Peripheral Blood DNA Methylation Profiles Do Not Predict Endoscopic Post-Operative Recurrence in Crohn’s Disease Patients

• Published in: International journal of molecular sciences Vol. 23; no. 18; p. 10467
• Main Authors: Joustra, Vincent W., Li Yim, Andrew Y. F., de Bruyn, Jessica R., Duijvestein, Marjolijn, Hageman, Ishtu L., de Jonge, Wouter J., Henneman, Peter, Wildenberg, Manon, D’Haens, Geert
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 09.09.2022; MDPI
• Subjects: Biomarkers; Blood; Crohn's disease; Crohns disease; Deoxyribonucleic acid; DNA; DNA methylation; Elastic analysis; endoscopic recurrence; Endoscopy; Epigenetics; Fibrosis; Gene expression; Genetic testing; Genomes; Genotype & phenotype; Monocytes; Pathogenesis; Patients; Peripheral blood; personalized medicine; predictive biomarker; Remission; Remission (Medicine); Risk analysis; Risk factors; Statistical analysis; Surgery; Wound healing

Prediction of endoscopic post-operative recurrence (POR) in Crohn’s disease (CD) patients following ileocolonic resection (ICR) using clinical risk factors alone has thus far been inadequate. While peripheral blood leukocyte (PBL) DNA methylation has shown promise as a tool for predicting recurrence...