Tenofovir Alafenamide for Pregnant Chinese Women With Active Chronic Hepatitis B: A Multicenter Prospective Study

• Published in: Clinical gastroenterology and hepatology Vol. 20; no. 12; pp. 2826 - 2837.e9
• Main Authors: Zeng, Qing-Lei, Zhang, Hong-Xu, Zhang, Ji-Yuan, Huang, Shuo, Li, Wei-Zhe, Li, Guang-Ming, Pan, Ya-Jie, Feng, Ying-Hua, Li, Zhi-Qin, Zhang, Guo-Fan, Xu, Jiang-Hai, Lin, Wan-Bao, Xu, Guang-Hua, Liu, Na, Zhang, Guo-Qiang, Li, Guo-Tao, Li, Wei, Zeng, Yan-Li, Song, Ning, Wang, Meng, Zhang, Da-Wei, Chen, Zhi-Min, Cui, Guang-Lin, Li, Juan, Lv, Jun, Liu, Yan-Min, Liang, Hong-Xia, Sun, Chang-Yu, Zhou, Yi-Hua, Yu, Zu-Jiang, Wang, Fu-Sheng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2022
• Subjects: Adenine - adverse effects; Adult; Antiviral Agents - adverse effects; China; Chronic Hepatitis B; Cleft Lip - chemically induced; Cleft Lip - drug therapy; Cleft Palate - chemically induced; Cleft Palate - drug therapy; Effectiveness; Female; Gastroenterology and Hepatology; Hepatitis B - diagnosis; Hepatitis B Surface Antigens; Hepatitis B, Chronic - drug therapy; Humans; Infant, Newborn; Mother-to-Child Transmission; Pregnancy; Pregnant Women; Prospective Studies; Safety; Tenofovir - adverse effects; Tenofovir Alafenamide; Tenofovir Disoproxil Fumarate; China; anti-HBs; eGFR; Chronic Hepatitis B; Effectiveness; HBeAg; ALT; HBsAg; Mother-to-Child Transmission; LMP; Pregnancy; Tenofovir Alafenamide; TDF; TAF; Safety; CHB; MTCT; Tenofovir Disoproxil Fumarate; HBV; WHO; estimated glomerular filtration rate; hepatitis B virus; alanine aminotransferase; hepatitis B e antigen; World Health Organization; hepatitis B surface antigen; last menstrual period; anti-hepatitis B surface antibody

Data on long-term tenofovir alafenamide (TAF) therapy for pregnant women with active chronic hepatitis B (CHB) (immune clearance and reactivation phases, currently and previously diagnosed) and their infants are lacking. Pregnant women with active CHB treated with TAF and tenofovir disoproxil fumara...