Radiological and histopathological examination of apparent lytic lesions in allograft long bones—No cause for concern

Abstract Objective Identify the nature of apparent lytic lesions within human allograft specimens from patients with no known malignancy, using radiological and histopathological analysis Methods 123 Post-retrieval radiographs from 23 donors were examined. Sixty-seven radiographs were noted to show...

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Published inJournal of orthopaedics Vol. 12; no. Suppl 2; pp. S152 - S156
Main Authors Kent, Mike, Brooker, Greg, Fisher, Ryan, Goh, Geraldine, Aguiar, Ranieri Falcao, Papadimitriou, John, Wong, Daniel, Carey-Smith, Richard, Cowie, Anne
Format Journal Article
LanguageEnglish
Published India Elsevier India Pvt Ltd 01.12.2015
Elsevier
Subjects
Bone and tissue banking
Long bone allografts
Lytic lesions
Original
Orthopedics
Quality control
Tumour reconstruction
Tumour reconstruction
Long bone allografts
Lytic lesions
Bone and tissue banking
Quality control
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Abstract Abstract Objective Identify the nature of apparent lytic lesions within human allograft specimens from patients with no known malignancy, using radiological and histopathological analysis Methods 123 Post-retrieval radiographs from 23 donors were examined. Sixty-seven radiographs were noted to show apparent lytic lesions. The number, size, character and position of the apparent lesions were recorded. Results CT scanning of 9 specimens confirmed the lesions to be of air pockets causing artefact. Histopathological analysis showed no malignant or pathological process. Conclusions Apparent lesions were not pathological. Practice implications Specimens with similar appearances, in donors with no malignancy, can be safely used in donation.
AbstractList Identify the nature of apparent lytic lesions within human allograft specimens from patients with no known malignancy, using radiological and histopathological analysis 123 Post-retrieval radiographs from 23 donors were examined. Sixty-seven radiographs were noted to show apparent lytic lesions. The number, size, character and position of the apparent lesions were recorded. CT scanning of 9 specimens confirmed the lesions to be of air pockets causing artefact. Histopathological analysis showed no malignant or pathological process. Apparent lesions were not pathological. Specimens with similar appearances, in donors with no malignancy, can be safely used in donation.
Abstract Objective Identify the nature of apparent lytic lesions within human allograft specimens from patients with no known malignancy, using radiological and histopathological analysis Methods 123 Post-retrieval radiographs from 23 donors were examined. Sixty-seven radiographs were noted to show apparent lytic lesions. The number, size, character and position of the apparent lesions were recorded. Results CT scanning of 9 specimens confirmed the lesions to be of air pockets causing artefact. Histopathological analysis showed no malignant or pathological process. Conclusions Apparent lesions were not pathological. Practice implications Specimens with similar appearances, in donors with no malignancy, can be safely used in donation.
Identify the nature of apparent lytic lesions within human allograft specimens from patients with no known malignancy, using radiological and histopathological analysis. 123 Post-retrieval radiographs from 23 donors were examined. Sixty-seven radiographs were noted to show apparent lytic lesions. The number, size, character and position of the apparent lesions were recorded. CT scanning of 9 specimens confirmed the lesions to be of air pockets causing artefact. Histopathological analysis showed no malignant or pathological process. Apparent lesions were not pathological. Specimens with similar appearances, in donors with no malignancy, can be safely used in donation.
OBJECTIVEIdentify the nature of apparent lytic lesions within human allograft specimens from patients with no known malignancy, using radiological and histopathological analysis.METHODS123 Post-retrieval radiographs from 23 donors were examined. Sixty-seven radiographs were noted to show apparent lytic lesions. The number, size, character and position of the apparent lesions were recorded.RESULTSCT scanning of 9 specimens confirmed the lesions to be of air pockets causing artefact. Histopathological analysis showed no malignant or pathological process.CONCLUSIONSApparent lesions were not pathological.PRACTICE IMPLICATIONSSpecimens with similar appearances, in donors with no malignancy, can be safely used in donation.
Author Papadimitriou, John
Carey-Smith, Richard
Aguiar, Ranieri Falcao
Cowie, Anne
Fisher, Ryan
Wong, Daniel
Kent, Mike
Goh, Geraldine
Brooker, Greg
AuthorAffiliation a PlusLife, Perth Orthopaedic Institute, Perth 6009, Western Australia, Australia
c PathWest, Sir Charles Gairdner Hospital, Perth 6009, Western Australia Australia
b Department of Radiology, Sir Charles Gairdner Hospital, Perth 6009, Western Australia Australia
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10.4103/0970-0358.101326
10.1098/rspl.1881.0025
10.5694/j.1326-5377.2005.tb07079.x
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2015 Prof. PK Surendran Memorial Education Foundation. Published by Elsevier, a division of Reed Elsevier India, Pvt. Ltd. All rights reserved. 2015 Prof. PK Surendran Memorial Education Foundation
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Keywords Tumour reconstruction
Long bone allografts
Lytic lesions
Bone and tissue banking
Quality control
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Snippet Abstract Objective Identify the nature of apparent lytic lesions within human allograft specimens from patients with no known malignancy, using radiological...
Identify the nature of apparent lytic lesions within human allograft specimens from patients with no known malignancy, using radiological and histopathological...
OBJECTIVEIdentify the nature of apparent lytic lesions within human allograft specimens from patients with no known malignancy, using radiological and...
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SubjectTerms Bone and tissue banking
Long bone allografts
Lytic lesions
Original
Orthopedics
Quality control
Tumour reconstruction
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Title Radiological and histopathological examination of apparent lytic lesions in allograft long bones—No cause for concern
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