Cyclooxygenase (COX)-2 Inhibitors Reduce Toxoplasma gondii Infection and Upregulate the Pro-inflammatory Immune Response in Calomys callosus Rodents and Human Monocyte Cell Line

• Published in: Frontiers in microbiology Vol. 10; p. 225
• Main Authors: Pereira, Ana Carolina Alcântara, Silva, Rafaela José, Franco, Priscila Silva, de Oliveira Gomes, Angelica, Souza, Guilherme, Milian, Iliana Claudia Balga, Ribeiro, Mayara, Rosini, Alessandra Monteiro, Guirelli, Pâmela Mendonça, Ramos, Eliézer Lucas Pires, Mineo, Tiago Wilson Patriarca, Mineo, José Roberto, Silva, Neide Maria, Ferro, Eloisa Amália Vieira, Barbosa, Bellisa Freitas
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 12.02.2019
• Subjects: Calomys callosus; cyclooxygenase-2; immune response; Microbiology; prostaglandin E2; THP-1 cells; Toxoplasma gondii; THP-1 cells; Calomys callosus; Toxoplasma gondii; immune response; prostaglandin E2; cyclooxygenase-2

is able to infect a wide range of vertebrates, including humans. Studies show that cyclooxygenase-2 (COX-2) is a modulator of immune response in multiple types of infection, such as . However, the role of COX-2 during infection is still unclear. The aim of this study was to investigate the role of C...