Innate immunity in the postmortem brain of depressed and suicide subjects: Role of Toll-like receptors

• Published in: Brain, behavior, and immunity Vol. 75; pp. 101 - 111
• Main Authors: Pandey, Ghanshyam N., Rizavi, Hooriyah S., Bhaumik, Runa, Ren, Xinguo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2019
• Subjects: Adult; Aged; Aged, 80 and over; Autopsy; Brain - immunology; Cytokines; Cytokines - metabolism; Depression; Depression - immunology; Female; Gene Expression Regulation - genetics; Humans; Immunity, Innate - immunology; Immunity, Innate - physiology; Innate immunity; Male; Middle Aged; Postmortem brain; RNA, Messenger - metabolism; Signal Transduction; Suicide; Suicide, Completed - psychology; Toll-like receptors (TLRs); Toll-Like Receptors - metabolism; Toll-Like Receptors - physiology; Depression; Innate immunity; Toll-like receptors (TLRs); Cytokines; Suicide; Postmortem brain

•The expression of several TLRs is increased in prefrontal cortex of depressed suicide subjects.•There is a dissociation in gene and protein expression of several TLRs in depressed suicide subjects.•These findings suggest an abnormality of innate immunity in depression and suicide. Abnormalities of...