Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury - Casha, Steven; Zygun, David; McGowan, M. Dan; Bains, Ish; Yong, V. Wee; John Hurlbert, R. (Brain (London, England : 1878), 2012)
Keywords: Acute Disease; Adult; Antibiotics; Apoptosis; Biological and medical sciences; Brain injury; Cerebrospinal fluid; Clinical trials; Dose-Response Relationship, Drug; Double-Blind Method; Drugs; Enzymes; Female; Follow-Up Studies; Humans; Inflammation; Injuries of the nervous system and the skull. Diseases due to physical agents; Intravenous administration; Liver; Male; Medical sciences; Mimicry; Minocycline; Minocycline - blood; Minocycline - cerebrospinal fluid; Minocycline - therapeutic use; Neurologic Examination; Neurological diseases; Neurology; Neuroprotection; Recovery of Function - drug effects; Recruitment; Retrospective Studies; Severity of Illness Index; Spinal Cord Injuries - blood; Spinal Cord Injuries - cerebrospinal fluid; Spinal Cord Injuries - drug therapy; Spinal Cord Injuries - physiopathology; Spinal cord injury; Statistical analysis; Statistics; Thorax; Time Factors; Traumas. Diseases due to physical agents; Young Adult; Human; spinal cord injury; Nervous system diseases; Spinal cord trauma; Central nervous system disease; Phase II trial; Placebo; Minocycline; randomized control trial; Spinal cord disease