Apple polyphenols extract (APE) improves colon damage in a rat model of colitis

• Published in: Digestive and liver disease Vol. 44; no. 7; pp. 555 - 562
• Main Authors: D’Argenio, Giuseppe, Mazzone, Giovanna, Tuccillo, Concetta, Ribecco, Maria T., Graziani, Giulia, Gravina, Antonietta G., Caserta, Sergio, Guido, Stefano, Fogliano, Vincenzo, Caporaso, Nicola, Romano, Marco
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.07.2012
• Subjects: Animals; Apple polyphenols; Calpain; Calpain - drug effects; Calpain - metabolism; Colitis - chemically induced; Colitis - drug therapy; Colitis - metabolism; Colitis - pathology; Cyclooxygenase 2 - drug effects; Cyclooxygenase 2 - metabolism; Gastroenterology and Hepatology; GTP-Binding Proteins - drug effects; GTP-Binding Proteins - metabolism; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Male; Malus; Mice; NIH 3T3 Cells; Phytotherapy; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Polyphenols - pharmacology; Polyphenols - therapeutic use; Rabbits; Rat colitis; Rats, Wistar; RNA, Messenger - metabolism; Tissue transglutaminase; Transglutaminases - drug effects; Transglutaminases - metabolism; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha - drug effects; Tumor Necrosis Factor-alpha - metabolism; Tissue transglutaminase; Calpain; Rat colitis; Apple polyphenols

Searching for alternative therapies that are effective, safe and less expensive of those currently used for ulcerative colitis, we investigated the efficacy of a polyphenol extract from apple in rat colitis. Rats with trinitrobenzensulphonic acid-induced colitis were treated daily with rectal admini...