Marathon running alters the DNA base excision repair in human skeletal muscle
Reactive oxygen and nitrogen species generated either as products of aerobic metabolism or as a consequence of environmental mutagens, oxidatively modify DNA. Formamidopyrimidine-DNA glycosylase (Fpg) and endonuclease III (endo III) or their functional mammalian homologues repair 7,8-dihydro-8-oxogu...
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| Published in | Life sciences (1973) Vol. 72; no. 14; pp. 1627 - 1633 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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Netherlands
Elsevier Inc
21.02.2003
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| Abstract | Reactive oxygen and nitrogen species generated either as products of aerobic metabolism or as a consequence of environmental mutagens, oxidatively modify DNA. Formamidopyrimidine-DNA glycosylase (Fpg) and endonuclease III (endo III) or their functional mammalian homologues repair 7,8-dihydro-8-oxoguanine (8-oxoG) and damaged pyrimidines, respectively, to curb the deleterious effects of oxidative DNA alterations. A single bout of physical exercise can induce oxidative DNA damage. However, its effect on the activity of repair enzymes is not known. Here we report that the activity of a functional homolog of Fpg, human 8-oxoG DNA glycosylase (hOGG1), is increased significantly, as measured by the excision of
32P labeled damaged oligonucleotide, in human skeletal muscle after a marathon race. The AP site repair enzyme did not change significantly. Despite the large individual differences among the six subjects measured, data suggest that a single-bout of aerobic exercise increases the activity of hOGG1 which is responsible for the excision of 8-oxoG. The up-regulation of DNA repair enzymes might be an important part of the regular exercise induced adaptation process. |
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| AbstractList | Reactive oxygen and nitrogen species generated either as products of aerobic metabolism or as a consequence of environmental mutagens, oxidatively modify DNA. Formamidopyrimidine-DNA glycosylase (Fpg) and endonuclease III (endo III) or their functional mammalian homologues repair 7,8-dihydro-8-oxoguanine (8-oxoG) and damaged pyrimidines, respectively, to curb the deleterious effects of oxidative DNA alterations. A single bout of physical exercise can induce oxidative DNA damage. However, its effect on the activity of repair enzymes is not known. Here we report that the activity of a functional homolog of Fpg, human 8-oxoG DNA glycosylase (hOGG1), is increased significantly, as measured by the excision of 32P labeled damaged oligonucleotide, in human skeletal muscle after a marathon race. The AP site repair enzyme did not change significantly. Despite the large individual differences among the six subjects measured, data suggest that a single-bout of aerobic exercise increases the activity of hOGG1 which is responsible for the excision of 8-oxoG. The up-regulation of DNA repair enzymes might be an important part of the regular exercise induced adaptation process.Reactive oxygen and nitrogen species generated either as products of aerobic metabolism or as a consequence of environmental mutagens, oxidatively modify DNA. Formamidopyrimidine-DNA glycosylase (Fpg) and endonuclease III (endo III) or their functional mammalian homologues repair 7,8-dihydro-8-oxoguanine (8-oxoG) and damaged pyrimidines, respectively, to curb the deleterious effects of oxidative DNA alterations. A single bout of physical exercise can induce oxidative DNA damage. However, its effect on the activity of repair enzymes is not known. Here we report that the activity of a functional homolog of Fpg, human 8-oxoG DNA glycosylase (hOGG1), is increased significantly, as measured by the excision of 32P labeled damaged oligonucleotide, in human skeletal muscle after a marathon race. The AP site repair enzyme did not change significantly. Despite the large individual differences among the six subjects measured, data suggest that a single-bout of aerobic exercise increases the activity of hOGG1 which is responsible for the excision of 8-oxoG. The up-regulation of DNA repair enzymes might be an important part of the regular exercise induced adaptation process. Reactive oxygen and nitrogen species generated either as products of aerobic metabolism or as a consequence of environmental mutagens, oxidatively modify DNA. Formamidopyrimidine-DNA glycosylase (Fpg) and endonuclease III (endo III) or their functional mammalian homologues repair 7,8-dihydro-8-oxoguanine (8-oxoG) and damaged pyrimidines, respectively, to curb the deleterious effects of oxidative DNA alterations. A single bout of physical exercise can induce oxidative DNA damage. However, its effect on the activity of repair enzymes is not known. Here we report that the activity of a functional homolog of Fpg, human 8-oxoG DNA glycosylase (hOGG1), is increased significantly, as measured by the excision of 32P labeled damaged oligonucleotide, in human skeletal muscle after a marathon race. The AP site repair enzyme did not change significantly. Despite the large individual differences among the six subjects measured, data suggest that a single-bout of aerobic exercise increases the activity of hOGG1 which is responsible for the excision of 8-oxoG. The up-regulation of DNA repair enzymes might be an important part of the regular exercise induced adaptation process. Reactive oxygen and nitrogen species generated either as products of aerobic metabolism or as a consequence of environmental mutagens, oxidatively modify DNA. Formamidopyrimidine-DNA glycosylase (Fpg) and endonuclease III (endo III) or their functional mammalian homologues repair 7,8-dihydro-8-oxoguanine (8- oxoG) and damaged pyrimidines, respectively, to curb the deleterious effects of oxidative DNA alterations. A single bout of physical exercise can induce oxidative DNA damage. However, its effect on the activity of repair enzymes is not known. Here we report that the activity of a functional homolog of Fpg, human 8-oxoG DNA glycosylase (hOGG1), is increased significantly, as measured by the excision of super(32)P labeled damaged oligonucleotide, in human skeletal muscle after a marathon race. The AP site repair enzyme did not change significantly. Despite the large individual differences among the six subjects measured, data suggest that a single-bout of aerobic exercise increases the activity of hOGG1 which is responsible for the excision of 8-oxoG. The up- regulation of DNA repair enzymes might be an important part of the regular exercise induced adaptation process. Reactive oxygen and nitrogen species generated either as products of aerobic metabolism or as a consequence of environmental mutagens, oxidatively modify DNA. Formamidopyrimidine-DNA glycosylase (Fpg) and endonuclease III (endo III) or their functional mammalian homologues repair 7,8-dihydro-8-oxoguanine (8-oxoG) and damaged pyrimidines, respectively, to curb the deleterious effects of oxidative DNA alterations. A single bout of physical exercise can induce oxidative DNA damage. However, its effect on the activity of repair enzymes is not known. Here we report that the activity of a functional homolog of Fpg, human 8-oxoG DNA glycosylase (hOGG1), is increased significantly, as measured by the excision of 32P labeled damaged oligonucleotide, in human skeletal muscle after a marathon race. The AP site repair enzyme did not change significantly. Despite the large individual differences among the six subjects measured, data suggest that a single-bout of aerobic exercise increases the activity of hOGG1 which is responsible for the excision of 8-oxoG. The up-regulation of DNA repair enzymes might be an important part of the regular exercise induced adaptation process. |
| Author | Radák, Zsolt Goto, Sataro Pavlik, Gabor Berkes, Istvan Ogonovszky, Helga Nakamoto, Hideko Pucsok, Jozsef Apor, Peter |
| Author_xml | – sequence: 1 givenname: Zsolt surname: Radák fullname: Radák, Zsolt email: radak@mail.hupe.hu organization: Laboratory of Exercise Physiology, School of Sport Sciences, Semmelweis University, Budapest, Alkotas u. 44, H-1123, Hungary – sequence: 2 givenname: Peter surname: Apor fullname: Apor, Peter organization: Svabhegy Pediatric Institute, Budapest, Hungary – sequence: 3 givenname: Jozsef surname: Pucsok fullname: Pucsok, Jozsef organization: National Institute of Sport Medicine, Budapest, Hungary – sequence: 4 givenname: Istvan surname: Berkes fullname: Berkes, Istvan organization: National Institute of Sport Medicine, Budapest, Hungary – sequence: 5 givenname: Helga surname: Ogonovszky fullname: Ogonovszky, Helga organization: Laboratory of Exercise Physiology, School of Sport Sciences, Semmelweis University, Budapest, Alkotas u. 44, H-1123, Hungary – sequence: 6 givenname: Gabor surname: Pavlik fullname: Pavlik, Gabor organization: Laboratory of Exercise Physiology, School of Sport Sciences, Semmelweis University, Budapest, Alkotas u. 44, H-1123, Hungary – sequence: 7 givenname: Hideko surname: Nakamoto fullname: Nakamoto, Hideko organization: Department Biochemistry, School of Pharmaceutical Sciences, Toho University, Funabashi, Japan – sequence: 8 givenname: Sataro surname: Goto fullname: Goto, Sataro organization: Department Biochemistry, School of Pharmaceutical Sciences, Toho University, Funabashi, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12551751$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1093/nar/29.9.1975 10.1073/pnas.94.14.7429 10.1016/S0006-2952(97)00448-6 10.1038/35077232 10.1074/jbc.273.33.21203 10.1073/pnas.94.15.8010 10.1016/0092-8674(85)90191-6 10.1016/S0891-5849(99)00038-6 10.1074/jbc.272.2.1148 10.1055/s-2007-972868 10.1080/02640419608727720 10.2307/3579809 10.1016/S0891-5849(00)00172-6 10.1093/carcin/22.2.265 10.1016/0168-9525(93)90089-Z 10.1096/fj.00-0703com 10.1073/pnas.94.1.109 10.1016/S0079-6603(01)68084-X 10.1016/S0891-5849(98)00309-8 10.1080/10715769800300621 10.1073/pnas.97.2.686 10.1093/carcin/11.9.1447 10.1073/pnas.95.17.9997 |
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| Keywords | Oxidative stress Exercise DNA repair Base excision repair DNA damage Adaptation |
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| References | Nakamura, Swenberg (BIB19) 1999; 59 Floyd (BIB16) 1990; 11 Grollman, Moriya (BIB17) 1993; 9 Cardozo-Pelaez, Brooks, Stedeford, Song, Sanchez-Ramos (BIB13) 2000; 28 Stecca, Gerber (BIB14) 1998; 55 Wallace (BIB21) 1998; 150 Glassner, Rasmussen, Najarian, Posnick, Samson (BIB25) 1998; 95 Moller, Loft, Lundby, Olsen (BIB5) 2001; 15 Rosenquist, Zharkov, Grollman (BIB15) 1997; 94 Niess, Hartmann, Grunert-Fuchs, Poch, Speit (BIB9) 1996; 17 Loeb (BIB23) 1985; 40 Hoeijmakers (BIB1) 2001; 411 Aspinwall, Rothwell, Roldan-Arjona, Anselmino, Ward, Cheadle, Sampson, Lindahl, Harris, Hickson (BIB4) 1997; 94 Radicella, Dherin, Desmaze, Fox, Boiteux (BIB3) 1997; 94 Srivastava, Berg, Prasad, Molina, Beard, Tomkinson, Wilson (BIB20) 1998; 273 Asami, Hirano, Yamaguchi, Itoh, Kasai (BIB18) 1998; 29 Poulsen, Loft, Vistisen (BIB6) 1996; 14 Radak, Pucsok, Mecseki, Csont, Ferdinandy (BIB7) 1999; 26 Radak, Taylor, Ohno, Goto (BIB8) 2001; 7 Niess, Baumann, Roecker, Horstmann, Mayer, Dickhuth (BIB10) 1998; 38 Atamna, Cheung, Ames (BIB2) 2000; 97 Kingma, Osheroff (BIB24) 1997; 272 Radak, Kaneko, Tahara, Nakamoto, Ohno, Sasvari, Nyakas, Goto (BIB11) 1999; 27 Matsumoto, Zhang, Takao, Yasui, Yone (BIB26) 2001; 29 Lindahl (BIB22) 2001; 68 Kim, Morimoto, Tsuda, Ootsuyama, Hirohashi, Hirano, Tanaka, Lim, Yun, Kasai (BIB12) 2001; 22 Lindahl (10.1016/S0024-3205(02)02476-1_BIB22) 2001; 68 Kingma (10.1016/S0024-3205(02)02476-1_BIB24) 1997; 272 Srivastava (10.1016/S0024-3205(02)02476-1_BIB20) 1998; 273 Matsumoto (10.1016/S0024-3205(02)02476-1_BIB26) 2001; 29 Nakamura (10.1016/S0024-3205(02)02476-1_BIB19) 1999; 59 Radak (10.1016/S0024-3205(02)02476-1_BIB8) 2001; 7 Glassner (10.1016/S0024-3205(02)02476-1_BIB25) 1998; 95 Aspinwall (10.1016/S0024-3205(02)02476-1_BIB4) 1997; 94 Loeb (10.1016/S0024-3205(02)02476-1_BIB23) 1985; 40 Rosenquist (10.1016/S0024-3205(02)02476-1_BIB15) 1997; 94 Radak (10.1016/S0024-3205(02)02476-1_BIB11) 1999; 27 Niess (10.1016/S0024-3205(02)02476-1_BIB10) 1998; 38 Atamna (10.1016/S0024-3205(02)02476-1_BIB2) 2000; 97 Kim (10.1016/S0024-3205(02)02476-1_BIB12) 2001; 22 Asami (10.1016/S0024-3205(02)02476-1_BIB18) 1998; 29 Radicella (10.1016/S0024-3205(02)02476-1_BIB3) 1997; 94 Floyd (10.1016/S0024-3205(02)02476-1_BIB16) 1990; 11 Niess (10.1016/S0024-3205(02)02476-1_BIB9) 1996; 17 Moller (10.1016/S0024-3205(02)02476-1_BIB5) 2001; 15 Cardozo-Pelaez (10.1016/S0024-3205(02)02476-1_BIB13) 2000; 28 Radak (10.1016/S0024-3205(02)02476-1_BIB7) 1999; 26 Grollman (10.1016/S0024-3205(02)02476-1_BIB17) 1993; 9 Hoeijmakers (10.1016/S0024-3205(02)02476-1_BIB1) 2001; 411 Stecca (10.1016/S0024-3205(02)02476-1_BIB14) 1998; 55 Wallace (10.1016/S0024-3205(02)02476-1_BIB21) 1998; 150 Poulsen (10.1016/S0024-3205(02)02476-1_BIB6) 1996; 14 |
| References_xml | – volume: 97 start-page: 686 year: 2000 end-page: 691 ident: BIB2 article-title: A method for detecting abasic sites in living cells: age-dependent changes in base excision repair publication-title: Proc Natl Acad Sci U S A – volume: 150 start-page: S60 year: 1998 end-page: S79 ident: BIB21 article-title: Enzymatic processing of radiation-induced free radical damage in DNA publication-title: Radiat Res – volume: 9 start-page: 246 year: 1993 end-page: 249 ident: BIB17 article-title: Mutagenesis by 8-oxoguanine: an enemy within publication-title: Trends Genet – volume: 14 start-page: 343 year: 1996 end-page: 346 ident: BIB6 article-title: Extreme exercise and oxidative DNA modification publication-title: J Sports Sci – volume: 95 start-page: 9997 year: 1998 end-page: 10002 ident: BIB25 article-title: Generation of a strong mutator phenotype in yeast by imbalanced base excision repair publication-title: Proc Natl Acad Sci U SA – volume: 11 start-page: 1447 year: 1990 end-page: 1450 ident: BIB16 article-title: The role of 8-hydroxyguanine in carcinogenesis publication-title: Carcinogenesis – volume: 38 start-page: 111 year: 1998 end-page: 1115 ident: BIB10 article-title: Effects of intensive endurance exercise on DNA damage in leucocytes publication-title: J Sports Med Phys Fitness – volume: 28 start-page: 779 year: 2000 end-page: 785 ident: BIB13 article-title: DNA damage, repair, and antioxidant systems in brain regions: a correlative study publication-title: Free Radic Biol Med – volume: 273 start-page: 21203 year: 1998 end-page: 21209 ident: BIB20 article-title: Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps publication-title: J. Biol. Chem. – volume: 94 start-page: 8010 year: 1997 end-page: 8015 ident: BIB3 article-title: Cloning and characterization of hOGG1 gene of saccharomyces cerevisiae publication-title: Proc Natl Acad Sci USA – volume: 94 start-page: 109 year: 1997 end-page: 114 ident: BIB4 article-title: Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III publication-title: Proc Natl Acad Sci USA – volume: 29 start-page: 1975 year: 2001 end-page: 1981 ident: BIB26 article-title: Escherichia Coli Nth and human hNTH1 DNA glycosylases are involved in removal of 8-oxoguanine from 8-oxguanine/guanine mispairs in DNA publication-title: Nucl. Acid Res. – volume: 29 start-page: 581 year: 1998 end-page: 585 ident: BIB18 article-title: Reduction of 8-hydroxyguanine in human leukocyte DNA by physical exercise publication-title: Free Radic Res – volume: 15 start-page: 1181 year: 2001 end-page: 1186 ident: BIB5 article-title: Acute hypoxia and hypoxic exercise induce DNA strand breaks and oxidative DNA damage in humans publication-title: FASEB J – volume: 27 start-page: 69 year: 1999 end-page: 74 ident: BIB11 article-title: The effect of exercise training on oxidative damage of lipids, proteins, and DNA in rat skeletal muscle: evidence for beneficial outcomes publication-title: Free Radic Biol Med – volume: 68 start-page: xvii year: 2001 end-page: xxx ident: BIB22 article-title: Keynote: past, present, and future aspects of base excision repair publication-title: Prog Nucleic Acid Res. Mol. Biol. – volume: 7 start-page: 90 year: 2001 end-page: 107 ident: BIB8 article-title: Adaptation to exercise-induced oxidative stress: from muscle to brain publication-title: Exerc Immun Rev – volume: 94 start-page: 7429 year: 1997 end-page: 7434 ident: BIB15 article-title: Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase publication-title: Proc Natl Acad Sci U S A – volume: 59 start-page: 2522 year: 1999 end-page: 2526 ident: BIB19 article-title: Endogenous apurinic/apyrimidic sites in genomic DNA of mammalian tissues publication-title: Cancer Res – volume: 17 start-page: 397 year: 1996 end-page: 403 ident: BIB9 article-title: DNA damage after exhaustive treadmill running in trained and untrained men publication-title: Int J Sports Med – volume: 411 start-page: 366 year: 2001 end-page: 374 ident: BIB1 article-title: Genome maintenance mechanisms for preventing cancer publication-title: Nature – volume: 26 start-page: 1059 year: 1999 end-page: 1063 ident: BIB7 article-title: Muscle soreness-induced reduction in force generation is accompanied by increased nitric oxide content and DNA damage in human skeletal muscle publication-title: Free Radic Biol Med – volume: 22 start-page: 265 year: 2001 end-page: 269 ident: BIB12 article-title: Changes in DNA 8-hydroxyguanine levels, 8-hydroxyguanine repair activity, and hOGG1 and hMTH1 mRNA expression in human lung alveolar epithelial cells induced by crocidolite asbestos publication-title: Carcinogenesis – volume: 272 start-page: 1148 year: 1997 end-page: 1155 ident: BIB24 article-title: Apurinic sites are position-specific topoisomerase II poisons publication-title: J. Biol. Chem. – volume: 55 start-page: 941 year: 1998 end-page: 951 ident: BIB14 article-title: Adaptive response to DNA-damaging agents publication-title: Biochem Pharmacol – volume: 40 start-page: 483 year: 1985 end-page: 484 ident: BIB23 article-title: Apurinic sites as mutagenic intermediates publication-title: Cell – volume: 59 start-page: 2522 year: 1999 ident: 10.1016/S0024-3205(02)02476-1_BIB19 article-title: Endogenous apurinic/apyrimidic sites in genomic DNA of mammalian tissues publication-title: Cancer Res – volume: 7 start-page: 90 year: 2001 ident: 10.1016/S0024-3205(02)02476-1_BIB8 article-title: Adaptation to exercise-induced oxidative stress: from muscle to brain publication-title: Exerc Immun Rev – volume: 29 start-page: 1975 year: 2001 ident: 10.1016/S0024-3205(02)02476-1_BIB26 article-title: Escherichia Coli Nth and human hNTH1 DNA glycosylases are involved in removal of 8-oxoguanine from 8-oxguanine/guanine mispairs in DNA publication-title: Nucl. Acid Res. doi: 10.1093/nar/29.9.1975 – volume: 94 start-page: 7429 year: 1997 ident: 10.1016/S0024-3205(02)02476-1_BIB15 article-title: Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.94.14.7429 – volume: 38 start-page: 111 year: 1998 ident: 10.1016/S0024-3205(02)02476-1_BIB10 article-title: Effects of intensive endurance exercise on DNA damage in leucocytes publication-title: J Sports Med Phys Fitness – volume: 55 start-page: 941 year: 1998 ident: 10.1016/S0024-3205(02)02476-1_BIB14 article-title: Adaptive response to DNA-damaging agents publication-title: Biochem Pharmacol doi: 10.1016/S0006-2952(97)00448-6 – volume: 411 start-page: 366 year: 2001 ident: 10.1016/S0024-3205(02)02476-1_BIB1 article-title: Genome maintenance mechanisms for preventing cancer publication-title: Nature doi: 10.1038/35077232 – volume: 273 start-page: 21203 year: 1998 ident: 10.1016/S0024-3205(02)02476-1_BIB20 article-title: Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.33.21203 – volume: 94 start-page: 8010 year: 1997 ident: 10.1016/S0024-3205(02)02476-1_BIB3 article-title: Cloning and characterization of hOGG1 gene of saccharomyces cerevisiae publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.94.15.8010 – volume: 40 start-page: 483 year: 1985 ident: 10.1016/S0024-3205(02)02476-1_BIB23 article-title: Apurinic sites as mutagenic intermediates publication-title: Cell doi: 10.1016/0092-8674(85)90191-6 – volume: 27 start-page: 69 year: 1999 ident: 10.1016/S0024-3205(02)02476-1_BIB11 article-title: The effect of exercise training on oxidative damage of lipids, proteins, and DNA in rat skeletal muscle: evidence for beneficial outcomes publication-title: Free Radic Biol Med doi: 10.1016/S0891-5849(99)00038-6 – volume: 272 start-page: 1148 year: 1997 ident: 10.1016/S0024-3205(02)02476-1_BIB24 article-title: Apurinic sites are position-specific topoisomerase II poisons publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.2.1148 – volume: 17 start-page: 397 year: 1996 ident: 10.1016/S0024-3205(02)02476-1_BIB9 article-title: DNA damage after exhaustive treadmill running in trained and untrained men publication-title: Int J Sports Med doi: 10.1055/s-2007-972868 – volume: 14 start-page: 343 year: 1996 ident: 10.1016/S0024-3205(02)02476-1_BIB6 article-title: Extreme exercise and oxidative DNA modification publication-title: J Sports Sci doi: 10.1080/02640419608727720 – volume: 150 start-page: S60 year: 1998 ident: 10.1016/S0024-3205(02)02476-1_BIB21 article-title: Enzymatic processing of radiation-induced free radical damage in DNA publication-title: Radiat Res doi: 10.2307/3579809 – volume: 28 start-page: 779 year: 2000 ident: 10.1016/S0024-3205(02)02476-1_BIB13 article-title: DNA damage, repair, and antioxidant systems in brain regions: a correlative study publication-title: Free Radic Biol Med doi: 10.1016/S0891-5849(00)00172-6 – volume: 22 start-page: 265 year: 2001 ident: 10.1016/S0024-3205(02)02476-1_BIB12 article-title: Changes in DNA 8-hydroxyguanine levels, 8-hydroxyguanine repair activity, and hOGG1 and hMTH1 mRNA expression in human lung alveolar epithelial cells induced by crocidolite asbestos publication-title: Carcinogenesis doi: 10.1093/carcin/22.2.265 – volume: 9 start-page: 246 year: 1993 ident: 10.1016/S0024-3205(02)02476-1_BIB17 article-title: Mutagenesis by 8-oxoguanine: an enemy within publication-title: Trends Genet doi: 10.1016/0168-9525(93)90089-Z – volume: 15 start-page: 1181 year: 2001 ident: 10.1016/S0024-3205(02)02476-1_BIB5 article-title: Acute hypoxia and hypoxic exercise induce DNA strand breaks and oxidative DNA damage in humans publication-title: FASEB J doi: 10.1096/fj.00-0703com – volume: 94 start-page: 109 year: 1997 ident: 10.1016/S0024-3205(02)02476-1_BIB4 article-title: Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.94.1.109 – volume: 68 start-page: xvii year: 2001 ident: 10.1016/S0024-3205(02)02476-1_BIB22 article-title: Keynote: past, present, and future aspects of base excision repair publication-title: Prog Nucleic Acid Res. Mol. Biol. doi: 10.1016/S0079-6603(01)68084-X – volume: 26 start-page: 1059 year: 1999 ident: 10.1016/S0024-3205(02)02476-1_BIB7 article-title: Muscle soreness-induced reduction in force generation is accompanied by increased nitric oxide content and DNA damage in human skeletal muscle publication-title: Free Radic Biol Med doi: 10.1016/S0891-5849(98)00309-8 – volume: 29 start-page: 581 year: 1998 ident: 10.1016/S0024-3205(02)02476-1_BIB18 article-title: Reduction of 8-hydroxyguanine in human leukocyte DNA by physical exercise publication-title: Free Radic Res doi: 10.1080/10715769800300621 – volume: 97 start-page: 686 year: 2000 ident: 10.1016/S0024-3205(02)02476-1_BIB2 article-title: A method for detecting abasic sites in living cells: age-dependent changes in base excision repair publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.97.2.686 – volume: 11 start-page: 1447 year: 1990 ident: 10.1016/S0024-3205(02)02476-1_BIB16 article-title: The role of 8-hydroxyguanine in carcinogenesis publication-title: Carcinogenesis doi: 10.1093/carcin/11.9.1447 – volume: 95 start-page: 9997 year: 1998 ident: 10.1016/S0024-3205(02)02476-1_BIB25 article-title: Generation of a strong mutator phenotype in yeast by imbalanced base excision repair publication-title: Proc Natl Acad Sci U SA doi: 10.1073/pnas.95.17.9997 |
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| SubjectTerms | Adaptation Base excision repair Biopsy Deoxyribonuclease (Pyrimidine Dimer) DNA - chemistry DNA Damage DNA Repair DNA-Formamidopyrimidine Glycosylase Endodeoxyribonucleases - genetics Endodeoxyribonucleases - metabolism Escherichia coli Proteins Exercise Humans Male Muscle, Skeletal - enzymology N-Glycosyl Hydrolases - genetics N-Glycosyl Hydrolases - metabolism Oxidative stress Running |
| Title | Marathon running alters the DNA base excision repair in human skeletal muscle |
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