A Regulatory Element in Intron 1 of the Cystic Fibrosis Transmembrane Conductance Regulator Gene

• Published in: The Journal of biological chemistry Vol. 271; no. 17; pp. 9947 - 9954
• Main Authors: Smith, Annabel N., Barth, Maria Luiza, McDowell, Tarra L., Moulin, Danielle S., Nuthall, Hugh N., Hollingsworth, Michael A., Harris, Ann
• Format: Journal Article
• Language: English
• Published: United States American Society for Biochemistry and Molecular Biology 26.04.1996
• Subjects: Base Sequence; Binding Sites; Cells, Cultured; Cystic Fibrosis Transmembrane Conductance Regulator - genetics; Deoxyribonuclease I; DNA Footprinting; DNA-Binding Proteins - metabolism; Gene Expression Regulation; Humans; Introns; Molecular Sequence Data; Oligodeoxyribonucleotides - chemistry; Protein Binding; Regulatory Sequences, Nucleic Acid; RNA, Messenger - genetics; Transcription, Genetic

The cystic fibrosis transmembrane conductance regulator (CFTR) gene exhibits a tightly regulated pattern of expression in human epithelial cells. The mechanism of this regulation is complex and is likely to involve a number of genetic elements that effect temporal and spatial expression. To date non...