Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia

• Published in: Antioxidants Vol. 8; no. 8; p. 261
• Main Authors: Kushairi, Naufal, Phan, Chia Wei, Sabaratnam, Vikineswary, David, Pamela, Naidu, Murali
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.08.2019; MDPI
• Subjects: Acids; anti-inflammation; Antioxidants; Apoptosis; Basidiocarps; BAX gene; Bcl-2 protein; Catalase; Ethanol; Free radicals; Gene expression; Glutathione; Heme; Hericium erinaceus; Hippocampus; Hydrogen peroxide; Inflammation; Lipopolysaccharides; Membrane potential; Microglia; Mitochondria; mushroom; NAD; Natural products; Neurodegenerative diseases; Neuronal-glial interactions; Neurons; Neuroprotection; Neurotoxicity; Nitric oxide; Oxidative stress; Reactive oxygen species; Reagents; Sodium; United States > US; Malaysia

Oxidative stress and inflammation in neuron-glia system are key factors in the pathogenesis of neurodegenerative diseases. As synthetic drugs may cause side effects, natural products have gained recognition for the prevention or management of diseases. In this study, hot water (HE-HWA) and ethanolic...