Renin–Angiotensin–Aldosterone System and Immunomodulation: A State-of-the-Art Review

• Published in: Cells (Basel, Switzerland) Vol. 10; no. 7; p. 1767
• Main Authors: Laghlam, Driss, Jozwiak, Mathieu, Nguyen, Lee S.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 13.07.2021; MDPI
• Subjects: Aldosterone; Angiogenesis; Angiotensin; Angiotensin II; Antihypertensives; Apoptosis; Blood pressure; Cell growth; Cell migration; Cell proliferation; Cell survival; Diabetes; Disease; Enzymes; Fibrosis; Glucose; Graft rejection; Homeostasis; Hypertension; Immunomodulation; Inflammation; Insulin resistance; Kidneys; Kinases; Liver; Lymphocytes; Metabolic disorders; Metabolic syndrome; Neutrophils; oncology; Oxidative stress; Peptides; Physiology; Proteins; Renin; renin–angiotensin system; Review; shock; Signal transduction; Transplantation

The renin–angiotensin system (RAS) has long been described in the field of cardiovascular physiology as the main player in blood pressure homeostasis. However, other effects have since been described, and include proliferation, fibrosis, and inflammation. To illustrate the immunomodulatory propertie...