Statin use, development of sarcopenia, and long-term survival after endovascular aortic repair

• Published in: Journal of vascular surgery Vol. 74; no. 5; pp. 1651 - 1658.e1
• Main Authors: Lindström, Iisa, Protto, Sara, Khan, Niina, Väärämäki, Suvi, Oksala, Niku, Hernesniemi, Jussi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2021
• Subjects: Abdominal aortic aneurysm; Aged; Aged, 80 and over; Aortic Aneurysm, Abdominal - diagnostic imaging; Aortic Aneurysm, Abdominal - mortality; Aortic Aneurysm, Abdominal - surgery; Blood Vessel Prosthesis Implantation - adverse effects; Blood Vessel Prosthesis Implantation - mortality; Computed tomography; Endovascular Procedures - adverse effects; Endovascular Procedures - mortality; Female; Finland; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects; Male; Predictive Value of Tests; Psoas muscle; Psoas Muscles - diagnostic imaging; Psoas Muscles - drug effects; Retrospective Studies; Risk Assessment; Risk Factors; Sarcopenia; Sarcopenia - chemically induced; Sarcopenia - diagnostic imaging; Sarcopenia - mortality; Statin medication; Surgery; Survival; Time Factors; Tomography, X-Ray Computed; Treatment Outcome; Finland; Psoas muscle; Sarcopenia; Statin medication; Computed tomography; Survival; Abdominal aortic aneurysm
• ISSN: 0741-5214; 1097-6809; 1097-6809
• DOI: 10.1016/j.jvs.2021.04.054

Statin therapy, associated with improved short-term survival after treatment of abdominal aortic aneurysms, may also predispose to muscle side effects. Evidence on statin-related sarcopenia is limited mainly to muscle function, and it is subject to several sources of bias. In the long term, postoper...