Advances and prospects of Bacillus subtilis cellular factories: From rational design to industrial applications

• Published in: Metabolic engineering Vol. 50; pp. 109 - 121
• Main Authors: Gu, Yang, Xu, Xianhao, Wu, Yaokang, Niu, Tengfei, Liu, Yanfeng, Li, Jianghua, Du, Guocheng, Liu, Long
• Format: Journal Article
• Language: English
• Published: Belgium Elsevier Inc 01.11.2018
• Subjects: Bacillus subtilis; carbon; factories; fermentation; genetic engineering; Gram-positive bacteria; hosts; Industrial applications; Metabolic engineering; Microbial cell factories; recombinant proteins; Synthetic biology; Metabolic engineering; Industrial applications; Synthetic biology; Microbial cell factories; Bacillus subtilis

Bacillus subtilis is the most characterized gram-positive bacterium that has significant attributes, such as growing well on cheap carbon sources, possessing clear inherited backgrounds, having mature genetic manipulation methods, and exhibiting robustness in large-scale fermentations. Till date, B....