Comparison on epidemiology, tumor location, histology, and prognosis of intracranial germ cell tumors between Mayo Clinic and Japanese consortium cohorts
Central nervous system (CNS) germ cell tumors (GCTs) are rare malignant neoplasms that arise predominantly in adolescents and young adults. CNS GCTs demonstrate characteristic trends in national associations, with implications for both tumor incidence and genetics. Although the incidence of CNS GCTs...
Saved in:
Published in | Journal of neurosurgery Vol. 134; no. 2; p. 446 |
---|---|
Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.02.2021
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | Central nervous system (CNS) germ cell tumors (GCTs) are rare malignant neoplasms that arise predominantly in adolescents and young adults. CNS GCTs demonstrate characteristic trends in national associations, with implications for both tumor incidence and genetics. Although the incidence of CNS GCTs is markedly higher in East Asia than Western countries, direct comparative analyses between these CNS GCT populations are limited.
In Japan, to facilitate the genomic analyses of CNS GCTs, the Intracranial Germ Cell Tumor Genome Analysis Consortium was established in 2011, and more than 200 cases of GCTs are available for both tumor tissue and clinical data, which is organized by the National Cancer Center (NCC) Japan. At the Mayo Clinic, there have been 98 cases of intracranial GCTs treated by the Department of Neurologic Surgery since 1988. In this paper, the authors compared the epidemiology, clinical presentation including location and histology, and prognosis between cases treated in the US and Japan.
There was no significant difference in age and sex distributions between the databases. However, there was a significant difference in the tumor locations; specifically, the frequency of basal ganglia was higher in the NCC database compared with the Mayo Clinic (8.4% vs 0%, p = 0.008), and bifocal location (neurohypophysis and pineal gland) was higher at the Mayo Clinic than at the NCC (18.8% vs 5.8%, p = 0.002). There was no difference in histological subdivisions between the databases. There was no difference in progression-free survival (PFS) and overall survival (OS) of germinoma cases and OS of nongerminomatous GCT (NGGCT) cases treated with chemotherapy and radiation therapy covering whole ventricles. However, PFS of NGGCTs differed significantly, and was better in the NCC cohorts (p = 0.04).
There appears to be a differential distribution of GCTs by neuroanatomical location between major geographic and national groups. Further study is warranted to better characterize any underlying genomic, epigenetic, or environmental factors that may be driving the phenotypic differences. |
---|---|
AbstractList | Central nervous system (CNS) germ cell tumors (GCTs) are rare malignant neoplasms that arise predominantly in adolescents and young adults. CNS GCTs demonstrate characteristic trends in national associations, with implications for both tumor incidence and genetics. Although the incidence of CNS GCTs is markedly higher in East Asia than Western countries, direct comparative analyses between these CNS GCT populations are limited.
In Japan, to facilitate the genomic analyses of CNS GCTs, the Intracranial Germ Cell Tumor Genome Analysis Consortium was established in 2011, and more than 200 cases of GCTs are available for both tumor tissue and clinical data, which is organized by the National Cancer Center (NCC) Japan. At the Mayo Clinic, there have been 98 cases of intracranial GCTs treated by the Department of Neurologic Surgery since 1988. In this paper, the authors compared the epidemiology, clinical presentation including location and histology, and prognosis between cases treated in the US and Japan.
There was no significant difference in age and sex distributions between the databases. However, there was a significant difference in the tumor locations; specifically, the frequency of basal ganglia was higher in the NCC database compared with the Mayo Clinic (8.4% vs 0%, p = 0.008), and bifocal location (neurohypophysis and pineal gland) was higher at the Mayo Clinic than at the NCC (18.8% vs 5.8%, p = 0.002). There was no difference in histological subdivisions between the databases. There was no difference in progression-free survival (PFS) and overall survival (OS) of germinoma cases and OS of nongerminomatous GCT (NGGCT) cases treated with chemotherapy and radiation therapy covering whole ventricles. However, PFS of NGGCTs differed significantly, and was better in the NCC cohorts (p = 0.04).
There appears to be a differential distribution of GCTs by neuroanatomical location between major geographic and national groups. Further study is warranted to better characterize any underlying genomic, epigenetic, or environmental factors that may be driving the phenotypic differences. |
Author | Perry, Avital Nishikawa, Ryo Matsutani, Masao Takami, Hirokazu Daniels, David J Saito, Nobuhito Giannini, Caterina Narita, Yoshitaka Nakazato, Yoichi Ichimura, Koichi Graffeo, Christopher S |
Author_xml | – sequence: 1 givenname: Hirokazu surname: Takami fullname: Takami, Hirokazu organization: 4Department of Neurosurgery, Faculty of Medicine, University of Tokyo, Japan – sequence: 2 givenname: Avital surname: Perry fullname: Perry, Avital organization: Departments of1Neurologic Surgery and – sequence: 3 givenname: Christopher S surname: Graffeo fullname: Graffeo, Christopher S organization: Departments of1Neurologic Surgery and – sequence: 4 givenname: Caterina surname: Giannini fullname: Giannini, Caterina organization: 2Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota – sequence: 5 givenname: Yoshitaka surname: Narita fullname: Narita, Yoshitaka organization: 5Department of Neurosurgery and Neuro-oncology, National Cancer Center Hospital, Tokyo, Japan – sequence: 6 givenname: Yoichi surname: Nakazato fullname: Nakazato, Yoichi organization: 6Department of Pathology, Hidaka Hospital, Gunma, Japan; and – sequence: 7 givenname: Nobuhito surname: Saito fullname: Saito, Nobuhito organization: 4Department of Neurosurgery, Faculty of Medicine, University of Tokyo, Japan – sequence: 8 givenname: Ryo surname: Nishikawa fullname: Nishikawa, Ryo organization: 7Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Saitama, Japan – sequence: 9 givenname: Masao surname: Matsutani fullname: Matsutani, Masao organization: 7Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Saitama, Japan – sequence: 10 givenname: Koichi surname: Ichimura fullname: Ichimura, Koichi organization: 3Division of Brain Tumor Translational Research, National Cancer Center, Tokyo, Japan – sequence: 11 givenname: David J surname: Daniels fullname: Daniels, David J organization: Departments of1Neurologic Surgery and |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32005022$$D View this record in MEDLINE/PubMed |
BookMark | eNo1kEtOwzAYhC0Eog84ABvkAzTFjySOlyjiqSI2sK4c50_rKvEf2a5Qj8JtqaBII81Io_kWMyPnHj0QcsPZUnLF7wTjesn5cucj17xQ5RmZci1lxkotJ2QW444xXualuCQTKRgrmBBT8l3jMJrgInp6FIyuhcFhj5vDgqb9gIH2aE1y6Bd062I6Vca3dAy48RhdpNhR51MwNhjvTE83EAZqoe__EJE2kL4APH0zB6R177yzv4hXMxoPEahFHzEktz_ucHtM8YpcdKaPcH3yOfl8fPion7PV-9NLfb_KbF5UKcutgFypjueV4lJz2RWtBdaI1raiU5pJbWUllTLadAB5qYQQDUChuwoYa8Wc3P5xx30zQLsegxtMOKz_PxI_WO5thg |
CitedBy_id | crossref_primary_10_1016_j_wnsx_2024_100336 crossref_primary_10_7887_jcns_32_172 crossref_primary_10_3389_fonc_2021_573798 crossref_primary_10_3390_jpm11070661 crossref_primary_10_1080_01658107_2022_2034890 crossref_primary_10_1007_s11060_023_04453_w crossref_primary_10_1159_000538088 crossref_primary_10_1093_neuonc_noab295 crossref_primary_10_1093_neuonc_noab252 crossref_primary_10_1007_s00381_024_06296_w crossref_primary_10_3389_fimmu_2022_1010146 crossref_primary_10_1007_s11060_022_04100_w crossref_primary_10_3389_fonc_2022_982608 crossref_primary_10_1007_s00234_024_03384_1 crossref_primary_10_3389_fonc_2022_991484 crossref_primary_10_1186_s40478_023_01682_y crossref_primary_10_3389_fonc_2024_1360158 |
ContentType | Journal Article |
DBID | NPM |
DOI | 10.3171/2019.11.jns191576 |
DatabaseName | PubMed |
DatabaseTitle | PubMed |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
EISSN | 1933-0693 |
ExternalDocumentID | 32005022 |
Genre | Journal Article |
GroupedDBID | --- .GJ 0R~ 11R 476 53G 5GY 5RE AALNN AAQQT ABCQX ABIMC ABOCM ABPPZ ACGFO AENEX AFOSN ALMA_UNASSIGNED_HOLDINGS CS3 DU5 EBS EJD EMOBN F5P HZ~ IH2 L7B N9A NEU NPM O9- OK1 P0W P2P SJN TR2 WH7 |
ID | FETCH-LOGICAL-c458t-4c2e477f148713913f5dce0b2dcd2f79039c38377a9afee467222bee59f8e00d2 |
IngestDate | Fri Oct 18 08:56:28 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 2 |
Keywords | basal ganglia tumor location international comparison germ cell tumor prognosis bifocal oncology |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c458t-4c2e477f148713913f5dce0b2dcd2f79039c38377a9afee467222bee59f8e00d2 |
OpenAccessLink | https://thejns.org/downloadpdf/journals/j-neurosurg/134/2/article-p446.pdf |
PMID | 32005022 |
ParticipantIDs | pubmed_primary_32005022 |
PublicationCentury | 2000 |
PublicationDate | 2021-02-01 |
PublicationDateYYYYMMDD | 2021-02-01 |
PublicationDate_xml | – month: 02 year: 2021 text: 2021-02-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Journal of neurosurgery |
PublicationTitleAlternate | J Neurosurg |
PublicationYear | 2021 |
SSID | ssj0016462 |
Score | 2.525542 |
Snippet | Central nervous system (CNS) germ cell tumors (GCTs) are rare malignant neoplasms that arise predominantly in adolescents and young adults. CNS GCTs... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 446 |
Title | Comparison on epidemiology, tumor location, histology, and prognosis of intracranial germ cell tumors between Mayo Clinic and Japanese consortium cohorts |
URI | https://www.ncbi.nlm.nih.gov/pubmed/32005022 |
Volume | 134 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELa2IKFeEIhXKUU-cNtNySbOOjlWFaWq1J5aqbfKccYQqk2qfSDRf8Lf4hd1xpMXC0WAtIp27Y0VZT7NjD_PQ4h34CB2EMZBblMIlE5NgGYIfHJOERuXTAvKdz49mx1fqJPL5HI0-jGIWlqv8n17-9u8kv-RKo6hXClL9h8k2y2KA_gd5YtXlDBe_0rGh4MmgtUY-mav_s2t1vN6MSZj5QM4cMQXF26nuUJATYF2XJOkJJ7Xou0iEv0Tauwxsfq8zLIL6Do13-oxVxP1S5ygtaUulhS_vkRfvlzjffVnOoi4x_HlEpqDdGxPHFybOTfQLhf1tbld9zp7wSf9B1-pv0kfL2Sca3jevj5CT-R-LH0zprLJcqQkRzNkOKJpGxRNBoq1chZTCwpupdip7YYELQfbZ1bCiknNTeOAnpLPf0GnFg3F_pdqiXvVRP_0X5TvzdyjJSa6LeSc6T_PbtTrbqe2xJZOSeeeEX_UnGvN1Czis3V6mve_PMu2eNTev7HP8f7O-RPxuJGXPGDUPRUjqJ6J7z3iJH6GiJtIDxTZ4m0iO7RNJAJFdliTtZNDrEnCmiSs8RJL2WBNEtYkY80v0WJN9liTDdaei4ujD-eHx0HT3COwKklXgbIRKK0dbsc17kKmsUsKC2EeFbaInM7COLPEnmiTGQeA9hw92RwgyVwKYVhEL8SDqq7glZDamrgIZ9Y6lSgDOktVnhRK4U8HUWF2xEt-k1c3XMHlqn3Hr--d2RXbPRTfiIcOVQbsof-5yt96kd4B84KPWA |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Comparison+on+epidemiology%2C+tumor+location%2C+histology%2C+and+prognosis+of+intracranial+germ+cell+tumors+between+Mayo+Clinic+and+Japanese+consortium+cohorts&rft.jtitle=Journal+of+neurosurgery&rft.au=Takami%2C+Hirokazu&rft.au=Perry%2C+Avital&rft.au=Graffeo%2C+Christopher+S&rft.au=Giannini%2C+Caterina&rft.date=2021-02-01&rft.eissn=1933-0693&rft.volume=134&rft.issue=2&rft.spage=446&rft_id=info:doi/10.3171%2F2019.11.jns191576&rft_id=info%3Apmid%2F32005022&rft_id=info%3Apmid%2F32005022&rft.externalDocID=32005022 |