Infrared microspectroscopy analysis of Ibuprofen release from drug eluting beads in uterine tissue
Ibuprofen loaded embolization beads (IBU-BB) have been developed to reduce inflammation and pain following uterine artery embolization for the treatment of uterine fibroids. The present work has investigated the elution properties of IBU-BB in situ after embolization with Fourier Transform Infrared...
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| Published in | Journal of controlled release Vol. 135; no. 3; pp. 198 - 202 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Kidlington
Elsevier B.V
05.05.2009
Elsevier |
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| Abstract | Ibuprofen loaded embolization beads (IBU-BB) have been developed to reduce inflammation and pain following uterine artery embolization for the treatment of uterine fibroids. The present work has investigated the elution properties of IBU-BB
in situ after embolization with Fourier Transform Infrared Microspectroscopy (FTIRMS). Twelve sheep underwent uterine artery embolization with IBU-BB (485 mM) or control unloaded beads. IBU concentration was determined inside the beads and in the tissue surrounding the beads using FTIRMS of uterine tissue sections sampled 24 h or 1 week after embolization.
After 24 h, IBU concentration inside the bead was only 18.6 mM out of the 485 mM initially loaded (
p
<
0.0001, univariate sign test). The concentration in the tissue around the beads was 8 mM, which is well above the
in vitro therapeutic levels (6 µM). After one week the concentration of IBU had decreased to 4.9 mM in the beads (
p
=
0.0502, Mann Whitney) and no IBU was detected in the surrounding tissue.
This work has demonstrated that IBU-BB can provide a sustained release of the anti-inflammatory drug over at least one week. The
in vivo elution properties of IBU-BB may be suitable to alleviate pain and inflammation after embolization.
[Display omitted] |
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| AbstractList | Ibuprofen loaded embolization beads (IBU-BB) have been developed to reduce inflammation and pain following uterine artery embolization for the treatment of uterine fibroids. The present work has investigated the elution properties of IBU-BB in situ after embolization with Fourier Transform Infrared Microspectroscopy (FTIRMS). Twelve sheep underwent uterine artery embolization with IBU-BB (485 mM) or control unloaded beads. IBU concentration was determined inside the beads and in the tissue surrounding the beads using FTIRMS of uterine tissue sections sampled 24 h or 1 week after embolization. After 24 h, IBU concentration inside the bead was only 18.6 mM out of the 485 mM initially loaded (p < 0.0001, univariate sign test). The concentration in the tissue around the beads was 8 mM, which is well above the in vitro therapeutic levels (6 microM). After one week the concentration of IBU had decreased to 4.9 mM in the beads (p = 0.0502, Mann Whitney) and no IBU was detected in the surrounding tissue. This work has demonstrated that IBU-BB can provide a sustained release of the anti-inflammatory drug over at least one week. The in vivo elution properties of IBU-BB may be suitable to alleviate pain and inflammation after embolization. Ibuprofen loaded embolization beads (IBU-BB) have been developed to reduce inflammation and pain following uterine artery embolization for the treatment of uterine fibroids. The present work has investigated the elution properties of IBU-BB in situ after embolization with Fourier Transform Infrared Microspectroscopy (FTIRMS). Twelve sheep underwent uterine artery embolization with IBU-BB (485 mM) or control unloaded beads. IBU concentration was determined inside the beads and in the tissue surrounding the beads using FTIRMS of uterine tissue sections sampled 24 h or 1 week after embolization. After 24 h, IBU concentration inside the bead was only 18.6 mM out of the 485 mM initially loaded ( p < 0.0001, univariate sign test). The concentration in the tissue around the beads was 8 mM, which is well above the in vitro therapeutic levels (6 µM). After one week the concentration of IBU had decreased to 4.9 mM in the beads ( p = 0.0502, Mann Whitney) and no IBU was detected in the surrounding tissue. This work has demonstrated that IBU-BB can provide a sustained release of the anti-inflammatory drug over at least one week. The in vivo elution properties of IBU-BB may be suitable to alleviate pain and inflammation after embolization. [Display omitted] Ibuprofen loaded embolization beads (IBU-BB) have been developed to reduce inflammation and pain following uterine artery embolization for the treatment of uterine fibroids. The present work has investigated the elution properties of IBU-BB in situ after embolization with Fourier Transform Infrared Microspectroscopy (FTIRMS). Twelve sheep underwent uterine artery embolization with IBU-BB (485 mM) or control unloaded beads. IBU concentration was determined inside the beads and in the tissue surrounding the beads using FTIRMS of uterine tissue sections sampled 24 h or 1 week after embolization. After 24 h, IBU concentration inside the bead was only 18.6 mM out of the 485 mM initially loaded (p < 0.0001, univariate sign test). The concentration in the tissue around the beads was 8 mM, which is well above the in vitro therapeutic levels (6 µM). After one week the concentration of IBU had decreased to 4.9 mM in the beads (p = 0.0502, Mann Whitney) and no IBU was detected in the surrounding tissue. This work has demonstrated that IBU-BB can provide a sustained release of the anti-inflammatory drug over at least one week. The in vivo elution properties of IBU-BB may be suitable to alleviate pain and inflammation after embolization. Ibuprofen loaded embolization beads (IBU-BB) have been developed to reduce inflammation and pain following uterine artery embolization for the treatment of uterine fibroids. The present work has investigated the elution properties of IBU-BB in situ after embolization with Fourier Transform Infrared Microspectroscopy (FTIRMS). Twelve sheep underwent uterine artery embolization with IBU-BB (485 mM) or control unloaded beads. IBU concentration was determined inside the beads and in the tissue surrounding the beads using FTIRMS of uterine tissue sections sampled 24 h or 1 week after embolization. After 24 h, IBU concentration inside the bead was only 18.6 mM out of the 485 mM initially loaded (p < 0.0001, univariate sign test). The concentration in the tissue around the beads was 8 mM, which is well above the in vitro therapeutic levels (6 microM). After one week the concentration of IBU had decreased to 4.9 mM in the beads (p = 0.0502, Mann Whitney) and no IBU was detected in the surrounding tissue. This work has demonstrated that IBU-BB can provide a sustained release of the anti-inflammatory drug over at least one week. The in vivo elution properties of IBU-BB may be suitable to alleviate pain and inflammation after embolization. |
| Author | Manfait, M. Wassef, M. Namur, J. Lewis, A. Laurent, A. Pelage, J.P. |
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| Cites_doi | 10.1016/0005-2760(76)90034-5 10.1042/bj3390607 10.1016/S0378-5173(01)00905-X 10.1038/sj.jid.5700491 10.1002/jemt.20416 10.1016/j.bbagen.2005.04.020 10.1002/elps.200305870 10.1097/01.RVI.0000092664.72261.F9 10.1016/S0009-9236(99)70128-1 10.1039/B408952A 10.1023/A:1020481305420 10.1117/1.2209549 10.1021/cc050041x 10.1039/b717164a 10.1016/j.jconrel.2006.08.008 10.1046/j.1523-1747.1999.00612.x 10.1002/jbm.b.30988 10.1007/s00249-007-0191-x |
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| Keywords | Embolization In vivo drug release Drug eluting beads Infrared microspectroscopy Ibuprofen Drug Prostaglandin-endoperoxide synthase Pharmaceutical technology Enzyme Enzyme inhibitor Non steroidal antiinflammatory agent In vivo Tissue Arylpropionic acid derivatives Oxidoreductases Release |
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| SubjectTerms | Animals Anti-Inflammatory Agents, Non-Steroidal - analysis Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Biological and medical sciences Calibration Delayed-Action Preparations Dose-Response Relationship, Drug Drug eluting beads Embolization Embolization, Therapeutic Female General pharmacology Ibuprofen Ibuprofen - analysis Ibuprofen - pharmacokinetics In vivo drug release Infrared microspectroscopy Medical sciences Microspheres Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Sensitivity and Specificity Sheep, Domestic Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Spectroscopy, Fourier Transform Infrared Time Factors Uterus - blood supply |
| Title | Infrared microspectroscopy analysis of Ibuprofen release from drug eluting beads in uterine tissue |
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