Sleep and hormonal changes in aging

• Published in: Endocrinology and metabolism clinics of North America Vol. 42; no. 2; p. 371
• Main Authors: Copinschi, Georges, Caufriez, Anne
• Format: Journal Article
• Language: English
• Published: United States 01.06.2013
• Subjects: Adrenocorticotropic Hormone - blood; Adrenocorticotropic Hormone - secretion; Aging; Animals; Female; Human Growth Hormone - blood; Human Growth Hormone - secretion; Humans; Hydrocortisone - blood; Hydrocortisone - secretion; Hypothalamo-Hypophyseal System - growth & development; Hypothalamo-Hypophyseal System - secretion; Male; Melatonin - secretion; Pineal Gland - growth & development; Pineal Gland - secretion; Pituitary Hormones, Anterior - blood; Pituitary Hormones, Anterior - secretion; Pituitary-Adrenal System - growth & development; Pituitary-Adrenal System - secretion; Sleep Wake Disorders - blood; Sleep Wake Disorders - epidemiology; Sleep Wake Disorders - etiology; Testis - growth & development; Testis - secretion; Testosterone - blood; Testosterone - secretion; Thyroid Gland - growth & development; Thyroid Gland - secretion; Thyroid Hormones - blood; Thyroid Hormones - secretion
• DOI: 10.1016/j.ecl.2013.02.009

Age-related sleep and endocrinometabolic alterations frequently interact with each other. For many hormones, sleep curtailment in young healthy subjects results in alterations strikingly similar to those observed in healthy old subjects not submitted to sleep restriction. Thus, recurrent sleep restriction, which is currently experienced by a substantial and rapidly growing proportion of children and young adults, might contribute to accelerate the senescence of endocrine and metabolic function. The mechanisms of sleep-hormonal interactions, and therefore the endocrinometabolic consequences of age-related sleep alterations, which markedly differ from one hormone to another, are reviewed in this article.