Comparative Burden of Metabolic Dysfunction in Lean NAFLD vs Non-lean NAFLD - A Systematic Review and Meta-analysis

• Published in: Clinical gastroenterology and hepatology Vol. 21; no. 7; pp. 1750 - 1760.e12
• Main Authors: Tang, Ansel, Ng, Cheng Han, Phang, Poh Hui, Chan, Kai En, Chin, Yip Han, Fu, Clarissa Elysia, Zeng, Rebecca Wenling, Xiao, Jieling, Tan, Darren Jun Hao, Quek, Jingxuan, Lim, Wen Hui, Mak, Lung Yi, Wang, Jiong-wei, Chew, Nicholas W.S., Syn, Nicholas, Huang, Daniel Q., Siddiqui, Mohammad Shadab, Sanyal, Arun, Muthiah, Mark, Noureddin, Mazen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2023
• Subjects: Comorbidity; Diabetes Mellitus - epidemiology; Gastroenterology and Hepatology; Humans; MAFLD; Metabolic Associated Fatty Liver Disease Definition; NAFLD; NAFLD in obese; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - epidemiology; Obesity - complications; Obesity - epidemiology; Overweight - complications; Overweight - epidemiology; SBP; NAFLD; CI; FBG; Metabolic Associated Fatty Liver Disease Definition; NAFLD in obese; MAFLD; HDL; HOMA-IR; DBP; TG; LDL; BMI; fasting blood glucose; body mass index; high-density lipoprotein; triglycerides; Homeostatic Model Assessment for Insulin Resistance; systolic blood pressure; low-density lipoprotein; nonalcoholic fatty liver disease; diastolic blood pressure; confidence interval; metabolic-associated fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is traditionally associated with obesity. However, there is a subtype of NAFLD, namely NAFLD in lean, that occurs without obesity. However, a recent call to redefine NAFLD to metabolic-associated fatty liver disease focuses on obesity and metabolic dysfunctio...