Examination of pathways involved in leukemia inhibitory factor (LIF)-induced cell growth arrest using label-free proteomics approach

• Published in: Journal of proteomics Vol. 168; pp. 37 - 52
• Main Authors: Ali, Syed Azmal, Kaur, Gurjeet, Kaushik, Jai Kumar, Malakar, Dhruba, Mohanty, Ashok Kumar, Kumar, Sudarshan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.09.2017
• Subjects: Animals; bioinformatics; caspases; Cell Cycle - drug effects; cell cycle checkpoints; Cell Cycle Checkpoints - drug effects; cell growth; Cell Proliferation - drug effects; cell viability; clinical trials; Cytoscape; embryo implantation; Female; glycosylation; Growth arrest; half life; histones; Humans; interleukin-6; KEGG; Leukemia inhibitory factor; Leukemia Inhibitory Factor - metabolism; Leukemia Inhibitory Factor - pharmacology; Male; mitogen-activated protein kinase; phosphatidylinositol 3-kinase; Pregnancy; proteome; proteomics; Proteomics - methods; Proto-Oncogene Proteins c-akt - metabolism; quantitative polymerase chain reaction; Quantitative proteomics; reverse transcriptase polymerase chain reaction; Signal Transduction; TOR Serine-Threonine Kinases - drug effects; TOR Serine-Threonine Kinases - metabolism; uterus; women; NCCS; Cytoscape; SUMO; Quantitative proteomics; GOEAST; JNK; Leukemia inhibitory factor; STAT3; LIF; GO; PSM; MAPK; PSO; PIAS; SHP2; PI3K; FDR; JAK; LFQ; KEGG; DEPs; Growth arrest; COS-1; ERK

Leukemia inhibitory factor (LIF) is a multifunctional highly glycosylated protein, synthesized and secreted in various body tissues. Besides the abundance in multiple organs, the molecular mechanism underlying the LIF interactions for cell survival and polarity is poorly understood. In the present s...