Stellate transformation of invasive trophoblast: a distinct phenotype of trophoblast that is involved in decidual vascular remodelling and controlled invasion during pregnancy
BACKGROUND: Successful implantation relies on the tightly regulated invasion of extravillous trophoblasts (EVTs). However, little is known about their phenotypic differentiation and relevant motile behaviour. Furthermore, the cell–cell interactions between EVTs and decidual arterioles during physiol...
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Published in | Human reproduction (Oxford) Vol. 21; no. 5; pp. 1299 - 1304 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Oxford University Press
01.05.2006
Oxford Publishing Limited (England) |
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Abstract | BACKGROUND: Successful implantation relies on the tightly regulated invasion of extravillous trophoblasts (EVTs). However, little is known about their phenotypic differentiation and relevant motile behaviour. Furthermore, the cell–cell interactions between EVTs and decidual arterioles during physiological transformation are also poorly understood. METHODS: A total of 128 decidual specimens from early and late gestations containing components of EVTs and spiral arterioles were investigated using immunohistochemistry and periodic acid–Schiff reaction. RESULTS: Unipolar, tadpole-like EVTs are observed throughout the interstitial area, with a tendency to decrease along the invasive pathway. The stellate differentiation of the EVTs is identified around and inside decidual arterioles or in the third-trimester myometrium. Furthermore, stellate transformation of EVTs precedes its interactions with the decidual arteriole. These specialized stellate trophoblasts invade and infiltrate the tunica media, accompanying lacuna formation inside the vessel wall and perturbation of actin fibre alignment of the tunica media. CONCLUSION: Stellate transformation of trophoblasts may explain controlled invasion of EVTs and probably plays a key role in initiating cell–cell interaction in decidual vascular remodelling. |
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AbstractList | BACKGROUND: Successful implantation relies on the tightly regulated invasion of extravillous trophoblasts (EVTs). However, little is known about their phenotypic differentiation and relevant motile behaviour. Furthermore, the cell–cell interactions between EVTs and decidual arterioles during physiological transformation are also poorly understood. METHODS: A total of 128 decidual specimens from early and late gestations containing components of EVTs and spiral arterioles were investigated using immunohistochemistry and periodic acid–Schiff reaction. RESULTS: Unipolar, tadpole-like EVTs are observed throughout the interstitial area, with a tendency to decrease along the invasive pathway. The stellate differentiation of the EVTs is identified around and inside decidual arterioles or in the third-trimester myometrium. Furthermore, stellate transformation of EVTs precedes its interactions with the decidual arteriole. These specialized stellate trophoblasts invade and infiltrate the tunica media, accompanying lacuna formation inside the vessel wall and perturbation of actin fibre alignment of the tunica media. CONCLUSION: Stellate transformation of trophoblasts may explain controlled invasion of EVTs and probably plays a key role in initiating cell–cell interaction in decidual vascular remodelling. BACKGROUNDSuccessful implantation relies on the tightly regulated invasion of extravillous trophoblasts (EVTs). However, little is known about their phenotypic differentiation and relevant motile behaviour. Furthermore, the cell-cell interactions between EVTs and decidual arterioles during physiological transformation are also poorly understood.METHODSA total of 128 decidual specimens from early and late gestations containing components of EVTs and spiral arterioles were investigated using immunohistochemistry and periodic acid-Schiff reaction.RESULTSUnipolar, tadpole-like EVTs are observed throughout the interstitial area, with a tendency to decrease along the invasive pathway. The stellate differentiation of the EVTs is identified around and inside decidual arterioles or in the third-trimester myometrium. Furthermore, stellate transformation of EVTs precedes its interactions with the decidual arteriole. These specialized stellate trophoblasts invade and infiltrate the tunica media, accompanying lacuna formation inside the vessel wall and perturbation of actin fibre alignment of the tunica media.CONCLUSIONStellate transformation of trophoblasts may explain controlled invasion of EVTs and probably plays a key role in initiating cell-cell interaction in decidual vascular remodelling. Successful implantation relies on the tightly regulated invasion of extravillous trophoblasts (EVTs). However, little is known about their phenotypic differentiation and relevant motile behaviour. Furthermore, the cell-cell interactions between EVTs and decidual arterioles during physiological transformation are also poorly understood. A total of 128 decidual specimens from early and late gestations containing components of EVTs and spiral arterioles were investigated using immunohistochemistry and periodic acid-Schiff reaction. Unipolar, tadpole-like EVTs are observed throughout the interstitial area, with a tendency to decrease along the invasive pathway. The stellate differentiation of the EVTs is identified around and inside decidual arterioles or in the third-trimester myometrium. Furthermore, stellate transformation of EVTs precedes its interactions with the decidual arteriole. These specialized stellate trophoblasts invade and infiltrate the tunica media, accompanying lacuna formation inside the vessel wall and perturbation of actin fibre alignment of the tunica media. Stellate transformation of trophoblasts may explain controlled invasion of EVTs and probably plays a key role in initiating cell-cell interaction in decidual vascular remodelling. |
Author | Ho, H.N. Hsieh, F.J. Chien, C.L. Shih, J.C. Lee, W.C. |
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Cites_doi | 10.1242/dev.120.12.3657 10.1172/JCI119388 10.1016/S0092-8674(00)80879-X 10.1016/S0165-0378(98)00022-9 10.1097/01.LAB.0000101730.69754.5A 10.1016/S0143-4004(81)80027-6 10.1172/JCI8316 10.1093/humrep/14.8.2131 10.1016/0002-9378(73)90500-0 10.1016/S0940-9602(96)80102-6 10.1002/1097-0169(200007)46:3<200::AID-CM5>3.0.CO;2-M 10.1126/science.277.5332.1669 10.1016/j.ydbio.2003.09.026 10.1095/biolreprod.102.014977 |
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Copyright | The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2006 2006 INIST-CNRS Copyright Oxford University Press(England) May 2006 |
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Keywords | vascular remodelling stellate transformation pregnancy interstitial trophoblast Pregnancy Trophoblaste Vertebrata Phenotype Transformation Mammalia Fetal membrane Interstitial Invasion |
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Notes | 4To whom correspondence should be addressed at: Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, No. 1 Jen-Ai Road, Sect. 1, Taipei 100, Taiwan. E-mail: clc@ha.mc.ntu.edu.tw local:489 ark:/67375/HXZ-SMN19RF6-L istex:58F1858C4D0A691952CA874194C55829DD26EB23 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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Snippet | BACKGROUND: Successful implantation relies on the tightly regulated invasion of extravillous trophoblasts (EVTs). However, little is known about their... Successful implantation relies on the tightly regulated invasion of extravillous trophoblasts (EVTs). However, little is known about their phenotypic... BACKGROUNDSuccessful implantation relies on the tightly regulated invasion of extravillous trophoblasts (EVTs). However, little is known about their phenotypic... |
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SubjectTerms | Arterioles - physiology Biological and medical sciences Cell Communication Cell Differentiation Cell Movement Decidua - blood supply Decidua - chemistry Decidua - cytology Embryo Implantation - physiology Female Gynecology. Andrology. Obstetrics Humans Immunochemistry interstitial trophoblast Keratin-7 Keratins - analysis Medical sciences Neovascularization, Physiologic Phenotype pregnancy Pregnancy - physiology stellate transformation Trophoblasts - chemistry Trophoblasts - cytology Trophoblasts - physiology vascular remodelling |
Title | Stellate transformation of invasive trophoblast: a distinct phenotype of trophoblast that is involved in decidual vascular remodelling and controlled invasion during pregnancy |
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