Advances and prospects of Bacillus subtilis cellular factories: From rational design to industrial applications

Bacillus subtilis is the most characterized gram-positive bacterium that has significant attributes, such as growing well on cheap carbon sources, possessing clear inherited backgrounds, having mature genetic manipulation methods, and exhibiting robustness in large-scale fermentations. Till date, B....

Full description

Saved in:
Bibliographic Details
Published inMetabolic engineering Vol. 50; pp. 109 - 121
Main Authors Gu, Yang, Xu, Xianhao, Wu, Yaokang, Niu, Tengfei, Liu, Yanfeng, Li, Jianghua, Du, Guocheng, Liu, Long
Format Journal Article
LanguageEnglish
Published Belgium Elsevier Inc 01.11.2018
Subjects
Bacillus subtilis
carbon
factories
fermentation
genetic engineering
Gram-positive bacteria
hosts
Industrial applications
Metabolic engineering
Microbial cell factories
recombinant proteins
Synthetic biology
Metabolic engineering
Industrial applications
Synthetic biology
Microbial cell factories
Bacillus subtilis
Online AccessGet full text

Cover

Abstract Bacillus subtilis is the most characterized gram-positive bacterium that has significant attributes, such as growing well on cheap carbon sources, possessing clear inherited backgrounds, having mature genetic manipulation methods, and exhibiting robustness in large-scale fermentations. Till date, B. subtilis has been identified as attractive hosts for the production of recombinant proteins and chemicals. By applying various systems and synthetic biology tools, the productivity features of B. subtilis can be thoroughly analyzed and further optimized via metabolic engineering. In the present review, we discussed why B. subtilis is the primary organisms used for metabolic engineering and industrial applications. Additionally, we summarized the recent advances in systems and synthetic biology, engineering strategies for improving cellular performances, and metabolic engineering applications of B. subtilis. In particular, we proposed emerging opportunities and essential strategies to enable the successful development of B. subtilis as microbial cell factories. •The product portfolio of B. subtilis is expanding from proteins to bio-chemicals.•Reason of B. subtilis as a primary strain for metabolic engineering was discussed.•Recent advances in basic studies and applications of B. subtilis were summarized.•Essential strategies of developing B. subtilis to be cell factories were proposed.
AbstractList Bacillus subtilis is the most characterized gram-positive bacterium that has significant attributes, such as growing well on cheap carbon sources, possessing clear inherited backgrounds, having mature genetic manipulation methods, and exhibiting robustness in large-scale fermentations. Till date, B. subtilis has been identified as attractive hosts for the production of recombinant proteins and chemicals. By applying various systems and synthetic biology tools, the productivity features of B. subtilis can be thoroughly analyzed and further optimized via metabolic engineering. In the present review, we discussed why B. subtilis is the primary organisms used for metabolic engineering and industrial applications. Additionally, we summarized the recent advances in systems and synthetic biology, engineering strategies for improving cellular performances, and metabolic engineering applications of B. subtilis. In particular, we proposed emerging opportunities and essential strategies to enable the successful development of B. subtilis as microbial cell factories.
Bacillus subtilis is the most characterized gram-positive bacterium that has significant attributes, such as growing well on cheap carbon sources, possessing clear inherited backgrounds, having mature genetic manipulation methods, and exhibiting robustness in large-scale fermentations. Till date, B. subtilis has been identified as attractive hosts for the production of recombinant proteins and chemicals. By applying various systems and synthetic biology tools, the productivity features of B. subtilis can be thoroughly analyzed and further optimized via metabolic engineering. In the present review, we discussed why B. subtilis is the primary organisms used for metabolic engineering and industrial applications. Additionally, we summarized the recent advances in systems and synthetic biology, engineering strategies for improving cellular performances, and metabolic engineering applications of B. subtilis. In particular, we proposed emerging opportunities and essential strategies to enable the successful development of B. subtilis as microbial cell factories.Bacillus subtilis is the most characterized gram-positive bacterium that has significant attributes, such as growing well on cheap carbon sources, possessing clear inherited backgrounds, having mature genetic manipulation methods, and exhibiting robustness in large-scale fermentations. Till date, B. subtilis has been identified as attractive hosts for the production of recombinant proteins and chemicals. By applying various systems and synthetic biology tools, the productivity features of B. subtilis can be thoroughly analyzed and further optimized via metabolic engineering. In the present review, we discussed why B. subtilis is the primary organisms used for metabolic engineering and industrial applications. Additionally, we summarized the recent advances in systems and synthetic biology, engineering strategies for improving cellular performances, and metabolic engineering applications of B. subtilis. In particular, we proposed emerging opportunities and essential strategies to enable the successful development of B. subtilis as microbial cell factories.
Bacillus subtilis is the most characterized gram-positive bacterium that has significant attributes, such as growing well on cheap carbon sources, possessing clear inherited backgrounds, having mature genetic manipulation methods, and exhibiting robustness in large-scale fermentations. Till date, B. subtilis has been identified as attractive hosts for the production of recombinant proteins and chemicals. By applying various systems and synthetic biology tools, the productivity features of B. subtilis can be thoroughly analyzed and further optimized via metabolic engineering. In the present review, we discussed why B. subtilis is the primary organisms used for metabolic engineering and industrial applications. Additionally, we summarized the recent advances in systems and synthetic biology, engineering strategies for improving cellular performances, and metabolic engineering applications of B. subtilis. In particular, we proposed emerging opportunities and essential strategies to enable the successful development of B. subtilis as microbial cell factories. •The product portfolio of B. subtilis is expanding from proteins to bio-chemicals.•Reason of B. subtilis as a primary strain for metabolic engineering was discussed.•Recent advances in basic studies and applications of B. subtilis were summarized.•Essential strategies of developing B. subtilis to be cell factories were proposed.
Author Liu, Yanfeng
Du, Guocheng
Xu, Xianhao
Wu, Yaokang
Niu, Tengfei
Liu, Long
Li, Jianghua
Gu, Yang
Author_xml – sequence: 1
  givenname: Yang
  surname: Gu
  fullname: Gu, Yang
  organization: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China
– sequence: 2
  givenname: Xianhao
  surname: Xu
  fullname: Xu, Xianhao
  organization: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China
– sequence: 3
  givenname: Yaokang
  orcidid: 0000-0003-2415-5739
  surname: Wu
  fullname: Wu, Yaokang
  organization: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China
– sequence: 4
  givenname: Tengfei
  surname: Niu
  fullname: Niu, Tengfei
  organization: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China
– sequence: 5
  givenname: Yanfeng
  surname: Liu
  fullname: Liu, Yanfeng
  organization: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China
– sequence: 6
  givenname: Jianghua
  surname: Li
  fullname: Li, Jianghua
  organization: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China
– sequence: 7
  givenname: Guocheng
  surname: Du
  fullname: Du, Guocheng
  organization: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China
– sequence: 8
  givenname: Long
  surname: Liu
  fullname: Liu, Long
  email: longliu@jiangnan.edu.cn
  organization: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29775652$$D View this record in MEDLINE/PubMed
BookMark eNqFkU1v3CAQhlGUqPlof0GlimMv6wAGjCv1kEZNEylSL7kjDOOIlQ0u4Ej592F3kx56SE986HlHM_Oco-MQAyD0mZKGEiovt83zPEBoGKGqIaIhRB6hM0p6uemo4sd_7508Rec5bwmhVPT0AzplfdcJKdgZilfuyQQLGZvg8JJiXsCWjOOIfxjrp2nNOK9D8ZPP2EJ9Tybh0dgSk4f8Dd-kOONkio_BTNhB9o8Bl4h9cGsuyddPsyyTt3skf0Qno5kyfHo9L9DDzc-H69vN_e9fd9dX9xvLhSob6YjrFet60REYlFUjkZSBsIOiauhGzo0BpaQRrgUOknd0HNpWtgq63rTtBfp6KFsn-rNCLnr2ede-CRDXrBljRCnFW_F_lHAq255xVtEvr-g6zOD0kvxs0rN-W2cF-gNg6yJzglFbX_aDl2T8pCnRO3V6q_fq9E6dJkJXdTXb_pN9K_9-6vshBXWZTx6SztZDFep8qiK1i_7d_AspLLTO
CitedBy_id crossref_primary_10_1021_acssynbio_0c00645
crossref_primary_10_1093_femsle_fnac017
crossref_primary_10_1039_C9RA07866E
crossref_primary_10_1016_j_copbio_2019_01_007
crossref_primary_10_1021_acs_jafc_3c09158
crossref_primary_10_1038_s41598_021_92627_9
crossref_primary_10_1186_s12866_024_03700_y
crossref_primary_10_1111_lam_13584
crossref_primary_10_3390_su13105499
crossref_primary_10_1080_07388551_2021_1888069
crossref_primary_10_1134_S0003683824606619
crossref_primary_10_1021_acs_jafc_2c06741
crossref_primary_10_1093_nar_gkab1124
crossref_primary_10_1360_TB_2022_0532
crossref_primary_10_3390_ma13214993
crossref_primary_10_1016_j_cej_2024_149102
crossref_primary_10_1155_2024_8846747
crossref_primary_10_1016_j_synbio_2018_12_001
crossref_primary_10_3934_microbiol_2019_3_232
crossref_primary_10_1016_j_synbio_2020_07_005
crossref_primary_10_1093_nar_gkaa810
crossref_primary_10_1128_MRA_00825_20
crossref_primary_10_1016_j_enzmictec_2020_109726
crossref_primary_10_1007_s11274_024_04065_0
crossref_primary_10_3390_foods12163084
crossref_primary_10_1016_j_btre_2020_e00540
crossref_primary_10_3390_microorganisms8040519
crossref_primary_10_1021_acs_jafc_4c03397
crossref_primary_10_1016_j_biotechadv_2022_107966
crossref_primary_10_1016_j_bcab_2021_102054
crossref_primary_10_1111_jam_14904
crossref_primary_10_1038_s41589_020_0637_3
crossref_primary_10_1590_fst_101422
crossref_primary_10_1021_acssynbio_3c00063
crossref_primary_10_1016_j_ygeno_2021_02_006
crossref_primary_10_1016_j_ymben_2020_08_008
crossref_primary_10_1038_s41540_022_00259_0
crossref_primary_10_1002_jobm_202300614
crossref_primary_10_1111_1751_7915_13292
crossref_primary_10_55230_mabjournal_v51i5_2370
crossref_primary_10_1016_j_cej_2023_143865
crossref_primary_10_1016_j_synbio_2023_03_008
crossref_primary_10_1016_j_biortech_2021_125671
crossref_primary_10_1002_jobm_202200134
crossref_primary_10_3389_fbioe_2020_00432
crossref_primary_10_1134_S0026261722020060
crossref_primary_10_1016_j_jbiotec_2021_07_010
crossref_primary_10_3390_microorganisms12050986
crossref_primary_10_1016_j_ymben_2023_06_004
crossref_primary_10_1007_s43393_022_00127_2
crossref_primary_10_1016_j_biotechadv_2023_108300
crossref_primary_10_3389_fmicb_2022_883122
crossref_primary_10_1002_jctb_7524
crossref_primary_10_1080_10408398_2020_1739000
crossref_primary_10_1007_s11274_020_02932_0
crossref_primary_10_1093_nar_gkac417
crossref_primary_10_1099_mic_0_000942
crossref_primary_10_1007_s00253_019_09788_x
crossref_primary_10_1007_s10529_022_03319_x
crossref_primary_10_3390_molecules29194749
crossref_primary_10_1007_s00253_023_12482_8
crossref_primary_10_3389_fbioe_2022_977215
crossref_primary_10_1007_s00449_022_02769_x
crossref_primary_10_1016_j_biortech_2023_129843
crossref_primary_10_1016_j_ymben_2020_03_012
crossref_primary_10_1038_s41467_020_20153_9
crossref_primary_10_1016_j_biortech_2021_125836
crossref_primary_10_1016_j_ymben_2024_03_001
crossref_primary_10_1016_j_synbio_2018_09_004
crossref_primary_10_1016_j_tibtech_2020_01_002
crossref_primary_10_2174_0929866529666220803163335
crossref_primary_10_1002_jctb_7017
crossref_primary_10_1016_j_biotechadv_2024_108396
crossref_primary_10_3389_fmicb_2021_714449
crossref_primary_10_1007_s12257_020_0397_7
crossref_primary_10_29105_bys7_13_108
crossref_primary_10_1038_s41598_024_81490_z
crossref_primary_10_1007_s00253_019_10200_x
crossref_primary_10_1021_acssynbio_4c00371
crossref_primary_10_1111_are_15571
crossref_primary_10_3389_fbioe_2024_1479626
crossref_primary_10_1016_j_bej_2018_10_023
crossref_primary_10_1186_s12934_020_01307_2
crossref_primary_10_1016_j_engmic_2023_100099
crossref_primary_10_1155_2022_8476412
crossref_primary_10_1021_acs_est_4c02533
crossref_primary_10_1021_acssynbio_4c00530
crossref_primary_10_1080_07388551_2022_2095499
crossref_primary_10_1021_acssynbio_3c00315
crossref_primary_10_1016_j_biotechadv_2022_108049
crossref_primary_10_1016_j_jare_2022_09_003
crossref_primary_10_1016_j_microb_2024_100092
crossref_primary_10_1007_s11084_024_09652_7
crossref_primary_10_1021_acs_biochem_3c00554
crossref_primary_10_1186_s12934_024_02334_z
crossref_primary_10_3390_microorganisms11010178
crossref_primary_10_1016_j_fbio_2024_104219
crossref_primary_10_1016_j_jfca_2024_105993
crossref_primary_10_3389_frspt_2023_1181843
crossref_primary_10_1007_s12257_020_0231_2
crossref_primary_10_1016_j_bej_2021_107948
crossref_primary_10_1016_j_synbio_2021_06_001
crossref_primary_10_1007_s11274_021_03051_0
crossref_primary_10_1007_s00203_019_01757_2
crossref_primary_10_1016_j_copbio_2023_103064
crossref_primary_10_1016_j_ijbiomac_2025_141727
crossref_primary_10_1042_EBC20210011
crossref_primary_10_1016_j_biotechadv_2020_107520
crossref_primary_10_1016_j_cbpa_2020_03_004
crossref_primary_10_1021_acs_jafc_8b05038
crossref_primary_10_3390_fermentation8090449
crossref_primary_10_1042_EBC20180045
crossref_primary_10_1093_bbb_zbae120
crossref_primary_10_1186_s12934_020_01436_8
crossref_primary_10_1016_j_ymben_2018_10_002
crossref_primary_10_1016_j_jbiotec_2019_01_012
crossref_primary_10_1128_spectrum_01322_22
crossref_primary_10_3389_fphar_2023_1208277
crossref_primary_10_1016_j_ijbiomac_2021_10_208
crossref_primary_10_1186_s13068_022_02253_4
crossref_primary_10_1016_j_enzmictec_2020_109531
crossref_primary_10_1016_j_jbiosc_2021_04_005
crossref_primary_10_1016_j_biotechadv_2022_108028
crossref_primary_10_1038_s41598_020_70314_5
crossref_primary_10_1007_s00253_021_11533_2
crossref_primary_10_1155_sci5_8968295
crossref_primary_10_1016_j_biortech_2025_132051
crossref_primary_10_1051_e3sconf_202338101073
crossref_primary_10_1002_smtd_201900596
crossref_primary_10_1016_j_enzmictec_2024_110485
crossref_primary_10_3390_foods9050671
crossref_primary_10_47280_RevFacAgron_LUZ__v41_n3_01
crossref_primary_10_1021_acssuschemeng_9b01527
crossref_primary_10_1134_S0026893320010082
crossref_primary_10_1007_s00217_019_03259_3
crossref_primary_10_1002_bit_26992
crossref_primary_10_1002_bit_27322
crossref_primary_10_3389_fmicb_2022_968439
crossref_primary_10_1002_jctb_7053
crossref_primary_10_1016_j_isci_2023_106065
crossref_primary_10_1007_s10930_020_09908_x
crossref_primary_10_1080_02648725_2018_1506898
crossref_primary_10_1016_j_ab_2023_115315
crossref_primary_10_1016_j_mtbio_2022_100518
crossref_primary_10_1016_j_procbio_2022_11_023
crossref_primary_10_1007_s00253_023_12889_3
crossref_primary_10_1007_s10529_021_03145_7
crossref_primary_10_1016_j_jtice_2022_104218
crossref_primary_10_18097_pbmc20236901019
crossref_primary_10_1007_s11356_019_06135_5
crossref_primary_10_1080_07388551_2021_1983516
crossref_primary_10_1111_lam_13312
crossref_primary_10_1080_07388551_2022_2095252
crossref_primary_10_1002_fbe2_12062
crossref_primary_10_1007_s00253_020_10528_9
crossref_primary_10_1016_j_tibtech_2018_10_005
crossref_primary_10_1002_biot_201800437
crossref_primary_10_1021_acs_jafc_1c02089
crossref_primary_10_3389_fbioe_2023_1098116
crossref_primary_10_1007_s10529_021_03190_2
crossref_primary_10_1016_j_renene_2022_04_124
crossref_primary_10_1016_j_ijbiomac_2025_142076
crossref_primary_10_1557_s43580_024_00868_3
crossref_primary_10_1021_acssynbio_9b00077
Cites_doi 10.1371/journal.pone.0093815
10.1080/07388551.2017.1299680
10.1128/AEM.01361-10
10.1038/nchembio.970
10.1016/j.ymben.2014.04.004
10.1074/mcp.M113.032631
10.1111/mmi.13633
10.1186/s12934-015-0374-6
10.1038/nbt.3365
10.1159/000355264
10.1128/AEM.71.12.8818-8824.2005
10.1002/jctb.1534
10.1038/nchem.2459
10.1002/bit.24846
10.1007/s00253-015-6552-y
10.1007/s00253-008-1462-x
10.1186/1475-2859-13-63
10.1016/j.ymben.2009.05.002
10.1038/ng1555
10.1128/JB.181.7.1975-1983.1999
10.1016/j.carbpol.2015.12.065
10.1023/A:1024445131925
10.1007/s11274-016-2184-3
10.1016/j.jbiotec.2013.09.020
10.1016/j.cell.2016.05.003
10.1002/elsc.201000133
10.1016/j.tibtech.2014.04.003
10.1016/j.ymben.2016.01.008
10.1016/j.copbio.2017.10.009
10.1016/j.pep.2013.02.008
10.1186/s13068-016-0537-7
10.1128/AEM.01159-16
10.1007/s12275-014-2622-6
10.1038/nchembio.580
10.1007/s10295-015-1630-9
10.1007/s00253-011-3774-5
10.1073/pnas.1321308111
10.1186/s12934-017-0688-7
10.1099/mic.0.079376-0
10.1016/j.jbiotec.2015.12.029
10.1038/nchembio.2535
10.1016/j.ymben.2015.09.011
10.1016/j.biotechadv.2014.01.002
10.1128/AEM.01156-08
10.1016/j.biortech.2017.10.007
10.1186/1754-6834-6-123
10.1186/s13068-016-0502-5
10.1007/s10529-014-1613-3
10.1016/j.ymben.2013.07.002
10.1002/bit.24900
10.1073/pnas.0504604102
10.1007/s00253-014-5569-y
10.1099/mic.0.081448-0
10.1038/36786
10.1016/j.jbiotec.2012.12.009
10.1038/nrmicro1772
10.15252/msb.20156236
10.1016/j.cell.2016.02.004
10.1007/s00253-012-4543-9
10.1007/s11274-012-1155-6
10.1111/j.1365-2958.2011.07952.x
10.1186/s12934-017-0772-z
10.1093/nar/gks248
10.1016/j.biortech.2017.09.063
10.1128/AEM.01453-16
10.1038/nprot.2012.102
10.1590/S1517-83822012000300036
10.1126/science.aag0804
10.1016/j.ymben.2014.02.002
10.1186/s12934-015-0341-2
10.1038/nbt.3763
10.1038/ncomms11933
10.1016/j.jbiotec.2013.07.031
10.1023/A:1010369325558
10.1016/j.biotechadv.2006.08.002
10.1007/s10295-014-1477-5
10.1038/nbt.1557
10.1016/j.cels.2016.12.013
10.1038/nbt.2055
10.1002/biot.200900247
10.1007/s10529-016-2193-1
10.1111/j.1751-7915.2010.00230.x
10.1186/s12934-017-0682-0
10.1093/nar/gkl358
10.1038/srep44023
10.1016/j.ymben.2014.02.005
10.1002/bit.25265
10.1038/s41598-017-15107-z
10.1016/j.jbiotec.2016.02.019
10.1093/nar/gkm910
10.1128/JB.185.16.5019-5022.2003
10.1002/biot.201400577
10.1016/j.tibtech.2016.02.010
10.1186/gb-2009-10-6-r69
10.1016/j.biortech.2010.01.080
10.1128/AEM.07209-11
10.1002/bit.26459
10.1021/acssynbio.6b00065
10.1038/srep27943
10.1093/nar/gku1380
10.1002/pmic.201300183
10.1126/science.aan3289
10.1039/c3cc40454d
10.1007/s00253-015-7256-z
10.1134/S0026893314060132
10.1007/s10295-014-1527-z
10.1016/j.ejcb.2006.05.009
10.1080/09168451.2015.1060843
10.1186/1475-2859-12-72
10.1128/MMBR.68.2.207-233.2004
10.1016/j.copbio.2017.06.007
10.1038/nbt.2509
10.1002/biot.201700020
10.1007/s10295-015-1672-z
10.1046/j.1365-2958.2002.03140.x
10.1016/j.copbio.2016.03.016
10.1093/nar/gkr888
10.1093/nar/gkv1006
10.1038/ncomms9224
10.1038/msb.2011.21
10.1038/ncomms8832
10.1007/s00449-013-0959-6
10.1007/s00253-013-4960-4
10.1186/1754-1611-7-29
10.1038/415263b
10.1128/MMBR.00024-06
10.1021/acs.jafc.6b05528
10.1016/j.bej.2009.04.008
10.1007/s00253-016-7816-x
10.1016/j.copbio.2014.05.005
10.1186/1472-6750-11-119
10.1016/j.tim.2014.10.003
10.1007/s11274-017-2338-y
10.1186/s13068-015-0320-1
10.1093/dnares/dsn002
10.1016/j.ymben.2008.06.002
10.1038/ncomms2425
10.1038/75398
10.1016/j.biortech.2013.12.080
10.1007/s00253-009-2247-6
10.1099/mic.0.2007/005959-0
10.1016/j.ymben.2011.07.006
10.1093/nar/gkt1007
10.1186/1475-2859-12-3
10.1007/s12010-014-0908-0
10.1016/j.biotechadv.2016.11.003
10.1186/1475-2859-7-10
10.1128/AEM.71.7.3747-3752.2005
10.1099/mic.0.000001
10.1038/sj.jim.2900587
10.1128/AEM.71.7.4101-4103.2005
10.1007/s10529-006-9143-2
10.1093/nar/gkv1164
10.1007/s11947-009-0186-y
10.1016/j.copbio.2014.12.015
10.1021/jf5013902
10.1016/j.bej.2012.04.006
10.1016/j.cbpa.2017.10.004
10.1007/s10295-014-1506-4
10.1016/j.pep.2012.03.015
10.1093/nar/29.1.278
10.1016/S0092-8674(03)00391-X
10.1007/s00253-017-8142-7
10.1007/s00253-013-4995-6
10.1021/ja2114486
10.1128/AEM.06017-11
10.1007/s11274-014-1611-6
10.1186/s12934-016-0469-8
10.1111/j.1365-2672.2010.04683.x
10.1016/j.jbiotec.2014.06.027
10.1128/AEM.70.12.7241-7250.2004
10.1074/mcp.M113.035741
ContentType Journal Article
Copyright 2018 International Metabolic Engineering Society
Copyright © 2018 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.
Copyright_xml – notice: 2018 International Metabolic Engineering Society
– notice: Copyright © 2018 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.
DBID AAYXX
CITATION
NPM
7X8
7S9
L.6
DOI 10.1016/j.ymben.2018.05.006
DatabaseName CrossRef
PubMed
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList AGRICOLA
MEDLINE - Academic
PubMed
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
Biology
EISSN 1096-7184
EndPage 121
ExternalDocumentID 29775652
10_1016_j_ymben_2018_05_006
S1096717617304822
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GroupedDBID ---
--K
--M
.~1
0R~
123
1B1
1RT
1~.
1~5
29M
4.4
457
4G.
53G
5VS
7-5
71M
8P~
AAAJQ
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AARKO
AAXUO
ABFNM
ABGSF
ABJNI
ABMAC
ABNUV
ABUDA
ABXDB
ABYKQ
ACDAQ
ACGFS
ACRLP
ADBBV
ADEWK
ADEZE
ADFGL
ADMUD
ADUVX
AEBSH
AEHWI
AEKER
AENEX
AFKWA
AFTJW
AFXIZ
AGEKW
AGHFR
AGRDE
AGUBO
AGYEJ
AHPOS
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
AKURH
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
CAG
CJTIS
COF
CS3
DM4
DOVZS
DU5
EBS
EFBJH
EFLBG
EJD
ENUVR
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-Q
GBLVA
HVGLF
HZ~
IHE
J1W
KOM
LG5
LUGTX
M41
MO0
N9A
O-L
O9-
OAUVE
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
ROL
RPZ
SDF
SDG
SDP
SES
SEW
SPC
SPCBC
SSG
SSI
SSU
SSZ
T5K
UHS
XPP
ZMT
ZU3
~G-
AAHBH
AATTM
AAXKI
AAYWO
AAYXX
ABWVN
ACRPL
ACVFH
ADCNI
ADNMO
AEIPS
AEUPX
AFJKZ
AFPUW
AGCQF
AGQPQ
AGRNS
AIGII
AIIUN
AKBMS
AKRWK
AKYEP
ANKPU
APXCP
BNPGV
CITATION
SSH
EFKBS
NPM
7X8
7S9
L.6
ID FETCH-LOGICAL-c458t-6d0d98279570eb8c8f0612e5cb818b7f44aae886a5d3e4e6471fb33638e79a33
IEDL.DBID .~1
ISSN 1096-7176
1096-7184
IngestDate Fri Jul 11 06:23:49 EDT 2025
Tue Aug 05 10:21:20 EDT 2025
Mon Jul 21 05:39:22 EDT 2025
Tue Jul 01 00:51:25 EDT 2025
Thu Apr 24 23:09:52 EDT 2025
Fri Feb 23 02:37:47 EST 2024
IsPeerReviewed true
IsScholarly true
Keywords Metabolic engineering
Industrial applications
Synthetic biology
Microbial cell factories
Bacillus subtilis
Language English
License Copyright © 2018 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c458t-6d0d98279570eb8c8f0612e5cb818b7f44aae886a5d3e4e6471fb33638e79a33
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ORCID 0000-0003-2415-5739
PMID 29775652
PQID 2041639242
PQPubID 23479
PageCount 13
ParticipantIDs proquest_miscellaneous_2220888435
proquest_miscellaneous_2041639242
pubmed_primary_29775652
crossref_citationtrail_10_1016_j_ymben_2018_05_006
crossref_primary_10_1016_j_ymben_2018_05_006
elsevier_sciencedirect_doi_10_1016_j_ymben_2018_05_006
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate November 2018
2018-11-00
20181101
PublicationDateYYYYMMDD 2018-11-01
PublicationDate_xml – month: 11
  year: 2018
  text: November 2018
PublicationDecade 2010
PublicationPlace Belgium
PublicationPlace_xml – name: Belgium
PublicationTitle Metabolic engineering
PublicationTitleAlternate Metab Eng
PublicationYear 2018
Publisher Elsevier Inc
Publisher_xml – name: Elsevier Inc
References Kabisch, Pratzka, Meyer, Albrecht, Lalk (bib68) 2013; 12
Muntel, Fromion, Goelzer, Maabeta, Mader (bib109) 2014; 13
Wang, Xia, Gu, Zhang, Chen (bib149) 2015; 14
Albertsen, Chen, Bach, Rattleff, Maury (bib2) 2011; 77
Deutscher, Francke, Postma (bib33) 2006; 70
Sutter, Greber, Aussignargues, Kerfeld (bib140) 2017; 356
Lee, Kim (bib82) 2015; 33
Xiao, Lu (bib160) 2014; 62
Piepenbreier, Fritz, Gebhard (bib116) 2017; 104
Jin, Kang, Yuan, Du, Chen (bib63) 2016; 35
Chen, Liu, Fu, Zhang, Tang (bib21) 2013; 168
Krom, Warner, Konings, Lolkema (bib74) 2003; 84
Ling Lin, Zi Rong, Wei Fen, Jiang Bing, Ping (bib87) 2007; 25
Song, Fu, Dong, Li, Du (bib137) 2017; 65
Dormeyer, Egelkamp, Thiele, Hammer, Gunka (bib36) 2015; 161
Zhou, Du, Kang, Li, Chen (bib183) 2017; 33
Henry, Zinner, Cohoon, Stevens (bib56) 2009; 10
Coutte, Leclere, Bechet, Guez, Lecouturier (bib29) 2010; 109
Biswas, Yamaoka, Nakayama, Kondo, Yoshida (bib12) 2012; 94
Defoor, Kryger, Martinussen (bib31) 2007; 153
Ling, Liu, Li, Shin, Chen (bib88) 2017; 245
de Cesaro, da Silva, Ayub (bib30) 2014; 41
Mulder, Bandola, Schumann (bib108) 2013; 89
Hemberger, Pedrolli, Stolz, Vogl, Lehmann (bib55) 2011; 11
Pohl, Bhavsar, Hulme, Bloor, Misirli (bib117) 2013; 13
Liu, Zhu, Li, Shin, Chen (bib95) 2014; 23
Sierro, Makita, de Hoon, Nakai (bib133) 2008; 36
Ajikumar, Xiao, Tyo, Wang, Simeon (bib1) 2010; 330
Qiao, Wasylenko, Zhou, Xu, Stephanopoulos (bib121) 2017; 35
Kind, Kreye, Wittmann (bib72) 2011; 13
Bassalo, Liu, Gill (bib10) 2016; 39
Welsch, Homuth, Schweder (bib152) 2015; 99
Widner, Behr, Von Dollen, Tang, Heu (bib156) 2005; 71
Maabeta, Wachlin, Bernhardt, Eymann, Fromion (bib101) 2014; 13
Schwechheimer, Park, Revuelta, Becker, Wittmann (bib126) 2016; 100
Zhu, Cai, Wu, Huang, Huang (bib186) 2013; 164
Koo, Kritikos, Farelli, Todor, Tong (bib73) 2017; 4
Wheeldon, Minteer, Banta, Barton, Atanassov (bib155) 2016; 8
Fabret, Feher, Hoch (bib43) 1999; 181
Li, Yang, Zhang, Li, Yu (bib84) 2015; 42
Fu, Wang, Chen, Liu, Shi (bib49) 2014; 111
Shiue, Prather (bib132) 2012; 65
Fabret, Ehrlich, Noirot (bib42) 2002; 46
Mu, Wen (bib106) 2013; 29
Xiao, Lu (bib159) 2014; 32
Xu, Jia, Liu (bib162) 2011
Leavitt, Alper (bib78) 2015; 34
Song, Nikoloff, Fu, Chen, Li (bib138) 2016; 11
Kunst, Ogasawara, Moszer, Albertini, Alloni (bib75) 1997; 390
Shi, Chen, Zhang, Chen, Zhao (bib129) 2009; 11
Kang, Yang, Du, Chen (bib69) 2014; 41
Kushwaha, Salis (bib76) 2015; 6
Liu, Banta, Chen (bib89) 2013; 49
Alper, Fischer, Nevoigt, Stephanopoulos (bib3) 2005; 102
Zhou, Zou, Zhang, Stephanopoulos, Too (bib182) 2013; 110
Bongers, Veening, Van Wieringen, Kuipers, Kleerebezem (bib14) 2005; 71
Nielsen, Keasling (bib110) 2016; 164
Lee, Lee, Cho, Jeong, Hwang (bib81) 2014; 173
Cai, Wang, He, Zhu, Wang (bib17) 2017; 16
Vuolanto, von Weymarn, Kerovuo, Ojamo, Leisola (bib147) 2001; 23
Chen, Gao, Guo, Hu, Luo (bib22) 2017
Eijlander, de Jong, Krawczyk, Holsappel, Kuipers (bib41) 2014; 42
Schumann (bib125) 2007; Vol. 62
Stern, Asari, Sugahara (bib139) 2006; 85
Wang, Weng, Waseem, Yin, Zhang (bib151) 2012; 40
Ju, Song, Jung, Park (bib65) 2014; 36
Li, Zhang, Li, Wang, Gao (bib83) 2013; 6
Kang, Zhang, Zhang, Jin, Zhang (bib70) 2014; 98
Dueber, Wu, Malmirchegini, Moon, Petzold (bib38) 2009; 27
Radeck, Kraft, Bartels, Cikovic, Durr (bib123) 2013; 7
Michna, Zhu, Mader, Stulke (bib104) 2016; 44
Phan, Nguyen, Schumann (bib115) 2013; 168
Westbrook, Ren, Moo-Young, Chou (bib154) 2018; 115
Liu, Du (bib92) 2012; 83
Yang, Kang, Cao, Du, Chen (bib168) 2016; 219
Juhas, Reuss, Zhu, Commichau (bib66) 2014; 160
Ma, Liu, Shin, Li, Chen (bib100) 2018; 250
Zhang, Huang, Wang, Chen, Du (bib176) 2016; 38
Dunlop, Dossani, Szmidt, Chu, Lee (bib40) 2011; 7
Clomburg, Crumbley, Gonzalez (bib26) 2017; 355
Shi, Shen, Chen, Chen, Zhao (bib130) 2009; 46
Perkins, Sloma, Hermann, Theriault, Zachgo (bib113) 1999; 22
Morimoto, Kadoya, Endo, Tohata, Sawada (bib105) 2008; 15
Zhou, Wang, Xu, Chen, Cai (bib185) 2015; 42
Qin, Zhou, Krivoruchko, Huang, Liu (bib122) 2015; 6
Wang, Xu, Rao, Yang, Zhang (bib150) 2015; 42
Yim, Haselbeck, Niu, Pujol-Baxley, Burgard (bib173) 2011; 7
Licona-Cassani, Lara, Cabrera-Valladares, Escalante, Hernandez-Chavez (bib85) 2014; 24
Panahi, Vasheghani-Farahani, Shojaosadati, Bambai (bib112) 2014; 48
Zhang, Zhang (bib180) 2011; 4
Tannler, Zamboni, Kiraly, Aymerich, Sauer (bib143) 2008; 10
Westbrook, Moo-Young, Chou (bib153) 2016; 82
Dong, Zhang (bib35) 2014; 13
Zweers, Barak, Becher, Driessen, Hecker (bib188) 2008; 7
Tjalsma, Antelmann, Jongbloed, Braun, Darmon (bib144) 2004; 68
Avalos, Fink, Stephanopoulos (bib7) 2013; 31
Jeong, Kim, Wee, Ryu (bib62) 2010; 101
Clarke, Mandelstam (bib25) 1987; 133
Delebecque, Silver, Lindner (bib32) 2012; 7
Blazeck, Alper (bib13) 2010; 5
Muhammadi, Afzal (bib107) 2014; 52
Zhao, Chen, Sun, Zhang (bib181) 2017; 7
Zhang, Zhang, Bao, Rao, Yang (bib177) 2014; 23
Caspi, Billington, Ferrer, Foerster, Fulcher (bib18) 2016; 44
Shamala, Vijayendra, Joshi (bib128) 2012; 43
Illing (bib58) 2002; 415
Lakowitz, Godard, Biedendieck, Krull (bib77) 2017
Peters, Colavin, Shi, Czarny, Larson (bib114) 2016; 165
Biggs, De Paepe, Santos, De Mey, Kumaran Ajikumar (bib11) 2014; 29
Promchai, Promdonkoy, Tanapongpipat, Visessanguan, Eurwilaichitr (bib119) 2016; 222
Wang, Bai, Wang, Shi, Chen (bib148) 2014; 30
Bao, Zhang, Zhao, Rao, Yang (bib9) 2015; 10
Zhu, Chen, Chen, Shi, Zhao (bib187) 2006; 28
Xu, Liu, Zhang, Jin, Qiu (bib161) 2013; 97
van Dijl, Hecker (bib146) 2013; 12
Yang, Du, Chen, Kang (bib167) 2017; 101
Zhang, Yan, Cui, Hong, Li (bib179) 2006; 34
Dugar, Stephanopoulos (bib39) 2011; 29
Han, Shang, Chang, Han, Kim (bib54) 2006; 81
Brans, Filee, Chevigne, Claessens, Joris (bib15) 2004; 70
Liu, Zhu, Ma, Shin, Li (bib96) 2014; 24
Sirisansaneeyakul, Cao, Kongklom, Chuensangjun, Shi (bib134) 2017; 33
Skoczinski, Volkenborn, Fulton, Bhadauriya, Nutschel (bib135) 2017; 16
Yang, Zhang (bib172) 2018
Zhang, Duan, Wu (bib175) 2016; 6
Tanaka, Natsume, Ishikawa, Takenaka, Yoshida (bib142) 2017; 16
Chen, Zhang, Cheng, Shi, Li (bib23) 2013; 36
Ishii, Yoshida, Terai, Fujita, Nakai (bib59) 2001; 29
Zhou, Gao, Rong, Jin, Chu (bib184) 2012; 134
Liu, Liu, Shin, Chen, Li (bib94) 2013; 19
Ogunleye, Bhat, Irorere, Hill, Williams (bib111) 2015; 161
Jeong, Park, Pan, Kim, Choi (bib61) 2015; 43
Sonenshein (bib136) 2007; 5
Liu, Liu, Shin, Chen, Li (bib91) 2013; 97
Juminaga, Baidoo, Redding-Johanson, Batth, Burd (bib67) 2012; 78
Shi, Wang, Wang, Wang, Liu (bib131) 2014; 13
Bajaj, Singhal (bib8) 2011; 4
Liu, Li, Du, Chen, Liu (bib97) 2017; 35
Popp, Dotzler, Radeck, Bartels, Mascher (bib118) 2017; 7
Xu (bib163) 2017; 53
Contesini, Melo, Sato (bib28) 2017
Jin, Zhang, Yuan, Kang, Du (bib64) 2016; 140
Young, Burton, Mahalik, Sumpter, Fuentes-Cabrera (bib174) 2017
Feng, Liu, Jiao, Gao, Wang (bib46) 2017; 101
Gong, Zheng, Chen, Yuan, Wang (bib50) 2009; 47
Xu, Gu, Wang, Wong, Bower (bib164) 2013; 4
Liu, Liu, Shin, Chen, Wang (bib90) 2013; 97
Arrieta-Ortiz, Hafemeister, Bate, Chu, Greenfield (bib5) 2015; 11
Meyer, Weidmann, Mader, Hecker, Volker (bib103) 2014; 10
Fu, Huo, Feng, Mao, Wang (bib48) 2016; 9
Chae, Choi, Kim, Ko, Lee (bib19) 2017; 47
Gu, Deng, Liu, Li, Shin (bib51) 2017; 12
Sauer, Syvertsson, Bohorquez, Cruz, Harwood (bib124) 2016; 5
Brinsmade, Alexander, Livny, Stettner, Segre (bib16) 2014; 111
Diao, Dong, Xu, Yang, Zhou (bib34) 2012; 78
Guan, Cui, Cheng, Zhou, Guo (bib52) 2015; 14
Wu, Xu, Shi, Yao, Li (bib158) 2008; 79
Yan, Yu, Hong, Li (bib166) 2008; 74
Guiziou, Sauveplane, Chang, Clerte, Declerck (bib53) 2016; 44
Qi, Li, Zhao, Huang, Xia (bib120) 2014; 9
Jahn, Preis, Wiedemann, Brantl (bib60) 2012; 83
Yang, Rao, Hu, Zhang, Liu (bib170) 2015; 8
Mandal, Boese, Barrick, Winkler, Breaker (bib102) 2003; 113
Toya, Hirasawa, Ishikawa, Chumsakul, Morimoto (bib145) 2015; 79
Yang, Rao, Zhang, Xu, Xu (bib171) 2017; 37
Altenbuchner (bib4) 2016; 82
Liu, Link, Liu, Du, Chen (bib93) 2016; 7
Liu, Zhu, Ma, Shin, Li (bib98) 2014; 24
Atalla, Schumann (bib6) 2003; 185
Chen, Zhao, Fu, Zhou, Sun (bib20) 2016; 15
Huang, Du, Xu, Zhang, Zhu (bib57) 2011; 11
Farmer, Liao (bib44) 2000; 18
Scoffone, Dondi, Biino, Borghese, Pasini (bib127) 2013; 110
Fischer, Sauer (bib47) 2005; 37
Conrado, Wu, Boock, Xu, Chen (bib27) 2012; 40
Tan, Prather (bib141) 2017; 41
Wu, Yan, Jones, Tang, Fong (bib157) 2016; 34
Lee, Na, Park, Lee, Choi (bib79) 2012; 8
Lee, Mantell, Hodgson, Alibhai, Fletcher (bib80) 2017; 14
Zhang, Cui, Hong, Li (bib178) 2005; 71
Feng, Gu, Quan, Cao, Gao (bib45) 2015; 32
Yang, Liu, Zhang, Du, Chen (bib169) 2017
Liebeton, Lengefeld, Eck (bib86) 2014; 191
Xu, Feng, Zhang, Tang, Lei (bib165) 2014; 155
Luo, Guo, Liu, Qiu, Zhao (bib99) 2016; 9
Kerfeld, Erbilgin (bib71) 2015; 23
Duan, Chen, Chen, Zhao (bib37) 2010; 85
Chen, Li, Liu (bib24) 2014; 32
Zweers (10.1016/j.ymben.2018.05.006_bib188) 2008; 7
Bassalo (10.1016/j.ymben.2018.05.006_bib10) 2016; 39
Xu (10.1016/j.ymben.2018.05.006_bib164) 2013; 4
Jahn (10.1016/j.ymben.2018.05.006_bib60) 2012; 83
Kerfeld (10.1016/j.ymben.2018.05.006_bib71) 2015; 23
Chen (10.1016/j.ymben.2018.05.006_bib24) 2014; 32
Skoczinski (10.1016/j.ymben.2018.05.006_bib135) 2017; 16
Atalla (10.1016/j.ymben.2018.05.006_bib6) 2003; 185
Cai (10.1016/j.ymben.2018.05.006_bib17) 2017; 16
Zhou (10.1016/j.ymben.2018.05.006_bib184) 2012; 134
Wang (10.1016/j.ymben.2018.05.006_bib149) 2015; 14
Blazeck (10.1016/j.ymben.2018.05.006_bib13) 2010; 5
Tanaka (10.1016/j.ymben.2018.05.006_bib142) 2017; 16
Wu (10.1016/j.ymben.2018.05.006_bib158) 2008; 79
Zhu (10.1016/j.ymben.2018.05.006_bib186) 2013; 164
Sauer (10.1016/j.ymben.2018.05.006_bib124) 2016; 5
Panahi (10.1016/j.ymben.2018.05.006_bib112) 2014; 48
Liu (10.1016/j.ymben.2018.05.006_bib96) 2014; 24
Dormeyer (10.1016/j.ymben.2018.05.006_bib36) 2015; 161
Piepenbreier (10.1016/j.ymben.2018.05.006_bib116) 2017; 104
Sutter (10.1016/j.ymben.2018.05.006_bib140) 2017; 356
Zhang (10.1016/j.ymben.2018.05.006_bib180) 2011; 4
Fabret (10.1016/j.ymben.2018.05.006_bib43) 1999; 181
Brans (10.1016/j.ymben.2018.05.006_bib15) 2004; 70
Diao (10.1016/j.ymben.2018.05.006_bib34) 2012; 78
Xiao (10.1016/j.ymben.2018.05.006_bib160) 2014; 62
Yang (10.1016/j.ymben.2018.05.006_bib172) 2018
Young (10.1016/j.ymben.2018.05.006_bib174) 2017
Shamala (10.1016/j.ymben.2018.05.006_bib128) 2012; 43
Lee (10.1016/j.ymben.2018.05.006_bib80) 2017; 14
Zhang (10.1016/j.ymben.2018.05.006_bib176) 2016; 38
Maabeta (10.1016/j.ymben.2018.05.006_bib101) 2014; 13
Zhu (10.1016/j.ymben.2018.05.006_bib187) 2006; 28
Li (10.1016/j.ymben.2018.05.006_bib84) 2015; 42
Liu (10.1016/j.ymben.2018.05.006_bib95) 2014; 23
Pohl (10.1016/j.ymben.2018.05.006_bib117) 2013; 13
Guiziou (10.1016/j.ymben.2018.05.006_bib53) 2016; 44
Gu (10.1016/j.ymben.2018.05.006_bib51) 2017; 12
Jeong (10.1016/j.ymben.2018.05.006_bib62) 2010; 101
Schwechheimer (10.1016/j.ymben.2018.05.006_bib126) 2016; 100
Krom (10.1016/j.ymben.2018.05.006_bib74) 2003; 84
Altenbuchner (10.1016/j.ymben.2018.05.006_bib4) 2016; 82
Zhao (10.1016/j.ymben.2018.05.006_bib181) 2017; 7
Zhou (10.1016/j.ymben.2018.05.006_bib183) 2017; 33
Dong (10.1016/j.ymben.2018.05.006_bib35) 2014; 13
Liu (10.1016/j.ymben.2018.05.006_bib94) 2013; 19
Jin (10.1016/j.ymben.2018.05.006_bib63) 2016; 35
Kang (10.1016/j.ymben.2018.05.006_bib69) 2014; 41
Chen (10.1016/j.ymben.2018.05.006_bib20) 2016; 15
Liu (10.1016/j.ymben.2018.05.006_bib98) 2014; 24
Illing (10.1016/j.ymben.2018.05.006_bib58) 2002; 415
Dunlop (10.1016/j.ymben.2018.05.006_bib40) 2011; 7
Bongers (10.1016/j.ymben.2018.05.006_bib14) 2005; 71
Delebecque (10.1016/j.ymben.2018.05.006_bib32) 2012; 7
Biswas (10.1016/j.ymben.2018.05.006_bib12) 2012; 94
Fabret (10.1016/j.ymben.2018.05.006_bib42) 2002; 46
Zhang (10.1016/j.ymben.2018.05.006_bib178) 2005; 71
Jin (10.1016/j.ymben.2018.05.006_bib64) 2016; 140
Ling (10.1016/j.ymben.2018.05.006_bib88) 2017; 245
Xiao (10.1016/j.ymben.2018.05.006_bib159) 2014; 32
Radeck (10.1016/j.ymben.2018.05.006_bib123) 2013; 7
Avalos (10.1016/j.ymben.2018.05.006_bib7) 2013; 31
Ju (10.1016/j.ymben.2018.05.006_bib65) 2014; 36
Song (10.1016/j.ymben.2018.05.006_bib137) 2017; 65
Yang (10.1016/j.ymben.2018.05.006_bib167) 2017; 101
Zhou (10.1016/j.ymben.2018.05.006_bib185) 2015; 42
Wheeldon (10.1016/j.ymben.2018.05.006_bib155) 2016; 8
Yang (10.1016/j.ymben.2018.05.006_bib169) 2017
Chen (10.1016/j.ymben.2018.05.006_bib21) 2013; 168
Shi (10.1016/j.ymben.2018.05.006_bib131) 2014; 13
Biggs (10.1016/j.ymben.2018.05.006_bib11) 2014; 29
Fischer (10.1016/j.ymben.2018.05.006_bib47) 2005; 37
Bajaj (10.1016/j.ymben.2018.05.006_bib8) 2011; 4
Wang (10.1016/j.ymben.2018.05.006_bib148) 2014; 30
Juhas (10.1016/j.ymben.2018.05.006_bib66) 2014; 160
Sonenshein (10.1016/j.ymben.2018.05.006_bib136) 2007; 5
Caspi (10.1016/j.ymben.2018.05.006_bib18) 2016; 44
van Dijl (10.1016/j.ymben.2018.05.006_bib146) 2013; 12
Liu (10.1016/j.ymben.2018.05.006_bib91) 2013; 97
Hemberger (10.1016/j.ymben.2018.05.006_bib55) 2011; 11
Tannler (10.1016/j.ymben.2018.05.006_bib143) 2008; 10
Xu (10.1016/j.ymben.2018.05.006_bib162) 2011
Nielsen (10.1016/j.ymben.2018.05.006_bib110) 2016; 164
Qiao (10.1016/j.ymben.2018.05.006_bib121) 2017; 35
Westbrook (10.1016/j.ymben.2018.05.006_bib153) 2016; 82
Fu (10.1016/j.ymben.2018.05.006_bib49) 2014; 111
Kushwaha (10.1016/j.ymben.2018.05.006_bib76) 2015; 6
Yang (10.1016/j.ymben.2018.05.006_bib171) 2017; 37
Zhou (10.1016/j.ymben.2018.05.006_bib182) 2013; 110
Westbrook (10.1016/j.ymben.2018.05.006_bib154) 2018; 115
de Cesaro (10.1016/j.ymben.2018.05.006_bib30) 2014; 41
Li (10.1016/j.ymben.2018.05.006_bib83) 2013; 6
Widner (10.1016/j.ymben.2018.05.006_bib156) 2005; 71
Fu (10.1016/j.ymben.2018.05.006_bib48) 2016; 9
Shi (10.1016/j.ymben.2018.05.006_bib130) 2009; 46
Welsch (10.1016/j.ymben.2018.05.006_bib152) 2015; 99
Conrado (10.1016/j.ymben.2018.05.006_bib27) 2012; 40
Zhang (10.1016/j.ymben.2018.05.006_bib179) 2006; 34
Dugar (10.1016/j.ymben.2018.05.006_bib39) 2011; 29
Yang (10.1016/j.ymben.2018.05.006_bib170) 2015; 8
Defoor (10.1016/j.ymben.2018.05.006_bib31) 2007; 153
Liu (10.1016/j.ymben.2018.05.006_bib92) 2012; 83
Wu (10.1016/j.ymben.2018.05.006_bib157) 2016; 34
Xu (10.1016/j.ymben.2018.05.006_bib163) 2017; 53
Perkins (10.1016/j.ymben.2018.05.006_bib113) 1999; 22
Morimoto (10.1016/j.ymben.2018.05.006_bib105) 2008; 15
Farmer (10.1016/j.ymben.2018.05.006_bib44) 2000; 18
Peters (10.1016/j.ymben.2018.05.006_bib114) 2016; 165
Xu (10.1016/j.ymben.2018.05.006_bib161) 2013; 97
Popp (10.1016/j.ymben.2018.05.006_bib118) 2017; 7
Shiue (10.1016/j.ymben.2018.05.006_bib132) 2012; 65
Alper (10.1016/j.ymben.2018.05.006_bib3) 2005; 102
Song (10.1016/j.ymben.2018.05.006_bib138) 2016; 11
Lakowitz (10.1016/j.ymben.2018.05.006_bib77) 2017
Duan (10.1016/j.ymben.2018.05.006_bib37) 2010; 85
Kunst (10.1016/j.ymben.2018.05.006_bib75) 1997; 390
Ajikumar (10.1016/j.ymben.2018.05.006_bib1) 2010; 330
Promchai (10.1016/j.ymben.2018.05.006_bib119) 2016; 222
Scoffone (10.1016/j.ymben.2018.05.006_bib127) 2013; 110
Chae (10.1016/j.ymben.2018.05.006_bib19) 2017; 47
Eijlander (10.1016/j.ymben.2018.05.006_bib41) 2014; 42
Liu (10.1016/j.ymben.2018.05.006_bib97) 2017; 35
Sierro (10.1016/j.ymben.2018.05.006_bib133) 2008; 36
Tjalsma (10.1016/j.ymben.2018.05.006_bib144) 2004; 68
Leavitt (10.1016/j.ymben.2018.05.006_bib78) 2015; 34
Sirisansaneeyakul (10.1016/j.ymben.2018.05.006_bib134) 2017; 33
Kind (10.1016/j.ymben.2018.05.006_bib72) 2011; 13
Vuolanto (10.1016/j.ymben.2018.05.006_bib147) 2001; 23
Luo (10.1016/j.ymben.2018.05.006_bib99) 2016; 9
Lee (10.1016/j.ymben.2018.05.006_bib81) 2014; 173
Yim (10.1016/j.ymben.2018.05.006_bib173) 2011; 7
Contesini (10.1016/j.ymben.2018.05.006_bib28) 2017
Xu (10.1016/j.ymben.2018.05.006_bib165) 2014; 155
Liu (10.1016/j.ymben.2018.05.006_bib90) 2013; 97
Clarke (10.1016/j.ymben.2018.05.006_bib25) 1987; 133
Meyer (10.1016/j.ymben.2018.05.006_bib103) 2014; 10
Han (10.1016/j.ymben.2018.05.006_bib54) 2006; 81
Michna (10.1016/j.ymben.2018.05.006_bib104) 2016; 44
Muntel (10.1016/j.ymben.2018.05.006_bib109) 2014; 13
Dueber (10.1016/j.ymben.2018.05.006_bib38) 2009; 27
Lee (10.1016/j.ymben.2018.05.006_bib79) 2012; 8
Mandal (10.1016/j.ymben.2018.05.006_bib102) 2003; 113
Feng (10.1016/j.ymben.2018.05.006_bib45) 2015; 32
Qin (10.1016/j.ymben.2018.05.006_bib122) 2015; 6
Ma (10.1016/j.ymben.2018.05.006_bib100) 2018; 250
Wang (10.1016/j.ymben.2018.05.006_bib150) 2015; 42
Liu (10.1016/j.ymben.2018.05.006_bib89) 2013; 49
Juminaga (10.1016/j.ymben.2018.05.006_bib67) 2012; 78
Kang (10.1016/j.ymben.2018.05.006_bib70) 2014; 98
Bao (10.1016/j.ymben.2018.05.006_bib9) 2015; 10
Huang (10.1016/j.ymben.2018.05.006_bib57) 2011; 11
Liebeton (10.1016/j.ymben.2018.05.006_bib86) 2014; 191
Ogunleye (10.1016/j.ymben.2018.05.006_bib111) 2015; 161
Yan (10.1016/j.ymben.2018.05.006_bib166) 2008; 74
Tan (10.1016/j.ymben.2018.05.006_bib141) 2017; 41
Clomburg (10.1016/j.ymben.2018.05.006_bib26) 2017; 355
Guan (10.1016/j.ymben.2018.05.006_bib52) 2015; 14
Chen (10.1016/j.ymben.2018.05.006_bib23) 2013; 36
Mulder (10.1016/j.ymben.2018.05.006_bib108) 2013; 89
Muhammadi (10.1016/j.ymben.2018.05.006_bib107) 2014; 52
Toya (10.1016/j.ymben.2018.05.006_bib145) 2015; 79
Kabisch (10.1016/j.ymben.2018.05.006_bib68) 2013; 12
Zhang (10.1016/j.ymben.2018.05.006_bib177) 2014; 23
Zhang (10.1016/j.ymben.2018.05.006_bib175) 2016; 6
Schumann (10.1016/j.ymben.2018.05.006_bib125) 2007; Vol. 62
Wang (10.1016/j.ymben.2018.05.006_bib151) 2012; 40
Ling Lin (10.1016/j.ymben.2018.05.006_bib87) 2007; 25
Feng (10.1016/j.ymben.2018.05.006_bib46) 2017; 101
Phan (10.1016/j.ymben.2018.05.006_bib115) 2013; 168
Licona-Cassani (10.1016/j.ymben.2018.05.006_bib85) 2014; 24
Ishii (10.1016/j.ymben.2018.05.006_bib59) 2001; 29
Koo (10.1016/j.ymben.2018.05.006_bib73) 2017; 4
Stern (10.1016/j.ymben.2018.05.006_bib139) 2006; 85
Shi (10.1016/j.ymben.2018.05.006_bib129) 2009; 11
Arrieta-Ortiz (10.1016/j.ymben.2018.05.006_bib5) 2015; 11
Lee (10.1016/j.ymben.2018.05.006_bib82) 2015; 33
Yang (10.1016/j.ymben.2018.05.006_bib168) 2016; 219
Albertsen (10.1016/j.ymben.2018.05.006_bib2) 2011; 77
Brinsmade (10.1016/j.ymben.2018.05.006_bib16) 2014; 111
Coutte (10.1016/j.ymben.2018.05.006_bib29) 2010; 109
Jeong (10.1016/j.ymben.2018.05.006_bib61) 2015; 43
Mu (10.1016/j.ymben.2018.05.006_bib106) 2013; 29
Chen (10.1016/j.ymben.2018.05.006_bib22) 2017
Henry (10.1016/j.ymben.2018.05.006_bib56) 2009; 10
Liu (10.1016/j.ymben.2018.05.006_bib93) 2016; 7
Deutscher (10.1016/j.ymben.2018.05.006_bib33) 2006; 70
Qi (10.1016/j.ymben.2018.05.006_bib120) 2014; 9
Gong (10.1016/j.ymben.2018.05.006_bib50) 2009; 47
References_xml – volume: 31
  start-page: 335
  year: 2013
  end-page: 341
  ident: bib7
  article-title: Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols
  publication-title: Nat. Biotechnol.
– volume: 24
  start-page: 61
  year: 2014
  end-page: 69
  ident: bib96
  article-title: Spatial modulation of key pathway enzymes by DNA-guided scaffold system and respiration chain engineering for improved N-acetylglucosamine production by
  publication-title: Metab. Eng.
– volume: 42
  start-page: D685
  year: 2014
  end-page: D691
  ident: bib41
  article-title: SporeWeb: an interactive journey through the complete sporulation cycle of
  publication-title: Nucleic Acids Res.
– volume: 42
  start-page: 93
  year: 2015
  end-page: 103
  ident: bib84
  article-title: Overexpression of specific proton motive force-dependent transporters facilitate the export of surfactin in
  publication-title: J. Ind. Microbiol. Biotechnol.
– volume: 71
  start-page: 3747
  year: 2005
  end-page: 3752
  ident: bib156
  article-title: Hyaluronic acid production in
  publication-title: Appl. Environ. Microbiol.
– volume: 41
  start-page: 1375
  year: 2014
  end-page: 1382
  ident: bib30
  article-title: Effects of metabolic pathway precursors and polydimethylsiloxane (PDMS) on poly-(gamma)-glutamic acid production by
  publication-title: J. Ind. Microbiol. Biotechnol.
– volume: 134
  start-page: 3234
  year: 2012
  end-page: 3241
  ident: bib184
  article-title: Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production
  publication-title: J. Am. Chem. Soc.
– volume: 13
  start-page: 3298
  year: 2013
  end-page: 3308
  ident: bib117
  article-title: Proteomic analysis of
  publication-title: Proteomics
– volume: 415
  start-page: 263
  year: 2002
  end-page: 264
  ident: bib58
  article-title: and its closest relatives: from genes to cells
  publication-title: Nature
– volume: 42
  start-page: 1427
  year: 2015
  end-page: 1437
  ident: bib150
  article-title: Construction of a highly efficient
  publication-title: J. Ind. Microbiol. Biotechnol.
– volume: 5
  start-page: 942
  year: 2016
  end-page: 947
  ident: bib124
  article-title: Effect of genome position on heterologous gene expression in
  publication-title: ACS Synth. Biol.
– volume: 164
  start-page: 67
  year: 2013
  end-page: 74
  ident: bib186
  article-title: The main byproducts and metabolic flux profiling of gamma-PGA-producing strain
  publication-title: J. Biotechnol.
– volume: 85
  start-page: 1907
  year: 2010
  end-page: 1914
  ident: bib37
  article-title: Overexpression of glucose-6-phosphate dehydrogenase enhances riboflavin production in
  publication-title: Appl. Microbiol. Biotechnol.
– year: 2017
  ident: bib22
  article-title: DCEO Biotechnology: tools to design, construct, evaluate, and optimize the metabolic pathway for biosynthesis of chemicals
  publication-title: Chem. Rev.
– volume: 78
  start-page: 89
  year: 2012
  end-page: 98
  ident: bib67
  article-title: Modular engineering of
  publication-title: Appl. Environ. Microbiol.
– volume: 82
  start-page: 5421
  year: 2016
  end-page: 5427
  ident: bib4
  article-title: Editing of the
  publication-title: Appl. Environ. Microbiol.
– volume: 35
  start-page: 21
  year: 2016
  end-page: 30
  ident: bib63
  article-title: Production of specific-molecular-weight hyaluronan by metabolically engineered
  publication-title: Metab. Eng.
– volume: 14
  start-page: 179
  year: 2015
  ident: bib149
  article-title: A new potential secretion pathway for recombinant proteins in
  publication-title: Microb. Cell Fact.
– volume: 4
  start-page: 291
  year: 2017
  end-page: 305
  ident: bib73
  article-title: Construction and analysis of two genome-scale deletion libraries for
  publication-title: Cell Syst.
– volume: 16
  start-page: 70
  year: 2017
  ident: bib17
  article-title: A novel strategy to improve protein secretion via overexpression of the SppA signal peptide peptidase in
  publication-title: Microb. Cell Fact.
– volume: 14
  start-page: 150
  year: 2015
  ident: bib52
  article-title: Construction and development of an auto-regulatory gene expression system in
  publication-title: Microb. Cell Fact.
– volume: 42
  start-page: 1073
  year: 2015
  end-page: 1082
  ident: bib185
  article-title: Increasing succinic acid production using the PTS-independent glucose transport system in a
  publication-title: J. Ind. Microbiol. Biotechnol.
– volume: 36
  start-page: 1851
  year: 2013
  end-page: 1859
  ident: bib23
  article-title: Enhancement of adenosine production by
  publication-title: Bioprocess Biosyst. Eng.
– volume: 14
  start-page: 142
  year: 2017
  end-page: 147
  ident: bib80
  article-title: Engineered synthetic scaffolds for organizing proteins within the bacterial cytoplasm
  publication-title: Nat. Chem. Biol.
– volume: 8
  start-page: 536
  year: 2012
  end-page: 546
  ident: bib79
  article-title: Systems metabolic engineering of microorganisms for natural and non-natural chemicals
  publication-title: Nat. Chem. Biol.
– year: 2017
  ident: bib169
  article-title: Construction and characterization of broad-spectrum promoters for synthetic biology
  publication-title: ACS Synth. Biol.
– volume: 13
  start-page: 617
  year: 2011
  end-page: 627
  ident: bib72
  article-title: Metabolic engineering of cellular transport for overproduction of the platform chemical 1,5-diaminopentane in
  publication-title: Metab. Eng.
– volume: 24
  start-page: 37
  year: 2014
  end-page: 45
  ident: bib85
  article-title: Inactivation of pyruvate kinase or the phosphoenolpyruvate: sugar phosphotransferase system increases shikimic and dehydroshikimic acid yields from glucose in
  publication-title: J. Mol. Microbiol. Biotechnol.
– volume: 9
  start-page: 134
  year: 2016
  ident: bib99
  article-title: Microbial synthesis of poly-gamma-glutamic acid: current progress, challenges, and future perspectives
  publication-title: Biotechnol. Biofuels
– start-page: 1
  year: 2017
  end-page: 14
  ident: bib28
  article-title: An overview of
  publication-title: Crit. Rev. Biotechnol.
– volume: 9
  start-page: 90
  year: 2016
  ident: bib48
  article-title: Metabolic engineering of
  publication-title: Biotechnol. Biofuels
– volume: 10
  start-page: 1812
  year: 2014
  end-page: 1823
  ident: bib103
  article-title: A time resolved metabolomics study: the influence of different carbon sources during growth and starvation of
  publication-title: Mol. Biol. Syst.
– volume: 11
  start-page: 119
  year: 2011
  ident: bib55
  article-title: RibM from
  publication-title: BMC Biotechnol.
– volume: 4
  start-page: 98
  year: 2011
  end-page: 105
  ident: bib180
  article-title: Simple, fast and high-efficiency transformation system for directed evolution of cellulase in
  publication-title: Microb. Biotechnol.
– volume: 12
  start-page: 3
  year: 2013
  ident: bib146
  article-title: : from soil bacterium to super-secreting cell factory
  publication-title: Microb. Cell Fact.
– volume: 40
  start-page: e91
  year: 2012
  ident: bib151
  article-title: genome editing using ssDNA with short homology regions
  publication-title: Nucleic Acids Res.
– volume: 140
  start-page: 424
  year: 2016
  end-page: 432
  ident: bib64
  article-title: Efficient biosynthesis of polysaccharides chondroitin and heparosan by metabolically engineered
  publication-title: Carbohydr. Polym.
– volume: 11
  start-page: 18
  year: 2016
  ident: bib138
  article-title: Promoter screening from
  publication-title: PLoS One
– volume: 111
  start-page: 8227
  year: 2014
  end-page: 8232
  ident: bib16
  article-title: Hierarchical expression of genes controlled by the
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 81
  start-page: 1071
  year: 2006
  end-page: 1074
  ident: bib54
  article-title: Fermentation characteristics of a low-oxygen inducible hmp promoter system in
  publication-title: J. Chem. Technol. Biotechnol.
– volume: 16
  start-page: 67
  year: 2017
  ident: bib142
  article-title: A new-generation of
  publication-title: Microb. Cell Fact.
– year: 2017
  ident: bib174
  article-title: Engineering the bacterial microcompartment domain for molecular scaffolding applications
  publication-title: Front. Microbiol.
– volume: 34
  start-page: 652
  year: 2016
  end-page: 664
  ident: bib157
  article-title: Metabolic burden: cornerstones in synthetic biology and metabolic engineering applications
  publication-title: Trends Biotechnol.
– volume: 4
  start-page: 1409
  year: 2013
  ident: bib164
  article-title: Modular optimization of multi-gene pathways for fatty acids production in
  publication-title: Nat. Commun.
– volume: 4
  start-page: 745
  year: 2011
  end-page: 752
  ident: bib8
  article-title: Flocculation properties of poly(gamma-glutamic acid) produced from
  publication-title: Food Bioprocess Technol.
– volume: 38
  start-page: 2103
  year: 2016
  end-page: 2108
  ident: bib176
  article-title: Rapid evolution of hyaluronan synthase to improve hyaluronan production and molecular mass in
  publication-title: Biotechnol. Lett.
– volume: 34
  start-page: 98
  year: 2015
  end-page: 104
  ident: bib78
  article-title: Advances and current limitations in transcript-level control of gene expression
  publication-title: Curr. Opin. Biotechnol.
– volume: 25
  start-page: 1
  year: 2007
  end-page: 12
  ident: bib87
  article-title: Protein secretion pathways in
  publication-title: Biotechnol. Adv.
– volume: 13
  start-page: 63
  year: 2014
  ident: bib35
  article-title: Current development in genetic engineering strategies of
  publication-title: Microb. Cell Fact.
– volume: 18
  start-page: 533
  year: 2000
  end-page: 537
  ident: bib44
  article-title: Improving lycopene production in
  publication-title: Nat. Biotechnol.
– volume: 29
  start-page: 278
  year: 2001
  end-page: 280
  ident: bib59
  article-title: DBTBS: a database of
  publication-title: Nucleic Acids Res.
– volume: 390
  start-page: 249
  year: 1997
  end-page: 256
  ident: bib75
  article-title: The complete genome sequence of the gram-positive bacterium
  publication-title: Nature
– volume: 115
  start-page: 216
  year: 2018
  end-page: 231
  ident: bib154
  article-title: Engineering of cell membrane to enhance heterologous production of hyaluronic acid in
  publication-title: Biotechnol. Bioeng.
– volume: 153
  start-page: 3645
  year: 2007
  end-page: 3659
  ident: bib31
  article-title: The orotate transporter encoded by oroP from
  publication-title: Microbiology
– volume: 12
  start-page: 72
  year: 2013
  ident: bib68
  article-title: Metabolic engineering of
  publication-title: Microb. Cell Fact.
– volume: 191
  start-page: 214
  year: 2014
  end-page: 220
  ident: bib86
  article-title: The nucleotide composition of the spacer sequence influences the expression yield of heterologously expressed genes in
  publication-title: J. Biotechnol.
– volume: 94
  start-page: 651
  year: 2012
  end-page: 658
  ident: bib12
  article-title: Enhanced production of 2,3-butanediol by engineered
  publication-title: Appl. Microbiol. Biotechnol.
– volume: 78
  start-page: 651
  year: 2012
  end-page: 659
  ident: bib34
  article-title: Functional implementation of the posttranslational SecB-SecA protein-targeting pathway in
  publication-title: Appl. Environ. Microbiol.
– volume: 27
  start-page: 753
  year: 2009
  end-page: 759
  ident: bib38
  article-title: Synthetic protein scaffolds provide modular control over metabolic flux
  publication-title: Nat. Biotechnol.
– volume: 83
  start-page: 579
  year: 2012
  end-page: 598
  ident: bib60
  article-title: BsrG/SR4 from
  publication-title: Mol. Microbiol.
– volume: 39
  start-page: 126
  year: 2016
  end-page: 133
  ident: bib10
  article-title: Directed evolution and synthetic biology applications to microbial systems
  publication-title: Curr. Opin. Biotechnol.
– volume: 35
  start-page: 20
  year: 2017
  end-page: 30
  ident: bib97
  article-title: Metabolic engineering of
  publication-title: Biotechnol. Adv.
– volume: 13
  start-page: 2260
  year: 2014
  end-page: 2276
  ident: bib101
  article-title: Highly precise quantification of protein molecules per cell during stress and starvation responses in
  publication-title: Mol. Cell. Proteom.: Mcp.
– volume: 101
  start-page: 1509
  year: 2017
  end-page: 1520
  ident: bib46
  article-title: Enhanced extracellular production of L-asparaginase from
  publication-title: Appl. Microbiol. Biotechnol.
– volume: 29
  start-page: 33
  year: 2013
  end-page: 41
  ident: bib106
  article-title: Engineered
  publication-title: World J. Microbiol. Biotechnol.
– volume: 10
  start-page: 1298
  year: 2015
  end-page: 1306
  ident: bib9
  article-title: Regulation of the NADH pool and NADH/NADPH ratio redistributes acetoin and 2,3-butanediol proportion in
  publication-title: Biotechnol. J.
– volume: 82
  start-page: 4876
  year: 2016
  end-page: 4895
  ident: bib153
  article-title: Development of a CRISPR-Cas9 tool kit for comprehensive engineering of
  publication-title: Appl. Environ. Microbiol.
– volume: 68
  start-page: 207
  year: 2004
  end-page: 233
  ident: bib144
  article-title: Proteomics of protein secretion by
  publication-title: Microbiol. Mol. Biol. Rev.
– volume: 101
  start-page: 4151
  year: 2017
  end-page: 4161
  ident: bib167
  article-title: Characterization and application of endogenous phase-dependent promoters in
  publication-title: Appl. Microbiol. Biotechnol.
– volume: 77
  start-page: 1033
  year: 2011
  end-page: 1040
  ident: bib2
  article-title: Diversion of flux toward sesquiterpene production in
  publication-title: Appl. Environ. Microbiol.
– volume: 24
  start-page: 61
  year: 2014
  end-page: 69
  ident: bib98
  article-title: Spatial modulation of key pathway enzymes by DNA-guided scaffold system and respiration chain engineering for improved N-acetylglucosamine production by
  publication-title: Metab. Eng.
– volume: 70
  start-page: 7241
  year: 2004
  end-page: 7250
  ident: bib15
  article-title: New integrative method to generate
  publication-title: Appl. Environ. Microbiol.
– volume: 355
  start-page: 11
  year: 2017
  ident: bib26
  article-title: Industrial biomanufacturing: the future of chemical production
  publication-title: Science
– volume: 34
  start-page: e71
  year: 2006
  ident: bib179
  article-title: mazF, a novel counter-selectable marker for unmarked chromosomal manipulation in
  publication-title: Nucleic Acids Res.
– volume: 111
  start-page: 2126
  year: 2014
  end-page: 2131
  ident: bib49
  article-title: NADH plays the vital role for chiral pure 2,3-butanediol production in
  publication-title: Biotechnol. Bioeng.
– volume: 100
  start-page: 2107
  year: 2016
  end-page: 2119
  ident: bib126
  article-title: Biotechnology of riboflavin
  publication-title: Appl. Microbiol. Biotechnol.
– volume: 70
  start-page: 939
  year: 2006
  end-page: 1031
  ident: bib33
  article-title: How phosphotransferase system-related protein phosphorylation regulates carbohydrate metabolism in bacteria
  publication-title: Microbiol. Mol. Biol. Rev.
– volume: 33
  start-page: 8
  year: 2017
  ident: bib134
  article-title: Microbial production of poly-gamma-glutamic acid
  publication-title: World J. Microbiol. Biotechnol.
– volume: 28
  start-page: 1667
  year: 2006
  end-page: 1672
  ident: bib187
  article-title: Over-expression of glucose dehydrogenase improves cell growth and riboflavin production in
  publication-title: Biotechnol. Lett.
– volume: 52
  start-page: 44
  year: 2014
  end-page: 52
  ident: bib107
  article-title: Optimization of water absorbing exopolysaccharide production on local cheap substrates by
  publication-title: J. Microbiol.
– volume: 41
  start-page: 28
  year: 2017
  end-page: 35
  ident: bib141
  article-title: Dynamic pathway regulation: recent advances and methods of construction
  publication-title: Curr. Opin. Chem. Biol.
– volume: 9
  start-page: e93815
  year: 2014
  ident: bib120
  article-title: Model-driven redox pathway manipulation for improved isobutanol production in
  publication-title: PLoS One
– volume: 33
  start-page: 10
  year: 2017
  ident: bib183
  article-title: The application of powerful promoters to enhance gene expression in industrial microorganisms
  publication-title: World J. Microbiol. Biotechnol.
– volume: 330
  start-page: 70
  year: 2010
  end-page: 74
  ident: bib1
  article-title: Isoprenoid pathway optimization for Taxol precursor overproduction in
  publication-title: Escherichia coli Science
– volume: 11
  start-page: 839
  year: 2015
  ident: bib5
  article-title: An experimentally supported model of the
  publication-title: Mol. Syst. Biol.
– volume: 181
  start-page: 1975
  year: 1999
  end-page: 1983
  ident: bib43
  article-title: Two-component signal transduction in
  publication-title: J. Bacteriol.
– volume: 53
  start-page: 12
  year: 2017
  end-page: 19
  ident: bib163
  article-title: Production of chemicals using dynamic control of metabolic fluxes
  publication-title: Curr. Opin. Biotechnol.
– volume: 79
  start-page: 527
  year: 2008
  end-page: 535
  ident: bib158
  article-title: Improvement of poly(gamma-glutamic acid) biosynthesis and redistribution of metabolic flux with the presence of different additives in
  publication-title: Appl. Microbiol. Biotechnol.
– volume: 7
  start-page: 445
  year: 2011
  end-page: 452
  ident: bib173
  article-title: Metabolic engineering of
  publication-title: Nat. Chem. Biol.
– volume: 23
  start-page: 34
  year: 2014
  end-page: 41
  ident: bib177
  article-title: The rebalanced pathway significantly enhances acetoin production by disruption of acetoin reductase gene and moderate-expression of a new water-forming NADH oxidase in
  publication-title: Metab. Eng.
– volume: 6
  start-page: 7832
  year: 2015
  ident: bib76
  article-title: A portable expression resource for engineering cross-species genetic circuits and pathways
  publication-title: Nat. Commun.
– volume: 168
  start-page: 499
  year: 2013
  end-page: 505
  ident: bib21
  article-title: Engineering
  publication-title: J. Biotechnol.
– year: 2017
  ident: bib77
  article-title: Mini review: recombinant production of tailored bio-pharmaceuticals in different Bacillus strains and future perspectives
  publication-title: Eur. J. Pharm. Biopharm.
– volume: Vol. 62
  start-page: 137
  year: 2007
  end-page: 189
  ident: bib125
  article-title: Production of recombinant proteins in
  publication-title: Advances in Applied Microbiology
– volume: 6
  start-page: 8224
  year: 2015
  ident: bib122
  article-title: Modular pathway rewiring of
  publication-title: Nat. Commun.
– volume: 37
  start-page: 636
  year: 2005
  end-page: 640
  ident: bib47
  article-title: Large-scale in vivo flux analysis shows rigidity and suboptimal performance of
  publication-title: Nat. Genet.
– volume: 13
  start-page: 101
  year: 2014
  ident: bib131
  article-title: Deregulation of purine pathway in
  publication-title: Microb. Cell Fact.
– volume: 99
  start-page: 6363
  year: 2015
  end-page: 6376
  ident: bib152
  article-title: Stepwise optimization of a low-temperature
  publication-title: Appl. Microbiol. Biotechnol.
– volume: 97
  start-page: 519
  year: 2013
  end-page: 539
  ident: bib161
  article-title: Genome-scale metabolic model in guiding metabolic engineering of microbial improvement
  publication-title: Appl. Microbiol. Biotechnol.
– volume: 155
  start-page: 8
  year: 2014
  end-page: 14
  ident: bib165
  article-title: Enhanced poly(gamma-glutamic acid) fermentation by
  publication-title: Bioresour. Technol.
– volume: 35
  start-page: 173
  year: 2017
  end-page: 177
  ident: bib121
  article-title: Lipid production in
  publication-title: Nat. Biotechnol.
– volume: 74
  start-page: 5556
  year: 2008
  end-page: 5562
  ident: bib166
  article-title: Cre/lox system and PCR-based genome engineering in
  publication-title: Appl. Environ. Microbiol.
– volume: 8
  start-page: 129
  year: 2015
  ident: bib170
  article-title: Metabolic engineering of
  publication-title: Biotechnol. Biofuels
– volume: 7
  start-page: 44023
  year: 2017
  ident: bib181
  article-title: Multimer recognition and secretion by the non-classical secretion pathway in
  publication-title: Sci. Rep.
– volume: 161
  start-page: 354
  year: 2015
  end-page: 361
  ident: bib36
  article-title: A novel engineering tool in the
  publication-title: Microbiology
– volume: 71
  start-page: 8818
  year: 2005
  end-page: 8824
  ident: bib14
  article-title: Development and characterization of a subtilin-regulated expression system in
  publication-title: Appl. Environ. Microbiol.
– volume: 10
  start-page: 216
  year: 2008
  end-page: 226
  ident: bib143
  article-title: Screening of
  publication-title: Metab. Eng.
– volume: 71
  start-page: 4101
  year: 2005
  end-page: 4103
  ident: bib178
  article-title: High-level expression and secretion of methyl parathion hydrolase in
  publication-title: Appl. Environ. Microbiol.
– volume: 160
  start-page: 2341
  year: 2014
  end-page: 2351
  ident: bib66
  article-title: and
  publication-title: Microbiology
– volume: 37
  start-page: 990
  year: 2017
  end-page: 1005
  ident: bib171
  article-title: Metabolic engineering strategies for acetoin and 2,3-butanediol production: advances and prospects
  publication-title: Crit. Rev. Biotechnol.
– volume: 23
  start-page: 22
  year: 2015
  end-page: 34
  ident: bib71
  article-title: Bacterial microcompartments and the modular construction of microbial metabolism
  publication-title: Trends Microbiol.
– volume: 6
  start-page: 123
  year: 2013
  ident: bib83
  article-title: A newly isolated
  publication-title: Biotechnol. Biofuels
– volume: 97
  start-page: 6113
  year: 2013
  end-page: 6127
  ident: bib90
  article-title: Developing
  publication-title: Appl. Microbiol. Biotechnol.
– volume: 219
  start-page: 40
  year: 2016
  end-page: 47
  ident: bib168
  article-title: Construction of a novel, stable, food-grade expression system by engineering the endogenous toxin-antitoxin system in
  publication-title: J. Biotechnol.
– volume: 33
  start-page: 1061
  year: 2015
  end-page: 1072
  ident: bib82
  article-title: Systems strategies for developing industrial microbial strains
  publication-title: Nat. Biotechnol.
– volume: 29
  start-page: 156
  year: 2014
  end-page: 162
  ident: bib11
  article-title: Multivariate modular metabolic engineering for pathway and strain optimization
  publication-title: Curr. Opin. Biotechnol.
– volume: 32
  start-page: 106
  year: 2015
  end-page: 115
  ident: bib45
  article-title: Improved poly-gamma-glutamic acid production in
  publication-title: Metab. Eng.
– volume: 36
  start-page: 2319
  year: 2014
  end-page: 2324
  ident: bib65
  article-title: Enhanced production of poly-gamma-glutamic acid by a newly-isolated
  publication-title: Biotechnol. Lett.
– volume: 15
  start-page: 73
  year: 2008
  end-page: 81
  ident: bib105
  article-title: Enhanced recombinant protein productivity by genome reduction in
  publication-title: DNA Res.
– volume: 109
  start-page: 480
  year: 2010
  end-page: 491
  ident: bib29
  article-title: Effect of pps disruption and constitutive expression of srfA on surfactin productivity, spreading and antagonistic properties of
  publication-title: J. Appl. Microbiol.
– volume: 164
  start-page: 1185
  year: 2016
  end-page: 1197
  ident: bib110
  article-title: Engineering cellular metabolism
  publication-title: Cell
– volume: 173
  start-page: 918
  year: 2014
  end-page: 932
  ident: bib81
  article-title: Improved production of poly-gamma-glutamic acid by
  publication-title: Appl. Biochem. Biotechnol.
– volume: 110
  start-page: 2556
  year: 2013
  end-page: 2561
  ident: bib182
  article-title: Optimization of amorphadiene synthesis in
  publication-title: Biotechnol. Bioeng.
– volume: 47
  start-page: 67
  year: 2017
  end-page: 82
  ident: bib19
  article-title: Recent advances in systems metabolic engineering tools and strategies
  publication-title: Curr. Opin. Biotechnol.
– volume: 32
  start-page: 337
  year: 2014
  end-page: 343
  ident: bib24
  article-title: Engineering redox balance through cofactor systerms
  publication-title: Trends Biotechnol.
– volume: 5
  start-page: 917
  year: 2007
  end-page: 927
  ident: bib136
  article-title: Control of key metabolic intersections in
  publication-title: Nat. Rev. Microbiol.
– volume: 23
  start-page: 42
  year: 2014
  end-page: 52
  ident: bib95
  article-title: Modular pathway engineering of
  publication-title: Metab. Eng.
– volume: 22
  start-page: 8
  year: 1999
  end-page: 18
  ident: bib113
  article-title: Genetic engineering of
  publication-title: J. Ind. Microbiol. Biotechnol.
– volume: 49
  start-page: 3766
  year: 2013
  end-page: 3768
  ident: bib89
  article-title: Functional assembly of a multi-enzyme methanol oxidation cascade on a surface-displayed trifunctional scaffold for enhanced NADH production
  publication-title: Chem. Commun.
– volume: 43
  start-page: 1094
  year: 2012
  end-page: 1102
  ident: bib128
  article-title: Agro-industrial residues and starch for growth and co-production of polyhydroxyalkanoate copolymer and alpha-amylase by
  publication-title: Braz. J. Microbiol.
– volume: 8
  start-page: 299
  year: 2016
  end-page: 309
  ident: bib155
  article-title: Substrate channelling as an approach to cascade reactions
  publication-title: Nat. Chem.
– volume: 97
  start-page: 6149
  year: 2013
  end-page: 6158
  ident: bib91
  article-title: Microbial production of glucosamine and N-acetylglucosamine: advances and perspectives
  publication-title: Appl. Microbiol. Biotechnol.
– volume: 65
  start-page: 2540
  year: 2017
  end-page: 2548
  ident: bib137
  article-title: High-efficiency secretion of beta-Mannanase in
  publication-title: J. Agric. Food Chem.
– volume: 46
  start-page: 28
  year: 2009
  end-page: 33
  ident: bib130
  article-title: Increased production of riboflavin by metabolic engineering of the purine pathway in Bacillus subtilis
  publication-title: Biochem. Eng. J.
– volume: 30
  start-page: 1893
  year: 2014
  end-page: 1900
  ident: bib148
  article-title: Enhancement of riboflavin production by deregulating gluconeogenesis in
  publication-title: World J. Microbiol. Biotechnol.
– volume: 7
  start-page: 10
  year: 2008
  ident: bib188
  article-title: Towards the development of
  publication-title: Microb. Cell Fact.
– volume: 48
  start-page: 970
  year: 2014
  end-page: 976
  ident: bib112
  article-title: Auto-inducible expression system based on the SigB-dependent ohrB promoter in
  publication-title: Mol. Biol.
– volume: 7
  start-page: 1797
  year: 2012
  end-page: 1807
  ident: bib32
  article-title: Designing and using RNA scaffolds to assemble proteins in vivo
  publication-title: Nat. Protoc.
– volume: 101
  start-page: 4533
  year: 2010
  end-page: 4539
  ident: bib62
  article-title: The statistically optimized production of poly(gamma-glutamic acid) by batch fermentation of a newly isolated
  publication-title: Bioresour. Technol.
– volume: 11
  start-page: 243
  year: 2009
  end-page: 252
  ident: bib129
  article-title: Transcriptome analysis guided metabolic engineering of
  publication-title: Metab. Eng.
– volume: 5
  start-page: 647
  year: 2010
  end-page: 659
  ident: bib13
  article-title: Systems metabolic engineering: genome-scale models and beyond
  publication-title: Biotechnol. J.
– volume: 23
  start-page: 761
  year: 2001
  end-page: 766
  ident: bib147
  article-title: Phytase production by high cell density culture of recombinant
  publication-title: Biotechnol. Let.
– volume: 46
  start-page: 25
  year: 2002
  end-page: 36
  ident: bib42
  article-title: A new mutation delivery system for genome-scale approaches in
  publication-title: Mol. Microbiol.
– volume: 84
  start-page: 69
  year: 2003
  end-page: 80
  ident: bib74
  article-title: Transporters involved in uptake of di- and tricarboxylates in
  publication-title: Antonie Van Leeuwenhoek
– volume: 222
  start-page: 86
  year: 2016
  end-page: 93
  ident: bib119
  article-title: A novel salt-inducible vector for efficient expression and secretion of heterologous proteins in
  publication-title: J. Biotechnol.
– volume: 15
  start-page: 69
  year: 2016
  ident: bib20
  article-title: A novel strategy for protein production using non-classical secretion pathway in
  publication-title: Microb. Cell Fact.
– volume: 113
  start-page: 577
  year: 2003
  end-page: 586
  ident: bib102
  article-title: Riboswitches control fundamental biochemical pathways in
  publication-title: Cell
– volume: 7
  start-page: 15058
  year: 2017
  ident: bib118
  article-title: The
  publication-title: Sci. Rep.
– volume: 83
  start-page: 164
  year: 2012
  end-page: 168
  ident: bib92
  article-title: Enhanced expression of an endoglucanase in
  publication-title: Protein Exp. Purif.
– volume: 6
  start-page: 27943
  year: 2016
  ident: bib175
  article-title: Multigene disruption in undomesticated
  publication-title: Sci. Rep.
– volume: 65
  start-page: 82
  year: 2012
  end-page: 89
  ident: bib132
  article-title: Synthetic biology devices as tools for metabolic engineering
  publication-title: Biochem. Eng. J.
– volume: 43
  start-page: e42
  year: 2015
  ident: bib61
  article-title: Genome engineering using a synthetic gene circuit in
  publication-title: Nucleic Acids Res.
– volume: 79
  start-page: 2073
  year: 2015
  end-page: 2080
  ident: bib145
  article-title: Enhanced dipicolinic acid production during the stationary phase in
  publication-title: Biosci. Biotechnol. Biochem.
– volume: 165
  start-page: 1493
  year: 2016
  end-page: 1506
  ident: bib114
  article-title: A comprehensive, CRISPR-based functional analysis of essential genes in bacteria
  publication-title: Cell
– volume: 10
  start-page: R69
  year: 2009
  ident: bib56
  article-title: iBsu1103: a new genome-scale metabolic model of
  publication-title: Genome Biol.
– volume: 13
  start-page: 1008
  year: 2014
  end-page: 1119
  ident: bib109
  article-title: Comprehensive absolute quantification of the cytosolic proteome of Bacillus subtilis by data independent, parallel fragmentation in liquid chromatography/mass spectrometry (LC/MS(E))
  publication-title: Mol. Cell. Proteom.
– volume: 161
  start-page: 1
  year: 2015
  end-page: 17
  ident: bib111
  article-title: Poly-gamma-glutamic acid: production, properties and applications
  publication-title: Microbiology
– volume: 44
  start-page: 7495
  year: 2016
  end-page: 7508
  ident: bib53
  article-title: A part toolbox to tune genetic expression in
  publication-title: Nucleic Acids Res.
– volume: 89
  start-page: 92
  year: 2013
  end-page: 96
  ident: bib108
  article-title: Construction of an artificial secYEG operon allowing high level secretion of alpha-amylase
  publication-title: Protein Expr. Purif.
– volume: 356
  start-page: 1293
  year: 2017
  end-page: 1297
  ident: bib140
  article-title: Assembly principles and structure of a 6.5-MDa bacterial microcompartment shell
  publication-title: Science
– volume: 29
  start-page: 1074
  year: 2011
  end-page: 1078
  ident: bib39
  article-title: Relative potential of biosynthetic pathways for biofuels and bio-based products
  publication-title: Nat. Biotechnol.
– volume: 7
  start-page: 11933
  year: 2016
  ident: bib93
  article-title: A dynamic pathway analysis approach reveals a limiting futile cycle in N-acetylglucosamine overproducing
  publication-title: Nat. Commun.
– volume: 44
  start-page: D654
  year: 2016
  end-page: D662
  ident: bib104
  article-title: SubtiWiki 2.0–an integrated database for the model organism
  publication-title: Nucleic Acids Res.
– volume: 41
  start-page: 1599
  year: 2014
  end-page: 1607
  ident: bib69
  article-title: Molecular engineering of secretory machinery components for high-level secretion of proteins in
  publication-title: J. Ind. Microbiol. Biotechnol.
– volume: 168
  start-page: 32
  year: 2013
  end-page: 39
  ident: bib115
  article-title: Construction of a 5′-controllable stabilizing element (CoSE) for over-production of heterologous proteins at high levels in
  publication-title: J. Biotechnol.
– volume: 185
  start-page: 5019
  year: 2003
  end-page: 5022
  ident: bib6
  article-title: The pst operon of
  publication-title: J. Bacteriol.
– year: 2018
  ident: bib172
  article-title: Recent advances on production of 2, 3-butanediol using engineered microbes
  publication-title: Biotechnol. Adv.
– volume: 40
  start-page: 1879
  year: 2012
  end-page: 1889
  ident: bib27
  article-title: DNA-guided assembly of biosynthetic pathways promotes improved catalytic efficiency
  publication-title: Nucleic Acids Res.
– volume: 47
  start-page: 27
  year: 2009
  end-page: 31
  ident: bib50
  article-title: Enhanced production of surfactin by
  publication-title: Food Technol. Biotechnol.
– volume: 250
  start-page: 642
  year: 2018
  end-page: 649
  ident: bib100
  article-title: Metabolic engineering of carbon overflow metabolism of
  publication-title: Bioresour. Technol.
– volume: 36
  start-page: D93
  year: 2008
  end-page: D96
  ident: bib133
  article-title: DBTBS: a database of transcriptional regulation in
  publication-title: Nucleic Acids Res.
– volume: 85
  start-page: 699
  year: 2006
  end-page: 715
  ident: bib139
  article-title: Hyaluronan fragments: an information-rich system
  publication-title: Eur. J. Cell Biol.
– volume: 102
  start-page: 12678
  year: 2005
  end-page: 12683
  ident: bib3
  article-title: Tuning genetic control through promoter engineering
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 19
  start-page: 107
  year: 2013
  end-page: 115
  ident: bib94
  article-title: Pathway engineering of
  publication-title: Metab. Eng.
– volume: 62
  start-page: 6487
  year: 2014
  end-page: 6497
  ident: bib160
  article-title: Generation of acetoin and its derivatives in foods
  publication-title: J. Agric. Food Chem.
– volume: 104
  start-page: 1
  year: 2017
  end-page: 15
  ident: bib116
  article-title: Transporters as information processors in bacterial signalling pathways
  publication-title: Mol. Microbiol.
– volume: 7
  start-page: 487
  year: 2011
  ident: bib40
  article-title: Engineering microbial biofuel tolerance and export using efflux pumps
  publication-title: Mol. Syst. Biol.
– volume: 133
  start-page: 2371
  year: 1987
  end-page: 2380
  ident: bib25
  article-title: Regulation of stage II of sporulation in
  publication-title: J. Gen. Microbiol.
– start-page: 1524
  year: 2011
  end-page: 1527
  ident: bib162
  article-title: Production of acetoin by Bacillus subtilis TH-49. International Conference on Consumer electronics
  publication-title: Commun. Netw.
– volume: 32
  start-page: 492
  year: 2014
  end-page: 503
  ident: bib159
  article-title: Strategies for enhancing fermentative production of acetoin: a review
  publication-title: Biotechnol. Adv.
– volume: 110
  start-page: 2006
  year: 2013
  end-page: 2012
  ident: bib127
  article-title: Knockout of pgdS and ggt genes improves gamma-PGA yield in
  publication-title: Biotechnol. Bioeng.
– volume: 44
  start-page: D471
  year: 2016
  end-page: D480
  ident: bib18
  article-title: The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases
  publication-title: Nucleic Acids Res.
– volume: 11
  start-page: 291
  year: 2011
  end-page: 297
  ident: bib57
  article-title: High yield and cost-effective production of poly(gamma-glutamic acid) with
  publication-title: Eng. Life Sci.
– volume: 7
  start-page: 29
  year: 2013
  ident: bib123
  article-title: The
  publication-title: J. Biol. Eng.
– volume: 16
  start-page: 160
  year: 2017
  ident: bib135
  article-title: Contribution of single amino acid and codon substitutions to the production and secretion of a lipase by
  publication-title: Microb. Cell Fact.
– volume: 12
  year: 2017
  ident: bib51
  article-title: Rewiring the glucose transportation and central metabolic pathways for overproduction of N-acetylglucosamine in
  publication-title: Biotechnol. J.
– volume: 245
  start-page: 1093
  year: 2017
  end-page: 1102
  ident: bib88
  article-title: Combinatorial promoter engineering of glucokinase and phosphoglucoisomerase for improved N-acetylglucosamine production in
  publication-title: Bioresour. Technol.
– volume: 98
  start-page: 3413
  year: 2014
  end-page: 3424
  ident: bib70
  article-title: Small RNA regulators in bacteria: powerful tools for metabolic engineering and synthetic biology
  publication-title: Appl. Microbiol. Biotechnol.
– volume: 9
  start-page: e93815
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib120
  article-title: Model-driven redox pathway manipulation for improved isobutanol production in Bacillus subtilis complemented with experimental validation and metabolic profiling analysis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0093815
– volume: 37
  start-page: 990
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib171
  article-title: Metabolic engineering strategies for acetoin and 2,3-butanediol production: advances and prospects
  publication-title: Crit. Rev. Biotechnol.
  doi: 10.1080/07388551.2017.1299680
– volume: 77
  start-page: 1033
  year: 2011
  ident: 10.1016/j.ymben.2018.05.006_bib2
  article-title: Diversion of flux toward sesquiterpene production in Saccharomyces cerevisiae by fusion of host and heterologous enzymes
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.01361-10
– volume: 8
  start-page: 536
  year: 2012
  ident: 10.1016/j.ymben.2018.05.006_bib79
  article-title: Systems metabolic engineering of microorganisms for natural and non-natural chemicals
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.970
– volume: 24
  start-page: 61
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib96
  article-title: Spatial modulation of key pathway enzymes by DNA-guided scaffold system and respiration chain engineering for improved N-acetylglucosamine production by Bacillus subtilis
  publication-title: Metab. Eng.
  doi: 10.1016/j.ymben.2014.04.004
– volume: 13
  start-page: 1008
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib109
  article-title: Comprehensive absolute quantification of the cytosolic proteome of Bacillus subtilis by data independent, parallel fragmentation in liquid chromatography/mass spectrometry (LC/MS(E))
  publication-title: Mol. Cell. Proteom.
  doi: 10.1074/mcp.M113.032631
– volume: 104
  start-page: 1
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib116
  article-title: Transporters as information processors in bacterial signalling pathways
  publication-title: Mol. Microbiol.
  doi: 10.1111/mmi.13633
– volume: 14
  start-page: 179
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib149
  article-title: A new potential secretion pathway for recombinant proteins in Bacillus subtilis
  publication-title: Microb. Cell Fact.
  doi: 10.1186/s12934-015-0374-6
– volume: 33
  start-page: 1061
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib82
  article-title: Systems strategies for developing industrial microbial strains
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3365
– volume: 24
  start-page: 37
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib85
  article-title: Inactivation of pyruvate kinase or the phosphoenolpyruvate: sugar phosphotransferase system increases shikimic and dehydroshikimic acid yields from glucose in Bacillus subtilis
  publication-title: J. Mol. Microbiol. Biotechnol.
  doi: 10.1159/000355264
– volume: 10
  start-page: 1812
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib103
  article-title: A time resolved metabolomics study: the influence of different carbon sources during growth and starvation of Bacillus subtilis
  publication-title: Mol. Biol. Syst.
– volume: 71
  start-page: 8818
  year: 2005
  ident: 10.1016/j.ymben.2018.05.006_bib14
  article-title: Development and characterization of a subtilin-regulated expression system in Bacillus subtilis: strict control of gene expression by addition of subtilin
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.71.12.8818-8824.2005
– volume: 81
  start-page: 1071
  year: 2006
  ident: 10.1016/j.ymben.2018.05.006_bib54
  article-title: Fermentation characteristics of a low-oxygen inducible hmp promoter system in Bacillus subtilis LAB1886
  publication-title: J. Chem. Technol. Biotechnol.
  doi: 10.1002/jctb.1534
– volume: 8
  start-page: 299
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib155
  article-title: Substrate channelling as an approach to cascade reactions
  publication-title: Nat. Chem.
  doi: 10.1038/nchem.2459
– volume: 110
  start-page: 2006
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib127
  article-title: Knockout of pgdS and ggt genes improves gamma-PGA yield in B. subtilis
  publication-title: Biotechnol. Bioeng.
  doi: 10.1002/bit.24846
– volume: 99
  start-page: 6363
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib152
  article-title: Stepwise optimization of a low-temperature Bacillus subtilis expression system for "difficult to express" proteins
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-015-6552-y
– volume: 79
  start-page: 527
  year: 2008
  ident: 10.1016/j.ymben.2018.05.006_bib158
  article-title: Improvement of poly(gamma-glutamic acid) biosynthesis and redistribution of metabolic flux with the presence of different additives in Bacillus subtilis CGMCC 0833
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-008-1462-x
– volume: 13
  start-page: 63
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib35
  article-title: Current development in genetic engineering strategies of Bacillus species
  publication-title: Microb. Cell Fact.
  doi: 10.1186/1475-2859-13-63
– volume: 11
  start-page: 243
  year: 2009
  ident: 10.1016/j.ymben.2018.05.006_bib129
  article-title: Transcriptome analysis guided metabolic engineering of Bacillus subtilis for riboflavin production
  publication-title: Metab. Eng.
  doi: 10.1016/j.ymben.2009.05.002
– year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib77
  article-title: Mini review: recombinant production of tailored bio-pharmaceuticals in different Bacillus strains and future perspectives
  publication-title: Eur. J. Pharm. Biopharm.
– volume: 13
  start-page: 101
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib131
  article-title: Deregulation of purine pathway in Bacillus subtilis and its use in riboflavin biosynthesis
  publication-title: Microb. Cell Fact.
– volume: 37
  start-page: 636
  year: 2005
  ident: 10.1016/j.ymben.2018.05.006_bib47
  article-title: Large-scale in vivo flux analysis shows rigidity and suboptimal performance of Bacillus subtilis metabolism
  publication-title: Nat. Genet.
  doi: 10.1038/ng1555
– volume: 181
  start-page: 1975
  year: 1999
  ident: 10.1016/j.ymben.2018.05.006_bib43
  article-title: Two-component signal transduction in Bacillus subtilis: how one organism sees its world
  publication-title: J. Bacteriol.
  doi: 10.1128/JB.181.7.1975-1983.1999
– volume: 140
  start-page: 424
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib64
  article-title: Efficient biosynthesis of polysaccharides chondroitin and heparosan by metabolically engineered Bacillus subtilis
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2015.12.065
– volume: 84
  start-page: 69
  year: 2003
  ident: 10.1016/j.ymben.2018.05.006_bib74
  article-title: Transporters involved in uptake of di- and tricarboxylates in Bacillus subtilis
  publication-title: Antonie Van Leeuwenhoek
  doi: 10.1023/A:1024445131925
– volume: 33
  start-page: 10
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib183
  article-title: The application of powerful promoters to enhance gene expression in industrial microorganisms
  publication-title: World J. Microbiol. Biotechnol.
  doi: 10.1007/s11274-016-2184-3
– volume: 330
  start-page: 70
  year: 2010
  ident: 10.1016/j.ymben.2018.05.006_bib1
  article-title: Isoprenoid pathway optimization for Taxol precursor overproduction in
  publication-title: Escherichia coli Science
– volume: 168
  start-page: 499
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib21
  article-title: Engineering Bacillus subtilis for acetoin production from glucose and xylose mixtures
  publication-title: J. Biotechnol.
  doi: 10.1016/j.jbiotec.2013.09.020
– volume: 165
  start-page: 1493
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib114
  article-title: A comprehensive, CRISPR-based functional analysis of essential genes in bacteria
  publication-title: Cell
  doi: 10.1016/j.cell.2016.05.003
– volume: 11
  start-page: 291
  year: 2011
  ident: 10.1016/j.ymben.2018.05.006_bib57
  article-title: High yield and cost-effective production of poly(gamma-glutamic acid) with Bacillus subtilis
  publication-title: Eng. Life Sci.
  doi: 10.1002/elsc.201000133
– volume: 32
  start-page: 337
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib24
  article-title: Engineering redox balance through cofactor systerms
  publication-title: Trends Biotechnol.
  doi: 10.1016/j.tibtech.2014.04.003
– volume: 35
  start-page: 21
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib63
  article-title: Production of specific-molecular-weight hyaluronan by metabolically engineered Bacillus subtilis 168
  publication-title: Metab. Eng.
  doi: 10.1016/j.ymben.2016.01.008
– volume: 53
  start-page: 12
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib163
  article-title: Production of chemicals using dynamic control of metabolic fluxes
  publication-title: Curr. Opin. Biotechnol.
  doi: 10.1016/j.copbio.2017.10.009
– volume: 89
  start-page: 92
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib108
  article-title: Construction of an artificial secYEG operon allowing high level secretion of alpha-amylase
  publication-title: Protein Expr. Purif.
  doi: 10.1016/j.pep.2013.02.008
– volume: 9
  start-page: 134
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib99
  article-title: Microbial synthesis of poly-gamma-glutamic acid: current progress, challenges, and future perspectives
  publication-title: Biotechnol. Biofuels
  doi: 10.1186/s13068-016-0537-7
– volume: 82
  start-page: 4876
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib153
  article-title: Development of a CRISPR-Cas9 tool kit for comprehensive engineering of Bacillus subtilis
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.01159-16
– volume: 52
  start-page: 44
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib107
  article-title: Optimization of water absorbing exopolysaccharide production on local cheap substrates by Bacillus strain CMG1403 using one variable at a time approach
  publication-title: J. Microbiol.
  doi: 10.1007/s12275-014-2622-6
– volume: 7
  start-page: 445
  year: 2011
  ident: 10.1016/j.ymben.2018.05.006_bib173
  article-title: Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.580
– volume: 42
  start-page: 1073
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib185
  article-title: Increasing succinic acid production using the PTS-independent glucose transport system in a Corynebacterium glutamicum PTS-defective mutant
  publication-title: J. Ind. Microbiol. Biotechnol.
  doi: 10.1007/s10295-015-1630-9
– volume: 94
  start-page: 651
  year: 2012
  ident: 10.1016/j.ymben.2018.05.006_bib12
  article-title: Enhanced production of 2,3-butanediol by engineered Bacillus subtilis
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-011-3774-5
– volume: 111
  start-page: 8227
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib16
  article-title: Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1321308111
– volume: 16
  start-page: 70
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib17
  article-title: A novel strategy to improve protein secretion via overexpression of the SppA signal peptide peptidase in Bacillus licheniformis
  publication-title: Microb. Cell Fact.
  doi: 10.1186/s12934-017-0688-7
– volume: 160
  start-page: 2341
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib66
  article-title: Bacillus subtilis and Escherichia coli essential genes and minimal cell factories after one decade of genome engineering
  publication-title: Microbiology
  doi: 10.1099/mic.0.079376-0
– volume: 219
  start-page: 40
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib168
  article-title: Construction of a novel, stable, food-grade expression system by engineering the endogenous toxin-antitoxin system in Bacillus subtilis
  publication-title: J. Biotechnol.
  doi: 10.1016/j.jbiotec.2015.12.029
– volume: 14
  start-page: 142
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib80
  article-title: Engineered synthetic scaffolds for organizing proteins within the bacterial cytoplasm
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.2535
– volume: 32
  start-page: 106
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib45
  article-title: Improved poly-gamma-glutamic acid production in Bacillus amyloliquefaciens by modular pathway engineering
  publication-title: Metab. Eng.
  doi: 10.1016/j.ymben.2015.09.011
– volume: 32
  start-page: 492
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib159
  article-title: Strategies for enhancing fermentative production of acetoin: a review
  publication-title: Biotechnol. Adv.
  doi: 10.1016/j.biotechadv.2014.01.002
– volume: 74
  start-page: 5556
  year: 2008
  ident: 10.1016/j.ymben.2018.05.006_bib166
  article-title: Cre/lox system and PCR-based genome engineering in Bacillus subtilis
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.01156-08
– volume: 250
  start-page: 642
  year: 2018
  ident: 10.1016/j.ymben.2018.05.006_bib100
  article-title: Metabolic engineering of carbon overflow metabolism of Bacillus subtilis for improved N-acetyl-glucosamine production
  publication-title: Bioresour. Technol.
  doi: 10.1016/j.biortech.2017.10.007
– volume: 6
  start-page: 123
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib83
  article-title: A newly isolated Bacillus licheniformis strain thermophilically produces 2,3-butanediol, a platform and fuel bio-chemical
  publication-title: Biotechnol. Biofuels
  doi: 10.1186/1754-6834-6-123
– volume: 9
  start-page: 90
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib48
  article-title: Metabolic engineering of Bacillus subtilis for chiral pure meso-2,3-butanediol production
  publication-title: Biotechnol. Biofuels
  doi: 10.1186/s13068-016-0502-5
– volume: 36
  start-page: 2319
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib65
  article-title: Enhanced production of poly-gamma-glutamic acid by a newly-isolated Bacillus subtilis
  publication-title: Biotechnol. Lett.
  doi: 10.1007/s10529-014-1613-3
– volume: 19
  start-page: 107
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib94
  article-title: Pathway engineering of Bacillus subtilis for microbial production of N-acetylglucosamine
  publication-title: Metab. Eng.
  doi: 10.1016/j.ymben.2013.07.002
– volume: 110
  start-page: 2556
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib182
  article-title: Optimization of amorphadiene synthesis in Bacillus subtilis via transcriptional, translational, and media modulation
  publication-title: Biotechnol. Bioeng.
  doi: 10.1002/bit.24900
– volume: 102
  start-page: 12678
  year: 2005
  ident: 10.1016/j.ymben.2018.05.006_bib3
  article-title: Tuning genetic control through promoter engineering
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0504604102
– volume: 24
  start-page: 61
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib98
  article-title: Spatial modulation of key pathway enzymes by DNA-guided scaffold system and respiration chain engineering for improved N-acetylglucosamine production by Bacillus subtilis
  publication-title: Metab. Eng.
  doi: 10.1016/j.ymben.2014.04.004
– volume: 44
  start-page: 7495
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib53
  article-title: A part toolbox to tune genetic expression in Bacillus subtilis
  publication-title: Nucleic Acids Res.
– volume: 98
  start-page: 3413
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib70
  article-title: Small RNA regulators in bacteria: powerful tools for metabolic engineering and synthetic biology
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-014-5569-y
– volume: 161
  start-page: 1
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib111
  article-title: Poly-gamma-glutamic acid: production, properties and applications
  publication-title: Microbiology
  doi: 10.1099/mic.0.081448-0
– volume: 390
  start-page: 249
  year: 1997
  ident: 10.1016/j.ymben.2018.05.006_bib75
  article-title: The complete genome sequence of the gram-positive bacterium Bacillus subtilis
  publication-title: Nature
  doi: 10.1038/36786
– volume: 164
  start-page: 67
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib186
  article-title: The main byproducts and metabolic flux profiling of gamma-PGA-producing strain B. subtilis ZJU-7 under different pH values
  publication-title: J. Biotechnol.
  doi: 10.1016/j.jbiotec.2012.12.009
– volume: 5
  start-page: 917
  year: 2007
  ident: 10.1016/j.ymben.2018.05.006_bib136
  article-title: Control of key metabolic intersections in Bacillus subtilis
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro1772
– volume: 11
  start-page: 839
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib5
  article-title: An experimentally supported model of the Bacillus subtilis global transcriptional regulatory network
  publication-title: Mol. Syst. Biol.
  doi: 10.15252/msb.20156236
– volume: 164
  start-page: 1185
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib110
  article-title: Engineering cellular metabolism
  publication-title: Cell
  doi: 10.1016/j.cell.2016.02.004
– volume: 97
  start-page: 519
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib161
  article-title: Genome-scale metabolic model in guiding metabolic engineering of microbial improvement
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-012-4543-9
– volume: 29
  start-page: 33
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib106
  article-title: Engineered Bacillus subtilis 168 produces L-malate by heterologous biosynthesis pathway construction and lactate dehydrogenase deletion
  publication-title: World J. Microbiol. Biotechnol.
  doi: 10.1007/s11274-012-1155-6
– volume: 83
  start-page: 579
  year: 2012
  ident: 10.1016/j.ymben.2018.05.006_bib60
  article-title: BsrG/SR4 from Bacillus subtilis- the first temperature-dependent type I toxin-antitoxin system
  publication-title: Mol. Microbiol.
  doi: 10.1111/j.1365-2958.2011.07952.x
– volume: 16
  start-page: 160
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib135
  article-title: Contribution of single amino acid and codon substitutions to the production and secretion of a lipase by Bacillus subtilis
  publication-title: Microb. Cell Fact.
  doi: 10.1186/s12934-017-0772-z
– volume: 40
  start-page: e91
  year: 2012
  ident: 10.1016/j.ymben.2018.05.006_bib151
  article-title: Bacillus subtilis genome editing using ssDNA with short homology regions
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks248
– volume: 245
  start-page: 1093
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib88
  article-title: Combinatorial promoter engineering of glucokinase and phosphoglucoisomerase for improved N-acetylglucosamine production in Bacillus subtilis
  publication-title: Bioresour. Technol.
  doi: 10.1016/j.biortech.2017.09.063
– volume: 82
  start-page: 5421
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib4
  article-title: Editing of the Bacillus subtilis genome by the CRISPR-Cas9 system
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.01453-16
– volume: 7
  start-page: 1797
  year: 2012
  ident: 10.1016/j.ymben.2018.05.006_bib32
  article-title: Designing and using RNA scaffolds to assemble proteins in vivo
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2012.102
– volume: 43
  start-page: 1094
  year: 2012
  ident: 10.1016/j.ymben.2018.05.006_bib128
  article-title: Agro-industrial residues and starch for growth and co-production of polyhydroxyalkanoate copolymer and alpha-amylase by Bacillus sp. CFR-67
  publication-title: Braz. J. Microbiol.
  doi: 10.1590/S1517-83822012000300036
– volume: 355
  start-page: 11
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib26
  article-title: Industrial biomanufacturing: the future of chemical production
  publication-title: Science
  doi: 10.1126/science.aag0804
– year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib174
  article-title: Engineering the bacterial microcompartment domain for molecular scaffolding applications
  publication-title: Front. Microbiol.
– volume: 23
  start-page: 34
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib177
  article-title: The rebalanced pathway significantly enhances acetoin production by disruption of acetoin reductase gene and moderate-expression of a new water-forming NADH oxidase in Bacillus subtilis
  publication-title: Metab. Eng.
  doi: 10.1016/j.ymben.2014.02.002
– volume: 14
  start-page: 150
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib52
  article-title: Construction and development of an auto-regulatory gene expression system in Bacillus subtilis
  publication-title: Microb. Cell Fact.
  doi: 10.1186/s12934-015-0341-2
– volume: 35
  start-page: 173
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib121
  article-title: Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3763
– volume: 7
  start-page: 11933
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib93
  article-title: A dynamic pathway analysis approach reveals a limiting futile cycle in N-acetylglucosamine overproducing Bacillus subtilis
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms11933
– volume: 168
  start-page: 32
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib115
  article-title: Construction of a 5′-controllable stabilizing element (CoSE) for over-production of heterologous proteins at high levels in Bacillus subtilis
  publication-title: J. Biotechnol.
  doi: 10.1016/j.jbiotec.2013.07.031
– volume: 23
  start-page: 761
  year: 2001
  ident: 10.1016/j.ymben.2018.05.006_bib147
  article-title: Phytase production by high cell density culture of recombinant Bacillus subtilis
  publication-title: Biotechnol. Let.
  doi: 10.1023/A:1010369325558
– volume: 25
  start-page: 1
  year: 2007
  ident: 10.1016/j.ymben.2018.05.006_bib87
  article-title: Protein secretion pathways in Bacillus subtilis: implication for optimization of heterologous protein secretion
  publication-title: Biotechnol. Adv.
  doi: 10.1016/j.biotechadv.2006.08.002
– volume: 41
  start-page: 1375
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib30
  article-title: Effects of metabolic pathway precursors and polydimethylsiloxane (PDMS) on poly-(gamma)-glutamic acid production by Bacillus subtilis BL53
  publication-title: J. Ind. Microbiol. Biotechnol.
  doi: 10.1007/s10295-014-1477-5
– volume: 27
  start-page: 753
  year: 2009
  ident: 10.1016/j.ymben.2018.05.006_bib38
  article-title: Synthetic protein scaffolds provide modular control over metabolic flux
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1557
– volume: 4
  start-page: 291
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib73
  article-title: Construction and analysis of two genome-scale deletion libraries for Bacillus subtilis
  publication-title: Cell Syst.
  doi: 10.1016/j.cels.2016.12.013
– volume: 29
  start-page: 1074
  year: 2011
  ident: 10.1016/j.ymben.2018.05.006_bib39
  article-title: Relative potential of biosynthetic pathways for biofuels and bio-based products
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2055
– volume: 5
  start-page: 647
  year: 2010
  ident: 10.1016/j.ymben.2018.05.006_bib13
  article-title: Systems metabolic engineering: genome-scale models and beyond
  publication-title: Biotechnol. J.
  doi: 10.1002/biot.200900247
– volume: 38
  start-page: 2103
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib176
  article-title: Rapid evolution of hyaluronan synthase to improve hyaluronan production and molecular mass in Bacillus subtilis
  publication-title: Biotechnol. Lett.
  doi: 10.1007/s10529-016-2193-1
– volume: 4
  start-page: 98
  year: 2011
  ident: 10.1016/j.ymben.2018.05.006_bib180
  article-title: Simple, fast and high-efficiency transformation system for directed evolution of cellulase in Bacillus subtilis
  publication-title: Microb. Biotechnol.
  doi: 10.1111/j.1751-7915.2010.00230.x
– volume: 16
  start-page: 67
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib142
  article-title: A new-generation of Bacillus subtilis cell factory for further elevated scyllo-inositol production
  publication-title: Microb. Cell Fact.
  doi: 10.1186/s12934-017-0682-0
– volume: 34
  start-page: e71
  year: 2006
  ident: 10.1016/j.ymben.2018.05.006_bib179
  article-title: mazF, a novel counter-selectable marker for unmarked chromosomal manipulation in Bacillus subtilis
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkl358
– volume: Vol. 62
  start-page: 137
  year: 2007
  ident: 10.1016/j.ymben.2018.05.006_bib125
  article-title: Production of recombinant proteins in Bacillus subtilis
– volume: 7
  start-page: 44023
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib181
  article-title: Multimer recognition and secretion by the non-classical secretion pathway in Bacillus subtilis
  publication-title: Sci. Rep.
  doi: 10.1038/srep44023
– volume: 23
  start-page: 42
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib95
  article-title: Modular pathway engineering of Bacillus subtilis for improved N-acetylglucosamine production
  publication-title: Metab. Eng.
  doi: 10.1016/j.ymben.2014.02.005
– volume: 111
  start-page: 2126
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib49
  article-title: NADH plays the vital role for chiral pure 2,3-butanediol production in Bacillus subtilis under limited oxygen conditions
  publication-title: Biotechnol. Bioeng.
  doi: 10.1002/bit.25265
– volume: 7
  start-page: 15058
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib118
  article-title: The Bacillus BioBrick Box 2.0: expanding the genetic toolbox for the standardized work with Bacillus subtilis
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-15107-z
– volume: 222
  start-page: 86
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib119
  article-title: A novel salt-inducible vector for efficient expression and secretion of heterologous proteins in Bacillus subtilis
  publication-title: J. Biotechnol.
  doi: 10.1016/j.jbiotec.2016.02.019
– volume: 36
  start-page: D93
  year: 2008
  ident: 10.1016/j.ymben.2018.05.006_bib133
  article-title: DBTBS: a database of transcriptional regulation in Bacillus subtilis containing upstream intergenic conservation information
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkm910
– volume: 185
  start-page: 5019
  year: 2003
  ident: 10.1016/j.ymben.2018.05.006_bib6
  article-title: The pst operon of Bacillus subtilis is specifically induced by alkali stress
  publication-title: J. Bacteriol.
  doi: 10.1128/JB.185.16.5019-5022.2003
– volume: 10
  start-page: 1298
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib9
  article-title: Regulation of the NADH pool and NADH/NADPH ratio redistributes acetoin and 2,3-butanediol proportion in Bacillus subtilis
  publication-title: Biotechnol. J.
  doi: 10.1002/biot.201400577
– volume: 34
  start-page: 652
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib157
  article-title: Metabolic burden: cornerstones in synthetic biology and metabolic engineering applications
  publication-title: Trends Biotechnol.
  doi: 10.1016/j.tibtech.2016.02.010
– volume: 10
  start-page: R69
  year: 2009
  ident: 10.1016/j.ymben.2018.05.006_bib56
  article-title: iBsu1103: a new genome-scale metabolic model of Bacillus subtilis based on SEED annotations
  publication-title: Genome Biol.
  doi: 10.1186/gb-2009-10-6-r69
– volume: 101
  start-page: 4533
  year: 2010
  ident: 10.1016/j.ymben.2018.05.006_bib62
  article-title: The statistically optimized production of poly(gamma-glutamic acid) by batch fermentation of a newly isolated Bacillus subtilis RKY3
  publication-title: Bioresour. Technol.
  doi: 10.1016/j.biortech.2010.01.080
– volume: 78
  start-page: 651
  year: 2012
  ident: 10.1016/j.ymben.2018.05.006_bib34
  article-title: Functional implementation of the posttranslational SecB-SecA protein-targeting pathway in Bacillus subtilis
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.07209-11
– volume: 115
  start-page: 216
  year: 2018
  ident: 10.1016/j.ymben.2018.05.006_bib154
  article-title: Engineering of cell membrane to enhance heterologous production of hyaluronic acid in Bacillus subtilis
  publication-title: Biotechnol. Bioeng.
  doi: 10.1002/bit.26459
– volume: 5
  start-page: 942
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib124
  article-title: Effect of genome position on heterologous gene expression in Bacillus subtilis: an unbiased analysis
  publication-title: ACS Synth. Biol.
  doi: 10.1021/acssynbio.6b00065
– volume: 6
  start-page: 27943
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib175
  article-title: Multigene disruption in undomesticated Bacillus subtilis ATCC 6051a using the CRISPR/Cas9 system
  publication-title: Sci. Rep.
  doi: 10.1038/srep27943
– year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib169
  article-title: Construction and characterization of broad-spectrum promoters for synthetic biology
  publication-title: ACS Synth. Biol.
– volume: 43
  start-page: e42
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib61
  article-title: Genome engineering using a synthetic gene circuit in Bacillus subtilis
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku1380
– volume: 13
  start-page: 3298
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib117
  article-title: Proteomic analysis of Bacillus subtilis strains engineered for improved production of heterologous proteins
  publication-title: Proteomics
  doi: 10.1002/pmic.201300183
– volume: 356
  start-page: 1293
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib140
  article-title: Assembly principles and structure of a 6.5-MDa bacterial microcompartment shell
  publication-title: Science
  doi: 10.1126/science.aan3289
– start-page: 1524
  year: 2011
  ident: 10.1016/j.ymben.2018.05.006_bib162
  article-title: Production of acetoin by Bacillus subtilis TH-49. International Conference on Consumer electronics
  publication-title: Commun. Netw.
– volume: 49
  start-page: 3766
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib89
  article-title: Functional assembly of a multi-enzyme methanol oxidation cascade on a surface-displayed trifunctional scaffold for enhanced NADH production
  publication-title: Chem. Commun.
  doi: 10.1039/c3cc40454d
– volume: 100
  start-page: 2107
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib126
  article-title: Biotechnology of riboflavin
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-015-7256-z
– volume: 48
  start-page: 970
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib112
  article-title: Auto-inducible expression system based on the SigB-dependent ohrB promoter in Bacillus subtilis
  publication-title: Mol. Biol.
  doi: 10.1134/S0026893314060132
– volume: 42
  start-page: 93
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib84
  article-title: Overexpression of specific proton motive force-dependent transporters facilitate the export of surfactin in Bacillus subtilis
  publication-title: J. Ind. Microbiol. Biotechnol.
  doi: 10.1007/s10295-014-1527-z
– volume: 85
  start-page: 699
  year: 2006
  ident: 10.1016/j.ymben.2018.05.006_bib139
  article-title: Hyaluronan fragments: an information-rich system
  publication-title: Eur. J. Cell Biol.
  doi: 10.1016/j.ejcb.2006.05.009
– volume: 79
  start-page: 2073
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib145
  article-title: Enhanced dipicolinic acid production during the stationary phase in Bacillus subtilis by blocking acetoin synthesis
  publication-title: Biosci. Biotechnol. Biochem.
  doi: 10.1080/09168451.2015.1060843
– year: 2018
  ident: 10.1016/j.ymben.2018.05.006_bib172
  article-title: Recent advances on production of 2, 3-butanediol using engineered microbes
  publication-title: Biotechnol. Adv.
– volume: 12
  start-page: 72
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib68
  article-title: Metabolic engineering of Bacillus subtilis for growth on overflow metabolites
  publication-title: Microb. Cell Fact.
  doi: 10.1186/1475-2859-12-72
– volume: 68
  start-page: 207
  year: 2004
  ident: 10.1016/j.ymben.2018.05.006_bib144
  article-title: Proteomics of protein secretion by Bacillus subtilis: separating the "secrets" of the secretome
  publication-title: Microbiol. Mol. Biol. Rev.
  doi: 10.1128/MMBR.68.2.207-233.2004
– volume: 47
  start-page: 67
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib19
  article-title: Recent advances in systems metabolic engineering tools and strategies
  publication-title: Curr. Opin. Biotechnol.
  doi: 10.1016/j.copbio.2017.06.007
– volume: 31
  start-page: 335
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib7
  article-title: Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2509
– volume: 12
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib51
  article-title: Rewiring the glucose transportation and central metabolic pathways for overproduction of N-acetylglucosamine in Bacillus subtilis
  publication-title: Biotechnol. J.
  doi: 10.1002/biot.201700020
– volume: 42
  start-page: 1427
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib150
  article-title: Construction of a highly efficient Bacillus subtilis 168 whole-cell biocatalyst and its application in the production of L-ornithine
  publication-title: J. Ind. Microbiol. Biotechnol.
  doi: 10.1007/s10295-015-1672-z
– volume: 46
  start-page: 25
  year: 2002
  ident: 10.1016/j.ymben.2018.05.006_bib42
  article-title: A new mutation delivery system for genome-scale approaches in Bacillus subtilis
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.2002.03140.x
– volume: 39
  start-page: 126
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib10
  article-title: Directed evolution and synthetic biology applications to microbial systems
  publication-title: Curr. Opin. Biotechnol.
  doi: 10.1016/j.copbio.2016.03.016
– volume: 40
  start-page: 1879
  year: 2012
  ident: 10.1016/j.ymben.2018.05.006_bib27
  article-title: DNA-guided assembly of biosynthetic pathways promotes improved catalytic efficiency
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkr888
– start-page: 1
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib28
  article-title: An overview of Bacillus proteases: from production to application
  publication-title: Crit. Rev. Biotechnol.
– volume: 44
  start-page: D654
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib104
  article-title: SubtiWiki 2.0–an integrated database for the model organism Bacillus subtilis
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv1006
– volume: 6
  start-page: 8224
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib122
  article-title: Modular pathway rewiring of Saccharomyces cerevisiae enables high-level production of L-ornithine
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms9224
– volume: 7
  start-page: 487
  year: 2011
  ident: 10.1016/j.ymben.2018.05.006_bib40
  article-title: Engineering microbial biofuel tolerance and export using efflux pumps
  publication-title: Mol. Syst. Biol.
  doi: 10.1038/msb.2011.21
– volume: 6
  start-page: 7832
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib76
  article-title: A portable expression resource for engineering cross-species genetic circuits and pathways
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms8832
– volume: 36
  start-page: 1851
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib23
  article-title: Enhancement of adenosine production by Bacillus subtilis CGMCC 4484 through metabolic flux analysis and simplified feeding strategies
  publication-title: Bioprocess Biosyst. Eng.
  doi: 10.1007/s00449-013-0959-6
– volume: 97
  start-page: 6113
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib90
  article-title: Developing Bacillus spp. as a cell factory for production of microbial enzymes and industrially important biochemicals in the context of systems and synthetic biology
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-013-4960-4
– volume: 7
  start-page: 29
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib123
  article-title: The Bacillus BioBrick Box: generation and evaluation of essential genetic building blocks for standardized work with Bacillus subtilis
  publication-title: J. Biol. Eng.
  doi: 10.1186/1754-1611-7-29
– volume: 415
  start-page: 263
  year: 2002
  ident: 10.1016/j.ymben.2018.05.006_bib58
  article-title: Bacillus subtilis and its closest relatives: from genes to cells
  publication-title: Nature
  doi: 10.1038/415263b
– volume: 70
  start-page: 939
  year: 2006
  ident: 10.1016/j.ymben.2018.05.006_bib33
  article-title: How phosphotransferase system-related protein phosphorylation regulates carbohydrate metabolism in bacteria
  publication-title: Microbiol. Mol. Biol. Rev.
  doi: 10.1128/MMBR.00024-06
– volume: 65
  start-page: 2540
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib137
  article-title: High-efficiency secretion of beta-Mannanase in Bacillus subtilis through protein synthesis and secretion optimization
  publication-title: J. Agric. Food Chem.
  doi: 10.1021/acs.jafc.6b05528
– volume: 46
  start-page: 28
  year: 2009
  ident: 10.1016/j.ymben.2018.05.006_bib130
  article-title: Increased production of riboflavin by metabolic engineering of the purine pathway in Bacillus subtilis
  publication-title: Biochem. Eng. J.
  doi: 10.1016/j.bej.2009.04.008
– volume: 101
  start-page: 1509
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib46
  article-title: Enhanced extracellular production of L-asparaginase from Bacillus subtilis 168 by B. subtilis WB600 through a combined strategy
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-016-7816-x
– volume: 47
  start-page: 27
  year: 2009
  ident: 10.1016/j.ymben.2018.05.006_bib50
  article-title: Enhanced production of surfactin by Bacillus subtilis E8 mutant obtained by ion beam implantation
  publication-title: Food Technol. Biotechnol.
– volume: 29
  start-page: 156
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib11
  article-title: Multivariate modular metabolic engineering for pathway and strain optimization
  publication-title: Curr. Opin. Biotechnol.
  doi: 10.1016/j.copbio.2014.05.005
– volume: 11
  start-page: 119
  year: 2011
  ident: 10.1016/j.ymben.2018.05.006_bib55
  article-title: RibM from Streptomyces davawensis is a riboflavin/roseoflavin transporter and may be useful for the optimization of riboflavin production strains
  publication-title: BMC Biotechnol.
  doi: 10.1186/1472-6750-11-119
– volume: 23
  start-page: 22
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib71
  article-title: Bacterial microcompartments and the modular construction of microbial metabolism
  publication-title: Trends Microbiol.
  doi: 10.1016/j.tim.2014.10.003
– volume: 33
  start-page: 8
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib134
  article-title: Microbial production of poly-gamma-glutamic acid
  publication-title: World J. Microbiol. Biotechnol.
  doi: 10.1007/s11274-017-2338-y
– year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib22
  article-title: DCEO Biotechnology: tools to design, construct, evaluate, and optimize the metabolic pathway for biosynthesis of chemicals
  publication-title: Chem. Rev.
– volume: 133
  start-page: 2371
  year: 1987
  ident: 10.1016/j.ymben.2018.05.006_bib25
  article-title: Regulation of stage II of sporulation in Bacillus subtilis
  publication-title: J. Gen. Microbiol.
– volume: 11
  start-page: 18
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib138
  article-title: Promoter screening from Bacillus subtilis in various conditions hunting for synthetic biology and industrial applications
  publication-title: PLoS One
– volume: 8
  start-page: 129
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib170
  article-title: Metabolic engineering of Bacillus subtilis for redistributing the carbon flux to 2,3-butanediol by manipulating NADH levels
  publication-title: Biotechnol. Biofuels
  doi: 10.1186/s13068-015-0320-1
– volume: 15
  start-page: 73
  year: 2008
  ident: 10.1016/j.ymben.2018.05.006_bib105
  article-title: Enhanced recombinant protein productivity by genome reduction in Bacillus subtilis
  publication-title: DNA Res.
  doi: 10.1093/dnares/dsn002
– volume: 10
  start-page: 216
  year: 2008
  ident: 10.1016/j.ymben.2018.05.006_bib143
  article-title: Screening of Bacillus subtilis transposon mutants with altered riboflavin production
  publication-title: Metab. Eng.
  doi: 10.1016/j.ymben.2008.06.002
– volume: 4
  start-page: 1409
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib164
  article-title: Modular optimization of multi-gene pathways for fatty acids production in E. coli
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms2425
– volume: 18
  start-page: 533
  year: 2000
  ident: 10.1016/j.ymben.2018.05.006_bib44
  article-title: Improving lycopene production in Escherichia coli by engineering metabolic control
  publication-title: Nat. Biotechnol.
  doi: 10.1038/75398
– volume: 155
  start-page: 8
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib165
  article-title: Enhanced poly(gamma-glutamic acid) fermentation by Bacillus subtilis NX-2 immobilized in an aerobic plant fibrous-bed bioreactor
  publication-title: Bioresour. Technol.
  doi: 10.1016/j.biortech.2013.12.080
– volume: 85
  start-page: 1907
  year: 2010
  ident: 10.1016/j.ymben.2018.05.006_bib37
  article-title: Overexpression of glucose-6-phosphate dehydrogenase enhances riboflavin production in Bacillus subtilis
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-009-2247-6
– volume: 153
  start-page: 3645
  year: 2007
  ident: 10.1016/j.ymben.2018.05.006_bib31
  article-title: The orotate transporter encoded by oroP from Lactococcus lactis is required for orotate utilization and has utility as a food-grade selectable marker
  publication-title: Microbiology
  doi: 10.1099/mic.0.2007/005959-0
– volume: 13
  start-page: 617
  year: 2011
  ident: 10.1016/j.ymben.2018.05.006_bib72
  article-title: Metabolic engineering of cellular transport for overproduction of the platform chemical 1,5-diaminopentane in Corynebacterium glutamicum
  publication-title: Metab. Eng.
  doi: 10.1016/j.ymben.2011.07.006
– volume: 42
  start-page: D685
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib41
  article-title: SporeWeb: an interactive journey through the complete sporulation cycle of Bacillus subtilis
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt1007
– volume: 12
  start-page: 3
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib146
  article-title: Bacillus subtilis: from soil bacterium to super-secreting cell factory
  publication-title: Microb. Cell Fact.
  doi: 10.1186/1475-2859-12-3
– volume: 173
  start-page: 918
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib81
  article-title: Improved production of poly-gamma-glutamic acid by Bacillus subtilis D7 isolated from Doenjang, a Korean traditional fermented food, and its antioxidant activity
  publication-title: Appl. Biochem. Biotechnol.
  doi: 10.1007/s12010-014-0908-0
– volume: 35
  start-page: 20
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib97
  article-title: Metabolic engineering of Bacillus subtilis fueled by systems biology: recent advances and future directions
  publication-title: Biotechnol. Adv.
  doi: 10.1016/j.biotechadv.2016.11.003
– volume: 7
  start-page: 10
  year: 2008
  ident: 10.1016/j.ymben.2018.05.006_bib188
  article-title: Towards the development of Bacillus subtilis as a cell factory for membrane proteins and protein complexes
  publication-title: Microb. Cell Fact.
  doi: 10.1186/1475-2859-7-10
– volume: 71
  start-page: 3747
  year: 2005
  ident: 10.1016/j.ymben.2018.05.006_bib156
  article-title: Hyaluronic acid production in Bacillus subtilis
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.71.7.3747-3752.2005
– volume: 161
  start-page: 354
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib36
  article-title: A novel engineering tool in the Bacillus subtilis toolbox: inducer-free activation of gene expression by selection-driven promoter decryptification
  publication-title: Microbiology
  doi: 10.1099/mic.0.000001
– volume: 22
  start-page: 8
  year: 1999
  ident: 10.1016/j.ymben.2018.05.006_bib113
  article-title: Genetic engineering of Bacillus subtilis for the commercial production of riboflavin
  publication-title: J. Ind. Microbiol. Biotechnol.
  doi: 10.1038/sj.jim.2900587
– volume: 71
  start-page: 4101
  year: 2005
  ident: 10.1016/j.ymben.2018.05.006_bib178
  article-title: High-level expression and secretion of methyl parathion hydrolase in Bacillus subtilis WB800
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.71.7.4101-4103.2005
– volume: 28
  start-page: 1667
  year: 2006
  ident: 10.1016/j.ymben.2018.05.006_bib187
  article-title: Over-expression of glucose dehydrogenase improves cell growth and riboflavin production in Bacillus subtilis
  publication-title: Biotechnol. Lett.
  doi: 10.1007/s10529-006-9143-2
– volume: 44
  start-page: D471
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib18
  article-title: The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv1164
– volume: 4
  start-page: 745
  year: 2011
  ident: 10.1016/j.ymben.2018.05.006_bib8
  article-title: Flocculation properties of poly(gamma-glutamic acid) produced from Bacillus subtilis isolate
  publication-title: Food Bioprocess Technol.
  doi: 10.1007/s11947-009-0186-y
– volume: 34
  start-page: 98
  year: 2015
  ident: 10.1016/j.ymben.2018.05.006_bib78
  article-title: Advances and current limitations in transcript-level control of gene expression
  publication-title: Curr. Opin. Biotechnol.
  doi: 10.1016/j.copbio.2014.12.015
– volume: 62
  start-page: 6487
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib160
  article-title: Generation of acetoin and its derivatives in foods
  publication-title: J. Agric. Food Chem.
  doi: 10.1021/jf5013902
– volume: 65
  start-page: 82
  year: 2012
  ident: 10.1016/j.ymben.2018.05.006_bib132
  article-title: Synthetic biology devices as tools for metabolic engineering
  publication-title: Biochem. Eng. J.
  doi: 10.1016/j.bej.2012.04.006
– volume: 41
  start-page: 28
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib141
  article-title: Dynamic pathway regulation: recent advances and methods of construction
  publication-title: Curr. Opin. Chem. Biol.
  doi: 10.1016/j.cbpa.2017.10.004
– volume: 41
  start-page: 1599
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib69
  article-title: Molecular engineering of secretory machinery components for high-level secretion of proteins in Bacillus species
  publication-title: J. Ind. Microbiol. Biotechnol.
  doi: 10.1007/s10295-014-1506-4
– volume: 83
  start-page: 164
  year: 2012
  ident: 10.1016/j.ymben.2018.05.006_bib92
  article-title: Enhanced expression of an endoglucanase in Bacillus subtilis by using the sucrose-inducible sacB promoter and improved properties of the recombinant enzyme
  publication-title: Protein Exp. Purif.
  doi: 10.1016/j.pep.2012.03.015
– volume: 29
  start-page: 278
  year: 2001
  ident: 10.1016/j.ymben.2018.05.006_bib59
  article-title: DBTBS: a database of Bacillus subtilis promoters and transcription factors
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/29.1.278
– volume: 113
  start-page: 577
  year: 2003
  ident: 10.1016/j.ymben.2018.05.006_bib102
  article-title: Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria
  publication-title: Cell
  doi: 10.1016/S0092-8674(03)00391-X
– volume: 101
  start-page: 4151
  year: 2017
  ident: 10.1016/j.ymben.2018.05.006_bib167
  article-title: Characterization and application of endogenous phase-dependent promoters in Bacillus subtilis
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-017-8142-7
– volume: 97
  start-page: 6149
  year: 2013
  ident: 10.1016/j.ymben.2018.05.006_bib91
  article-title: Microbial production of glucosamine and N-acetylglucosamine: advances and perspectives
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-013-4995-6
– volume: 134
  start-page: 3234
  year: 2012
  ident: 10.1016/j.ymben.2018.05.006_bib184
  article-title: Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja2114486
– volume: 78
  start-page: 89
  year: 2012
  ident: 10.1016/j.ymben.2018.05.006_bib67
  article-title: Modular engineering of L-tyrosine production in Escherichia coli
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.06017-11
– volume: 30
  start-page: 1893
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib148
  article-title: Enhancement of riboflavin production by deregulating gluconeogenesis in Bacillus subtilis
  publication-title: World J. Microbiol. Biotechnol.
  doi: 10.1007/s11274-014-1611-6
– volume: 15
  start-page: 69
  year: 2016
  ident: 10.1016/j.ymben.2018.05.006_bib20
  article-title: A novel strategy for protein production using non-classical secretion pathway in Bacillus subtilis
  publication-title: Microb. Cell Fact.
  doi: 10.1186/s12934-016-0469-8
– volume: 109
  start-page: 480
  year: 2010
  ident: 10.1016/j.ymben.2018.05.006_bib29
  article-title: Effect of pps disruption and constitutive expression of srfA on surfactin productivity, spreading and antagonistic properties of Bacillus subtilis 168 derivatives
  publication-title: J. Appl. Microbiol.
  doi: 10.1111/j.1365-2672.2010.04683.x
– volume: 191
  start-page: 214
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib86
  article-title: The nucleotide composition of the spacer sequence influences the expression yield of heterologously expressed genes in Bacillus subtilis
  publication-title: J. Biotechnol.
  doi: 10.1016/j.jbiotec.2014.06.027
– volume: 70
  start-page: 7241
  year: 2004
  ident: 10.1016/j.ymben.2018.05.006_bib15
  article-title: New integrative method to generate Bacillus subtilis recombinant strains free of selection markers
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.70.12.7241-7250.2004
– volume: 13
  start-page: 2260
  year: 2014
  ident: 10.1016/j.ymben.2018.05.006_bib101
  article-title: Highly precise quantification of protein molecules per cell during stress and starvation responses in Bacillus subtilis
  publication-title: Mol. Cell. Proteom.: Mcp.
  doi: 10.1074/mcp.M113.035741
SSID ssj0011591
Score 2.6022196
SecondaryResourceType review_article
Snippet Bacillus subtilis is the most characterized gram-positive bacterium that has significant attributes, such as growing well on cheap carbon sources, possessing...
SourceID proquest
pubmed
crossref
elsevier
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 109
SubjectTerms Bacillus subtilis
carbon
factories
fermentation
genetic engineering
Gram-positive bacteria
hosts
Industrial applications
Metabolic engineering
Microbial cell factories
recombinant proteins
Synthetic biology
Title Advances and prospects of Bacillus subtilis cellular factories: From rational design to industrial applications
URI https://dx.doi.org/10.1016/j.ymben.2018.05.006
https://www.ncbi.nlm.nih.gov/pubmed/29775652
https://www.proquest.com/docview/2041639242
https://www.proquest.com/docview/2220888435
Volume 50
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5VRUhwQKW8lpbKSBwJu-s4ic1tW7FaQPRCkXqz_IoUtE2qTfbQC7-dGSdZFQn2wDHROLI845lv4vF8AO9cYVOMWjKx2SwkwimbqFKpxLjCOOVToQKd6H67zFc_xJfr7PoALsa7MFRWOfj-3qdHbz28mQ6rOb2tqun3OaJvTEYwBGNKjnGObrCLgqz8w69dmQcCnsiaR8IJSY-dh2KN192NDdQEdS5j-06iPfp7dPoX-oxRaHkETwb4yBb9DJ_CQaiP4WFPKHl3DI_vtRd8Bs2iP-Bvmak9w2_Ha5Uta0p2bly1Xm9b1m5tV62rltEffCpJZT0DDybQH9ly09ywzfC7kPlY7MG6hlU7vg92_wD8OVwtP11drJKBYCFxIpNdkvuZV5IXKitmwUonSwI8IXMWw7gtSiGMCVLmJvNpECHHQFbaNMUtGwpl0vQFHNZNHV4BmxMxIOZeyjgvMssNwkwjLToQx1Nv_AT4uK7aDc3HiQNjrccqs586KkOTMvQs06iMCbzfDbrte2_sF89Hhek_TEhjdNg_8O2oXo2bi9bb1KHZtihEeBVTVL5HhnP01BJh5wRe9raxmy1HdI2Imb_-36mdwCN66i8_nsJht9mGN4iCOnsWzfwMHiw-f11d_gYkLwep
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9swDCa6FMXWw7A-tqZ7VAN2rJFEtmxpt6xYkCxtLkuB3gS9DHhI7SJ2Dv33pfwIOmDNYVebMgRR4vfRpEiAbybRIaIWDzQbuiAyQgciFSJQJlFG2DASzkd0bxbx9Db6dcfu9uCquwvj0ypb29_Y9Npat08G7WoOHrJs8HuE7BudEYRgdMkR517Bvq9OxXqwP57Np4ttMAERu_a7UD7wA7riQ3Wa1-O9dr4O6ojXFTx956N_A9RLBLQGosk7eNsySDJuJnkEey4_hoOmp-TjMRw-qzB4AsW4ifGXROWW4Lfrm5UlKVLyQ5lstdqUpNzoKltlJfE_8X1WKmma8KAP_Z1M1sU9Wbd_DImt8z1IVZBs2_KDPI-Bn8Jy8nN5NQ3aHguBiRivgtgOreA0ESwZOs0NTz3nccxoRHKdpFGklOM8VsyGLnIxYlmqwxBPrUuECsP30MuL3J0BGfnegOh-CWVsxDRVyDQV12hDDA2tsn2g3bpK09Yf920wVrJLNPsja2VIrww5ZBKV0YfL7aCHpvzGbvG4U5j8axdJBIjdA7926pV4vvx6q9wVmxKFPGVFL5XukKEUjTVH5tmHD83e2M6WIsFG0kzP_3dqF_B6ury5ltezxfwjvPFvmruQn6BXrTfuM5KiSn9pN_0TIyQKWg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Advances+and+prospects+of+Bacillus+subtilis+cellular+factories%3A+From+rational+design+to+industrial+applications&rft.jtitle=Metabolic+engineering&rft.au=Gu%2C+Yang&rft.au=Xu%2C+Xianhao&rft.au=Wu%2C+Yaokang&rft.au=Niu%2C+Tengfei&rft.date=2018-11-01&rft.issn=1096-7184&rft.eissn=1096-7184&rft.volume=50&rft.spage=109&rft_id=info:doi/10.1016%2Fj.ymben.2018.05.006&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1096-7176&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1096-7176&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1096-7176&client=summon