Developmental systems of plasticity and trans-generational epigenetic inheritance in nematodes

• Published in: Current opinion in genetics & development Vol. 45; pp. 51 - 57
• Main Authors: Serobyan, Vahan, Sommer, Ralf J
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2017
• Subjects: Animals; Caenorhabditis elegans - genetics; Caenorhabditis elegans - growth & development; Chromatin Assembly and Disassembly; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Helminth Proteins - genetics; Helminth Proteins - metabolism; Medical Education; Mutation; Nematoda - genetics; Nematoda - growth & development; Phenotype; Selection, Genetic; Stress, Physiological - genetics

•Nematode phenotypic plasticity involves developmental switch genes.•Switch genes are regulated by chromatin remodeling and epigenetic mechanisms.•Trans-generational inheritance in C. elegans is induced by various stressors.•Epigenetic transmission of small RNAs is mediated by Argonaute proteins.•Ge...