Purkinje cell fusion and binucleate heterokaryon formation in multiple sclerosis cerebellum

• Published in: Brain (London, England : 1878) Vol. 135; no. 10; pp. 2962 - 2972
• Main Authors: Kemp, K., Gray, E., Wilkins, A., Scolding, N.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.10.2012
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Cell Fusion; Cell Nucleus - genetics; Cell Nucleus - pathology; Central Nervous System - pathology; Cerebellum - pathology; Female; Humans; In Situ Hybridization, Fluorescence; Indexing in process; Inflammation - genetics; Inflammation - pathology; Male; Medical sciences; Middle Aged; Multiple Sclerosis - genetics; Multiple Sclerosis - pathology; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Neurology; Purkinje Cells - pathology; Cerebellum; fusion; Nervous system diseases; Multiple sclerosis; Purkinje cells; Central nervous system disease; Central nervous system; heterokaryon; Encephalon; Inflammatory disease

A major conceptual consideration in both endogenous and therapeutic central nervous system repair is how damaged (or senescent) neurons, given their often enormously complex and extensive network of connections, can possibly be replaced. The recent observation of fusion of circulating bone marrow ce...