC1 represses an overlapping and distinct set of genes, including novel BC tumor suppressors. On the basis of these observations, we developed an integrated model of BC that facilitated the identification of combinatorial therapies capable of reversing BC reprogramming (decitabine+PRC1 inhibitors), novel PRC-silenced tumor suppressor genes (NR4A2), and gene expression signatures predictive of disease progression and drug resistance in CP. Targeted therapies against the BCR-ABL1 kinase have revolutionized treatment of chronic phase (CP) chronic myeloid leukemia (CML). In contrast, management of blast crisis (BC) CML remains challenging because BC cells acquire complex molecular alterations that confer stemness features to progenitor populations and resistance to BCR-ABL1 tyrosine kinase inhibitors. Comprehensive models of BC transformation have proved elusive because of the rarity and genetic heterogeneity of BC, but are important for developing biomarkers predicting BC progression and effective therapies. To better understand BC, we performed an integrated multiomics analysis of 74 CP and BC samples using whole-genome and exome sequencing, transcriptome and methylome profiling, and chromatin immunoprecipitation followed by high-throughput sequencing. Employing pathway-based analysis, we found the BC genome was significantly enriched for mutations affecting components of the polycomb repressive complex (PRC) pathway. While transcriptomically, BC progenitors were enriched and depleted for PRC1- and PRC2-related gene sets respectively. By integrating our data sets, we determined that BC progenitors undergo PRC-driven epigenetic reprogramming toward a convergent transcriptomic state. Specifically, PRC2 directs BC DNA hypermethylation, which in turn silences key genes involved in myeloid differentiation and tumor suppressor function via so-called epigenetic switching, whereas PRC1 represses an overlapping and distinct set of genes, including novel BC tumor suppressors. On the basis of these observations, we developed an integrated model of BC that facilitated the identification of combinatorial therapies capable of reversing BC reprogramming (decitabine+PRC1 inhibitors), novel PRC-silenced tumor suppressor genes (NR4A2), and gene expression signatures predictive of disease progression and drug resistance in CP. •Genetically heterogeneous BC progenitors demonstrate molecular convergence on PRC1- and PRC2-regulated pathways.•A model of PRC-driven reprogramming identifies novel BC combination therapies, tumor suppressor genes, and biomarkers for transformation. [Display omitted] |
Author | Malik, Simeen Bhatia, Ravi Velazquez Camacho, Oscar Ng, King Pan Xie, Kim Jiajing Ong, S. Tiong Chng, Wee-Joo Hoi, Qiangze Takahashi, Naoto Meah, Wee Yang Soh, Sheila Xinxuan Lee, Kian Leong Khor, Chiea Chuen Soon, Wei Jia W. Fruman, David A. Ko, Tun Kiat Hillmer, Axel M. Ong, Chin Thing J. Chan, Zhu En Khng, Alexis J. Tan, Joanna H.J. Heng, Xiu Ting Tan, Patrick Pathiraja, Thushangi N. Javed, Asif Sia, Yee Yen Teo, Audrey S.M. Chuah, Charles Liu, Xingliang Chan, Cheryl Xueli Ng, Pauline C. |
Author_xml | – sequence: 1 givenname: Tun Kiat surname: Ko fullname: Ko, Tun Kiat organization: Cancer & Stem Cell Biology Signature Research Programme, Duke-NUS Medical School, Singapore – sequence: 2 givenname: Asif orcidid: 0000-0002-6945-9624 surname: Javed fullname: Javed, Asif email: javed@hku.hk organization: Cancer Therapeutics & Stratified Oncology, Genome Institute of Singapore, Singapore – sequence: 3 givenname: Kian Leong orcidid: 0000-0002-0443-2746 surname: Lee fullname: Lee, Kian Leong organization: Cancer & Stem Cell Biology Signature Research Programme, Duke-NUS Medical School, Singapore – sequence: 4 givenname: Thushangi N. surname: Pathiraja fullname: Pathiraja, Thushangi N. organization: Cancer Therapeutics & Stratified Oncology, Genome Institute of Singapore, Singapore – sequence: 5 givenname: Xingliang surname: Liu fullname: Liu, Xingliang organization: Cancer Therapeutics & Stratified Oncology, Genome Institute of Singapore, Singapore – sequence: 6 givenname: 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Signature Research Programme, Duke-NUS Medical School, Singapore – sequence: 17 givenname: Zhu En surname: Chan fullname: Chan, Zhu En organization: Cancer & Stem Cell Biology Signature Research Programme, Duke-NUS Medical School, Singapore – sequence: 18 givenname: Kim Jiajing surname: Xie fullname: Xie, Kim Jiajing organization: Cancer & Stem Cell Biology Signature Research Programme, Duke-NUS Medical School, Singapore – sequence: 19 givenname: Qiangze surname: Hoi fullname: Hoi, Qiangze organization: Computational and Systems Biology, Genome Institute of Singapore, Singapore – sequence: 20 givenname: Cheryl Xueli surname: Chan fullname: Chan, Cheryl Xueli organization: Cancer Therapeutics & Stratified Oncology, Genome Institute of Singapore, Singapore – sequence: 21 givenname: Audrey S.M. surname: Teo fullname: Teo, Audrey S.M. organization: Cancer Therapeutics & Stratified Oncology, Genome Institute of Singapore, Singapore – sequence: 22 givenname: Oscar orcidid: 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Tiong orcidid: 0000-0001-9460-3483 surname: Ong fullname: Ong, S. Tiong organization: Cancer & Stem Cell Biology Signature Research Programme, Duke-NUS Medical School, Singapore |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32157296$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/j.ccell.2017.08.006 10.1038/nrc1991 10.1073/pnas.0510423103 10.1038/leu.2010.63 10.1126/scitranslmed.aad6066 10.1182/blood-2017-02-739490 10.1182/blood-2011-08-370981 10.1111/j.1600-0609.1988.tb00805.x 10.18632/oncotarget.20612 10.1172/JCI41246 10.1038/nm.2415 10.1101/gr.147942.112 10.1038/ng.620 10.1200/JCO.2005.11.981 10.1038/sj.leu.2404227 10.1016/j.stem.2011.12.017 10.1186/1471-2164-11-41 10.1038/ncomms8091 10.1016/j.stem.2010.08.002 10.1182/blood-2018-02-832253 10.1182/blood-2006-12-065599 10.1016/j.stem.2014.05.006 10.1016/j.ccr.2011.12.029 10.1101/gad.381706 10.1371/journal.pone.0074864 10.1038/s41568-018-0056-x 10.1038/ng1950 10.1200/JCO.2017.35.15_suppl.2574 10.1016/j.ccr.2013.03.030 10.1038/nature09165 10.1038/ng.621 10.1182/blood-2010-02-270660 10.1158/0008-5472.CAN-03-3247 10.1621/nrs.04002 10.1038/nature12213 10.1038/ng1972 10.1200/JCO.2015.66.2866 10.1093/carcin/bgp220 10.1158/0008-5472.CAN-10-1438 10.1182/blood-2011-06-363424 10.1182/blood-2014-06-581173 10.1182/blood-2010-02-267906 10.1128/MCB.02244-06 10.1038/onc.2015.195 10.1182/blood.V94.7.2452.419k23_2452_2460 10.1038/nature04431 10.1038/nature12477 10.1038/ncb1403 10.1182/blood-2015-02-626127 10.1182/blood-2014-10-606822 10.1038/nrc3130 10.1182/blood.V84.2.446.446 10.1093/molbev/msv212 10.1084/jem.20062662 10.1126/science.7809631 10.1038/nrc2931 10.1056/NEJMoa040258 10.1016/j.cell.2006.02.041 10.1182/blood-2017-07-795757 10.1016/0091-6749(94)90328-X 10.1158/2159-8290.CD-15-1439 10.1084/jem.20181276 10.1016/j.semcancer.2017.07.006 10.1182/blood-2011-06-359232 10.1016/j.cels.2015.12.004 10.1083/jcb.201808028 10.1038/nm.3418 10.1038/nm1579 10.1016/j.molimm.2010.10.016 10.1073/pnas.1301838110 10.1016/j.ccell.2018.03.025 10.1093/database/bav006 10.1182/blood-2009-03-210732 10.1038/nm.4336 10.1126/science.1075762 10.1038/leu.2016.143 10.1074/jbc.M007997200 10.1038/ng1941 10.1158/2159-8290.CD-16-0263 10.1634/stemcells.19-2-125 10.1038/ncb2125 10.1038/nrg3607 10.1001/jama.2010.1862 10.1182/blood-2017-05-783845 10.1038/ng.127 10.1074/jbc.M205121200 10.1002/cncr.11543 10.1371/journal.pone.0022110 10.1038/nm.4036 10.1016/j.ccr.2004.10.015 10.1210/me.2003-0247 10.1182/blood-2005-05-2155 10.1016/j.cell.2017.01.018 10.1038/nature11606 10.1038/sj.leu.2400796 10.1038/nature06866 10.1016/S2352-3026(15)00048-4 10.1016/j.cell.2017.08.002 10.3727/096504013X13786659070271 10.1182/blood-2012-03-380147 10.1186/gb-2011-12-4-r41 |
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References | Widschwendter, Fiegl, Egle (bib85) 2007; 39 Schuettengruber, Bourbon, Di Croce, Cavalli (bib20) 2017; 171 Beer, Knapp, Miller (bib49) 2015; 125 Jelinek, Gharibyan, Estecio (bib65) 2011; 6 Mullican, Zhang, Konopleva (bib102) 2007; 13 Sparmann, van Lohuizen (bib21) 2006; 6 Kantarjian, O'Brien, Cortes (bib61) 2003; 98 Belinky, Nativ, Stelzer (bib34) 2015; 2015 Serrano, Gómez-Lahoz, DePinho, Beach, Bar-Sagi (bib44) 1995; 267 Scott, Korfi, Saffrey (bib14) 2016; 6 Bracken, Dietrich, Pasini, Hansen, Helin (bib83) 2006; 20 Lytle, Barber, Reya (bib8) 2018; 18 Freire, Conneely (bib104) 2018; 131 Yamamoto, Tsuzuki, Minami (bib50) 2013; 8 Perrotti, Jamieson, Goldman, Skorski (bib3) 2010; 120 Alexandrov, Nik-Zainal, Wedge, ICGC PedBrain (bib26) 2013; 500 Viré, Brenner, Deplus (bib87) 2006; 439 Azuara, Perry, Sauer (bib89) 2006; 8 Manning, Whyte, Martinez, Hunter, Sudarsanam (bib42) 2002; 298 Mills (bib40) 2010; 10 Issa, Gharibyan, Cortes (bib60) 2005; 23 Vaz, Hwang, Kagiampakis (bib88) 2017; 32 Nikoloski, Langemeijer, Kuiper (bib58) 2010; 42 Liberzon, Birger, Thorvaldsdóttir, Ghandi, Mesirov, Tamayo (bib52) 2015; 1 Lim, Saw, Zhang (bib10) 2013; 110 Branford, Wang, Yeung (bib4) 2018; 132 Koppens, van Lohuizen (bib22) 2016; 35 Varley, Gertz, Bowling (bib68) 2013; 23 Ernst, Chase, Score (bib57) 2010; 42 Schlesinger, Straussman, Keshet (bib86) 2007; 39 Hehlmann (bib51) 2012; 120 Ben-Porath, Thomson, Carey (bib36) 2008; 40 Kantarjian, O'Brien, Keating (bib62) 1997; 11 Mermel, Schumacher, Hill, Meyerson, Beroukhim, Getz (bib32) 2011; 12 Zheng, Li, Haak (bib12) 2006; 20 Asimakopoulos, Shteper, Krichevsky (bib64) 1999; 94 Nauseef, Olsson, Arnljots (bib73) 1988; 40 McCabe, Ott, Ganji (bib79) 2012; 492 Heller, Topakian, Altenberger (bib63) 2016; 30 Koschmieder, Vetrie (bib13) 2018; 51 Eppert, Takenaka, Lechman (bib37) 2011; 17 Bai, Lu, Lin, Sun, Wang, Wang (bib43) 2013; 21 Rizo, Horton, Olthof (bib17) 2010; 116 Batliner, Mancarelli, Jenal (bib72) 2011; 48 Mohty, Yong, Szydlo, Apperley, Melo (bib16) 2007; 110 Pellicano, Park, Hopcroft (bib92) 2018; 131 Nacheva, Brazma, Virgili (bib33) 2010; 11 Gaymes, Mufti, Rassool (bib31) 2002; 62 Lawrence, Stojanov, Polak (bib29) 2013; 499 Laugesen, Helin (bib39) 2014; 14 Gruber, Chang, Sposto, Müschen (bib27) 2010; 70 Wang, Konze, Tao (bib98) 2015; 125 Zhao, Wang, Li (bib47) 2012; 119 Gargiulo, Cesaroni, Serresi (bib81) 2013; 23 Giustacchini, Thongjuea, Barkas (bib53) 2017; 23 Sasaki, Strom, O'Brien (bib1) 2015; 2 McGranahan, Swanton (bib5) 2017; 168 Feldhahn, Henke, Melchior (bib28) 2007; 204 Gentles, Plevritis, Majeti, Alizadeh (bib55) 2010; 304 Dawson, Elstner, Kizaki (bib71) 1994; 84 McWeeney, Pemberton, Loriaux (bib96) 2010; 115 Bower, Björkholm, Dickman, Höglund, Lambert, Andersson (bib2) 2016; 34 Infante, Bedard, Shapiro (bib105) 2017; 35 Dang, Wei, de Ridder (bib46) 2015; 125 Basheer, Giotopoulos, Meduri (bib24) 2019; 216 Sengupta, Ficker, Dunn, Madhu, Cancelas (bib18) 2012; 119 Brady, Gaymes, Cheung, Mufti, Rassool (bib30) 2003; 63 Iwama (bib23) 2017; 130 Kim, Roberts (bib25) 2016; 22 Getting, Mahoney, Cao (bib76) 2002; 277 Yong, Szydlo, Goldman, Apperley, Melo (bib97) 2006; 107 Kang, Yi, Guo (bib75) 2001; 276 Huntly, Shigematsu, Deguchi (bib91) 2004; 6 Amabile, Di Ruscio, Müller (bib99) 2015; 6 Virely, Moulin, Cobaleda (bib45) 2010; 24 Konieczkowski, Johannessen, Garraway (bib6) 2018; 33 Di Carlo, Mocavini, Di Croce (bib19) 2019; 218 Chen, He (bib7) 2016; 33 Radich, Dai, Mao (bib11) 2006; 103 Chen, Dent (bib38) 2014; 15 Ramirez-Herrick, Mullican, Sheehan, Conneely (bib103) 2011; 117 Jamieson, Ailles, Dylla (bib9) 2004; 351 Sauvageau, Sauvageau (bib41) 2010; 7 Bernstein, Mikkelsen, Xie (bib90) 2006; 125 Sharma, Kelly, Jones (bib100) 2010; 31 Maunakea, Nagarajan, Bilenky (bib67) 2010; 466 Mullighan, Miller, Radtke (bib48) 2008; 453 Baylin, Jones (bib66) 2011; 11 Yong, Basseres, Welner (bib80) 2016; 8 Kahn, Dorafshan, Schultheis (bib77) 2016; 44 Wiederschain, Chen, Johnson (bib82) 2007; 27 Maxwell, Muscat (bib94) 2006; 4 Lekstrom-Himes (bib70) 2001; 19 Maifrede, Magimaidas, Sha, Mukherjee, Liebermann, Hoffman (bib93) 2017; 8 Ly, Arechiga, Melo, Walsh, Ong (bib54) 2003; 63 Thomas, Haskell, Sarmiento, Bilimoria (bib74) 1994; 94 Sirin, Lukov, Mao, Conneely, Goodell (bib101) 2010; 12 Kreso, van Galen, Pedley (bib78) 2014; 20 Lammi, Huppunen, Aarnisalo (bib95) 2004; 18 Georgantas, Tanadve, Malehorn (bib56) 2004; 64 Brookes, de Santiago, Hebenstreit (bib35) 2012; 10 Ohm, McGarvey, Yu (bib84) 2007; 39 Guglielmelli, Biamonte, Score (bib59) 2011; 118 Xie, Peng, Huang (bib15) 2016; 6 Tsai, Li, Van Neste (bib69) 2012; 21 32585023 - Blood. 2020 Jun 25;135(26):2327-2328 Vaz (2020062511295764200_B88) 2017; 32 Schuettengruber (2020062511295764200_B20) 2017; 171 Mullican (2020062511295764200_B102) 2007; 13 Mohty (2020062511295764200_B16) 2007; 110 Bai (2020062511295764200_B43) 2013; 21 Amabile (2020062511295764200_B99) 2015; 6 Maunakea (2020062511295764200_B67) 2010; 466 Lekstrom-Himes (2020062511295764200_B70) 2001; 19 Koschmieder (2020062511295764200_B13) 2018; 51 McCabe (2020062511295764200_B79) 2012; 492 Batliner (2020062511295764200_B72) 2011; 48 Laugesen (2020062511295764200_B39) 2014; 14 Viré (2020062511295764200_B87) 2006; 439 Huntly (2020062511295764200_B91) 2004; 6 Chen (2020062511295764200_B7) 2016; 33 Issa (2020062511295764200_B60) 2005; 23 Scott (2020062511295764200_B14) 2016; 6 Chen (2020062511295764200_B38) 2014; 15 Gentles (2020062511295764200_B55) 2010; 304 Lammi (2020062511295764200_B95) 2004; 18 Koppens (2020062511295764200_B22) 2016; 35 Gargiulo (2020062511295764200_B81) 2013; 23 Iwama (2020062511295764200_B23) 2017; 130 Radich (2020062511295764200_B11) 2006; 103 Mermel (2020062511295764200_B32) 2011; 12 Xie (2020062511295764200_B15) 2016; 6 Feldhahn (2020062511295764200_B28) 2007; 204 Wang (2020062511295764200_B98) 2015; 125 Ohm (2020062511295764200_B84) 2007; 39 Varley (2020062511295764200_B68) 2013; 23 Alexandrov (2020062511295764200_B26) 2013; 500 Dawson (2020062511295764200_B71) 1994; 84 Schlesinger (2020062511295764200_B86) 2007; 39 Kang (2020062511295764200_B75) 2001; 276 Getting (2020062511295764200_B76) 2002; 277 Rizo (2020062511295764200_B17) 2010; 116 Kantarjian (2020062511295764200_B62) 1997; 11 Asimakopoulos (2020062511295764200_B64) 1999; 94 Bracken (2020062511295764200_B83) 2006; 20 Ramirez-Herrick (2020062511295764200_B103) 2011; 117 Brookes (2020062511295764200_B35) 2012; 10 Sauvageau (2020062511295764200_B41) 2010; 7 Guglielmelli (2020062511295764200_B59) 2011; 118 Manning (2020062511295764200_B42) 2002; 298 Ernst (2020062511295764200_B57) 2010; 42 Sharma (2020062511295764200_B100) 2010; 31 Maifrede (2020062511295764200_B93) 2017; 8 McWeeney (2020062511295764200_B96) 2010; 115 Jelinek (2020062511295764200_B65) 2011; 6 Basheer (2020062511295764200_B24) 2019; 216 Widschwendter (2020062511295764200_B85) 2007; 39 Nikoloski (2020062511295764200_B58) 2010; 42 Azuara (2020062511295764200_B89) 2006; 8 Liberzon (2020062511295764200_B52) 2015; 1 Lytle (2020062511295764200_B8) 2018; 18 Kim (2020062511295764200_B25) 2016; 22 Ly (2020062511295764200_B54) 2003; 63 Kreso (2020062511295764200_B78) 2014; 20 Freire (2020062511295764200_B104) 2018; 131 Zheng (2020062511295764200_B12) 2006; 20 Konieczkowski (2020062511295764200_B6) 2018; 33 Sengupta (2020062511295764200_B18) 2012; 119 Gruber (2020062511295764200_B27) 2010; 70 Beer (2020062511295764200_B49) 2015; 125 Georgantas (2020062511295764200_B56) 2004; 64 Branford (2020062511295764200_B4) 2018; 132 Serrano (2020062511295764200_B44) 1995; 267 Yong (2020062511295764200_B80) 2016; 8 Sirin (2020062511295764200_B101) 2010; 12 Mullighan (2020062511295764200_B48) 2008; 453 Mills (2020062511295764200_B40) 2010; 10 Lawrence (2020062511295764200_B29) 2013; 499 Brady (2020062511295764200_B30) 2003; 63 Bower (2020062511295764200_B2) 2016; 34 Jamieson (2020062511295764200_B9) 2004; 351 Lim (2020062511295764200_B10) 2013; 110 Zhao (2020062511295764200_B47) 2012; 119 Ben-Porath (2020062511295764200_B36) 2008; 40 Eppert (2020062511295764200_B37) 2011; 17 Tsai (2020062511295764200_B69) 2012; 21 Dang (2020062511295764200_B46) 2015; 125 Perrotti (2020062511295764200_B3) 2010; 120 Yong (2020062511295764200_B97) 2006; 107 Yamamoto (2020062511295764200_B50) 2013; 8 Gaymes (2020062511295764200_B31) 2002; 62 Bernstein (2020062511295764200_B90) 2006; 125 Thomas (2020062511295764200_B74) 1994; 94 Pellicano (2020062511295764200_B92) 2018; 131 Di Carlo (2020062511295764200_B19) 2019; 218 Baylin (2020062511295764200_B66) 2011; 11 Giustacchini (2020062511295764200_B53) 2017; 23 Maxwell (2020062511295764200_B94) 2006; 4 Infante (2020062511295764200_B105) 2017; 35 Heller (2020062511295764200_B63) 2016; 30 McGranahan (2020062511295764200_B5) 2017; 168 Hehlmann (2020062511295764200_B51) 2012; 120 Wiederschain (2020062511295764200_B82) 2007; 27 Nauseef (2020062511295764200_B73) 1988; 40 Kantarjian (2020062511295764200_B61) 2003; 98 Belinky (2020062511295764200_B34) 2015; 2015 Sparmann (2020062511295764200_B21) 2006; 6 Virely (2020062511295764200_B45) 2010; 24 Kahn (2020062511295764200_B77) 2016; 44 Nacheva (2020062511295764200_B33) 2010; 11 Sasaki (2020062511295764200_B1) 2015; 2 |
References_xml | – volume: 125 start-page: 315 year: 2006 end-page: 326 ident: bib90 article-title: A bivalent chromatin structure marks key developmental genes in embryonic stem cells publication-title: Cell contributor: fullname: Xie – volume: 22 start-page: 128 year: 2016 end-page: 134 ident: bib25 article-title: Targeting EZH2 in cancer publication-title: Nat Med contributor: fullname: Roberts – volume: 14 start-page: 735 year: 2014 end-page: 751 ident: bib39 article-title: Chromatin repressive complexes in stem cells, development, and cancer publication-title: Cell Stem Cell contributor: fullname: Helin – volume: 35 start-page: 1341 year: 2016 end-page: 1352 ident: bib22 article-title: Context-dependent actions of Polycomb repressors in cancer publication-title: Oncogene contributor: fullname: van Lohuizen – volume: 8 start-page: e74864 year: 2013 ident: bib50 article-title: Functionally deregulated AML1/RUNX1 cooperates with BCR-ABL to induce a blastic phase-like phenotype of chronic myelogenous leukemia in mice publication-title: PLoS One contributor: fullname: Minami – volume: 32 start-page: 360 year: 2017 end-page: 376 ident: bib88 article-title: Chronic cigarette smoke-induced epigenomic changes precede sensitization of bronchial epithelial cells to single-step transformation by KRAS mutations publication-title: Cancer Cell contributor: fullname: Kagiampakis – volume: 8 start-page: 69281 year: 2017 end-page: 69294 ident: bib93 article-title: Loss of Egr1, a human del5q gene, accelerates BCR-ABL driven chronic myelogenous leukemia publication-title: Oncotarget contributor: fullname: Hoffman – volume: 11 start-page: 41 year: 2010 ident: bib33 article-title: Deletions of immunoglobulin heavy chain and T cell receptor gene regions are uniquely associated with lymphoid blast transformation of chronic myeloid leukemia publication-title: BMC Genomics contributor: fullname: Virgili – volume: 23 start-page: 555 year: 2013 end-page: 567 ident: bib68 article-title: Dynamic DNA methylation across diverse human cell lines and tissues publication-title: Genome Res contributor: fullname: Bowling – volume: 119 start-page: 494 year: 2012 end-page: 502 ident: bib18 article-title: Bmi1 reprograms CML B-lymphoid progenitors to become B-ALL-initiating cells publication-title: Blood contributor: fullname: Cancelas – volume: 11 start-page: 1617 year: 1997 end-page: 1620 ident: bib62 article-title: Results of decitabine therapy in the accelerated and blastic phases of chronic myelogenous leukemia publication-title: Leukemia contributor: fullname: Keating – volume: 267 start-page: 249 year: 1995 end-page: 252 ident: bib44 article-title: Inhibition of ras-induced proliferation and cellular transformation by p16INK4 publication-title: Science contributor: fullname: Bar-Sagi – volume: 19 start-page: 125 year: 2001 end-page: 133 ident: bib70 article-title: The role of C/EBP(epsilon) in the terminal stages of granulocyte differentiation publication-title: Stem Cells contributor: fullname: Lekstrom-Himes – volume: 63 start-page: 1798 year: 2003 end-page: 1805 ident: bib30 article-title: Increased error-prone NHEJ activity in myeloid leukemias is associated with DNA damage at sites that recruit key nonhomologous end-joining proteins publication-title: Cancer Res contributor: fullname: Rassool – volume: 62 start-page: 2791 year: 2002 end-page: 2797 ident: bib31 article-title: Myeloid leukemias have increased activity of the nonhomologous end-joining pathway and concomitant DNA misrepair that is dependent on the Ku70/86 heterodimer publication-title: Cancer Res contributor: fullname: Rassool – volume: 2 start-page: e186 year: 2015 end-page: e193 ident: bib1 article-title: Relative survival in patients with chronic-phase chronic myeloid leukaemia in the tyrosine-kinase inhibitor era: analysis of patient data from six prospective clinical trials publication-title: Lancet Haematol contributor: fullname: O'Brien – volume: 216 start-page: 966 year: 2019 end-page: 981 ident: bib24 article-title: Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML publication-title: J Exp Med contributor: fullname: Meduri – volume: 39 start-page: 157 year: 2007 end-page: 158 ident: bib85 article-title: Epigenetic stem cell signature in cancer publication-title: Nat Genet contributor: fullname: Egle – volume: 132 start-page: 948 year: 2018 end-page: 961 ident: bib4 article-title: Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease publication-title: Blood contributor: fullname: Yeung – volume: 1 start-page: 417 year: 2015 end-page: 425 ident: bib52 article-title: The Molecular Signatures Database (MSigDB) hallmark gene set collection publication-title: Cell Syst contributor: fullname: Tamayo – volume: 6 start-page: 587 year: 2004 end-page: 596 ident: bib91 article-title: MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors publication-title: Cancer Cell contributor: fullname: Deguchi – volume: 34 start-page: 2851 year: 2016 end-page: 2857 ident: bib2 article-title: Life expectancy of patients with chronic myeloid leukemia approaches the life expectancy of the general population publication-title: J Clin Oncol contributor: fullname: Andersson – volume: 10 start-page: 157 year: 2012 end-page: 170 ident: bib35 article-title: Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs publication-title: Cell Stem Cell contributor: fullname: Hebenstreit – volume: 18 start-page: 1546 year: 2004 end-page: 1557 ident: bib95 article-title: Regulation of the osteopontin gene by the orphan nuclear receptor NURR1 in osteoblasts publication-title: Mol Endocrinol contributor: fullname: Aarnisalo – volume: 118 start-page: 5227 year: 2011 end-page: 5234 ident: bib59 article-title: EZH2 mutational status predicts poor survival in myelofibrosis publication-title: Blood contributor: fullname: Score – volume: 17 start-page: 1086 year: 2011 end-page: 1093 ident: bib37 article-title: Stem cell gene expression programs influence clinical outcome in human leukemia publication-title: Nat Med contributor: fullname: Lechman – volume: 120 start-page: 737 year: 2012 end-page: 747 ident: bib51 article-title: How I treat CML blast crisis publication-title: Blood contributor: fullname: Hehlmann – volume: 48 start-page: 714 year: 2011 end-page: 719 ident: bib72 article-title: CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation publication-title: Mol Immunol contributor: fullname: Jenal – volume: 33 start-page: 801 year: 2018 end-page: 815 ident: bib6 article-title: A convergence-based framework for cancer drug resistance publication-title: Cancer Cell contributor: fullname: Garraway – volume: 27 start-page: 4968 year: 2007 end-page: 4979 ident: bib82 article-title: Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis publication-title: Mol Cell Biol contributor: fullname: Johnson – volume: 42 start-page: 665 year: 2010 end-page: 667 ident: bib58 article-title: Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes publication-title: Nat Genet contributor: fullname: Kuiper – volume: 116 start-page: 4621 year: 2010 end-page: 4630 ident: bib17 article-title: BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells publication-title: Blood contributor: fullname: Olthof – volume: 439 start-page: 871 year: 2006 end-page: 874 ident: bib87 article-title: The Polycomb group protein EZH2 directly controls DNA methylation [published correction appears in publication-title: Nature contributor: fullname: Deplus – volume: 20 start-page: 29 year: 2014 end-page: 36 ident: bib78 article-title: Self-renewal as a therapeutic target in human colorectal cancer publication-title: Nat Med contributor: fullname: Pedley – volume: 10 start-page: 669 year: 2010 end-page: 682 ident: bib40 article-title: Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins publication-title: Nat Rev Cancer contributor: fullname: Mills – volume: 40 start-page: 97 year: 1988 end-page: 110 ident: bib73 article-title: Biosynthesis and processing of myeloperoxidase--a marker for myeloid cell differentiation publication-title: Eur J Haematol contributor: fullname: Arnljots – volume: 24 start-page: 1200 year: 2010 end-page: 1204 ident: bib45 article-title: Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia publication-title: Leukemia contributor: fullname: Cobaleda – volume: 8 start-page: 350ra104 year: 2016 ident: bib80 article-title: Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression publication-title: Sci Transl Med contributor: fullname: Welner – volume: 31 start-page: 27 year: 2010 end-page: 36 ident: bib100 article-title: Epigenetics in cancer publication-title: Carcinogenesis contributor: fullname: Jones – volume: 21 start-page: 430 year: 2012 end-page: 446 ident: bib69 article-title: Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells publication-title: Cancer Cell contributor: fullname: Van Neste – volume: 130 start-page: 23 year: 2017 end-page: 29 ident: bib23 article-title: Polycomb repressive complexes in hematological malignancies publication-title: Blood contributor: fullname: Iwama – volume: 107 start-page: 205 year: 2006 end-page: 212 ident: bib97 article-title: Molecular profiling of CD34+ cells identifies low expression of CD7, along with high expression of proteinase 3 or elastase, as predictors of longer survival in patients with CML publication-title: Blood contributor: fullname: Melo – volume: 110 start-page: 380 year: 2007 end-page: 383 ident: bib16 article-title: The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia publication-title: Blood contributor: fullname: Melo – volume: 277 start-page: 51068 year: 2002 end-page: 51076 ident: bib76 article-title: The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner publication-title: J Biol Chem contributor: fullname: Cao – volume: 63 start-page: 5716 year: 2003 end-page: 5722 ident: bib54 article-title: Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin publication-title: Cancer Res contributor: fullname: Ong – volume: 6 start-page: e22110 year: 2011 ident: bib65 article-title: Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia publication-title: PLoS One contributor: fullname: Estecio – volume: 51 start-page: 180 year: 2018 end-page: 197 ident: bib13 article-title: Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options publication-title: Semin Cancer Biol contributor: fullname: Vetrie – volume: 131 start-page: 1532 year: 2018 end-page: 1544 ident: bib92 article-title: -mediated regulation of E2F1 is required for CML stem/progenitor cell survival publication-title: Blood contributor: fullname: Hopcroft – volume: 23 start-page: 692 year: 2017 end-page: 702 ident: bib53 article-title: Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia publication-title: Nat Med contributor: fullname: Barkas – volume: 8 start-page: 532 year: 2006 end-page: 538 ident: bib89 article-title: Chromatin signatures of pluripotent cell lines publication-title: Nat Cell Biol contributor: fullname: Sauer – volume: 21 start-page: 23 year: 2013 end-page: 31 ident: bib43 article-title: Restoration of INK4a/ARF gene inhibits cell growth and cooperates with imatinib mesylate in Philadelphia chromosome-positive leukemias publication-title: Oncol Res contributor: fullname: Wang – volume: 304 start-page: 2706 year: 2010 end-page: 2715 ident: bib55 article-title: Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia publication-title: JAMA contributor: fullname: Alizadeh – volume: 171 start-page: 34 year: 2017 end-page: 57 ident: bib20 article-title: Genome regulation by polycomb and trithorax: 70 years and counting publication-title: Cell contributor: fullname: Cavalli – volume: 500 start-page: 415 year: 2013 end-page: 421 ident: bib26 article-title: Signatures of mutational processes in human cancer [published correction appears in publication-title: Nature contributor: fullname: ICGC PedBrain – volume: 84 start-page: 446 year: 1994 end-page: 452 ident: bib71 article-title: Myeloid differentiation mediated through retinoic acid receptor/retinoic X receptor (RXR) not RXR/RXR pathway publication-title: Blood contributor: fullname: Kizaki – volume: 33 start-page: 4 year: 2016 end-page: 12 ident: bib7 article-title: The convergent cancer evolution toward a single cellular destination publication-title: Mol Biol Evol contributor: fullname: He – volume: 98 start-page: 522 year: 2003 end-page: 528 ident: bib61 article-title: Results of decitabine (5-aza-2'deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia publication-title: Cancer contributor: fullname: Cortes – volume: 492 start-page: 108 year: 2012 end-page: 112 ident: bib79 article-title: EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations publication-title: Nature contributor: fullname: Ganji – volume: 6 start-page: 7091 year: 2015 ident: bib99 article-title: Dissecting the role of aberrant DNA methylation in human leukaemia publication-title: Nat Commun contributor: fullname: Müller – volume: 351 start-page: 657 year: 2004 end-page: 667 ident: bib9 article-title: Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML publication-title: N Engl J Med contributor: fullname: Dylla – volume: 39 start-page: 232 year: 2007 end-page: 236 ident: bib86 article-title: Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer publication-title: Nat Genet contributor: fullname: Keshet – volume: 18 start-page: 669 year: 2018 end-page: 680 ident: bib8 article-title: Stem cell fate in cancer growth, progression and therapy resistance publication-title: Nat Rev Cancer contributor: fullname: Reya – volume: 23 start-page: 660 year: 2013 end-page: 676 ident: bib81 article-title: In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis publication-title: Cancer Cell contributor: fullname: Serresi – volume: 20 start-page: 1123 year: 2006 end-page: 1136 ident: bib83 article-title: Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions publication-title: Genes Dev contributor: fullname: Helin – volume: 499 start-page: 214 year: 2013 end-page: 218 ident: bib29 article-title: Mutational heterogeneity in cancer and the search for new cancer-associated genes publication-title: Nature contributor: fullname: Polak – volume: 11 start-page: 726 year: 2011 end-page: 734 ident: bib66 article-title: A decade of exploring the cancer epigenome - biological and translational implications publication-title: Nat Rev Cancer contributor: fullname: Jones – volume: 13 start-page: 730 year: 2007 end-page: 735 ident: bib102 article-title: Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia publication-title: Nat Med contributor: fullname: Konopleva – volume: 42 start-page: 722 year: 2010 end-page: 726 ident: bib57 article-title: Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders publication-title: Nat Genet contributor: fullname: Score – volume: 64 start-page: 4434 year: 2004 end-page: 4441 ident: bib56 article-title: Microarray and serial analysis of gene expression analyses identify known and novel transcripts overexpressed in hematopoietic stem cells publication-title: Cancer Res contributor: fullname: Malehorn – volume: 94 start-page: 2452 year: 1999 end-page: 2460 ident: bib64 article-title: ABL1 methylation is a distinct molecular event associated with clonal evolution of chronic myeloid leukemia publication-title: Blood contributor: fullname: Krichevsky – volume: 20 start-page: 1028 year: 2006 end-page: 1034 ident: bib12 article-title: Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis publication-title: Leukemia contributor: fullname: Haak – volume: 6 start-page: 1237 year: 2016 end-page: 1247 ident: bib15 article-title: Chronic myelogenous leukemia- initiating cells require polycomb group protein EZH2 publication-title: Cancer Discov contributor: fullname: Huang – volume: 40 start-page: 499 year: 2008 end-page: 507 ident: bib36 article-title: An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors publication-title: Nat Genet contributor: fullname: Carey – volume: 7 start-page: 299 year: 2010 end-page: 313 ident: bib41 article-title: Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer publication-title: Cell Stem Cell contributor: fullname: Sauvageau – volume: 276 start-page: 21960 year: 2001 end-page: 21968 ident: bib75 article-title: Subcellular distribution and cytokine- and chemokine-regulated secretion of leukolysin/MT6-MMP/MMP-25 in neutrophils publication-title: J Biol Chem contributor: fullname: Guo – volume: 131 start-page: 1081 year: 2018 end-page: 1093 ident: bib104 article-title: NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling publication-title: Blood contributor: fullname: Conneely – volume: 6 start-page: 846 year: 2006 end-page: 856 ident: bib21 article-title: Polycomb silencers control cell fate, development and cancer publication-title: Nat Rev Cancer contributor: fullname: van Lohuizen – volume: 466 start-page: 253 year: 2010 end-page: 257 ident: bib67 article-title: Conserved role of intragenic DNA methylation in regulating alternative promoters publication-title: Nature contributor: fullname: Bilenky – volume: 115 start-page: 315 year: 2010 end-page: 325 ident: bib96 article-title: A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib publication-title: Blood contributor: fullname: Loriaux – volume: 12 start-page: R41 year: 2011 ident: bib32 article-title: GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers publication-title: Genome Biol contributor: fullname: Getz – volume: 168 start-page: 613 year: 2017 end-page: 628 ident: bib5 article-title: Clonal heterogeneity and tumor evolution: past, present, and the future publication-title: Cell contributor: fullname: Swanton – volume: 298 start-page: 1912 year: 2002 end-page: 1934 ident: bib42 article-title: The protein kinase complement of the human genome publication-title: Science contributor: fullname: Sudarsanam – volume: 23 start-page: 3948 year: 2005 end-page: 3956 ident: bib60 article-title: Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate publication-title: J Clin Oncol contributor: fullname: Cortes – volume: 2015 start-page: bav006 year: 2015 ident: bib34 article-title: PathCards: multi-source consolidation of human biological pathways publication-title: Database (Oxford) contributor: fullname: Stelzer – volume: 103 start-page: 2794 year: 2006 end-page: 2799 ident: bib11 article-title: Gene expression changes associated with progression and response in chronic myeloid leukemia publication-title: Proc Natl Acad Sci USA contributor: fullname: Mao – volume: 120 start-page: 2254 year: 2010 end-page: 2264 ident: bib3 article-title: Chronic myeloid leukemia: mechanisms of blastic transformation publication-title: J Clin Invest contributor: fullname: Skorski – volume: 117 start-page: 2681 year: 2011 end-page: 2690 ident: bib103 article-title: Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice publication-title: Blood contributor: fullname: Conneely – volume: 204 start-page: 1157 year: 2007 end-page: 1166 ident: bib28 article-title: Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells publication-title: J Exp Med contributor: fullname: Melchior – volume: 12 start-page: 1213 year: 2010 end-page: 1219 ident: bib101 article-title: The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells publication-title: Nat Cell Biol contributor: fullname: Goodell – volume: 125 start-page: 504 year: 2015 end-page: 515 ident: bib49 article-title: Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression publication-title: Blood contributor: fullname: Miller – volume: 218 start-page: 55 year: 2019 end-page: 69 ident: bib19 article-title: Polycomb complexes in normal and malignant hematopoiesis publication-title: J Cell Biol contributor: fullname: Di Croce – volume: 35 start-page: 2574 year: 2017 ident: bib105 article-title: Phase 1 results of PTC596, a novel small molecule targeting cancer stem cells (CSCs) by reducing levels of BMI1 protein publication-title: J Clin Oncol contributor: fullname: Shapiro – volume: 119 start-page: 2873 year: 2012 end-page: 2882 ident: bib47 article-title: Functional features of RUNX1 mutants in acute transformation of chronic myeloid leukemia and their contribution to inducing murine full-blown leukemia publication-title: Blood contributor: fullname: Li – volume: 110 start-page: E2298 year: 2013 end-page: E2307 ident: bib10 article-title: Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function publication-title: Proc Natl Acad Sci USA contributor: fullname: Zhang – volume: 44 start-page: 10132 year: 2016 end-page: 10149 ident: bib77 article-title: Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements publication-title: Nucleic Acids Res contributor: fullname: Schultheis – volume: 30 start-page: 1861 year: 2016 end-page: 1868 ident: bib63 article-title: Next-generation sequencing identifies major DNA methylation changes during progression of Ph+ chronic myeloid leukemia publication-title: Leukemia contributor: fullname: Altenberger – volume: 125 start-page: 3609 year: 2015 end-page: 3617 ident: bib46 article-title: PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia publication-title: Blood contributor: fullname: de Ridder – volume: 453 start-page: 110 year: 2008 end-page: 114 ident: bib48 article-title: BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros publication-title: Nature contributor: fullname: Radtke – volume: 6 start-page: 1248 year: 2016 end-page: 1257 ident: bib14 article-title: Epigenetic reprogramming sensitizes CML stem cells to combined EZH2 and tyrosine kinase inhibition publication-title: Cancer Discov contributor: fullname: Saffrey – volume: 70 start-page: 7411 year: 2010 end-page: 7420 ident: bib27 article-title: Activation-induced cytidine deaminase accelerates clonal evolution in BCR-ABL1-driven B-cell lineage acute lymphoblastic leukemia publication-title: Cancer Res contributor: fullname: Müschen – volume: 4 start-page: e002 year: 2006 ident: bib94 article-title: The NR4A subgroup: immediate early response genes with pleiotropic physiological roles publication-title: Nucl Recept Signal contributor: fullname: Muscat – volume: 39 start-page: 237 year: 2007 end-page: 242 ident: bib84 article-title: A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing publication-title: Nat Genet contributor: fullname: Yu – volume: 94 start-page: 1171 year: 1994 end-page: 1176 ident: bib74 article-title: Distinguishing features of basophil and neutrophil activation by major basic protein publication-title: J Allergy Clin Immunol contributor: fullname: Bilimoria – volume: 125 start-page: 1217 year: 2015 end-page: 1225 ident: bib98 article-title: Polycomb genes, miRNA, and their deregulation in B-cell malignancies publication-title: Blood contributor: fullname: Tao – volume: 15 start-page: 93 year: 2014 end-page: 106 ident: bib38 article-title: Chromatin modifiers and remodellers: regulators of cellular differentiation publication-title: Nat Rev Genet contributor: fullname: Dent – volume: 32 start-page: 360 issue: 3 year: 2017 ident: 2020062511295764200_B88 article-title: Chronic cigarette smoke-induced epigenomic changes precede sensitization of bronchial epithelial cells to single-step transformation by KRAS mutations publication-title: Cancer Cell doi: 10.1016/j.ccell.2017.08.006 contributor: fullname: Vaz – volume: 6 start-page: 846 issue: 11 year: 2006 ident: 2020062511295764200_B21 article-title: Polycomb silencers control cell fate, development and cancer publication-title: Nat Rev Cancer doi: 10.1038/nrc1991 contributor: fullname: Sparmann – volume: 103 start-page: 2794 issue: 8 year: 2006 ident: 2020062511295764200_B11 article-title: Gene expression changes associated with progression and response in chronic myeloid leukemia publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0510423103 contributor: fullname: Radich – volume: 24 start-page: 1200 issue: 6 year: 2010 ident: 2020062511295764200_B45 article-title: Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia publication-title: Leukemia doi: 10.1038/leu.2010.63 contributor: fullname: Virely – volume: 8 start-page: 350ra104 issue: 350 year: 2016 ident: 2020062511295764200_B80 article-title: Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aad6066 contributor: fullname: Yong – volume: 130 start-page: 23 issue: 1 year: 2017 ident: 2020062511295764200_B23 article-title: Polycomb repressive complexes in hematological malignancies publication-title: Blood doi: 10.1182/blood-2017-02-739490 contributor: fullname: Iwama – volume: 119 start-page: 2873 issue: 12 year: 2012 ident: 2020062511295764200_B47 article-title: Functional features of RUNX1 mutants in acute transformation of chronic myeloid leukemia and their contribution to inducing murine full-blown leukemia publication-title: Blood doi: 10.1182/blood-2011-08-370981 contributor: fullname: Zhao – volume: 40 start-page: 97 issue: 2 year: 1988 ident: 2020062511295764200_B73 article-title: Biosynthesis and processing of myeloperoxidase--a marker for myeloid cell differentiation publication-title: Eur J Haematol doi: 10.1111/j.1600-0609.1988.tb00805.x contributor: fullname: Nauseef – volume: 8 start-page: 69281 issue: 41 year: 2017 ident: 2020062511295764200_B93 article-title: Loss of Egr1, a human del5q gene, accelerates BCR-ABL driven chronic myelogenous leukemia publication-title: Oncotarget doi: 10.18632/oncotarget.20612 contributor: fullname: Maifrede – volume: 120 start-page: 2254 issue: 7 year: 2010 ident: 2020062511295764200_B3 article-title: Chronic myeloid leukemia: mechanisms of blastic transformation publication-title: J Clin Invest doi: 10.1172/JCI41246 contributor: fullname: Perrotti – volume: 17 start-page: 1086 issue: 9 year: 2011 ident: 2020062511295764200_B37 article-title: Stem cell gene expression programs influence clinical outcome in human leukemia publication-title: Nat Med doi: 10.1038/nm.2415 contributor: fullname: Eppert – volume: 23 start-page: 555 issue: 3 year: 2013 ident: 2020062511295764200_B68 article-title: Dynamic DNA methylation across diverse human cell lines and tissues publication-title: Genome Res doi: 10.1101/gr.147942.112 contributor: fullname: Varley – volume: 42 start-page: 665 issue: 8 year: 2010 ident: 2020062511295764200_B58 article-title: Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes publication-title: Nat Genet doi: 10.1038/ng.620 contributor: fullname: Nikoloski – volume: 23 start-page: 3948 issue: 17 year: 2005 ident: 2020062511295764200_B60 article-title: Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate publication-title: J Clin Oncol doi: 10.1200/JCO.2005.11.981 contributor: fullname: Issa – volume: 44 start-page: 10132 issue: 21 year: 2016 ident: 2020062511295764200_B77 article-title: Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements publication-title: Nucleic Acids Res contributor: fullname: Kahn – volume: 20 start-page: 1028 issue: 6 year: 2006 ident: 2020062511295764200_B12 article-title: Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis publication-title: Leukemia doi: 10.1038/sj.leu.2404227 contributor: fullname: Zheng – volume: 10 start-page: 157 issue: 2 year: 2012 ident: 2020062511295764200_B35 article-title: Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs publication-title: Cell Stem Cell doi: 10.1016/j.stem.2011.12.017 contributor: fullname: Brookes – volume: 11 start-page: 41 issue: 1 year: 2010 ident: 2020062511295764200_B33 article-title: Deletions of immunoglobulin heavy chain and T cell receptor gene regions are uniquely associated with lymphoid blast transformation of chronic myeloid leukemia publication-title: BMC Genomics doi: 10.1186/1471-2164-11-41 contributor: fullname: Nacheva – volume: 63 start-page: 1798 issue: 8 year: 2003 ident: 2020062511295764200_B30 article-title: Increased error-prone NHEJ activity in myeloid leukemias is associated with DNA damage at sites that recruit key nonhomologous end-joining proteins publication-title: Cancer Res contributor: fullname: Brady – volume: 6 start-page: 7091 issue: 1 year: 2015 ident: 2020062511295764200_B99 article-title: Dissecting the role of aberrant DNA methylation in human leukaemia publication-title: Nat Commun doi: 10.1038/ncomms8091 contributor: fullname: Amabile – volume: 7 start-page: 299 issue: 3 year: 2010 ident: 2020062511295764200_B41 article-title: Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer publication-title: Cell Stem Cell doi: 10.1016/j.stem.2010.08.002 contributor: fullname: Sauvageau – volume: 132 start-page: 948 issue: 9 year: 2018 ident: 2020062511295764200_B4 article-title: Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease publication-title: Blood doi: 10.1182/blood-2018-02-832253 contributor: fullname: Branford – volume: 110 start-page: 380 issue: 1 year: 2007 ident: 2020062511295764200_B16 article-title: The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia publication-title: Blood doi: 10.1182/blood-2006-12-065599 contributor: fullname: Mohty – volume: 14 start-page: 735 issue: 6 year: 2014 ident: 2020062511295764200_B39 article-title: Chromatin repressive complexes in stem cells, development, and cancer publication-title: Cell Stem Cell doi: 10.1016/j.stem.2014.05.006 contributor: fullname: Laugesen – volume: 21 start-page: 430 issue: 3 year: 2012 ident: 2020062511295764200_B69 article-title: Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells publication-title: Cancer Cell doi: 10.1016/j.ccr.2011.12.029 contributor: fullname: Tsai – volume: 20 start-page: 1123 issue: 9 year: 2006 ident: 2020062511295764200_B83 article-title: Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions publication-title: Genes Dev doi: 10.1101/gad.381706 contributor: fullname: Bracken – volume: 8 start-page: e74864 issue: 9 year: 2013 ident: 2020062511295764200_B50 article-title: Functionally deregulated AML1/RUNX1 cooperates with BCR-ABL to induce a blastic phase-like phenotype of chronic myelogenous leukemia in mice publication-title: PLoS One doi: 10.1371/journal.pone.0074864 contributor: fullname: Yamamoto – volume: 18 start-page: 669 issue: 11 year: 2018 ident: 2020062511295764200_B8 article-title: Stem cell fate in cancer growth, progression and therapy resistance publication-title: Nat Rev Cancer doi: 10.1038/s41568-018-0056-x contributor: fullname: Lytle – volume: 39 start-page: 232 issue: 2 year: 2007 ident: 2020062511295764200_B86 article-title: Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer publication-title: Nat Genet doi: 10.1038/ng1950 contributor: fullname: Schlesinger – volume: 35 start-page: 2574 issue: 15_suppl year: 2017 ident: 2020062511295764200_B105 article-title: Phase 1 results of PTC596, a novel small molecule targeting cancer stem cells (CSCs) by reducing levels of BMI1 protein publication-title: J Clin Oncol doi: 10.1200/JCO.2017.35.15_suppl.2574 contributor: fullname: Infante – volume: 23 start-page: 660 issue: 5 year: 2013 ident: 2020062511295764200_B81 article-title: In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis publication-title: Cancer Cell doi: 10.1016/j.ccr.2013.03.030 contributor: fullname: Gargiulo – volume: 466 start-page: 253 issue: 7303 year: 2010 ident: 2020062511295764200_B67 article-title: Conserved role of intragenic DNA methylation in regulating alternative promoters publication-title: Nature doi: 10.1038/nature09165 contributor: fullname: Maunakea – volume: 42 start-page: 722 issue: 8 year: 2010 ident: 2020062511295764200_B57 article-title: Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders publication-title: Nat Genet doi: 10.1038/ng.621 contributor: fullname: Ernst – volume: 116 start-page: 4621 issue: 22 year: 2010 ident: 2020062511295764200_B17 article-title: BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells publication-title: Blood doi: 10.1182/blood-2010-02-270660 contributor: fullname: Rizo – volume: 64 start-page: 4434 issue: 13 year: 2004 ident: 2020062511295764200_B56 article-title: Microarray and serial analysis of gene expression analyses identify known and novel transcripts overexpressed in hematopoietic stem cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-03-3247 contributor: fullname: Georgantas – volume: 4 start-page: e002 issue: 1 year: 2006 ident: 2020062511295764200_B94 article-title: The NR4A subgroup: immediate early response genes with pleiotropic physiological roles publication-title: Nucl Recept Signal doi: 10.1621/nrs.04002 contributor: fullname: Maxwell – volume: 499 start-page: 214 issue: 7457 year: 2013 ident: 2020062511295764200_B29 article-title: Mutational heterogeneity in cancer and the search for new cancer-associated genes publication-title: Nature doi: 10.1038/nature12213 contributor: fullname: Lawrence – volume: 39 start-page: 237 issue: 2 year: 2007 ident: 2020062511295764200_B84 article-title: A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing publication-title: Nat Genet doi: 10.1038/ng1972 contributor: fullname: Ohm – volume: 34 start-page: 2851 issue: 24 year: 2016 ident: 2020062511295764200_B2 article-title: Life expectancy of patients with chronic myeloid leukemia approaches the life expectancy of the general population publication-title: J Clin Oncol doi: 10.1200/JCO.2015.66.2866 contributor: fullname: Bower – volume: 31 start-page: 27 issue: 1 year: 2010 ident: 2020062511295764200_B100 article-title: Epigenetics in cancer publication-title: Carcinogenesis doi: 10.1093/carcin/bgp220 contributor: fullname: Sharma – volume: 63 start-page: 5716 issue: 18 year: 2003 ident: 2020062511295764200_B54 article-title: Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin publication-title: Cancer Res contributor: fullname: Ly – volume: 70 start-page: 7411 issue: 19 year: 2010 ident: 2020062511295764200_B27 article-title: Activation-induced cytidine deaminase accelerates clonal evolution in BCR-ABL1-driven B-cell lineage acute lymphoblastic leukemia publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-10-1438 contributor: fullname: Gruber – volume: 118 start-page: 5227 issue: 19 year: 2011 ident: 2020062511295764200_B59 article-title: EZH2 mutational status predicts poor survival in myelofibrosis publication-title: Blood doi: 10.1182/blood-2011-06-363424 contributor: fullname: Guglielmelli – volume: 125 start-page: 504 issue: 3 year: 2015 ident: 2020062511295764200_B49 article-title: Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression publication-title: Blood doi: 10.1182/blood-2014-06-581173 contributor: fullname: Beer – volume: 117 start-page: 2681 issue: 9 year: 2011 ident: 2020062511295764200_B103 article-title: Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice publication-title: Blood doi: 10.1182/blood-2010-02-267906 contributor: fullname: Ramirez-Herrick – volume: 27 start-page: 4968 issue: 13 year: 2007 ident: 2020062511295764200_B82 article-title: Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis publication-title: Mol Cell Biol doi: 10.1128/MCB.02244-06 contributor: fullname: Wiederschain – volume: 35 start-page: 1341 issue: 11 year: 2016 ident: 2020062511295764200_B22 article-title: Context-dependent actions of Polycomb repressors in cancer publication-title: Oncogene doi: 10.1038/onc.2015.195 contributor: fullname: Koppens – volume: 94 start-page: 2452 issue: 7 year: 1999 ident: 2020062511295764200_B64 article-title: ABL1 methylation is a distinct molecular event associated with clonal evolution of chronic myeloid leukemia publication-title: Blood doi: 10.1182/blood.V94.7.2452.419k23_2452_2460 contributor: fullname: Asimakopoulos – volume: 439 start-page: 871 issue: 7078 year: 2006 ident: 2020062511295764200_B87 article-title: The Polycomb group protein EZH2 directly controls DNA methylation [published correction appears in Nature. 2007;446(7137):824] publication-title: Nature doi: 10.1038/nature04431 contributor: fullname: Viré – volume: 500 start-page: 415 issue: 7463 year: 2013 ident: 2020062511295764200_B26 article-title: Signatures of mutational processes in human cancer [published correction appears in Nature. 2013;502(7470):258] publication-title: Nature doi: 10.1038/nature12477 contributor: fullname: Alexandrov – volume: 8 start-page: 532 issue: 5 year: 2006 ident: 2020062511295764200_B89 article-title: Chromatin signatures of pluripotent cell lines publication-title: Nat Cell Biol doi: 10.1038/ncb1403 contributor: fullname: Azuara – volume: 125 start-page: 3609 issue: 23 year: 2015 ident: 2020062511295764200_B46 article-title: PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia publication-title: Blood doi: 10.1182/blood-2015-02-626127 contributor: fullname: Dang – volume: 125 start-page: 1217 issue: 8 year: 2015 ident: 2020062511295764200_B98 article-title: Polycomb genes, miRNA, and their deregulation in B-cell malignancies publication-title: Blood doi: 10.1182/blood-2014-10-606822 contributor: fullname: Wang – volume: 11 start-page: 726 issue: 10 year: 2011 ident: 2020062511295764200_B66 article-title: A decade of exploring the cancer epigenome - biological and translational implications publication-title: Nat Rev Cancer doi: 10.1038/nrc3130 contributor: fullname: Baylin – volume: 84 start-page: 446 issue: 2 year: 1994 ident: 2020062511295764200_B71 article-title: Myeloid differentiation mediated through retinoic acid receptor/retinoic X receptor (RXR) not RXR/RXR pathway publication-title: Blood doi: 10.1182/blood.V84.2.446.446 contributor: fullname: Dawson – volume: 33 start-page: 4 issue: 1 year: 2016 ident: 2020062511295764200_B7 article-title: The convergent cancer evolution toward a single cellular destination publication-title: Mol Biol Evol doi: 10.1093/molbev/msv212 contributor: fullname: Chen – volume: 204 start-page: 1157 issue: 5 year: 2007 ident: 2020062511295764200_B28 article-title: Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells publication-title: J Exp Med doi: 10.1084/jem.20062662 contributor: fullname: Feldhahn – volume: 267 start-page: 249 issue: 5195 year: 1995 ident: 2020062511295764200_B44 article-title: Inhibition of ras-induced proliferation and cellular transformation by p16INK4 publication-title: Science doi: 10.1126/science.7809631 contributor: fullname: Serrano – volume: 10 start-page: 669 issue: 10 year: 2010 ident: 2020062511295764200_B40 article-title: Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins publication-title: Nat Rev Cancer doi: 10.1038/nrc2931 contributor: fullname: Mills – volume: 351 start-page: 657 issue: 7 year: 2004 ident: 2020062511295764200_B9 article-title: Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML publication-title: N Engl J Med doi: 10.1056/NEJMoa040258 contributor: fullname: Jamieson – volume: 125 start-page: 315 issue: 2 year: 2006 ident: 2020062511295764200_B90 article-title: A bivalent chromatin structure marks key developmental genes in embryonic stem cells publication-title: Cell doi: 10.1016/j.cell.2006.02.041 contributor: fullname: Bernstein – volume: 131 start-page: 1081 issue: 10 year: 2018 ident: 2020062511295764200_B104 article-title: NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling publication-title: Blood doi: 10.1182/blood-2017-07-795757 contributor: fullname: Freire – volume: 94 start-page: 1171 issue: 6 Pt 2 year: 1994 ident: 2020062511295764200_B74 article-title: Distinguishing features of basophil and neutrophil activation by major basic protein publication-title: J Allergy Clin Immunol doi: 10.1016/0091-6749(94)90328-X contributor: fullname: Thomas – volume: 6 start-page: 1237 issue: 11 year: 2016 ident: 2020062511295764200_B15 article-title: Chronic myelogenous leukemia- initiating cells require polycomb group protein EZH2 publication-title: Cancer Discov doi: 10.1158/2159-8290.CD-15-1439 contributor: fullname: Xie – volume: 216 start-page: 966 issue: 4 year: 2019 ident: 2020062511295764200_B24 article-title: Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML publication-title: J Exp Med doi: 10.1084/jem.20181276 contributor: fullname: Basheer – volume: 51 start-page: 180 year: 2018 ident: 2020062511295764200_B13 article-title: Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options publication-title: Semin Cancer Biol doi: 10.1016/j.semcancer.2017.07.006 contributor: fullname: Koschmieder – volume: 119 start-page: 494 issue: 2 year: 2012 ident: 2020062511295764200_B18 article-title: Bmi1 reprograms CML B-lymphoid progenitors to become B-ALL-initiating cells publication-title: Blood doi: 10.1182/blood-2011-06-359232 contributor: fullname: Sengupta – volume: 1 start-page: 417 issue: 6 year: 2015 ident: 2020062511295764200_B52 article-title: The Molecular Signatures Database (MSigDB) hallmark gene set collection publication-title: Cell Syst doi: 10.1016/j.cels.2015.12.004 contributor: fullname: Liberzon – volume: 218 start-page: 55 issue: 1 year: 2019 ident: 2020062511295764200_B19 article-title: Polycomb complexes in normal and malignant hematopoiesis publication-title: J Cell Biol doi: 10.1083/jcb.201808028 contributor: fullname: Di Carlo – volume: 20 start-page: 29 issue: 1 year: 2014 ident: 2020062511295764200_B78 article-title: Self-renewal as a therapeutic target in human colorectal cancer publication-title: Nat Med doi: 10.1038/nm.3418 contributor: fullname: Kreso – volume: 13 start-page: 730 issue: 6 year: 2007 ident: 2020062511295764200_B102 article-title: Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia publication-title: Nat Med doi: 10.1038/nm1579 contributor: fullname: Mullican – volume: 48 start-page: 714 issue: 4 year: 2011 ident: 2020062511295764200_B72 article-title: CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation publication-title: Mol Immunol doi: 10.1016/j.molimm.2010.10.016 contributor: fullname: Batliner – volume: 110 start-page: E2298 issue: 25 year: 2013 ident: 2020062511295764200_B10 article-title: Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1301838110 contributor: fullname: Lim – volume: 33 start-page: 801 issue: 5 year: 2018 ident: 2020062511295764200_B6 article-title: A convergence-based framework for cancer drug resistance publication-title: Cancer Cell doi: 10.1016/j.ccell.2018.03.025 contributor: fullname: Konieczkowski – volume: 2015 start-page: bav006 year: 2015 ident: 2020062511295764200_B34 article-title: PathCards: multi-source consolidation of human biological pathways publication-title: Database (Oxford) doi: 10.1093/database/bav006 contributor: fullname: Belinky – volume: 115 start-page: 315 issue: 2 year: 2010 ident: 2020062511295764200_B96 article-title: A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib publication-title: Blood doi: 10.1182/blood-2009-03-210732 contributor: fullname: McWeeney – volume: 23 start-page: 692 issue: 6 year: 2017 ident: 2020062511295764200_B53 article-title: Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia publication-title: Nat Med doi: 10.1038/nm.4336 contributor: fullname: Giustacchini – volume: 298 start-page: 1912 issue: 5600 year: 2002 ident: 2020062511295764200_B42 article-title: The protein kinase complement of the human genome publication-title: Science doi: 10.1126/science.1075762 contributor: fullname: Manning – volume: 30 start-page: 1861 issue: 9 year: 2016 ident: 2020062511295764200_B63 article-title: Next-generation sequencing identifies major DNA methylation changes during progression of Ph+ chronic myeloid leukemia publication-title: Leukemia doi: 10.1038/leu.2016.143 contributor: fullname: Heller – volume: 276 start-page: 21960 issue: 24 year: 2001 ident: 2020062511295764200_B75 article-title: Subcellular distribution and cytokine- and chemokine-regulated secretion of leukolysin/MT6-MMP/MMP-25 in neutrophils publication-title: J Biol Chem doi: 10.1074/jbc.M007997200 contributor: fullname: Kang – volume: 39 start-page: 157 issue: 2 year: 2007 ident: 2020062511295764200_B85 article-title: Epigenetic stem cell signature in cancer publication-title: Nat Genet doi: 10.1038/ng1941 contributor: fullname: Widschwendter – volume: 6 start-page: 1248 issue: 11 year: 2016 ident: 2020062511295764200_B14 article-title: Epigenetic reprogramming sensitizes CML stem cells to combined EZH2 and tyrosine kinase inhibition publication-title: Cancer Discov doi: 10.1158/2159-8290.CD-16-0263 contributor: fullname: Scott – volume: 19 start-page: 125 issue: 2 year: 2001 ident: 2020062511295764200_B70 article-title: The role of C/EBP(epsilon) in the terminal stages of granulocyte differentiation publication-title: Stem Cells doi: 10.1634/stemcells.19-2-125 contributor: fullname: Lekstrom-Himes – volume: 12 start-page: 1213 issue: 12 year: 2010 ident: 2020062511295764200_B101 article-title: The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells publication-title: Nat Cell Biol doi: 10.1038/ncb2125 contributor: fullname: Sirin – volume: 15 start-page: 93 issue: 2 year: 2014 ident: 2020062511295764200_B38 article-title: Chromatin modifiers and remodellers: regulators of cellular differentiation publication-title: Nat Rev Genet doi: 10.1038/nrg3607 contributor: fullname: Chen – volume: 304 start-page: 2706 issue: 24 year: 2010 ident: 2020062511295764200_B55 article-title: Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia publication-title: JAMA doi: 10.1001/jama.2010.1862 contributor: fullname: Gentles – volume: 131 start-page: 1532 issue: 14 year: 2018 ident: 2020062511295764200_B92 article-title: hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival publication-title: Blood doi: 10.1182/blood-2017-05-783845 contributor: fullname: Pellicano – volume: 40 start-page: 499 issue: 5 year: 2008 ident: 2020062511295764200_B36 article-title: An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors publication-title: Nat Genet doi: 10.1038/ng.127 contributor: fullname: Ben-Porath – volume: 277 start-page: 51068 issue: 52 year: 2002 ident: 2020062511295764200_B76 article-title: The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner publication-title: J Biol Chem doi: 10.1074/jbc.M205121200 contributor: fullname: Getting – volume: 98 start-page: 522 issue: 3 year: 2003 ident: 2020062511295764200_B61 article-title: Results of decitabine (5-aza-2’deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia publication-title: Cancer doi: 10.1002/cncr.11543 contributor: fullname: Kantarjian – volume: 6 start-page: e22110 issue: 7 year: 2011 ident: 2020062511295764200_B65 article-title: Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia publication-title: PLoS One doi: 10.1371/journal.pone.0022110 contributor: fullname: Jelinek – volume: 22 start-page: 128 issue: 2 year: 2016 ident: 2020062511295764200_B25 article-title: Targeting EZH2 in cancer publication-title: Nat Med doi: 10.1038/nm.4036 contributor: fullname: Kim – volume: 6 start-page: 587 issue: 6 year: 2004 ident: 2020062511295764200_B91 article-title: MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors publication-title: Cancer Cell doi: 10.1016/j.ccr.2004.10.015 contributor: fullname: Huntly – volume: 62 start-page: 2791 issue: 10 year: 2002 ident: 2020062511295764200_B31 article-title: Myeloid leukemias have increased activity of the nonhomologous end-joining pathway and concomitant DNA misrepair that is dependent on the Ku70/86 heterodimer publication-title: Cancer Res contributor: fullname: Gaymes – volume: 18 start-page: 1546 issue: 6 year: 2004 ident: 2020062511295764200_B95 article-title: Regulation of the osteopontin gene by the orphan nuclear receptor NURR1 in osteoblasts publication-title: Mol Endocrinol doi: 10.1210/me.2003-0247 contributor: fullname: Lammi – volume: 107 start-page: 205 issue: 1 year: 2006 ident: 2020062511295764200_B97 article-title: Molecular profiling of CD34+ cells identifies low expression of CD7, along with high expression of proteinase 3 or elastase, as predictors of longer survival in patients with CML publication-title: Blood doi: 10.1182/blood-2005-05-2155 contributor: fullname: Yong – volume: 168 start-page: 613 issue: 4 year: 2017 ident: 2020062511295764200_B5 article-title: Clonal heterogeneity and tumor evolution: past, present, and the future publication-title: Cell doi: 10.1016/j.cell.2017.01.018 contributor: fullname: McGranahan – volume: 492 start-page: 108 issue: 7427 year: 2012 ident: 2020062511295764200_B79 article-title: EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations publication-title: Nature doi: 10.1038/nature11606 contributor: fullname: McCabe – volume: 11 start-page: 1617 issue: 10 year: 1997 ident: 2020062511295764200_B62 article-title: Results of decitabine therapy in the accelerated and blastic phases of chronic myelogenous leukemia publication-title: Leukemia doi: 10.1038/sj.leu.2400796 contributor: fullname: Kantarjian – volume: 453 start-page: 110 issue: 7191 year: 2008 ident: 2020062511295764200_B48 article-title: BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros publication-title: Nature doi: 10.1038/nature06866 contributor: fullname: Mullighan – volume: 2 start-page: e186 issue: 5 year: 2015 ident: 2020062511295764200_B1 article-title: Relative survival in patients with chronic-phase chronic myeloid leukaemia in the tyrosine-kinase inhibitor era: analysis of patient data from six prospective clinical trials publication-title: Lancet Haematol doi: 10.1016/S2352-3026(15)00048-4 contributor: fullname: Sasaki – volume: 171 start-page: 34 issue: 1 year: 2017 ident: 2020062511295764200_B20 article-title: Genome regulation by polycomb and trithorax: 70 years and counting publication-title: Cell doi: 10.1016/j.cell.2017.08.002 contributor: fullname: Schuettengruber – volume: 21 start-page: 23 issue: 1 year: 2013 ident: 2020062511295764200_B43 article-title: Restoration of INK4a/ARF gene inhibits cell growth and cooperates with imatinib mesylate in Philadelphia chromosome-positive leukemias publication-title: Oncol Res doi: 10.3727/096504013X13786659070271 contributor: fullname: Bai – volume: 120 start-page: 737 issue: 4 year: 2012 ident: 2020062511295764200_B51 article-title: How I treat CML blast crisis publication-title: Blood doi: 10.1182/blood-2012-03-380147 contributor: fullname: Hehlmann – volume: 12 start-page: R41 issue: 4 year: 2011 ident: 2020062511295764200_B32 article-title: GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers publication-title: Genome Biol doi: 10.1186/gb-2011-12-4-r41 contributor: fullname: Mermel |
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Snippet | Targeted therapies against the BCR-ABL1 kinase have revolutionized treatment of chronic phase (CP) chronic myeloid leukemia (CML). In contrast, management of... |
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SubjectTerms | Blast Crisis - genetics Cell Differentiation Chromatin Immunoprecipitation Datasets as Topic DNA Methylation Enhancer of Zeste Homolog 2 Protein - physiology Gene Dosage Gene Expression Regulation, Leukemic - genetics Gene Ontology High-Throughput Nucleotide Sequencing Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Mutation Polycomb Repressive Complex 1 - genetics Polycomb Repressive Complex 1 - physiology Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - physiology Transcriptome Whole Exome Sequencing Whole Genome Sequencing |
Title | An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia |
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