Saffron Extract Attenuates Anxiogenic Effect and Improves Cognitive Behavior in an Adult Zebrafish Model of Traumatic Brain Injury

• Published in: International journal of molecular sciences Vol. 23; no. 19; p. 11600
• Main Authors: Chaoul, Victoria, Awad, Maria, Harb, Frederic, Najjar, Fadia, Hamade, Aline, Nabout, Rita, Soueid, Jihane
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.10.2022; MDPI
• Subjects: Alzheimer's disease; Animal cognition; Anxiety; anxiolytic; Behavior; Blood-brain barrier; Cell signaling; Danio rerio; Disease prevention; Edema; Endoplasmic reticulum; Fear; fear disinhibition; Homology; Inflammation; Memory; memory performance; Motor skill; Neurodegeneration; Neuroprotection; PMS; Premenstrual syndrome; Regeneration; Saffron; Traumatic brain injury; Zebrafish

Traumatic brain injury (TBI) has the highest mortality rates worldwide, yet effective treatment remains unavailable. TBI causes inflammatory responses, endoplasmic reticulum stress, disruption of the blood–brain barrier and neurodegeneration that lead to loss of cognition, memory and motor skills. S...