Saffron Extract Attenuates Anxiogenic Effect and Improves Cognitive Behavior in an Adult Zebrafish Model of Traumatic Brain Injury
Traumatic brain injury (TBI) has the highest mortality rates worldwide, yet effective treatment remains unavailable. TBI causes inflammatory responses, endoplasmic reticulum stress, disruption of the blood–brain barrier and neurodegeneration that lead to loss of cognition, memory and motor skills. S...
Saved in:
| Published in | International journal of molecular sciences Vol. 23; no. 19; p. 11600 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Basel
MDPI AG
01.10.2022
MDPI |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Traumatic brain injury (TBI) has the highest mortality rates worldwide, yet effective treatment remains unavailable. TBI causes inflammatory responses, endoplasmic reticulum stress, disruption of the blood–brain barrier and neurodegeneration that lead to loss of cognition, memory and motor skills. Saffron (Crocus sativus L.) is known for its anti-inflammatory and neuroprotective effects, which makes it a potential candidate for TBI treatment. Zebrafish (Danio rerio) shares a high degree of genetic homology and cell signaling pathways with mammals. Its active neuro-regenerative function makes it an excellent model organism for TBI therapeutic drug identification. The objective of this study was to assess the effect of saffron administration to a TBI zebrafish model by investigating behavioral outcomes such as anxiety, fear and memory skills using a series of behavioral tests. Saffron exhibited anxiolytic effect on anxiety-like behaviors, and showed prevention of fear inhibition observed after TBI. It improved learning and enhanced memory performance. These results suggest that saffron could be a novel therapeutic enhancer for neural repair and regeneration of networks post-TBI. |
|---|---|
| AbstractList | Traumatic brain injury (TBI) has the highest mortality rates worldwide, yet effective treatment remains unavailable. TBI causes inflammatory responses, endoplasmic reticulum stress, disruption of the blood–brain barrier and neurodegeneration that lead to loss of cognition, memory and motor skills. Saffron (Crocus sativus L.) is known for its anti-inflammatory and neuroprotective effects, which makes it a potential candidate for TBI treatment. Zebrafish (Danio rerio) shares a high degree of genetic homology and cell signaling pathways with mammals. Its active neuro-regenerative function makes it an excellent model organism for TBI therapeutic drug identification. The objective of this study was to assess the effect of saffron administration to a TBI zebrafish model by investigating behavioral outcomes such as anxiety, fear and memory skills using a series of behavioral tests. Saffron exhibited anxiolytic effect on anxiety-like behaviors, and showed prevention of fear inhibition observed after TBI. It improved learning and enhanced memory performance. These results suggest that saffron could be a novel therapeutic enhancer for neural repair and regeneration of networks post-TBI. Traumatic brain injury (TBI) has the highest mortality rates worldwide, yet effective treatment remains unavailable. TBI causes inflammatory responses, endoplasmic reticulum stress, disruption of the blood–brain barrier and neurodegeneration that lead to loss of cognition, memory and motor skills. Saffron ( Crocus sativus L.) is known for its anti-inflammatory and neuroprotective effects, which makes it a potential candidate for TBI treatment. Zebrafish ( Danio rerio ) shares a high degree of genetic homology and cell signaling pathways with mammals. Its active neuro-regenerative function makes it an excellent model organism for TBI therapeutic drug identification. The objective of this study was to assess the effect of saffron administration to a TBI zebrafish model by investigating behavioral outcomes such as anxiety, fear and memory skills using a series of behavioral tests. Saffron exhibited anxiolytic effect on anxiety-like behaviors, and showed prevention of fear inhibition observed after TBI. It improved learning and enhanced memory performance. These results suggest that saffron could be a novel therapeutic enhancer for neural repair and regeneration of networks post-TBI. |
| Author | Hamade, Aline Chaoul, Victoria Harb, Frederic Soueid, Jihane Najjar, Fadia Awad, Maria Nabout, Rita |
| AuthorAffiliation | 4 Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon 1 Department of Life and Earth Sciences, Faculty of Sciences, Lebanese University, Jdeidet P.O. Box 90656, Lebanon 2 Department of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand, Kalhat, Al Kurah P.O. Box 100, Lebanon 3 Laboratoire d’Innovation Thérapeutique, Departments of Biology, Chemistry and Biochemistry, Faculty of Sciences II, Lebanese University, Jdeidet P.O. Box 90656, Lebanon |
| AuthorAffiliation_xml | – name: 3 Laboratoire d’Innovation Thérapeutique, Departments of Biology, Chemistry and Biochemistry, Faculty of Sciences II, Lebanese University, Jdeidet P.O. Box 90656, Lebanon – name: 1 Department of Life and Earth Sciences, Faculty of Sciences, Lebanese University, Jdeidet P.O. Box 90656, Lebanon – name: 2 Department of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand, Kalhat, Al Kurah P.O. Box 100, Lebanon – name: 4 Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon |
| Author_xml | – sequence: 1 givenname: Victoria surname: Chaoul fullname: Chaoul, Victoria – sequence: 2 givenname: Maria orcidid: 0000-0002-7386-4331 surname: Awad fullname: Awad, Maria – sequence: 3 givenname: Frederic orcidid: 0000-0001-5882-1619 surname: Harb fullname: Harb, Frederic – sequence: 4 givenname: Fadia surname: Najjar fullname: Najjar, Fadia – sequence: 5 givenname: Aline surname: Hamade fullname: Hamade, Aline – sequence: 6 givenname: Rita surname: Nabout fullname: Nabout, Rita – sequence: 7 givenname: Jihane orcidid: 0000-0002-1973-8705 surname: Soueid fullname: Soueid, Jihane |
| BookMark | eNpdkk1vEzEQhleoiH7AkbslLlxC_bXe9QUpjQJEKuJAuXCxputx4mjXDvZu1F755TikQg0nj_w-ejR6NZfVWYgBq-otox-E0PTab4fMBdOMKUpfVBdMcj6jVDVnz-bz6jLnLaVc8Fq_qs6FKpOm_KL6_R2cSzGQ5cOYoBvJfBwxTDBiJvPw4OMag-_I0jksIQRLVsMuxX2JF3Ed_Oj3SG5wA3sfE_GhIGRup34kP_E-gfN5Q75Giz2JjtwlmAYYi-8mQWFXYTulx9fVSwd9xjdP71X149PybvFldvvt82oxv511sm7HmeJaU2y1BUfb1rpWSuZcp0TnakTFhBNSKMlaZ51uLNOyUJoLwRwqQCWuqtXRayNszS75AdKjieDN34-Y1gZSWa5HA7Juiq7RLQXZgW0boJar1oKVSgpbXB-Prt10P6DtMJT2-hPpaRL8xqzj3ui6oVTLInj_JEjx14R5NIPPHfY9BIxTNrzhNdO6Fm1B3_2HbuOUQqnqQEnelmIOwtmR6lLMOaH7twyj5nAp5uRSxB-UMbMH |
| CitedBy_id | crossref_primary_10_1080_01480545_2023_2250576 crossref_primary_10_31857_S0869813923110043 crossref_primary_10_1016_j_etap_2023_104358 crossref_primary_10_1134_S0022093023060224 crossref_primary_10_3390_ijms241914898 |
| Cites_doi | 10.1016/j.pbb.2015.05.014 10.1515/revneuro-2018-0020 10.3945/an.113.005264 10.1242/dev.123.1.1 10.3934/Neuroscience.2019.1.25 10.1021/acs.jafc.6b04398 10.1186/s13054-016-1318-1 10.1080/10496475.2016.1272522 10.4103/JPBS.JPBS_83_18 10.1093/bja/aem131 10.1523/ENEURO.0208-17.2017 10.1016/j.neuron.2017.07.010 10.1038/s41598-022-09109-9 10.1038/nature12111 10.4236/jbbs.2013.33031 10.3390/antiox2040293 10.1089/neu.2016.4718 10.3390/molecules21030303 10.1163/1568539X-00003029 10.1186/s12906-020-03102-3 10.3109/02699059109008087 10.1101/cshperspect.a020602 10.1089/neu.2018.6171 10.1201/NOE1420052343 10.1007/s11033-021-06506-7 10.3389/fnut.2020.606124 10.1016/j.expneurol.2012.03.012 10.1007/s10354-007-0428-4 10.3389/fnbeh.2020.00160 10.1111/j.1468-5884.2009.00397.x 10.3390/nu14030597 10.1177/0963689717714102 10.1523/JNEUROSCI.1180-12.2012 10.1089/neu.2015.4373 10.3390/nu13030904 10.1080/23262133.2016.1148101 10.1002/ptr.2597 10.1016/j.neulet.2018.02.040 10.1523/JNEUROSCI.22-07-02894.2002 10.1176/appi.ajp.2009.08111676 10.4103/1673-5374.262574 10.52547/rbmb.9.4.426 10.1016/j.bbadis.2011.10.017 10.1007/s11910-015-0545-1 10.3390/ijms22041585 10.1016/j.neuron.2013.04.009 10.1016/j.jad.2014.11.035 10.2174/138161206776843340 10.1017/S0007114508965776 10.1002/ana.22455 10.1186/2110-5820-2-27 10.5897/AJB11.406 10.1002/jsfa.8134 10.1089/neu.2014.3504 10.2174/1573403X14666180628095918 10.7314/APJCP.2016.17.3.1499 10.1089/neu.2011.2273 10.1016/j.expneurol.2016.01.004 10.3390/biomedicines9080861 10.1126/scitranslmed.3000330 10.1007/s11682-015-9399-z 10.1242/dmm.007336 10.1080/02699052.2018.1540797 10.1073/pnas.1219167110 10.1016/j.mcna.2019.11.001 10.3390/molecules26164906 10.1016/j.eujim.2020.101250 10.1155/2012/315941 10.1523/JNEUROSCI.4930-03.2004 10.3389/fnins.2017.00750 10.1016/j.mrrev.2003.06.017 10.1016/j.neulet.2015.02.016 |
| ContentType | Journal Article |
| Copyright | 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2022 by the authors. 2022 |
| Copyright_xml | – notice: 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2022 by the authors. 2022 |
| DBID | AAYXX CITATION 3V. 7X7 7XB 88E 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH K9. M0S M1P M2O MBDVC PIMPY PQEST PQQKQ PQUKI PRINS Q9U 7X8 5PM DOA |
| DOI | 10.3390/ijms231911600 |
| DatabaseName | CrossRef ProQuest Central (Corporate) ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) Medical Database ProQuest research library Research Library (Corporate) Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
| DatabaseTitle | CrossRef Publicly Available Content Database Research Library Prep ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College Research Library (Alumni Edition) ProQuest Central China ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Research Library ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | CrossRef Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1422-0067 |
| ExternalDocumentID | oai_doaj_org_article_a457f347980a4cad87a0d268dad4643d 10_3390_ijms231911600 |
| GrantInformation_xml | – fundername: Lebanese University |
| GroupedDBID | --- 29J 2WC 3V. 53G 5GY 5VS 7X7 88E 8FE 8FG 8FH 8FI 8FJ 8G5 A8Z AADQD AAFWJ AAHBH AAYXX ABDBF ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ADBBV AEAQA AENEX AFKRA AFZYC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI CCPQU CITATION CS3 D1I DIK DU5 DWQXO E3Z EBD EBS EJD ESTFP ESX F5P FRP FYUFA GNUQQ GROUPED_DOAJ GUQSH GX1 HCIFZ HH5 HMCUK HYE IAO ITC KB. KQ8 LK8 M1P M2O M48 M7P MODMG M~E O5R O5S OK1 P2P PDBOC PIMPY PQQKQ PROAC PSQYO RNS RPM TR2 TUS UKHRP ~8M 7XB 8FK K9. MBDVC PQEST PQUKI PRINS Q9U RIG 7X8 5PM AFPKN |
| ID | FETCH-LOGICAL-c458t-62990e89daf088df8441ffc63cf5ee613f3436418fdf97d19488d92331fe6ae63 |
| IEDL.DBID | RPM |
| ISSN | 1422-0067 1661-6596 |
| IngestDate | Tue Oct 22 15:15:51 EDT 2024 Tue Sep 17 21:31:00 EDT 2024 Wed Dec 04 12:03:15 EST 2024 Fri Nov 22 09:18:57 EST 2024 Fri Dec 06 08:53:40 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 19 |
| Language | English |
| License | https://creativecommons.org/licenses/by/4.0 Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c458t-62990e89daf088df8441ffc63cf5ee613f3436418fdf97d19488d92331fe6ae63 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. |
| ORCID | 0000-0002-1973-8705 0000-0001-5882-1619 0000-0002-7386-4331 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570094/ |
| PMID | 36232902 |
| PQID | 2724282994 |
| PQPubID | 2032341 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_a457f347980a4cad87a0d268dad4643d pubmedcentral_primary_oai_pubmedcentral_nih_gov_9570094 proquest_miscellaneous_2725199538 proquest_journals_2724282994 crossref_primary_10_3390_ijms231911600 |
| PublicationCentury | 2000 |
| PublicationDate | 2022-10-01 20221001 |
| PublicationDateYYYYMMDD | 2022-10-01 |
| PublicationDate_xml | – month: 10 year: 2022 text: 20221001 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Basel |
| PublicationPlace_xml | – name: Basel |
| PublicationTitle | International journal of molecular sciences |
| PublicationYear | 2022 |
| Publisher | MDPI AG MDPI |
| Publisher_xml | – name: MDPI AG – name: MDPI |
| References | Razak (ref_26) 2017; 23 Yamamoto (ref_37) 2009; 51 ref_14 ref_56 ref_55 Liu (ref_74) 2012; 109 Vargas (ref_70) 2002; 22 Milajerdi (ref_28) 2018; 23 ref_51 Silver (ref_32) 2014; 7 Haffter (ref_34) 1996; 123 Dewan (ref_4) 2018; 130 Gupte (ref_82) 2019; 36 Helmick (ref_16) 2015; 9 Kishimoto (ref_38) 2012; 5 Galgano (ref_10) 2017; 26 Anand (ref_41) 2021; 48 ref_61 Baxter (ref_72) 2012; 109 Bigford (ref_21) 2014; 5 Makhlouf (ref_50) 2011; 10 Rodgers (ref_60) 2012; 29 Mashmoul (ref_30) 2013; 2 Kayser (ref_76) 2012; 32 Hatziagapiou (ref_63) 2018; 14 Talaei (ref_29) 2015; 174 Ceci (ref_81) 2018; 30 Dwyer (ref_46) 2011; 16 Mallya (ref_52) 2015; 32 Javadi (ref_45) 2013; 16 Hosseinzadeh (ref_54) 2009; 23 Bains (ref_79) 2012; 1822 Howe (ref_35) 2013; 496 Lindsey (ref_33) 2017; 11 Schmidt (ref_44) 2007; 157 Prins (ref_5) 2013; 6 Scheff (ref_23) 2017; 34 Woodard (ref_83) 2019; 6 Siddiqui (ref_49) 2018; 10 Jonathan (ref_11) 2009; 166 ref_78 ref_77 Nassar (ref_84) 2020; 40 Capizzi (ref_2) 2020; 104 Meyer (ref_13) 2012; 235 Stocchetti (ref_1) 2016; 20 Theadom (ref_53) 2018; 32 Guerriero (ref_62) 2015; 15 Pugin (ref_58) 2012; 2 Spencer (ref_22) 2008; 99 Gasquoine (ref_15) 1991; 5 Anand (ref_66) 2018; 672 Khazdair (ref_47) 2015; 5 Hirsiger (ref_57) 2012; 2012 Cacialli (ref_39) 2019; 14 Marklund (ref_19) 2006; 12 Rezaee (ref_64) 2013; 16 Aoki (ref_80) 2013; 78 Wang (ref_17) 2015; 591 Ghasemi (ref_67) 2015; 65 Maximino (ref_69) 2012; 149 Portavella (ref_71) 2004; 24 Janowitz (ref_18) 2010; 2 Palmer (ref_73) 2016; 277 Bakshi (ref_24) 2016; 17 ref_42 Ramlackhansingh (ref_59) 2011; 70 ref_40 Werner (ref_9) 2007; 99 Jackson (ref_65) 2020; 7 ref_3 Jassam (ref_6) 2017; 95 Blaze (ref_12) 2020; 14 Barbosa (ref_36) 2016; 3 Salem (ref_31) 2022; 12 Finley (ref_27) 2017; 65 ref_48 Aruoma (ref_20) 2003; 544 Najafi (ref_68) 2021; 9 Razavi (ref_25) 2017; 97 Lan (ref_75) 2019; 11 ref_7 Dorsett (ref_8) 2017; 34 Magno (ref_43) 2015; 135 |
| References_xml | – volume: 135 start-page: 169 year: 2015 ident: ref_43 article-title: Pharmacological study of the light/dark preference test in zebrafish (Danio rerio): Waterborne administration publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/j.pbb.2015.05.014 contributor: fullname: Magno – volume: 30 start-page: 45 year: 2018 ident: ref_81 article-title: Zebrafish as a translational regeneration model to study the activation of neural stem cells and role of their environment publication-title: Rev. Neurosci. doi: 10.1515/revneuro-2018-0020 contributor: fullname: Ceci – volume: 5 start-page: 394 year: 2014 ident: ref_21 article-title: Supplemental substances derived from foods as adjunctive therapeutic agents for treatment of neurodegenerative diseases and disorders publication-title: Adv. Nutr. doi: 10.3945/an.113.005264 contributor: fullname: Bigford – volume: 123 start-page: 1 year: 1996 ident: ref_34 article-title: The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio publication-title: Development doi: 10.1242/dev.123.1.1 contributor: fullname: Haffter – volume: 6 start-page: 25 year: 2019 ident: ref_83 article-title: The role of neuronal nitric oxide and its pathways in the protection and recovery from neurotoxin-induced de novo hypokinetic motor behaviors in the embryonic zebrafish (Danio rerio) publication-title: AIMS Neurosci. doi: 10.3934/Neuroscience.2019.1.25 contributor: fullname: Woodard – volume: 65 start-page: 1005 year: 2017 ident: ref_27 article-title: A Perspective on Crocus sativus L. (Saffron) Constituent Crocin: A Potent Water-Soluble Antioxidant and Potential Therapy for Alzheimer’s Disease publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.6b04398 contributor: fullname: Finley – volume: 20 start-page: 148 year: 2016 ident: ref_1 article-title: Chronic impact of traumatic brain injury on outcome and quality of life: A narra-tive review publication-title: Crit. Care doi: 10.1186/s13054-016-1318-1 contributor: fullname: Stocchetti – volume: 23 start-page: 98 year: 2017 ident: ref_26 article-title: A Review on Medicinal Properties of Saffron toward Major Diseases publication-title: J. Herbs Spices Med. Plants doi: 10.1080/10496475.2016.1272522 contributor: fullname: Razak – volume: 10 start-page: 173 year: 2018 ident: ref_49 article-title: Saffron (Crocus sativus L.): As an Antidepressant publication-title: J. Pharm. Bioallied. Sci. doi: 10.4103/JPBS.JPBS_83_18 contributor: fullname: Siddiqui – volume: 23 start-page: 16 year: 2018 ident: ref_28 article-title: The effect of saffron (Crocus sativus L.) hydroalcoholic extract on metabolic control in type 2 diabetes mellitus: A triple-blinded randomized clinical trial publication-title: J. Res. Med. Sci. Off. J. Isfahan Univ. Med. Sci. contributor: fullname: Milajerdi – volume: 6 start-page: 1307 year: 2013 ident: ref_5 article-title: The pathophysiology of traumatic brain injury at a glance publication-title: Dis. Models Mech. contributor: fullname: Prins – volume: 99 start-page: 4 year: 2007 ident: ref_9 article-title: Pathophysiology of traumatic brain injury publication-title: Br. J. Anaesth. doi: 10.1093/bja/aem131 contributor: fullname: Werner – ident: ref_14 doi: 10.1523/ENEURO.0208-17.2017 – volume: 5 start-page: 376 year: 2015 ident: ref_47 article-title: The effects of Crocus sativus (saffron) and its constituents on nervous system: A review publication-title: Avicenna J. Phytomed. contributor: fullname: Khazdair – volume: 95 start-page: 1246 year: 2017 ident: ref_6 article-title: Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift publication-title: Neuron doi: 10.1016/j.neuron.2017.07.010 contributor: fullname: Jassam – volume: 12 start-page: 5004 year: 2022 ident: ref_31 article-title: Saffron extract and crocin exert anti-inflammatory and anti-oxidative effects in a repetitive mild traumatic brain injury mouse model publication-title: Sci. Rep. doi: 10.1038/s41598-022-09109-9 contributor: fullname: Salem – volume: 496 start-page: 498 year: 2013 ident: ref_35 article-title: The zebrafish reference genome sequence and its relationship to the human genome publication-title: Nature doi: 10.1038/nature12111 contributor: fullname: Howe – ident: ref_77 doi: 10.4236/jbbs.2013.33031 – volume: 2 start-page: 293 year: 2013 ident: ref_30 article-title: Saffron: A Natural Potent Antioxidant as a Promising Anti-Obesity Drug publication-title: Antioxidants doi: 10.3390/antiox2040293 contributor: fullname: Mashmoul – volume: 34 start-page: 1491 year: 2017 ident: ref_23 article-title: Natural Compounds as a Therapeutic Intervention following Traumatic Brain Injury: The Role of Phytochemicals publication-title: J. Neurotrauma doi: 10.1089/neu.2016.4718 contributor: fullname: Scheff – ident: ref_56 doi: 10.3390/molecules21030303 – volume: 149 start-page: 1099 year: 2012 ident: ref_69 article-title: A comparison of the light/dark and novel tank tests in zebrafish publication-title: Behaviour doi: 10.1163/1568539X-00003029 contributor: fullname: Maximino – ident: ref_78 doi: 10.1186/s12906-020-03102-3 – volume: 5 start-page: 169 year: 1991 ident: ref_15 article-title: Learning in post-traumatic amnesia following extremely severe closed head injury publication-title: Brain Inj. doi: 10.3109/02699059109008087 contributor: fullname: Gasquoine – volume: 7 start-page: a020602 year: 2014 ident: ref_32 article-title: Central nervous system regenerative failure: Role of oligodendrocytes, astrocytes, and microglia publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a020602 contributor: fullname: Silver – ident: ref_61 – volume: 36 start-page: 3063 year: 2019 ident: ref_82 article-title: Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know publication-title: J. Neurotrauma doi: 10.1089/neu.2018.6171 contributor: fullname: Gupte – ident: ref_42 doi: 10.1201/NOE1420052343 – volume: 48 start-page: 5099 year: 2021 ident: ref_41 article-title: Induction of oxidative stress and apoptosis in the injured brain: Potential relevance to brain regeneration in zebrafish publication-title: Mol. Biol. Rep. doi: 10.1007/s11033-021-06506-7 contributor: fullname: Anand – volume: 16 start-page: 1 year: 2013 ident: ref_45 article-title: A survey on saffron in major islamic traditional medicine books publication-title: Iran J. Basic Med. Sci. contributor: fullname: Javadi – volume: 7 start-page: 606124 year: 2020 ident: ref_65 article-title: Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel Group, Clinical Trial publication-title: Front. Nutr. doi: 10.3389/fnut.2020.606124 contributor: fullname: Jackson – volume: 235 start-page: 574 year: 2012 ident: ref_13 article-title: Mild traumatic brain injury in the rat alters neuronal number in the limbic system and increases conditioned fear and anxiety-like behaviors publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2012.03.012 contributor: fullname: Meyer – volume: 157 start-page: 315 year: 2007 ident: ref_44 article-title: Saffron in phytotherapy: Pharmacology and clinical uses publication-title: Wien Med. Wochenschr. doi: 10.1007/s10354-007-0428-4 contributor: fullname: Schmidt – volume: 14 start-page: 160 year: 2020 ident: ref_12 article-title: Blast-Related Mild TBI Alters Anxiety-Like Behavior and Transcriptional Signatures in the Rat Amygdala publication-title: Front. Behav. Neurosci. doi: 10.3389/fnbeh.2020.00160 contributor: fullname: Blaze – volume: 51 start-page: 154 year: 2009 ident: ref_37 article-title: Studies on the teleost brain morphology in search of the origin of cognition publication-title: Jpn. Psychol. Res. doi: 10.1111/j.1468-5884.2009.00397.x contributor: fullname: Yamamoto – volume: 65 start-page: 337 year: 2015 ident: ref_67 article-title: Antidepressant Effect of Crocus sativus Aqueous Extract and its Effect on CREB, BDNF, and VGF Transcript and Protein Levels in Rat Hippocampus publication-title: Drug Res. contributor: fullname: Ghasemi – ident: ref_48 doi: 10.3390/nu14030597 – volume: 26 start-page: 1118 year: 2017 ident: ref_10 article-title: Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors publication-title: Cell Transplant. doi: 10.1177/0963689717714102 contributor: fullname: Galgano – volume: 32 start-page: 9402 year: 2012 ident: ref_76 article-title: Dopamine, corticostriatal connectivity, and intertemporal choice publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1180-12.2012 contributor: fullname: Kayser – volume: 34 start-page: 263 year: 2017 ident: ref_8 article-title: Glutamate Neurotransmission in Rodent Models of Traumatic Brain Injury publication-title: J. Neurotrauma doi: 10.1089/neu.2015.4373 contributor: fullname: Dorsett – ident: ref_55 doi: 10.3390/nu13030904 – volume: 3 start-page: e1148101 year: 2016 ident: ref_36 article-title: Adult neural stem cell behavior underlying constitutive and restorative neurogenesis in zebrafish publication-title: Neurogenesis doi: 10.1080/23262133.2016.1148101 contributor: fullname: Barbosa – volume: 23 start-page: 768 year: 2009 ident: ref_54 article-title: Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice publication-title: Phyther. Res. doi: 10.1002/ptr.2597 contributor: fullname: Hosseinzadeh – volume: 672 start-page: 28 year: 2018 ident: ref_66 article-title: TrkB receptor antagonism inhibits stab injury induced proliferative response in adult zebrafish (Danio rerio) brain publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2018.02.040 contributor: fullname: Anand – volume: 22 start-page: 2894 year: 2002 ident: ref_70 article-title: Conservation of spatial memory function in the pallial forebrain of reptiles and ray-finned fishes publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.22-07-02894.2002 contributor: fullname: Vargas – volume: 109 start-page: E3640 year: 2012 ident: ref_74 article-title: Amygdala lesions disrupt modulation of functional MRI activity evoked by facial expression in the monkey inferior temporal cortex publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Liu – volume: 166 start-page: 653 year: 2009 ident: ref_11 article-title: Arciniegas, M.D. Depression and Cognitive Complaints Following Mild Traumatic Brain Injury publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2009.08111676 contributor: fullname: Jonathan – volume: 14 start-page: 2067 year: 2019 ident: ref_39 article-title: Adult neurogenesis and regeneration in zebrafish brain: Are the neurotrophins involved in? publication-title: Neural Regen. Res. doi: 10.4103/1673-5374.262574 contributor: fullname: Cacialli – volume: 9 start-page: 426 year: 2021 ident: ref_68 article-title: Saffron (Crocus Sativus L.), Combined with Endurance Exercise, Synergistically Enhances BDNF, Serotonin, and NT-3 in Wistar Rats publication-title: Rep. Biochem. Mol. Biol. doi: 10.52547/rbmb.9.4.426 contributor: fullname: Najafi – volume: 1822 start-page: 675 year: 2012 ident: ref_79 article-title: Antioxidant therapies in traumatic brain and spinal cord injury publication-title: Biochim. Et Biophys. Acta doi: 10.1016/j.bbadis.2011.10.017 contributor: fullname: Bains – volume: 15 start-page: 27 year: 2015 ident: ref_62 article-title: Glutamate and GABA imbalance following traumatic brain injury publication-title: Curr. Neurol. Neurosci. Rep. doi: 10.1007/s11910-015-0545-1 contributor: fullname: Guerriero – ident: ref_40 doi: 10.3390/ijms22041585 – volume: 78 start-page: 881 year: 2013 ident: ref_80 article-title: Imaging of neural ensemble for the retrieval of a learned behavioral program publication-title: Neuron doi: 10.1016/j.neuron.2013.04.009 contributor: fullname: Aoki – volume: 174 start-page: 51 year: 2015 ident: ref_29 article-title: Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: A randomized, double-blind, placebo-controlled, pilot clinical trial publication-title: J. Affect. Disord. doi: 10.1016/j.jad.2014.11.035 contributor: fullname: Talaei – volume: 12 start-page: 1645 year: 2006 ident: ref_19 article-title: Evaluation of pharmacological treatment strategies in traumatic brain injury publication-title: Curr. Pharm. Des. doi: 10.2174/138161206776843340 contributor: fullname: Marklund – volume: 99 start-page: ES60 year: 2008 ident: ref_22 article-title: Flavonoids: Modulators of brain function? publication-title: Br. J. Nutr. doi: 10.1017/S0007114508965776 contributor: fullname: Spencer – ident: ref_3 – volume: 70 start-page: 374 year: 2011 ident: ref_59 article-title: Inflammation after trauma: Microglial activation and traumatic brain injury publication-title: Ann. Neurol. doi: 10.1002/ana.22455 contributor: fullname: Ramlackhansingh – volume: 2 start-page: 27 year: 2012 ident: ref_58 article-title: How tissue injury alarms the immune system and causes a systemic inflammatory response syndrome publication-title: Ann. Intensive Care doi: 10.1186/2110-5820-2-27 contributor: fullname: Pugin – volume: 130 start-page: 1 year: 2018 ident: ref_4 article-title: Estimating the global incidence of traumatic brain injury publication-title: J. Neurosurg. contributor: fullname: Dewan – volume: 10 start-page: 8093 year: 2011 ident: ref_50 article-title: Determination of antioxidant activity of saffron taken from the flower of Crocus sativus grown in Lebanon publication-title: Afr. J. Biotechnol. doi: 10.5897/AJB11.406 contributor: fullname: Makhlouf – volume: 97 start-page: 1679 year: 2017 ident: ref_25 article-title: Saffron: A promising natural medicine in the treatment of metabolic syndrome publication-title: J. Sci. Food Agric. doi: 10.1002/jsfa.8134 contributor: fullname: Razavi – volume: 32 start-page: 411 year: 2015 ident: ref_52 article-title: The manifestation of anxiety disorders after traumatic brain injury: A review publication-title: J. Neurotrauma doi: 10.1089/neu.2014.3504 contributor: fullname: Mallya – volume: 14 start-page: 272 year: 2018 ident: ref_63 article-title: The Protective Role of Crocus Sativus L. (Saffron) Against Ischemia- Reperfusion Injury, Hyperlipidemia and Atherosclerosis: Nature Opposing Cardiovascular Diseases publication-title: Curr. Cardiol. Rev. doi: 10.2174/1573403X14666180628095918 contributor: fullname: Hatziagapiou – volume: 17 start-page: 1499 year: 2016 ident: ref_24 article-title: Molecular Mechanism of Crocin Induced Caspase Mediated MCF-7 Cell Death: In Vivo Toxicity Profiling and Ex Vivo Macrophage Activation publication-title: Asian Pac. J. Cancer Prev. doi: 10.7314/APJCP.2016.17.3.1499 contributor: fullname: Bakshi – volume: 29 start-page: 1886 year: 2012 ident: ref_60 article-title: Acute neuroimmune modulation attenuates the development of anxiety-like freezing behavior in an animal model of traumatic brain injury publication-title: J. Neurotrauma doi: 10.1089/neu.2011.2273 contributor: fullname: Rodgers – volume: 277 start-page: 215 year: 2016 ident: ref_73 article-title: Diminished amygdala activation and behavioral threat response following traumatic brain injury publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2016.01.004 contributor: fullname: Palmer – ident: ref_7 doi: 10.3390/biomedicines9080861 – volume: 16 start-page: 40 year: 2011 ident: ref_46 article-title: Herbal medicines, other than St. John’s Wort, in the treatment of depression: A systematic review publication-title: Altern Med. Rev. contributor: fullname: Dwyer – volume: 2 start-page: 27rv21 year: 2010 ident: ref_18 article-title: Exploring new routes for neuroprotective drug development in traumatic brain injury publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3000330 contributor: fullname: Janowitz – volume: 9 start-page: 358 year: 2015 ident: ref_16 article-title: Traumatic brain injury in the US military: Epidemiology and key clinical and research programs publication-title: Brain Imaging Behav. doi: 10.1007/s11682-015-9399-z contributor: fullname: Helmick – volume: 11 start-page: 2616 year: 2019 ident: ref_75 article-title: The potential roles of dopamine in traumatic brain injury: A preclinical and clinical update publication-title: Am. J. Transl. Res. contributor: fullname: Lan – volume: 5 start-page: 200 year: 2012 ident: ref_38 article-title: Neuronal regeneration in a zebrafish model of adult brain injury publication-title: Dis. Models Mech. doi: 10.1242/dmm.007336 contributor: fullname: Kishimoto – volume: 32 start-page: 1651 year: 2018 ident: ref_53 article-title: Depression and anxiety across the first 4 years after mild traumatic brain injury: Findings from a community-based study publication-title: Brain Inj. doi: 10.1080/02699052.2018.1540797 contributor: fullname: Theadom – volume: 109 start-page: 21180 year: 2012 ident: ref_72 article-title: Facing the role of the amygdala in emotional information processing publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1219167110 contributor: fullname: Baxter – volume: 104 start-page: 213 year: 2020 ident: ref_2 article-title: Traumatic Brain Injury: An Overview of Epidemiology, Pathophysiology, and Medical Management publication-title: Med. Clin. N. Am. doi: 10.1016/j.mcna.2019.11.001 contributor: fullname: Capizzi – ident: ref_51 doi: 10.3390/molecules26164906 – volume: 16 start-page: 12 year: 2013 ident: ref_64 article-title: Safranal: From an aromatic natural product to a rewarding pharmacological agent publication-title: Iran J. Basic Med. Sci. contributor: fullname: Rezaee – volume: 40 start-page: 101250 year: 2020 ident: ref_84 article-title: Antioxidant effects of lebanese Crocus sativus L. and its main components, crocin and safranal, on human skeletal muscle cells publication-title: Eur. J. Integr. Med. doi: 10.1016/j.eujim.2020.101250 contributor: fullname: Nassar – volume: 2012 start-page: 315941 year: 2012 ident: ref_57 article-title: Danger Signals Activating the Immune Response after Trauma publication-title: Mediat. Inflamm. doi: 10.1155/2012/315941 contributor: fullname: Hirsiger – volume: 24 start-page: 2335 year: 2004 ident: ref_71 article-title: Avoidance Response in Goldfish: Emotional and Temporal Involvement of Medial and Lateral Telencephalic Pallium publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.4930-03.2004 contributor: fullname: Portavella – volume: 11 start-page: 750 year: 2017 ident: ref_33 article-title: A Whole Brain Staining, Embedding, and Clearing Pipeline for Adult Zebrafish to Visualize Cell Proliferation and Morphology in 3-Dimensions publication-title: Front. Neurosci. doi: 10.3389/fnins.2017.00750 contributor: fullname: Lindsey – volume: 544 start-page: 203 year: 2003 ident: ref_20 article-title: Neuroprotection by bioactive components in medicinal and food plant extracts publication-title: Mutat. Res. doi: 10.1016/j.mrrev.2003.06.017 contributor: fullname: Aruoma – volume: 591 start-page: 53 year: 2015 ident: ref_17 article-title: Neuroprotective effects of crocin against traumatic brain injury in mice: Involvement of notch signaling pathway publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2015.02.016 contributor: fullname: Wang |
| SSID | ssj0023259 |
| Score | 2.4306052 |
| Snippet | Traumatic brain injury (TBI) has the highest mortality rates worldwide, yet effective treatment remains unavailable. TBI causes inflammatory responses,... |
| SourceID | doaj pubmedcentral proquest crossref |
| SourceType | Open Website Open Access Repository Aggregation Database |
| StartPage | 11600 |
| SubjectTerms | Alzheimer's disease Animal cognition Anxiety anxiolytic Behavior Blood-brain barrier Cell signaling Danio rerio Disease prevention Edema Endoplasmic reticulum Fear fear disinhibition Homology Inflammation Memory memory performance Motor skill Neurodegeneration Neuroprotection PMS Premenstrual syndrome Regeneration Saffron Traumatic brain injury Zebrafish |
| SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Na9wwEBUlUOiltGlL3SZhCqU3k7W-LB83ISEJtJc2EHoxsiURh1YOu15Ir_3lmZG9YX3qpUd7dJBnRpo3luYNY58tgnTTEL9dQDMgAm_zxnt8XHjPeemaQlGB89dv-uJaXt2om51WX3QnbKQHHhV3bKUqA5U7moWVrXWmtAvHtXHWSYymLu2-C75NpqZUS_DUJq3A6JNrVemRXVNggn_c3f1eI6jBRa6prG0nGiXS_hnSnN-T3Ak856_YywkxwnKc6Wv2zMd99nzsIfnnDfv73Yaw6iOcPQxU8QTLAWHwhiAkLOND16OHdC2MLMVgo4PxPwKKT7dXh2BiSVxBF3EILImUA37SmXLo1rdADdN-QR8AI9smcbzCCbWWgMt4hzZ5y67Pz36cXuRTY4W8lcoMuaYY5E3lbMBNxgWDmCiEVos2KDRUIVDhQsvCBBeq0hUVrnKHSFAUwWvrtXjH9mIf_XsGQbfSCu4cSjFVM1YJ6UuhvDW8QbCRsS9bBdf3I39GjXkHWaKeWSJjJ6T-p0FEe51eoDPUkzPU_3KGjB1sjVdPa3Fd8xJhiMFPlhn79CTGVURHIzb6fpPGKCpWFyZj5czoswnNJbG7TXzcFfUIqOSH__EFH9kLTgUW6brgAdsbVht_iLBnaI6Shz8CFD0Bpg priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Technology Collection dbid: 8FG link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwELZaUKVeENBWDY_KlareIjZ-xTlVC2KBSu2lRUK9RE5sl6DWgd2sRK_8cmac7JZcOCZjKZHHM_PZnvmGkE8GQLqukN_OgxoAgddp5Rw8TpxjLLdVJrHA-dt3dX4pvl7Jq-HAbTGkVa58YnTUtq3xjPyI5RBMNDhP8eX2LsWuUXi7OrTQeEk2M5YrTOnTs7P1houz2CwtgxiUKlmonmOTwzb_qLn5uwBoA6ausLjtSUyK1P0jvDnOlnwSfmbbZGvAjXTaK3qHvHBhl7zqO0n-e0Mefhjv522gp_cd1j3RaQdgeIlAkk7DfdPCOmlq2nMVUxMs7U8TQHyySiCiA1finDYBhtApUnPQX3iz7JvFNcW2aX9o6ynEt2VkeqXH2GCCXoQb0Mxbcjk7_Xlyng7tFdJaSN2lCiOR04U1HlyN9RqQkfe14rWXoK6Mey64Epn21he5zQqwdQt4kGfeKeMUf0c2Qhvce0K9qoXhzFqQwoZNG8mFy7l0RrMKIEdCPq8muLztWTRK2H2gJsqRJhJyjNO_HoTk1_FFO_9dDrZUGiFzjxWwemJEbazOzcQypa2xAgCWTcjBSnnlYJGL8v_6ScjHtRhsCS9ITHDtMo6RWLLOdULykdJHPzSWhOY6snIX2CmgEHvPf3yfvGZYQBHTAQ_IRjdfukOANV31Ia7dR4m5-Qw priority: 102 providerName: ProQuest – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Nb9QwEB1BERIXRPkQgYIGCXELbGIncQ4IbatWBalcYKWKS-TENk3VOpDNStsrv5yZJLs0KoceEztS7PF43tgzbwDeagLpqmR-O0diIARehaW19DizNo4zU0YJJziffE2PF_LLaXL6j1JonMDlf107rie1aC_er39ffSKF_8geJ7nsH-rzyyXBFFJbst534V5MRpGju07k9kKBcENfN41PPELeoQe6zZufT8xTz-I_gZ7TwMlrlujoETwcISTOB5nvwh3rH8P9oajk1RP480071zYeD9cdp0DhvCNcvGJMiXO_rhtaMnWFA20xam9wOFig5oNNLBGOtIkt1p664JxZOvAHXzK7enmGXEHtAhuHZOpWPekr7nOtCfzsz0lIT2FxdPj94DgcKy2ElUxUF6ZslKzKjXa06xinCCQ5V6WicglJLhJOSJHKSDnj8sxEOam9IWgoImdTbVPxDHZ84-1zQJdWUovYGGol303pREibicRqFZeEPgJ4t5ng4tdAqFGQI8KSKCaSCGCfp3_biXmw-xdN-7MY1arQMskcJ8OqmZaVNirTMxOnymgjCWuZAPY2wis2a6uIM8IlioYsA3izbSa14rsS7W2z6vsknL0uVADZROiTH5q2-PqsJ-jOuWhALl_cdqgv4UHMWRV9jOAe7HTtyr4irNOVr_tV_BcsnP6q priority: 102 providerName: Scholars Portal |
| Title | Saffron Extract Attenuates Anxiogenic Effect and Improves Cognitive Behavior in an Adult Zebrafish Model of Traumatic Brain Injury |
| URI | https://www.proquest.com/docview/2724282994 https://search.proquest.com/docview/2725199538 https://pubmed.ncbi.nlm.nih.gov/PMC9570094 https://doaj.org/article/a457f347980a4cad87a0d268dad4643d |
| Volume | 23 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fa9swED7ajo2-lP1kXjujwdhbmtiSbPkxCcm6QUrZVgh7MbIlrS6NXBIHutf95TvJdplf9yKwJYOsO-m-k-4-AXyUCNJF4fjtDIoBEXg5KrTGx4nWcZyqIuIuwXl1mVxcs69rvj4A3ufC-KD9sqjO7d3m3FY3PrbyflOO-zix8dVqnjlS9oyND-EQzW_vondeFkVA35JpUvTnx9XtZocYBuc0mvZjeIYLNo2zbhelt0Oern-AMYcRkv-YnOVzOOmwIpm2fXoBB9q-hKft7ZG_X8Gf79KYbW3J4qFxuU5k2iAA3jvwSKb2oapRN6qStPzERFpF2h0ErJ73QUOk40fckspiEzJ1dBzkpztNNtXuhrir0u5IbQjatL1ndyUzd6kE-WJvURqv4Xq5-DG_GHVXKoxKxkUzSpz10SJT0uDyooxANGRMmdDScBRRRA1lNGGRMMpkqYoynN8KMSCNjE6kTugbOLK11W-BmKRkksZKYS06aUJyynRKuZYiLhBmBPCpH-D8vmXOyNHjcELJB0IJYOaG_7GRI7z2L-rtr7wTey4ZT43LehUTyUqpRConKk6EkoohqFIBnPXCy7tZuMvjFAGIwF9mAXx4rMb54w5FpNX13rfhLk2digDSgdAHHRrWoGJ6Ju5OEd_995encBy7fAofHXgGR812r98jymmKEHV7nWIplp9DeDJbXF59C_2OQeisD8dyxUTodf8vrkcGPQ |
| link.rule.ids | 230,314,727,780,784,864,885,2102,2221,12056,12765,21388,24318,27924,27925,31719,31720,33373,33374,33744,33745,43310,43600,43805,53791,53793,73745,74035,74302 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELZgKwQXxFOkFDAS4hZ1Ez_inNButdUW2hWCVqq4RE5st6nAaXezUrnyy5lJvEtz4ZiMpUQez8w3tucbQj5oAOmqRH47B2oABF7FpbXwOLY2TTNTJgILnE8Wcn7GP5-L87DhtgrXKjc-sXPUpqlwj3w_zSCYKHCe_NP1TYxdo_B0NbTQuE92kDldjMjOdLb4-m2bcrG0a5eWQBSKpchlz7LJINHfr69-rQDcgLFLLG-7E5U68v4B4hzel7wTgA6fkMcBOdJJr-qn5J71z8iDvpfk7-fkz3ft3LLxdHbbYuUTnbQAh9cIJenE39YNrJS6oj1bMdXe0H4_AcQHmytENLAlLmntYQidIDkH_YFny65eXVJsnPaTNo5ChFt3XK90ii0m6JG_At28IGeHs9ODeRwaLMQVF6qNJcYiq3KjHTgb4xRgI-cqySonQGEJc4wzyRPljMszk-Rg7QYQIUucldpK9pKMfOPtK0KdrLhmqTEghZRNacG4zZiwWqUlgI6IfNxMcHHd82gUkH-gJoqBJiIyxenfDkL66-5Fs7wogjUVmovMYQ2sGmteaaMyPTapVEYbDhDLRGRvo7wi2OSq-LeCIvJ-KwZrwiMS7W2z7sYILFpnKiLZQOmDHxpKfH3Z8XLn2Csg57v___g78nB-enJcHB8tvrwmj1Isp-guB-6RUbtc2zcActrybVjJfwGQzf1d |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELZgKxAXxFOkFDAS4hbtJn7EOaHdsquWx6oCKlVcIie2aSrqlN2sVK78cmYS79JcOCZjKZHH4_nGnvmGkDcaQLoqkd_OgRoAgVdxaS08TqxN08yUicAC589LeXTKP5yJs5D_tA5plds9sduoTVPhGfk4zcCZKNg8-diFtIiT94t3V79i7CCFN62hncZtsgdecZKOyN5svjz5sgu_WNq1TkvAI8VS5LJn3GQQ9I_ri8s1AB0wfImlbjc8VEfkP0Cfw9zJG85o8YDcDyiSTnu1PyS3rH9E7vR9JX8_Jn--audWjafz6xaroOi0BWi8QVhJp_66bmDV1BXtmYup9ob2ZwsgPtymE9HAnLiitYchdIpEHfQ73jO7en1OsYnaT9o4Ct5u0_G-0hm2m6DH_gL09IScLubfDo_i0GwhrrhQbSzRL1mVG-1g4zFOAU5yrpKscgKUlzDHOJM8Uc64PDNJDpZvAB2yxFmprWRPycg33j4j1MmKa5YaA1II35QWjNuMCatVWgIAicjb7QQXVz2nRgGxCGqiGGgiIjOc_t0gpMLuXjSrH0WwrEJzkTmsh1UTzSttVKYnJpXKaMMBbpmIHGyVVwT7XBf_VlNEXu_EYFl4XaK9bTbdGIEF7ExFJBsoffBDQ4mvzzuO7hz7BuR8__8ff0XuwiIuPh0vPz4n91KsrOjyBA_IqF1t7AvAO235MizkvzihAZk |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Saffron+Extract+Attenuates+Anxiogenic+Effect+and+Improves+Cognitive+Behavior+in+an+Adult+Zebrafish+Model+of+Traumatic+Brain+Injury&rft.jtitle=International+journal+of+molecular+sciences&rft.au=Chaoul%2C+Victoria&rft.au=Awad%2C+Maria&rft.au=Harb%2C+Frederic&rft.au=Najjar%2C+Fadia&rft.date=2022-10-01&rft.issn=1422-0067&rft.eissn=1422-0067&rft.volume=23&rft.issue=19&rft.spage=11600&rft_id=info:doi/10.3390%2Fijms231911600&rft.externalDBID=n%2Fa&rft.externalDocID=10_3390_ijms231911600 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1422-0067&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1422-0067&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1422-0067&client=summon |