Activity-Dependent Neuroprotective Protein (ADNP): An Overview of Its Role in the Eye

Vision is one of the dominant senses in humans and eye health is essential to ensure a good quality of life. Therefore, there is an urgent necessity to identify effective therapeutic candidates to reverse the progression of different ocular pathologies. Activity-dependent neuroprotective protein (AD...

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Published inInternational journal of molecular sciences Vol. 23; no. 21; p. 13654
Main Authors Maugeri, Grazia, D’Amico, Agata Grazia, Magrì, Benedetta, Musumeci, Giuseppe, D’Agata, Velia
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.11.2022
MDPI
Subjects
ADNP
ADNP protein
Alzheimer's disease
anatomy
Apoptosis
Autism
Brain
Cell cycle
Collagen
Connective tissue
Cornea
Diabetic retinopathy
Endothelium
Eye
Eye (anatomy)
Genes
Homeostasis
Iris
Kinases
NAP
Neuroprotection
Photoreceptors
Polypeptides
Proteins
Quality of life
Retina
Review
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Summary:Vision is one of the dominant senses in humans and eye health is essential to ensure a good quality of life. Therefore, there is an urgent necessity to identify effective therapeutic candidates to reverse the progression of different ocular pathologies. Activity-dependent neuroprotective protein (ADNP) is a protein involved in the physio-pathological processes of the eye. Noteworthy, is the small peptide derived from ADNP, known as NAP, which shows protective, antioxidant, and anti-apoptotic properties. Herein, we review the current state of knowledge concerning the role of ADNP in ocular pathologies, while providing an overview of eye anatomy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232113654