The Impact of Intermittent Hypoxia on Metabolism and Cognition

• Published in: International journal of molecular sciences Vol. 23; no. 21; p. 12957
• Main Authors: Shobatake, Ryogo, Ota, Hiroyo, Takahashi, Nobuyuki, Ueno, Satoshi, Sugie, Kazuma, Takasawa, Shin
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 26.10.2022; MDPI
• Subjects: Airway management; Appetite; Body mass index; Dementia; Gene expression; Glucagon; Homeostasis; Hormones; Hypertension; Hypothalamus; Hypoxia; Insulin; Lymphoma; Metabolic syndrome; Nervous system; Neuropeptides; Obesity; Peptides; Review; Signal transduction; Sleep apnea; Sleep disorders; Transcription factors

Intermittent hypoxia (IH), one of the primary pathologies of sleep apnea syndrome (SAS), exposes cells throughout the body to repeated cycles of hypoxia/normoxia that result in oxidative stress and systemic inflammation. Since SAS is epidemiologically strongly correlated with type 2 diabetes/insulin...