The nuclear pore complex: nucleocytoplasmic transport and beyond

Over the past two years, it has become evident that there is an unexpected link between nuclear pore complex structure and dynamics, nucleocytoplasmic transport and chromosome segregation. In addition, a tomographic three-dimensional reconstruction of native nuclear pore complexes preserved in thick...

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Bibliographic Details
Published inNature reviews. Molecular cell biology Vol. 4; no. 10; pp. 757 - 766
Main Authors Aebi, Ueli, Fahrenkrog, Birthe
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.10.2003
Subjects
Active Transport, Cell Nucleus - physiology
Animals
Biological transport
chromosome segregation
Cytoplasm
Gold
Microscopy
Models, Biological
Models, Molecular
Nuclear membranes
Nuclear Pore - metabolism
Nuclear Pore - ultrastructure
Nuclear Pore Complex Proteins - metabolism
Nucleocytoplasmic transport
Physiological aspects
ran GTP-Binding Protein - metabolism
RanGDP
RanGTP
Ribonucleoproteins
Structure
Xenopus laevis
United States
Switzerland
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Summary:Over the past two years, it has become evident that there is an unexpected link between nuclear pore complex structure and dynamics, nucleocytoplasmic transport and chromosome segregation. In addition, a tomographic three-dimensional reconstruction of native nuclear pore complexes preserved in thick amorphous ice has unveiled a number of new structural features of this supramolecular machine. These data, together with some of the elementary physical principles that underlie nucleocytoplasmic transport, will be discussed in this review.
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ISSN:1471-0072
1471-0080
DOI:10.1038/nrm1230