Molecular Pathways Involved in LRRK2-Linked Parkinson’s Disease: A Systematic Review

• Published in: International journal of molecular sciences Vol. 23; no. 19; p. 11744
• Main Authors: Ravinther, Ailyn Irvita, Dewadas, Hemaniswarri Dewi, Tong, Shi Ruo, Foo, Chai Nien, Lin, Yu-En, Chien, Cheng-Ting, Lim, Yang Mooi
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.10.2022; MDPI
• Subjects: Aging; Alzheimer's disease; Autophagy; Genes; In vivo methods and tests; Kinases; LRRK2; LRRK2 protein; mechanism; Molecular modelling; Mutation; Nervous system; Neurodegeneration; Neurons; Neuropathology; Neurotoxicity; Parkinson's disease; Pathogenesis; Population; Proteins; Review; Reviews; Systematic review

Parkinson’s disease is one of the most common neurodegenerative diseases affecting the ageing population, with a prevalence that has doubled over the last 30 years. As the mechanism of the disease is not fully elucidated, the current treatments are unable to effectively prevent neurodegeneration. St...