Claudin-1, -2, -3, -4, -7, -8, and -10 Protein Expression in Biliary Tract Cancers

• Published in: The journal of histochemistry and cytochemistry Vol. 57; no. 2; pp. 113 - 121
• Main Authors: Nemeth, Zsuzsanna, Szasz, Attila Marcell, Tatrai, Peter, Nemeth, Julia, Gyorffy, Hajnalka, Somoracz, Aron, Szijarto, Attila, Kupcsulik, Peter, Kiss, Andras, Schaff, Zsuzsa
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA Histochemical Soc 01.02.2009; SAGE Publications; Histochemical Society
• Subjects: Biliary Tract - metabolism; Biliary Tract Neoplasms - metabolism; Biomarkers, Tumor - biosynthesis; Claudin-1; Claudin-3; Claudin-4; Claudins; Female; Humans; Immunohistochemistry; Male; Membrane Proteins - biosynthesis; Middle Aged; Tight Junctions - metabolism; gallbladder cancer; claudins; cholangiocarcinoma; tight junction

Biliary tract cancers are relatively common malignant gastrointestinal tumors in the elderly. Claudins are integral components of tight junctions that play important roles in maintaining epithelial cell polarity, controlling paracellular diffusion, and regulating cell growth and differentiation. The...