CD80 DNA methylation and single-nucleotide polymorphism associated with clopidogrel response: a whole-genome DNA methylation analysis in acute coronary syndrome

• Published in: Research and practice in thrombosis and haemostasis Vol. 7; no. 2; p. 100093
• Main Authors: Song, Pei-Yuan, Li, Mu-Peng, Peng, Li-Ming, Chen, Xiao-Ping
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2023; Elsevier
• Subjects: acute coronary syndrome (ACS); clopidogrel; DNA methylation; Original; platelet; single-nucleotide polymorphism (SNP); clopidogrel; DNA methylation; acute coronary syndrome (ACS); platelet; single-nucleotide polymorphism (SNP)

Dual antiplatelet therapy with clopidogrel and aspirin is the primary treatment for patients who undergo percutaneous coronary intervention. However, the interindividual difference in clopidogrel response is remarkable, and high on-treatment platelet reactivity (HTPR) can increase the risk of thromb...