The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal

• Published in: Blood Vol. 139; no. 6; pp. 845 - 858
• Main Authors: Yang, Yuqing, Kueh, Andrew J., Grant, Zoe L., Abeysekera, Waruni, Garnham, Alexandra L., Wilcox, Stephen, Hyland, Craig D., Di Rago, Ladina, Metcalf, Don, Alexander, Warren S., Coultas, Leigh, Smyth, Gordon K., Voss, Anne K., Thomas, Tim
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.02.2022
• Subjects: Animals; Cell Self Renewal; Cells, Cultured; Cellular Senescence; Gene Deletion; Hematopoiesis; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - metabolism; Histone Acetyltransferases - genetics; Histone Acetyltransferases - metabolism; Mice; Mice, Inbred C57BL

The histone acetyltransferase HBO1 (MYST2, KAT7) is indispensable for postgastrulation development, histone H3 lysine 14 acetylation (H3K14Ac), and the expression of embryonic patterning genes. In this study, we report the role of HBO1 in regulating hematopoietic stem cell function in adult hematopo...