Microsporum gypseum Isolated from Ailuropoda melanoleuca Provokes Inflammation and Triggers Th17 Adaptive Immunity Response

Microsporum gypseum causes dermatomycoses in giant pandas (Ailuropoda melanoleuca). This study aimed to investigate the immune response of M. gypseum following deep infection. The degree of damage to the heart, liver, spleen, lungs, and kidneys was evaluated using tissue fungal load, organ index, an...

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Published inInternational journal of molecular sciences Vol. 23; no. 19; p. 12037
Main Authors Ma, Xiaoping, Liu, Zhen, Yu, Yan, Jiang, Yaozhang, Wang, Chengdong, Zuo, Zhicai, Ling, Shanshan, He, Ming, Cao, Sanjie, Wen, Yiping, Zhao, Qin, Wu, Rui, Huang, Xiaobo, Zhong, Zhijun, Peng, Guangneng, Gu, Yu
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.10.2022
MDPI
Subjects
Adaptive immunity
Ailuropoda melanoleuca
Chemokines
Conidia
cytokine
Cytokines
Dendritic cells
Flow cytometry
Fungi
Gene expression
Heart
Helper cells
Histology
IL-1β
immune response
Immune system
Immunofluorescence
Infections
Inflammation
Interleukin 10
Interleukin 12
Interleukin 22
Interleukin 23
Interleukin 6
Kidneys
Leukocytes (neutrophilic)
Leukocytes (polymorphonuclear)
Ligands
Liver
lung
Lungs
Lymphocytes T
Macrophages
Microsporum gypseum
Mortality
Neutrophils
Pathogens
Polymerase chain reaction
receptor
Reverse transcription
Skin
Spleen
TLR2 protein
Toll-like receptors
Tumor necrosis factor-α
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Abstract Microsporum gypseum causes dermatomycoses in giant pandas (Ailuropoda melanoleuca). This study aimed to investigate the immune response of M. gypseum following deep infection. The degree of damage to the heart, liver, spleen, lungs, and kidneys was evaluated using tissue fungal load, organ index, and histopathological methods. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) detected the mRNA expression of receptors and cytokines in the lung, and immunofluorescence staining and flow cytometry, were used to assess immune cells in the lung. The results indicated that conidia mainly colonized the lungs and caused serious injury with M. gypseum infection. Furthermore, dectin-1, TLR-2, and TLR-4 played a role in recognizing M. gypseum cells. Numerous inflammatory cells, mainly macrophages, dendritic cells, polymorphonuclear neutrophils, and inflammatory cytokines (TGF-β, TNF-α, IL-1β, IL-6, IL-10, IL-12, and IL-23), were activated in the early stages of infection. With the high expression of IL-22, IL-17A, and IL-17F, the Th17 pathway exerted an adaptive immune response to M. gypseum infection. These results can potentially aid in the diagnosis and treatment of diseases caused by M. gypseum in giant pandas.
AbstractList Microsporum gypseum causes dermatomycoses in giant pandas ( Ailuropoda melanoleuca ). This study aimed to investigate the immune response of M. gypseum following deep infection. The degree of damage to the heart, liver, spleen, lungs, and kidneys was evaluated using tissue fungal load, organ index, and histopathological methods. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) detected the mRNA expression of receptors and cytokines in the lung, and immunofluorescence staining and flow cytometry, were used to assess immune cells in the lung. The results indicated that conidia mainly colonized the lungs and caused serious injury with M. gypseum infection. Furthermore, dectin-1, TLR-2, and TLR-4 played a role in recognizing M. gypseum cells. Numerous inflammatory cells, mainly macrophages, dendritic cells, polymorphonuclear neutrophils, and inflammatory cytokines (TGF-β, TNF-α, IL-1β, IL-6, IL-10, IL-12, and IL-23), were activated in the early stages of infection. With the high expression of IL-22, IL-17A, and IL-17F, the Th17 pathway exerted an adaptive immune response to M. gypseum infection. These results can potentially aid in the diagnosis and treatment of diseases caused by M. gypseum in giant pandas.
Microsporum gypseum causes dermatomycoses in giant pandas (Ailuropoda melanoleuca). This study aimed to investigate the immune response of M. gypseum following deep infection. The degree of damage to the heart, liver, spleen, lungs, and kidneys was evaluated using tissue fungal load, organ index, and histopathological methods. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) detected the mRNA expression of receptors and cytokines in the lung, and immunofluorescence staining and flow cytometry, were used to assess immune cells in the lung. The results indicated that conidia mainly colonized the lungs and caused serious injury with M. gypseum infection. Furthermore, dectin-1, TLR-2, and TLR-4 played a role in recognizing M. gypseum cells. Numerous inflammatory cells, mainly macrophages, dendritic cells, polymorphonuclear neutrophils, and inflammatory cytokines (TGF-β, TNF-α, IL-1β, IL-6, IL-10, IL-12, and IL-23), were activated in the early stages of infection. With the high expression of IL-22, IL-17A, and IL-17F, the Th17 pathway exerted an adaptive immune response to M. gypseum infection. These results can potentially aid in the diagnosis and treatment of diseases caused by M. gypseum in giant pandas.
Author Wang, Chengdong
He, Ming
Zhong, Zhijun
Ling, Shanshan
Zuo, Zhicai
Wen, Yiping
Ma, Xiaoping
Cao, Sanjie
Huang, Xiaobo
Liu, Zhen
Zhao, Qin
Jiang, Yaozhang
Peng, Guangneng
Gu, Yu
Wu, Rui
Yu, Yan
AuthorAffiliation 2 China Conservation and Research Center for the Giant Panda, Chengdu 611800, China
1 Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
3 College of Life Sciences, Sichuan Agricultural University, Chengdu 611130, China
AuthorAffiliation_xml – name: 3 College of Life Sciences, Sichuan Agricultural University, Chengdu 611130, China
– name: 1 Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
– name: 2 China Conservation and Research Center for the Giant Panda, Chengdu 611800, China
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CitedBy_id crossref_primary_10_1016_j_fhfh_2023_100136
crossref_primary_10_1186_s12931_024_02743_z
Cites_doi 10.1016/j.jaci.2016.02.031
10.1111/bjd.12673
10.4049/jimmunol.165.9.4773
10.1080/21505594.2015.1020273
10.1016/j.vetmic.2012.10.016
10.1093/mmy/myt011
10.1016/B978-0-12-381300-8.00001-0
10.1084/jem.20081666
10.4049/jimmunol.168.3.1362
10.1016/j.semcdb.2018.03.003
10.1111/j.1751-0813.1974.tb05342.x
10.1007/s11046-016-0069-5
10.1038/ni.2797
10.1016/j.mycmed.2013.05.005
10.1007/s11046-016-0093-5
10.1016/j.smim.2019.101344
10.1002/eji.200838543
10.3389/fcimb.2014.00050
10.4049/jimmunol.1500909
10.1086/375784
10.1038/nmeth.1905
10.1016/j.coi.2009.01.003
10.3748/wjg.v23.i31.5692
10.1016/j.cell.2010.01.022
10.1016/j.chom.2012.04.005
10.1111/vde.12295
10.1016/j.immuni.2006.03.008
10.1016/j.jid.2018.02.042
10.1002/eji.201646723
10.1177/1753425916645392
10.1111/cei.13544
10.1007/s11046-016-0079-3
10.1038/s41598-020-79642-y
10.1016/j.immuni.2010.07.014
10.1155/2012/925135
10.1590/S1517-83822008000300018
10.1638/2016-0097R1.1
10.1016/j.immuni.2015.11.017
10.1007/s11430-014-4953-x
10.1002/eji.200737409
10.1016/j.gene.2020.144819
10.1038/nri.2016.55
10.1084/jem.20011128
10.1248/bpb.30.184
10.1084/jem.20081463
10.1016/j.immuni.2004.07.007
10.1172/JCI27114
10.1007/s11046-016-0077-5
10.1590/s1678-9946202062042
10.1007/BF00493584
10.1016/j.cytogfr.2010.10.001
10.1016/j.immuni.2015.07.015
10.1084/jem.20071450
10.1016/j.micpath.2021.105384
10.1016/j.micinf.2006.10.012
10.1146/annurev.immunol.21.120601.140942
10.1046/j.1462-5822.2003.00301.x
10.1111/j.1439-0507.1987.tb04393.x
10.1016/j.jaut.2017.12.007
10.1111/j.0022-202X.2005.23841.x
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These authors contributed equally to this work.
Current address: Bioengineering Department, Sichuan Water Conservancy Vocational College, Chengdu 611231, China.
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References Araviysky (ref_9) 1975; 56
Taylor (ref_43) 2014; 15
Yamada (ref_58) 2017; 182
Roy (ref_18) 2012; 11
ref_55
ref_10
Cambier (ref_29) 2014; 170
Vautier (ref_45) 2010; 21
Randall (ref_53) 2016; 44
Imperiale (ref_47) 2021; 203
Coquet (ref_52) 2015; 43
Tittel (ref_59) 2012; 9
Heinen (ref_11) 2017; 182
Santos (ref_27) 2014; 52
Zelante (ref_31) 2007; 37
Esche (ref_38) 2005; 125
Lambrecht (ref_60) 2006; 24
Conti (ref_44) 2015; 195
Wu (ref_63) 2007; 9
Dennehy (ref_20) 2009; 39
ref_22
Lee (ref_32) 2007; 30
Cambier (ref_33) 2017; 182
Reid (ref_13) 2009; 21
Boever (ref_2) 1975; 70
Burstein (ref_25) 2018; 138
ref_26
Sonnenberg (ref_48) 2010; 107
Rengarajan (ref_51) 2002; 195
Yoshikawa (ref_19) 2017; 182
Wolk (ref_46) 2004; 21
Cambier (ref_24) 2016; 27
ref_36
ref_35
Eyerich (ref_42) 2017; 47
ref_34
Zhang (ref_41) 2017; 139
Conti (ref_30) 2009; 206
Stadhouders (ref_54) 2018; 87
Netea (ref_12) 2006; 116
ref_39
Staudt (ref_61) 2010; 33
Zhang (ref_8) 2015; 45
Zhu (ref_57) 2009; 206
Meier (ref_16) 2003; 5
(ref_1) 2018; 116
Xavier (ref_7) 2008; 39
Takeuchi (ref_23) 2010; 140
Knight (ref_62) 2017; 23
Nardoni (ref_5) 2013; 23
Gorelik (ref_56) 2000; 165
Pascoe (ref_6) 1974; 50
Wang (ref_40) 2006; 32
Bozza (ref_50) 2002; 168
Marine (ref_37) 2015; 6
Geijtenbeek (ref_14) 2016; 16
Yoshikawa (ref_28) 2016; 22
Cambier (ref_17) 2013; 162
Fischman (ref_3) 1987; 30
Jouault (ref_15) 2003; 188
ref_49
Hackworth (ref_4) 2017; 48
Gerosa (ref_21) 2008; 205
References_xml – volume: 139
  start-page: 54
  year: 2017
  ident: ref_41
  article-title: beta-Glucan exacerbates allergic asthma independent of fungal sensitization and promotes steroid-resistant TH2/TH17 responses
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2016.02.031
  contributor:
    fullname: Zhang
– volume: 170
  start-page: 625
  year: 2014
  ident: ref_29
  article-title: Assessment of the cutaneous immune response during Arthroderma benhamiae and A. vanbreuseghemii infection using an experimental mouse model
  publication-title: Br. J. Dermatol.
  doi: 10.1111/bjd.12673
  contributor:
    fullname: Cambier
– volume: 165
  start-page: 4773
  year: 2000
  ident: ref_56
  article-title: Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.165.9.4773
  contributor:
    fullname: Gorelik
– volume: 6
  start-page: 476
  year: 2015
  ident: ref_37
  article-title: The development of animal infection models and antifungal efficacy assays against clinical isolates of Trichosporon asahii, T. asteroides and T. inkin
  publication-title: Virulence
  doi: 10.1080/21505594.2015.1020273
  contributor:
    fullname: Marine
– volume: 162
  start-page: 800
  year: 2013
  ident: ref_17
  article-title: Feline polymorphonuclear neutrophils produce pro-inflammatory cytokines following exposure to Microsporum canis
  publication-title: Vet. Microbiol.
  doi: 10.1016/j.vetmic.2012.10.016
  contributor:
    fullname: Cambier
– volume: 52
  start-page: 293
  year: 2014
  ident: ref_27
  article-title: IFN-gamma impairs Trichophyton rubrum proliferation in a murine model of dermatophytosis through the production of IL-1beta and reactive oxygen species
  publication-title: Med. Mycol.
  doi: 10.1093/mmy/myt011
  contributor:
    fullname: Santos
– volume: 107
  start-page: 1
  year: 2010
  ident: ref_48
  article-title: Functional biology of the IL-22-IL-22R pathway in regulating immunity and inflammation at barrier surfaces
  publication-title: Adv. Immunol.
  doi: 10.1016/B978-0-12-381300-8.00001-0
  contributor:
    fullname: Sonnenberg
– volume: 206
  start-page: 329
  year: 2009
  ident: ref_57
  article-title: Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20081666
  contributor:
    fullname: Zhu
– volume: 168
  start-page: 1362
  year: 2002
  ident: ref_50
  article-title: Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.168.3.1362
  contributor:
    fullname: Bozza
– ident: ref_22
  doi: 10.1016/j.semcdb.2018.03.003
– volume: 50
  start-page: 380
  year: 1974
  ident: ref_6
  article-title: Dermatomycosis due to Microsporum gypseum in horses
  publication-title: Aust. Vet. J.
  doi: 10.1111/j.1751-0813.1974.tb05342.x
  contributor:
    fullname: Pascoe
– volume: 182
  start-page: 263
  year: 2017
  ident: ref_58
  article-title: The Role of Phagocytes and NETs in Dermatophytosis
  publication-title: Mycopathologia
  doi: 10.1007/s11046-016-0069-5
  contributor:
    fullname: Yamada
– volume: 15
  start-page: 143
  year: 2014
  ident: ref_43
  article-title: Autocrine IL-17A–IL-17RC neutrophil activation in fungal infections is regulated by IL-6, IL-23, RORγt and Dectin-2
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2797
  contributor:
    fullname: Taylor
– volume: 23
  start-page: 164
  year: 2013
  ident: ref_5
  article-title: Canine and feline dermatophytosis due to Microsporum gypseum: A retrospective study of clinical data and therapy outcome with griseofulvin
  publication-title: J. Mycol. Med.
  doi: 10.1016/j.mycmed.2013.05.005
  contributor:
    fullname: Nardoni
– volume: 182
  start-page: 251
  year: 2017
  ident: ref_11
  article-title: Are Th17 Cells Playing a Role in Immunity to Dermatophytosis?
  publication-title: Mycopathologia
  doi: 10.1007/s11046-016-0093-5
  contributor:
    fullname: Heinen
– ident: ref_49
  doi: 10.1016/j.smim.2019.101344
– volume: 39
  start-page: 1379
  year: 2009
  ident: ref_20
  article-title: Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.200838543
  contributor:
    fullname: Dennehy
– ident: ref_39
  doi: 10.3389/fcimb.2014.00050
– volume: 195
  start-page: 780
  year: 2015
  ident: ref_44
  article-title: IL-17-Mediated Immunity to the Opportunistic Fungal Pathogen Candida albicans
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1500909
  contributor:
    fullname: Conti
– volume: 70
  start-page: 1190
  year: 1975
  ident: ref_2
  article-title: Microsporum gypseum infection in a dromedary camel
  publication-title: Vet. Med. Small Anim. Clin.
  contributor:
    fullname: Boever
– volume: 188
  start-page: 165
  year: 2003
  ident: ref_15
  article-title: Candida albicans phospholipomannan is sensed through toll-like receptors
  publication-title: J. Infect. Dis.
  doi: 10.1086/375784
  contributor:
    fullname: Jouault
– volume: 9
  start-page: 385
  year: 2012
  ident: ref_59
  article-title: Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1905
  contributor:
    fullname: Tittel
– volume: 21
  start-page: 30
  year: 2009
  ident: ref_13
  article-title: Pattern recognition: Recent insights from Dectin-1
  publication-title: Curr. Opin. Immunol.
  doi: 10.1016/j.coi.2009.01.003
  contributor:
    fullname: Reid
– volume: 32
  start-page: 90
  year: 2006
  ident: ref_40
  article-title: Immune responses to cutaneous fungal infections
  publication-title: Int. J. Dermatol. Venereol.
  contributor:
    fullname: Wang
– volume: 23
  start-page: 5692
  year: 2017
  ident: ref_62
  article-title: Cytoplasmic domain of tissue factor promotes liver fibrosis in mice
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v23.i31.5692
  contributor:
    fullname: Knight
– volume: 140
  start-page: 805
  year: 2010
  ident: ref_23
  article-title: Pattern recognition receptors and inflammation
  publication-title: Cell
  doi: 10.1016/j.cell.2010.01.022
  contributor:
    fullname: Takeuchi
– volume: 11
  start-page: 436
  year: 2012
  ident: ref_18
  article-title: Dendritic cells in antifungal immunity and vaccine design
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2012.04.005
  contributor:
    fullname: Roy
– volume: 27
  start-page: 78
  year: 2016
  ident: ref_24
  article-title: Overexpression of TLR-2 and TLR-4 mRNA in feline polymorphonuclear neutrophils exposed to Microsporum canis
  publication-title: Vet. Dermatol.
  doi: 10.1111/vde.12295
  contributor:
    fullname: Cambier
– volume: 24
  start-page: 366
  year: 2006
  ident: ref_60
  article-title: Alveolar macrophage in the driver’s seat
  publication-title: Immunity
  doi: 10.1016/j.immuni.2006.03.008
  contributor:
    fullname: Lambrecht
– volume: 138
  start-page: 1744
  year: 2018
  ident: ref_25
  article-title: IL-17-Mediated Immunity Controls Skin Infection and T Helper 1 Response during Experimental Microsporum canis Dermatophytosis
  publication-title: J. Investig. Dermatol.
  doi: 10.1016/j.jid.2018.02.042
  contributor:
    fullname: Burstein
– volume: 47
  start-page: 607
  year: 2017
  ident: ref_42
  article-title: IL-17 and IL-22 in immunity: Driving protection and pathology
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.201646723
  contributor:
    fullname: Eyerich
– volume: 22
  start-page: 316
  year: 2016
  ident: ref_28
  article-title: Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis
  publication-title: Innate Immun.
  doi: 10.1177/1753425916645392
  contributor:
    fullname: Yoshikawa
– volume: 203
  start-page: 267
  year: 2021
  ident: ref_47
  article-title: Th22 response induced by Mycobacterium tuberculosis strains is closely related to severity of pulmonary lesions and bacillary load in patients with multi-drug-resistant tuberculosis
  publication-title: Clin. Exp. Immunol.
  doi: 10.1111/cei.13544
  contributor:
    fullname: Imperiale
– volume: 182
  start-page: 229
  year: 2017
  ident: ref_33
  article-title: Relevant Animal Models in Dermatophyte Research
  publication-title: Mycopathologia
  doi: 10.1007/s11046-016-0079-3
  contributor:
    fullname: Cambier
– ident: ref_35
  doi: 10.1038/s41598-020-79642-y
– volume: 33
  start-page: 192
  year: 2010
  ident: ref_61
  article-title: Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells
  publication-title: Immunity
  doi: 10.1016/j.immuni.2010.07.014
  contributor:
    fullname: Staudt
– ident: ref_26
  doi: 10.1155/2012/925135
– volume: 39
  start-page: 508
  year: 2008
  ident: ref_7
  article-title: Dermatophytosis caused by Microsporum canis and Microsporum gypseum in free-living Bradypus variegatus (Schiz, 1825) in the state of Pernambuco, Brazil
  publication-title: Braz. J. Microbiol.
  doi: 10.1590/S1517-83822008000300018
  contributor:
    fullname: Xavier
– volume: 48
  start-page: 549
  year: 2017
  ident: ref_4
  article-title: Diagnosis and Successful Treatment of a Potentially Zoonotic Dermatophytosis Caused by Microsporum gypseum in a Zoo-Housed North American Porcupine (Erethizon dorsatum)
  publication-title: J. Zoo Wildl. Med.
  doi: 10.1638/2016-0097R1.1
  contributor:
    fullname: Hackworth
– volume: 116
  start-page: e296
  year: 2018
  ident: ref_1
  article-title: Tinea capitis by Microsporum gypseum, an infrequent species
  publication-title: Arch. Argent. Pediatr.
– volume: 44
  start-page: 259
  year: 2016
  ident: ref_53
  article-title: T Follicular Helper Cell Plasticity Shapes Pathogenic T Helper 2 Cell-Mediated Immunity to Inhaled House Dust Mite
  publication-title: Immunity
  doi: 10.1016/j.immuni.2015.11.017
  contributor:
    fullname: Randall
– volume: 45
  start-page: 551
  year: 2015
  ident: ref_8
  article-title: Identification and pathogenicity of Microsporum gypseum isolated from Ailuropoda melanoleuca
  publication-title: Vet. Sci. China
  doi: 10.1007/s11430-014-4953-x
  contributor:
    fullname: Zhang
– volume: 37
  start-page: 2695
  year: 2007
  ident: ref_31
  article-title: IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.200737409
  contributor:
    fullname: Zelante
– ident: ref_36
  doi: 10.1016/j.gene.2020.144819
– volume: 16
  start-page: 433
  year: 2016
  ident: ref_14
  article-title: C-type lectin receptors in the control of T helper cell differentiation
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri.2016.55
  contributor:
    fullname: Geijtenbeek
– volume: 195
  start-page: 1003
  year: 2002
  ident: ref_51
  article-title: Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20011128
  contributor:
    fullname: Rengarajan
– volume: 30
  start-page: 184
  year: 2007
  ident: ref_32
  article-title: Antifungal effect of eugenol and nerolidol against Microsporum gypseum in a guinea pig model
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.30.184
  contributor:
    fullname: Lee
– volume: 206
  start-page: 299
  year: 2009
  ident: ref_30
  article-title: Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20081463
  contributor:
    fullname: Conti
– volume: 21
  start-page: 241
  year: 2004
  ident: ref_46
  article-title: IL-22 increases the innate immunity of tissues
  publication-title: Immunity
  doi: 10.1016/j.immuni.2004.07.007
  contributor:
    fullname: Wolk
– volume: 116
  start-page: 1642
  year: 2006
  ident: ref_12
  article-title: Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI27114
  contributor:
    fullname: Netea
– volume: 182
  start-page: 241
  year: 2017
  ident: ref_19
  article-title: An In Vitro Model for the Study of the Macrophage Response Upon Trichophyton rubrum Challenge
  publication-title: Mycopathologia
  doi: 10.1007/s11046-016-0077-5
  contributor:
    fullname: Yoshikawa
– ident: ref_10
  doi: 10.1590/s1678-9946202062042
– volume: 56
  start-page: 47
  year: 1975
  ident: ref_9
  article-title: Deep generalized trichophytosis. (Endothrix in tissues of different origin)
  publication-title: Mycopathologia
  doi: 10.1007/BF00493584
  contributor:
    fullname: Araviysky
– volume: 21
  start-page: 405
  year: 2010
  ident: ref_45
  article-title: C-type lectins, fungi and Th17 responses
  publication-title: Cytokine Growth Factor Rev.
  doi: 10.1016/j.cytogfr.2010.10.001
  contributor:
    fullname: Vautier
– volume: 43
  start-page: 318
  year: 2015
  ident: ref_52
  article-title: Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites
  publication-title: Immunity
  doi: 10.1016/j.immuni.2015.07.015
  contributor:
    fullname: Coquet
– volume: 205
  start-page: 1447
  year: 2008
  ident: ref_21
  article-title: Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20071450
  contributor:
    fullname: Gerosa
– ident: ref_34
  doi: 10.1016/j.micpath.2021.105384
– volume: 9
  start-page: 78
  year: 2007
  ident: ref_63
  article-title: IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection
  publication-title: Microbes Infect.
  doi: 10.1016/j.micinf.2006.10.012
  contributor:
    fullname: Wu
– ident: ref_55
  doi: 10.1146/annurev.immunol.21.120601.140942
– volume: 5
  start-page: 561
  year: 2003
  ident: ref_16
  article-title: Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages
  publication-title: Cell. Microbiol.
  doi: 10.1046/j.1462-5822.2003.00301.x
  contributor:
    fullname: Meier
– volume: 30
  start-page: 295
  year: 1987
  ident: ref_3
  article-title: Microsporum gypseum infection in a gray wolf (Canis lupus) and a camel (Camelus bactrianus) in a zoological garden
  publication-title: Mykosen
  doi: 10.1111/j.1439-0507.1987.tb04393.x
  contributor:
    fullname: Fischman
– volume: 87
  start-page: 1
  year: 2018
  ident: ref_54
  article-title: A cellular and molecular view of T helper 17 cell plasticity in autoimmunity
  publication-title: J. Autoimmun.
  doi: 10.1016/j.jaut.2017.12.007
  contributor:
    fullname: Stadhouders
– volume: 125
  start-page: 615
  year: 2005
  ident: ref_38
  article-title: Chemokines: Key players in innate and adaptive immunity
  publication-title: J. Investig. Dermatol.
  doi: 10.1111/j.0022-202X.2005.23841.x
  contributor:
    fullname: Esche
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Snippet Microsporum gypseum causes dermatomycoses in giant pandas (Ailuropoda melanoleuca). This study aimed to investigate the immune response of M. gypseum following...
Microsporum gypseum causes dermatomycoses in giant pandas ( Ailuropoda melanoleuca ). This study aimed to investigate the immune response of M. gypseum...
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SubjectTerms Adaptive immunity
Ailuropoda melanoleuca
Chemokines
Conidia
cytokine
Cytokines
Dendritic cells
Flow cytometry
Fungi
Gene expression
Heart
Helper cells
Histology
IL-1β
immune response
Immune system
Immunofluorescence
Infections
Inflammation
Interleukin 10
Interleukin 12
Interleukin 22
Interleukin 23
Interleukin 6
Kidneys
Leukocytes (neutrophilic)
Leukocytes (polymorphonuclear)
Ligands
Liver
lung
Lungs
Lymphocytes T
Macrophages
Microsporum gypseum
Mortality
Neutrophils
Pathogens
Polymerase chain reaction
receptor
Reverse transcription
Skin
Spleen
TLR2 protein
Toll-like receptors
Tumor necrosis factor-α
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Title Microsporum gypseum Isolated from Ailuropoda melanoleuca Provokes Inflammation and Triggers Th17 Adaptive Immunity Response
URI https://www.proquest.com/docview/2724285302
https://search.proquest.com/docview/2725199097
https://pubmed.ncbi.nlm.nih.gov/PMC9570494
https://doaj.org/article/95e2b70e032a4c08a45a0981b8782a16
Volume 23
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