Marathon running alters the DNA base excision repair in human skeletal muscle

• Published in: Life sciences (1973) Vol. 72; no. 14; pp. 1627 - 1633
• Main Authors: Radák, Zsolt, Apor, Peter, Pucsok, Jozsef, Berkes, Istvan, Ogonovszky, Helga, Pavlik, Gabor, Nakamoto, Hideko, Goto, Sataro
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 21.02.2003
• Subjects: Adaptation; Base excision repair; Biopsy; Deoxyribonuclease (Pyrimidine Dimer); DNA - chemistry; DNA Damage; DNA Repair; DNA-Formamidopyrimidine Glycosylase; Endodeoxyribonucleases - genetics; Endodeoxyribonucleases - metabolism; Escherichia coli Proteins; Exercise; Humans; Male; Muscle, Skeletal - enzymology; N-Glycosyl Hydrolases - genetics; N-Glycosyl Hydrolases - metabolism; Oxidative stress; Running; Oxidative stress; Exercise; DNA repair; Base excision repair; DNA damage; Adaptation

Reactive oxygen and nitrogen species generated either as products of aerobic metabolism or as a consequence of environmental mutagens, oxidatively modify DNA. Formamidopyrimidine-DNA glycosylase (Fpg) and endonuclease III (endo III) or their functional mammalian homologues repair 7,8-dihydro-8-oxogu...