Claudin-1, -2, -3, -4, -7, -8, and -10 Protein Expression in Biliary Tract Cancers

Biliary tract cancers are relatively common malignant gastrointestinal tumors in the elderly. Claudins are integral components of tight junctions that play important roles in maintaining epithelial cell polarity, controlling paracellular diffusion, and regulating cell growth and differentiation. The...

Full description

Saved in:
Bibliographic Details
Published inThe journal of histochemistry and cytochemistry Vol. 57; no. 2; pp. 113 - 121
Main Authors Nemeth, Zsuzsanna, Szasz, Attila Marcell, Tatrai, Peter, Nemeth, Julia, Gyorffy, Hajnalka, Somoracz, Aron, Szijarto, Attila, Kupcsulik, Peter, Kiss, Andras, Schaff, Zsuzsa
Format Journal Article
LanguageEnglish
Published Los Angeles, CA Histochemical Soc 01.02.2009
SAGE Publications
Histochemical Society
Subjects
Biliary Tract - metabolism
Biliary Tract Neoplasms - metabolism
Biomarkers, Tumor - biosynthesis
Claudin-1
Claudin-3
Claudin-4
Claudins
Female
Humans
Immunohistochemistry
Male
Membrane Proteins - biosynthesis
Middle Aged
Tight Junctions - metabolism
gallbladder cancer
claudins
cholangiocarcinoma
tight junction
Online AccessGet full text

Cover

Abstract Biliary tract cancers are relatively common malignant gastrointestinal tumors in the elderly. Claudins are integral components of tight junctions that play important roles in maintaining epithelial cell polarity, controlling paracellular diffusion, and regulating cell growth and differentiation. The expression profile of claudins has been extensively characterized, but few reports exist on their expression in the normal and neoplastic biliary tract. Our aim was therefore to study claudins by IHC reactions in normal and neoplastic biliary tract samples. We detected that claudin expressions differ in the normal sample groups: the normal gallbladder strongly expressed claudin-2, −3, −4, and −10, but only weak reactions were seen in normal intrahepatic bile ducts. Although each cancer type expressed several claudins with various intensities, only claudin-4 presented especially strong immunoreactions in extrahepatic bile duct cancers and gallbladder carcinomas, whereas claudin-1 and −10 presented in intrahepatic bile duct cancers. Comparing the normal and carcinoma groups, the most significant decrease was detected in the expression of claudin-10. In conclusion, the expression pattern of claudins is different in the various parts of the normal and neoplastic biliary tract; moreover, an unequivocal decrease was detected in the carcinomas compared with their corresponding normal samples. This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials.
AbstractList Biliary tract cancers are relatively common malignant gastrointestinal tumors in the elderly. Claudins are integral components of tight junctions that play important roles in maintaining epithelial cell polarity, controlling paracellular diffusion, and regulating cell growth and differentiation. The expression profile of claudins has been extensively characterized, but few reports exist on their expression in the normal and neoplastic biliary tract. Our aim was therefore to study claudins by IHC reactions in normal and neoplastic biliary tract samples. We detected that claudin expressions differ in the normal sample groups: the normal gallbladder strongly expressed claudin-2, -3, -4, and -10, but only weak reactions were seen in normal intrahepatic bile ducts. Although each cancer type expressed several claudins with various intensities, only claudin-4 presented especially strong immunoreactions in extrahepatic bile duct cancers and gallbladder carcinomas, whereas claudin-1 and -10 presented in intrahepatic bile duct cancers. Comparing the normal and carcinoma groups, the most significant decrease was detected in the expression of claudin-10. In conclusion, the expression pattern of claudins is different in the various parts of the normal and neoplastic biliary tract; moreover, an unequivocal decrease was detected in the carcinomas compared with their corresponding normal samples. This manuscript contains online supplemental material at http://www.jhc.org . Please visit this article online to view these materials. (J Histochem Cytochem 57:113–121, 2009)
Biliary tract cancers are relatively common malignant gastrointestinal tumors in the elderly. Claudins are integral components of tight junctions that play important roles in maintaining epithelial cell polarity, controlling paracellular diffusion, and regulating cell growth and differentiation. The expression profile of claudins has been extensively characterized, but few reports exist on their expression in the normal and neoplastic biliary tract. Our aim was therefore to study claudins by IHC reactions in normal and neoplastic biliary tract samples. We detected that claudin expressions differ in the normal sample groups: the normal gallbladder strongly expressed claudin-2, -3, -4, and -10, but only weak reactions were seen in normal intrahepatic bile ducts. Although each cancer type expressed several claudins with various intensities, only claudin-4 presented especially strong immunoreactions in extrahepatic bile duct cancers and gallbladder carcinomas, whereas claudin-1 and -10 presented in intrahepatic bile duct cancers. Comparing the normal and carcinoma groups, the most significant decrease was detected in the expression of claudin-10. In conclusion, the expression pattern of claudins is different in the various parts of the normal and neoplastic biliary tract; moreover, an unequivocal decrease was detected in the carcinomas compared with their corresponding normal samples. This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials.
Biliary tract cancers are relatively common malignant gastrointestinal tumors in the elderly. Claudins are integral components of tight junctions that play important roles in maintaining epithelial cell polarity, controlling paracellular diffusion, and regulating cell growth and differentiation. The expression profile of claudins has been extensively characterized, but few reports exist on their expression in the normal and neoplastic biliary tract. Our aim was therefore to study claudins by IHC reactions in normal and neoplastic biliary tract samples. We detected that claudin expressions differ in the normal sample groups: the normal gallbladder strongly expressed claudin-2, −3, −4, and −10, but only weak reactions were seen in normal intrahepatic bile ducts. Although each cancer type expressed several claudins with various intensities, only claudin-4 presented especially strong immunoreactions in extrahepatic bile duct cancers and gallbladder carcinomas, whereas claudin-1 and −10 presented in intrahepatic bile duct cancers. Comparing the normal and carcinoma groups, the most significant decrease was detected in the expression of claudin-10. In conclusion, the expression pattern of claudins is different in the various parts of the normal and neoplastic biliary tract; moreover, an unequivocal decrease was detected in the carcinomas compared with their corresponding normal samples. This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials.
Author Gyorffy, Hajnalka
Kupcsulik, Peter
Schaff, Zsuzsa
Somoracz, Aron
Tatrai, Peter
Szijarto, Attila
Kiss, Andras
Szasz, Attila Marcell
Nemeth, Zsuzsanna
Nemeth, Julia
AuthorAffiliation 2nd Department of Pathology (ZN,AMS,PT,JN,HG,ÁS,AK,ZS) and 1st Department of Surgery (AS,PK), Semmelweis University, Budapest, Hungary
AuthorAffiliation_xml – name: 2nd Department of Pathology (ZN,AMS,PT,JN,HG,ÁS,AK,ZS) and 1st Department of Surgery (AS,PK), Semmelweis University, Budapest, Hungary
Author_xml – sequence: 1
  fullname: Nemeth, Zsuzsanna
– sequence: 2
  fullname: Szasz, Attila Marcell
– sequence: 3
  fullname: Tatrai, Peter
– sequence: 4
  fullname: Nemeth, Julia
– sequence: 5
  fullname: Gyorffy, Hajnalka
– sequence: 6
  fullname: Somoracz, Aron
– sequence: 7
  fullname: Szijarto, Attila
– sequence: 8
  fullname: Kupcsulik, Peter
– sequence: 9
  fullname: Kiss, Andras
– sequence: 10
  fullname: Schaff, Zsuzsa
BackLink https://www.ncbi.nlm.nih.gov/pubmed/18854598$$D View this record in MEDLINE/PubMed
BookMark eNp9kU1vEzEYhC3UiqYtZ25oL3DKpq8_174gQVTaSpVAqD1bjtebONrYwd4l8O9xtRG0Fw4jy_bj8eidc3QSYnAIvcWwwFSoq-3GLgiAXChOiMKv0AxzjmsOjJ2gGQAhdTlgZ-g85y0AZozL1-gMS8kZV3KGvi97M7Y-1Hhe1aSIFrGipkjOKxPaqsZQfUtxcD5U17_2yeXsY6jK7rPvvUm_q4dk7FAtTbAu5Ut02pk-uzfH9QI9frl-WN7W919v7paf7mtbQgw1A9WVQJa0UoClzkEnpWkNJaRdWdEo0zZUtEo0zUoKC7TpHJMdW4EigiqgF-jj5LsfVzvXWheGZHq9T35XMulovH55E_xGr-NPTQSRlPBi8OFokOKP0eVB73y2ru9NcHHMWghJgXFRwKsJtCnmnFz39xMM-qkHXXrQTz3oqYfy4t3zbP_44-ALMJ-AbNZOb-OYQpnVf_zeT_jGrzcHn5zOO9P3xR3rw-HAG000xpT-AY6LnA4
CitedBy_id crossref_primary_10_1369_0022155413479123
crossref_primary_10_1007_s12253_015_9936_5
crossref_primary_10_1007_s00428_011_1077_y
crossref_primary_10_1016_j_humpath_2012_06_010
crossref_primary_10_1556_MOnkol_53_2009_4_7
crossref_primary_10_1007_s00428_011_1092_z
crossref_primary_10_1038_cddiscovery_2017_69
crossref_primary_10_1369_0022155411418829
crossref_primary_10_1016_j_semcdb_2015_05_006
crossref_primary_10_3390_diagnostics12112848
crossref_primary_10_1002_hep_24761
crossref_primary_10_3389_fphys_2018_01942
crossref_primary_10_1152_physrev_00019_2012
crossref_primary_10_1111_cge_14432
crossref_primary_10_3390_ijms21030825
crossref_primary_10_25259_CMAS_02_15_2021
crossref_primary_10_1371_journal_pone_0162076
crossref_primary_10_1111_j_1365_2559_2012_04189_x
crossref_primary_10_1186_1746_1596_7_86
crossref_primary_10_1136_gutjnl_2022_327099
crossref_primary_10_1007_s12253_014_9758_x
crossref_primary_10_1016_j_ajpath_2021_02_008
crossref_primary_10_3727_105221619X15469715711907
crossref_primary_10_15279_kpba_2018_23_1_1
crossref_primary_10_1007_s12253_011_9481_9
crossref_primary_10_1097_MOG_0000000000000996
crossref_primary_10_2174_1574893618666230316122534
crossref_primary_10_1016_j_ydbio_2011_10_004
crossref_primary_10_3892_ijo_2020_5105
crossref_primary_10_1007_s12253_014_9886_3
crossref_primary_10_3389_fphys_2021_715611
crossref_primary_10_11569_wcjd_v30_i15_668
crossref_primary_10_1074_jbc_M110_146621
crossref_primary_10_3390_cancers14071800
crossref_primary_10_1007_s00432_011_0987_z
crossref_primary_10_1097_MPG_0000000000002301
crossref_primary_10_1007_s10620_014_3107_5
crossref_primary_10_1007_s12253_018_0491_8
crossref_primary_10_1002_dvdy_23740
crossref_primary_10_4161_tisb_25718
crossref_primary_10_4251_wjgo_v3_i4_49
crossref_primary_10_1007_s00428_012_1195_1
crossref_primary_10_1128_mBio_01911_20
Cites_doi 10.1016/j.jss.2006.08.038
10.1681/ASN.V134875
10.1007/s00268-004-7447-8
10.1016/j.bbamem.2007.08.017
10.1242/jcs.00165
10.1016/j.proghi.2007.01.001
10.1002/cncr.21236
10.1242/jcs.111.5.541
10.1016/j.surg.2005.07.028
10.1016/j.addr.2005.01.008
10.1097/01.pgp.0000215298.38114.cc
10.1158/0008-5472.CAN-05-2782
10.1369/jhc.6A7155.2007
10.1016/j.humpath.2005.12.015
10.1017/S1462399406000056
10.1016/j.jhep.2008.05.001
10.1016/j.addr.2005.01.006
10.1016/S0955-0674(99)00016-2
10.1186/1471-2407-6-186
10.1007/s00428-007-0406-7
10.1097/01.pas.0000213435.99492.8a
10.1007/s00018-006-6314-1
10.1152/ajpcell.00558.2003
10.1016/j.ygyno.2006.04.005
10.1083/jcb.123.6.1631
10.1038/modpathol.3800549
10.1038/modpathol.3800959
10.1126/science.2672330
10.1111/j.1365-2559.2005.02127.x
10.1136/jcp.2005.028589
10.1083/jcb.141.7.1539
10.1016/j.bbamem.2007.07.012
10.1007/978-0-387-33751-7_7
10.1073/pnas.96.2.511
10.1002/hep.20718
10.1158/1078-0432.551.11.2
10.1016/j.jhep.2008.03.025
10.1002/bies.20203
ContentType Journal Article
Copyright 2009 Authors
Copyright © 2009, The Histochemical Society, Inc.
Copyright_xml – notice: 2009 Authors
– notice: Copyright © 2009, The Histochemical Society, Inc.
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
5PM
DOI 10.1369/jhc.2008.952291
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList
MEDLINE

MEDLINE - Academic
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
Biology
EISSN 1551-5044
EndPage 121
ExternalDocumentID 10_1369_jhc_2008_952291
18854598
10.1369_jhc.2008.952291
www57_2_113
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID -
0R
1~K
29K
2E
2J
2M
2N
2WC
3O-
4.4
54M
55
5GY
5RE
5VS
85S
8RP
AABOD
AACTG
AAGHA
AAGMC
AAICN
AAMGE
AANGY
AANSI
AARDL
AATBZ
AAUAS
AAWVI
ABAWP
ABCCA
ABEIX
ABFLS
ABFWQ
ABJIS
ABNLC
ABOCM
ABQXT
ABUFD
ACDSZ
ACDXX
ACGFS
ACGZU
ACJTF
ACNCT
ACROE
ACSBE
ACTQU
ADACO
ADBBV
ADGDL
ADKZR
ADZZY
AECGH
AEDTQ
AEKYL
AEMII
AENEX
AEPTA
AEQLS
AERKM
AERUW
AEUIJ
AEWDL
AFEET
AGCAB
AGTGN
AGWFA
AIFIH
AIOMO
AJUZI
AJYGW
ALJHS
ALMA_UNASSIGNED_HOLDINGS
AMCVQ
AUTPY
AYAKG
B3H
B8M
B8R
B8Z
B94
BAWUL
BBRGL
BDDNI
BFDSU
BKIIM
BKSCU
BSEHC
BWJAD
BYIEH
C1A
CS3
D-I
DB
DB0
DC-
DF0
DIK
DO-
DOPDO
DU5
DV7
E3Z
EBS
EJD
F5P
FRP
GROUPED_SAGE_PREMIER_JOURNAL_COLLECTION
GX1
H13
HH5
HZ
IH2
J8X
K.F
L7B
MK
O0-
O9-
OK1
P.9
P.B
P2P
Q1R
Q7L
Q7U
Q83
ROL
SCNPE
SFC
SHG
SPQ
SPV
THC
TM
TN5
UHB
UPT
WH7
WOQ
X
X7M
ZA5
---
-MK
-TM
-~X
.2E
.2J
.2N
.55
.GJ
01A
0R~
18M
AABMB
AACKU
AACMV
AADTT
AADUE
AAEWN
AAGGD
AAJIQ
AAJOX
AAJPV
AAKGS
AAPEO
AAQXH
AARIX
AATAA
AAYTG
ABDWY
ABHKI
ABJNI
ABKRH
ABLUO
ABPGX
ABPNF
ABQKF
ABRHV
ABVFX
ABVVC
ABYTW
ACARO
ACFEJ
ACFMA
ACGBL
ACLFY
ACLHI
ACLZU
ACOFE
ACOXC
ACSIQ
ACUAV
ACUIR
ACXKE
ACXMB
ADEIA
ADNWM
ADRRZ
ADTBJ
ADUKL
AECVZ
AESZF
AETEA
AEUHG
AEWHI
AEXNY
AFFNX
AFKBI
AFKRG
AFMOU
AFQAA
AFUIA
AGKLV
AGNHF
AHJOV
AI.
AJEFB
AJMMQ
AJXAJ
ALTZF
ANDLU
ARTOV
AUVAJ
BPACV
C45
CBRKF
CDWPY
CFDXU
CORYS
CQQTX
DD-
DD0
DE-
DE.
DN0
FHBDP
HF~
HZ~
H~9
J5H
JCYGO
M4V
MVM
OHT
OVD
S01
TEORI
TR2
UQL
VH1
W8F
YBU
YHG
YQT
YWH
ZGI
ZONMY
ZPPRI
ZRKOI
ZSSAH
ACJER
ALKWR
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
ADVBO
5PM
ID FETCH-LOGICAL-c458t-409f014c2d860c3ee0f88ada322dbc679ad736d9677b86c037fe48f4b09263903
ISSN 0022-1554
IngestDate Tue Sep 17 21:14:34 EDT 2024
Fri Oct 25 09:27:53 EDT 2024
Thu Sep 26 20:29:31 EDT 2024
Sat Sep 28 08:41:15 EDT 2024
Tue Jul 16 20:30:09 EDT 2024
Tue Nov 10 19:15:40 EST 2020
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords gallbladder cancer
claudins
cholangiocarcinoma
tight junction
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c458t-409f014c2d860c3ee0f88ada322dbc679ad736d9677b86c037fe48f4b09263903
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Correspondence to: Zsuzsa Schaff, 2nd Department of Pathology, Semmelweis University, Üllői u. 93, 1091 Budapest, Hungary. E-mail: schaff@korb2.sote.hu
These authors contributed equally to this work.
OpenAccessLink https://journals.sagepub.com/doi/pdf/10.1369/jhc.2008.952291
PMID 18854598
PQID 66830456
PQPubID 23479
PageCount 9
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_2628325
proquest_miscellaneous_66830456
crossref_primary_10_1369_jhc_2008_952291
pubmed_primary_18854598
sage_journals_10_1369_jhc_2008_952291
highwire_smallpub1_www57_2_113
PublicationCentury 2000
PublicationDate 20090201
20090200
2009-Feb
2009-02-00
PublicationDateYYYYMMDD 2009-02-01
PublicationDate_xml – month: 02
  year: 2009
  text: 20090201
  day: 01
PublicationDecade 2000
PublicationPlace Los Angeles, CA
PublicationPlace_xml – name: Los Angeles, CA
– name: United States
PublicationTitle The journal of histochemistry and cytochemistry
PublicationTitleAlternate J Histochem Cytochem
PublicationYear 2009
Publisher Histochemical Soc
SAGE Publications
Histochemical Society
Publisher_xml – name: Histochemical Soc
– name: SAGE Publications
– name: Histochemical Society
References Higashi, Suzuki, Sakaguchi, Nakamura, Baba, Reinecker, Nakamura 2007; 139
Anderson, Van Itallie 1995; 269
Morita, Furuse, Fujimoto, Tsukita 1999; 96
Lewis, Talwalkar, Rosen, Smyrk, Abraham 2007; 31
Ivanov, Nusrat, Parkos 2005; 27
Sobel, Nemeth, Kiss, Lotz, Szabó, Udvarhelyi, Schaff 2006; 103
Balda, Matter 1998; 111
Gumbiner 1993; 123
Oliveira, Morgado-Diaz 2007; 64
Chuang, Lee, Tsai, Sheen, Nagai, Mizumoto, Tanaka 2004; 28
Schneeberger, Lynch 2004; 286
Kobayashi, Ohnuma, Yoshida, Ohtsuka, Terui, Asano, Ryu 2006; 139
Halasz, Holczbauer, Paska, Kovacs, Benyo, Verebely, Schaff 2006; 37
Obama, Ura, Li, Katagiri, Tsunoda, Nomura, Satoh 2005; 41
Bajor, Bero, Garamszegi, Grexa, Anga, Szilágyi 2001; 142
Hartsock, Nelson 2008; 1778
Laurila, Karttunen, Koivukangas, Laurila, Syrjälä, Saarnio, Soini 2007; 55
Kiuchi-Saishin, Gotoh, Furuse, Takasuga, Tano, Tsukita 2002; 13
Blechacz, Gores 2008; 49
Nishino, Honda, Yamashita, Takatori, Minato, Zen, Sasaki 2008; 49
Soini 2005; 46
Swisshelm, Macek, Kubbies 2005; 57
Amasheh, Meiri, Gitter, Schöneberg, Mankertz, Schulzke, Fromm 2002; 115
Lódi, Szabó, Holczbauer, Batmunkh, Szíjártó, Kupcsulik, Kovalszky 2006; 19
Hong, Kim, Pi, Jo, Cho, Yu, Ro 2005; 104
Tsukita, Furuse, Itoh 1999; 11
Kominsky 2006; 8
Morin 2005; 65
Rodriguez-Boulan, Nelson 1989; 245
Cheung, Leung, Ip, Chen, Fong, Ng, Fan 2005; 11
Borka, Kaliszky, Szabo, Lotz, Kupcsulik, Schaff, Kiss 2007; 450
Gonzalez-Mariscal, Lechuga, Garay 2007; 42
Miyoshi, Takai 2005; 57
Chiba, Osanai, Murata, Kojima, Sawada 2008; 1778
Furuse, Fujita, Hiiragi, Fujimoto, Tsukita 1998; 141
Soini, Kinnula, Kahlos, Pääkkö 2006; 59
Tzelepi, Tsamandas, Vlotinou, Vagianos, Scopa 2008; 21
Hewitt, Agarwal, Morin 2006; 6
Soini, Talvensaari-Mattila 2006; 25
Kiuchi-Saishin Y (bibr21-jhc.2008.952291) 2002; 13
Bajor J (bibr3-jhc.2008.952291) 2001; 142
bibr36-jhc.2008.952291
bibr40-jhc.2008.952291
bibr24-jhc.2008.952291
bibr9-jhc.2008.952291
bibr17-jhc.2008.952291
bibr12-jhc.2008.952291
bibr29-jhc.2008.952291
bibr14-jhc.2008.952291
bibr6-jhc.2008.952291
bibr31-jhc.2008.952291
bibr26-jhc.2008.952291
bibr34-jhc.2008.952291
bibr22-jhc.2008.952291
bibr38-jhc.2008.952291
bibr41-jhc.2008.952291
Kakar S (bibr20-jhc.2008.952291) 2007
bibr10-jhc.2008.952291
bibr19-jhc.2008.952291
bibr13-jhc.2008.952291
bibr16-jhc.2008.952291
bibr28-jhc.2008.952291
bibr5-jhc.2008.952291
Anderson JM (bibr2-jhc.2008.952291) 1995; 269
Balda MS (bibr4-jhc.2008.952291) 1998; 111
bibr8-jhc.2008.952291
bibr25-jhc.2008.952291
bibr32-jhc.2008.952291
bibr35-jhc.2008.952291
Cheung ST (bibr7-jhc.2008.952291) 2005; 11
bibr37-jhc.2008.952291
bibr23-jhc.2008.952291
bibr11-jhc.2008.952291
bibr15-jhc.2008.952291
bibr18-jhc.2008.952291
bibr33-jhc.2008.952291
bibr27-jhc.2008.952291
bibr30-jhc.2008.952291
bibr39-jhc.2008.952291
bibr1-jhc.2008.952291
References_xml – volume: 1778
  start-page: 588
  year: 2008
  end-page: 600
  article-title: Transmembrane proteins of tight junctions
  publication-title: Biochim Biophys Acta
  contributor:
    fullname: Sawada
– volume: 57
  start-page: 815
  year: 2005
  end-page: 855
  article-title: Molecular perspective on tight-junction assembly and epithelial polarity
  publication-title: Adv Drug Deliv Rev
  contributor:
    fullname: Takai
– volume: 27
  start-page: 356
  year: 2005
  end-page: 365
  article-title: Endocytosis of the apical junctional complex: mechanisms and possible roles in regulation of epithelial barriers
  publication-title: Bioessays
  contributor:
    fullname: Parkos
– volume: 96
  start-page: 511
  year: 1999
  end-page: 516
  article-title: Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Tsukita
– volume: 13
  start-page: 875
  year: 2002
  end-page: 886
  article-title: Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments
  publication-title: J Am Soc Nephrol
  contributor:
    fullname: Tsukita
– volume: 11
  start-page: 628
  year: 1999
  end-page: 633
  article-title: Structural and signalling molecules come together at tight junctions
  publication-title: Curr Opin Cell Biol
  contributor:
    fullname: Itoh
– volume: 139
  start-page: 68
  year: 2007
  end-page: 76
  article-title: Loss of claudin-1 expression correlates with malignancy of hepatocellular carcinoma
  publication-title: J Surg Res
  contributor:
    fullname: Nakamura
– volume: 103
  start-page: 591
  year: 2006
  end-page: 598
  article-title: Claudin 1 differentiates endometrioid and serous papillary endometrial adenocarcinoma
  publication-title: Gynecol Oncol
  contributor:
    fullname: Schaff
– volume: 28
  start-page: 995
  year: 2004
  end-page: 1000
  article-title: Immunohistochemical study of DPC4 and p53 proteins in gallbladder and bile duct cancers
  publication-title: World J Surg
  contributor:
    fullname: Tanaka
– volume: 269
  start-page: G467
  year: 1995
  end-page: 475
  article-title: Tight junctions and the molecular basis for regulation of paracellular permeability
  publication-title: Am J Physiol
  contributor:
    fullname: Van Itallie
– volume: 31
  start-page: 907
  year: 2007
  end-page: 913
  article-title: Prevalence and risk factors for gallbladder neoplasia in patients with primary sclerosing cholangitis: evidence for a metaplasia-dysplasia-carcinoma sequence
  publication-title: Am J Surg Pathol
  contributor:
    fullname: Abraham
– volume: 286
  start-page: C1213
  year: 2004
  end-page: 1228
  article-title: The tight junction: a multifunctional complex
  publication-title: Am J Physiol Cell Physiol
  contributor:
    fullname: Lynch
– volume: 104
  start-page: 802
  year: 2005
  end-page: 810
  article-title: Analysis of extrahepatic bile duct carcinomas according to the New American Joint Committee on Cancer staging system focused on tumor classification problems in 222 patients
  publication-title: Cancer
  contributor:
    fullname: Ro
– volume: 19
  start-page: 460
  year: 2006
  end-page: 469
  article-title: Claudin-4 differentiates biliary tract cancers from hepatocellular carcinomas
  publication-title: Mod Pathol
  contributor:
    fullname: Kovalszky
– volume: 245
  start-page: 718
  year: 1989
  end-page: 725
  article-title: Morphogenesis of the polarized epithelial cell phenotype
  publication-title: Science
  contributor:
    fullname: Nelson
– volume: 21
  start-page: 22
  year: 2008
  end-page: 30
  article-title: Tight junctions in thyroid carcinogenesis: diverse expression of claudin-1, claudin-4, claudin-7 and occludin in thyroid neoplasms
  publication-title: Mod Pathol
  contributor:
    fullname: Scopa
– volume: 59
  start-page: 250
  year: 2006
  end-page: 254
  article-title: Claudins in differential diagnosis between mesothelioma and metastatic adenocarcinoma of the pleura
  publication-title: J Clin Pathol
  contributor:
    fullname: Pääkkö
– volume: 1778
  start-page: 660
  year: 2008
  end-page: 669
  article-title: Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton
  publication-title: Biochim Biophys Acta
  contributor:
    fullname: Nelson
– volume: 25
  start-page: 330
  year: 2006
  end-page: 335
  article-title: Expression of claudin 1, 4, 5, and 7 in ovarian tumors of diverse types
  publication-title: Int J Gynecol Pathol
  contributor:
    fullname: Talvensaari-Mattila
– volume: 450
  start-page: 549
  year: 2007
  end-page: 557
  article-title: Claudin expression in pancreatic endocrine tumors as compared with ductal adenocarcinomas
  publication-title: Virchows Arch
  contributor:
    fullname: Kiss
– volume: 11
  start-page: 551
  year: 2005
  end-page: 556
  article-title: Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma
  publication-title: Clin Cancer Res
  contributor:
    fullname: Fan
– volume: 49
  start-page: 160
  year: 2008
  end-page: 162
  article-title: Tumor-specific marker genes for intra-hepatic cholangiocarcinoma: utility and mechanistic insight
  publication-title: J Hepatol
  contributor:
    fullname: Gores
– volume: 115
  start-page: 4969
  year: 2002
  end-page: 4976
  article-title: Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells
  publication-title: J Cell Sci
  contributor:
    fullname: Fromm
– volume: 37
  start-page: 555
  year: 2006
  end-page: 561
  article-title: Claudin-1 and claudin-2 differentiate fetal and embryonal components in human hepatoblastoma
  publication-title: Hum Pathol
  contributor:
    fullname: Schaff
– volume: 8
  start-page: 1
  year: 2006
  end-page: 11
  article-title: Claudins: emerging targets for cancer therapy
  publication-title: Expert Rev Mol Med
  contributor:
    fullname: Kominsky
– volume: 142
  start-page: 1231
  year: 2001
  end-page: 1234
  article-title: Common bile duct tumor in a young woman with ulcerative colitis
  publication-title: Orv Hetil
  contributor:
    fullname: Szilágyi
– volume: 141
  start-page: 1539
  year: 1998
  end-page: 1550
  article-title: Claudin-1 and −2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
  publication-title: J Cell Biol
  contributor:
    fullname: Tsukita
– volume: 42
  start-page: 1
  year: 2007
  end-page: 57
  article-title: Role of tight junctions in cell proliferation and cancer
  publication-title: Prog Histochem Cytochem
  contributor:
    fullname: Garay
– volume: 111
  start-page: 541
  year: 1998
  end-page: 547
  article-title: Tight junctions
  publication-title: J Cell Sci
  contributor:
    fullname: Matter
– volume: 49
  start-page: 207
  year: 2008
  end-page: 216
  article-title: Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma
  publication-title: J Hepatol
  contributor:
    fullname: Sasaki
– volume: 46
  start-page: 551
  year: 2005
  end-page: 560
  article-title: Expression of claudins 1, 2, 3, 4, 5 and 7 in various types of tumors
  publication-title: Histopathology
  contributor:
    fullname: Soini
– volume: 55
  start-page: 567
  year: 2007
  end-page: -573
  article-title: Tight junction proteins in gallbladder epithelium: different expression in acute acalculous and calculous cholecystitis
  publication-title: J Histochem Cytochem
  contributor:
    fullname: Soini
– volume: 64
  start-page: 17
  year: 2007
  end-page: 28
  article-title: Claudins: multifunctional players in epithelial tight junctions and their role in cancer
  publication-title: Cell Mol Life Sci
  contributor:
    fullname: Morgado-Diaz
– volume: 65
  start-page: 9603
  year: 2005
  end-page: 9606
  article-title: Claudin proteins in human cancer: promising new targets for diagnosis and therapy
  publication-title: Cancer Res
  contributor:
    fullname: Morin
– volume: 41
  start-page: 1339
  year: 2005
  end-page: 1348
  article-title: Genome-wide analysis of gene expression in human intrahepatic cholangiocarcinoma
  publication-title: Hepatology
  contributor:
    fullname: Satoh
– volume: 57
  start-page: 919
  year: 2005
  end-page: 928
  article-title: Role of claudins in tumorigenesis
  publication-title: Adv Drug Deliv Rev
  contributor:
    fullname: Kubbies
– volume: 123
  start-page: 1631
  year: 1993
  end-page: 1633
  article-title: Breaking through the tight junction barrier
  publication-title: J Cell Biol
  contributor:
    fullname: Gumbiner
– volume: 139
  start-page: 33
  year: 2006
  end-page: 38
  article-title: Preferable operative age of choledochal dilation types to prevent patients with pancreaticobiliary maljunction from developing biliary tract carcinogenesis
  publication-title: Surgery
  contributor:
    fullname: Ryu
– volume: 6
  start-page: 186
  year: 2006
  article-title: The claudin gene family: expression in normal and neoplastic tissues
  publication-title: BMC Cancer
  contributor:
    fullname: Morin
– ident: bibr17-jhc.2008.952291
  doi: 10.1016/j.jss.2006.08.038
– volume: 13
  start-page: 875
  year: 2002
  ident: bibr21-jhc.2008.952291
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.V134875
  contributor:
    fullname: Kiuchi-Saishin Y
– ident: bibr9-jhc.2008.952291
  doi: 10.1007/s00268-004-7447-8
– volume: 269
  start-page: G467
  year: 1995
  ident: bibr2-jhc.2008.952291
  publication-title: Am J Physiol
  contributor:
    fullname: Anderson JM
– ident: bibr8-jhc.2008.952291
  doi: 10.1016/j.bbamem.2007.08.017
– ident: bibr1-jhc.2008.952291
  doi: 10.1242/jcs.00165
– ident: bibr11-jhc.2008.952291
  doi: 10.1016/j.proghi.2007.01.001
– ident: bibr18-jhc.2008.952291
  doi: 10.1002/cncr.21236
– volume: 111
  start-page: 541
  year: 1998
  ident: bibr4-jhc.2008.952291
  publication-title: J Cell Sci
  doi: 10.1242/jcs.111.5.541
  contributor:
    fullname: Balda MS
– ident: bibr22-jhc.2008.952291
  doi: 10.1016/j.surg.2005.07.028
– ident: bibr27-jhc.2008.952291
  doi: 10.1016/j.addr.2005.01.008
– ident: bibr38-jhc.2008.952291
  doi: 10.1097/01.pgp.0000215298.38114.cc
– ident: bibr28-jhc.2008.952291
  doi: 10.1158/0008-5472.CAN-05-2782
– ident: bibr24-jhc.2008.952291
  doi: 10.1369/jhc.6A7155.2007
– ident: bibr14-jhc.2008.952291
  doi: 10.1016/j.humpath.2005.12.015
– ident: bibr23-jhc.2008.952291
  doi: 10.1017/S1462399406000056
– ident: bibr5-jhc.2008.952291
  doi: 10.1016/j.jhep.2008.05.001
– ident: bibr39-jhc.2008.952291
  doi: 10.1016/j.addr.2005.01.006
– ident: bibr40-jhc.2008.952291
  doi: 10.1016/S0955-0674(99)00016-2
– ident: bibr16-jhc.2008.952291
  doi: 10.1186/1471-2407-6-186
– ident: bibr6-jhc.2008.952291
  doi: 10.1007/s00428-007-0406-7
– ident: bibr25-jhc.2008.952291
  doi: 10.1097/01.pas.0000213435.99492.8a
– ident: bibr32-jhc.2008.952291
  doi: 10.1007/s00018-006-6314-1
– volume: 142
  start-page: 1231
  year: 2001
  ident: bibr3-jhc.2008.952291
  publication-title: Orv Hetil
  contributor:
    fullname: Bajor J
– ident: bibr34-jhc.2008.952291
  doi: 10.1152/ajpcell.00558.2003
– ident: bibr35-jhc.2008.952291
  doi: 10.1016/j.ygyno.2006.04.005
– ident: bibr12-jhc.2008.952291
  doi: 10.1083/jcb.123.6.1631
– ident: bibr26-jhc.2008.952291
  doi: 10.1038/modpathol.3800549
– ident: bibr41-jhc.2008.952291
  doi: 10.1038/modpathol.3800959
– ident: bibr33-jhc.2008.952291
  doi: 10.1126/science.2672330
– ident: bibr36-jhc.2008.952291
  doi: 10.1111/j.1365-2559.2005.02127.x
– ident: bibr37-jhc.2008.952291
  doi: 10.1136/jcp.2005.028589
– ident: bibr10-jhc.2008.952291
  doi: 10.1083/jcb.141.7.1539
– ident: bibr15-jhc.2008.952291
  doi: 10.1016/j.bbamem.2007.07.012
– ident: bibr13-jhc.2008.952291
  doi: 10.1007/978-0-387-33751-7_7
– ident: bibr29-jhc.2008.952291
  doi: 10.1073/pnas.96.2.511
– ident: bibr31-jhc.2008.952291
  doi: 10.1002/hep.20718
– volume: 11
  start-page: 551
  year: 2005
  ident: bibr7-jhc.2008.952291
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.551.11.2
  contributor:
    fullname: Cheung ST
– ident: bibr30-jhc.2008.952291
  doi: 10.1016/j.jhep.2008.03.025
– ident: bibr19-jhc.2008.952291
  doi: 10.1002/bies.20203
– start-page: 417
  volume-title: Diagnostic Histopathology of Tumors
  year: 2007
  ident: bibr20-jhc.2008.952291
  contributor:
    fullname: Kakar S
SSID ssj0014458
Score 2.168691
Snippet Biliary tract cancers are relatively common malignant gastrointestinal tumors in the elderly. Claudins are integral components of tight junctions that play...
SourceID pubmedcentral
proquest
crossref
pubmed
sage
highwire
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 113
SubjectTerms Biliary Tract - metabolism
Biliary Tract Neoplasms - metabolism
Biomarkers, Tumor - biosynthesis
Claudin-1
Claudin-3
Claudin-4
Claudins
Female
Humans
Immunohistochemistry
Male
Membrane Proteins - biosynthesis
Middle Aged
Tight Junctions - metabolism
Title Claudin-1, -2, -3, -4, -7, -8, and -10 Protein Expression in Biliary Tract Cancers
URI http://www.jhc.org/cgi/content/abstract/57/2/113
https://journals.sagepub.com/doi/full/10.1369/jhc.2008.952291
https://www.ncbi.nlm.nih.gov/pubmed/18854598
https://search.proquest.com/docview/66830456
https://pubmed.ncbi.nlm.nih.gov/PMC2628325
Volume 57
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKEBIvCDYu4TL8AAiJZSSOayePXQUqQ0MIOmlvkeMkWqc0nUiqqv23_BOOL0mTbUiwB1tN6saNz2f72D7nOwi9kZ4vI0Eil_IMFiiJ9N1EEN8VNOciymSYaiLtk29sckqPz4Zng8HvjtXSsk4O5eZGv5LbSBXugVyVl-x_SLZ9KNyAzyBfyEHCkP-TjMeFWMLc4_qqoVyi80DnVOdc52FjoQmDoXIMUPEtFcWxsYDVlo5Hs2KmzOemymfqw1ghwZ7yXGzR1CGZ0CzFsokVZ3zj1p077RazOYdXYar1KUi13FSiLNup4OdGF_ArvY09qutZIZT7kDpOaPcUTBEVy0KrvOaRHaviK5Ucq8ujUTETvR2NqDGCthictK-gUGqNV7tjOCyflRZkZjA7bA99d-gZJslmXDfE1xa_pDNI-8b71c73vvHQvjaVBEwxsV6cS2NwG4GiGvVKAhYu5xpZfhiCImqiafcpvb-fjAlT0aCGd9BdAmOhtiT48rU96KJ0GDaE9uqlLPsUVP7xStWK3tbW09ehGl7rm9ZI1019O_aKWoWaPkQP7NoHjwyQH6FBVu6ivVEp6sV8jd9hbY2sj3l20T0TJHW9h360KD_ALoEUQKKQOKTwAAP4MCAbW2TjLbIxXFlkY41sbJH9GJ1-_jQdT1wbCcSV0D61S70oh7aSJA2ZJ4Ms8_IwFKmA2ShNJOORSHnA0ohxnoRMegHPMxrmNPEiAiq4FzxBO-WizJ4hzHMpAxLkJKeUJjkRlMFPIpbnaQLqduqg903bxpeG8CXWp74sikEiJmyrkYiD9pu2j6u5KApoaj9erVZDHhNYWgcOet1IJIbup_qOKLPFsooZC5WJAnPQUyOfbV1Wxg7iPcm1BRQffP-bcnaueeEt0hz0Vsk4tqNC9be___zWNbxA97f99iXaqX8ts1egm9fJvkb3HzDx1wI
link.rule.ids 230,315,783,787,888,27936,27937
linkProvider Flying Publisher
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Claudin-1%2C+-2%2C+-3%2C+-4%2C+-7%2C+-8%2C+and+-10+Protein+Expression+in+Biliary+Tract+Cancers&rft.jtitle=The+journal+of+histochemistry+and+cytochemistry&rft.au=N%C3%A9meth%2C+Zsuzsanna&rft.au=Sz%C3%A1sz%2C+Attila+Marcell&rft.au=T%C3%A1trai%2C+P%C3%A9ter&rft.au=N%C3%A9meth%2C+J%C3%BAlia&rft.date=2009-02-01&rft.pub=Histochemical+Society&rft.issn=0022-1554&rft.eissn=1551-5044&rft.volume=57&rft.issue=2&rft.spage=113&rft.epage=121&rft_id=info:doi/10.1369%2Fjhc.2008.952291&rft_id=info%3Apmid%2F18854598&rft.externalDBID=PMC2628325
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-1554&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-1554&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-1554&client=summon