Metabolic engineering of Corynebacterium glutamicum for the production of 3-hydroxypropionic acid from glucose and xylose

• Published in: Metabolic engineering Vol. 39; pp. 151 - 158
• Main Authors: Chen, Zhen, Huang, Jinhai, Wu, Yao, Wu, Wenjun, Zhang, Ye, Liu, Dehua
• Format: Journal Article
• Language: English
• Published: Belgium Elsevier Inc 01.01.2017
• Subjects: 3-Hydroxypropionic acid; aldehydes; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; batch fermentation; Biosynthetic Pathways - physiology; Corynebacterium glutamicum; Corynebacterium glutamicum - physiology; feedstocks; Gene Expression Regulation, Bacterial - genetics; genes; genetic engineering; Genetic Enhancement - methods; glucokinase; glucose; Glucose - metabolism; glycerol; Glycerol - metabolism; Glycerol pathway; Klebsiella pneumoniae; Lactic Acid - analogs & derivatives; Lactic Acid - biosynthesis; Lactic Acid - isolation & purification; Lignocellulose; Metabolic engineering; Metabolic Engineering - methods; Metabolic Networks and Pathways - physiology; pentoses; Saccharomyces cerevisiae; screening; xylose; Xylose - metabolism; Glycerol pathway; Metabolic engineering; Lignocellulose; 3-Hydroxypropionic acid; Corynebacterium glutamicum

3-Hydroxypropionic acid (3-HP) is a promising platform chemical which can be used for the production of various value-added chemicals. In this study,Corynebacterium glutamicum was metabolically engineered to efficiently produce 3-HP from glucose and xylose via the glycerol pathway. A functional 3-HP...