Rosuvastatin Treatment Reduces Markers of Monocyte Activation in HIV-Infected Subjects on Antiretroviral Therapy

• Published in: Clinical infectious diseases Vol. 58; no. 4; pp. 588 - 595
• Main Authors: Funderburg, Nicholas T., Jiang, Ying, Debanne, Sara M., Storer, Norma, Labbato, Danielle, Clagett, Brian, Robinson, Janet, Lederman, Michael M., McComsey, Grace A.
• Format: Journal Article
• Language: English
• Published: Oxford OXFORD UNIVERSITY PRESS 15.02.2014; Oxford University Press
• Subjects: Adult; AIDS; Anti-Inflammatory Agents - therapeutic use; Anti-Retroviral Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiretroviral drugs; Antiretroviral Therapy, Highly Active - methods; Antiretrovirals; Antiviral agents; Biological and medical sciences; Biomarkers; Clinical trials; Diabetes; Disease risks; Drug therapy; Female; Fluorobenzenes - therapeutic use; HIV; HIV 1; HIV Infections - drug therapy; HIV Infections - immunology; HIV/AIDS; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Male; Medical sciences; Middle Aged; Monocytes; Monocytes - immunology; Pharmacology. Drug treatments; Placebos; Placebos - administration & dosage; Pyrimidines - therapeutic use; RNA; Rosuvastatin Calcium; Statins; Sulfonamides - therapeutic use; T lymphocytes; Treatment Outcome; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Immunopathology; Antiretroviral agent; Monocyte; Enzyme; Enzyme inhibitor; AIDS; Statin derivative; Rosuvastatin; Hypocholesterolemic agent; Immune deficiency; Infection; Chemotherapy; Treatment; HMG-CoA reductase inhibitor; Viral disease; Hydroxymethylglutaryl-CoA reductase; Antiviral; Oxidoreductases; Antilipemic agent; HIV-1; monocytes; tissue factor; rosuvastatin

Background. Statins, or 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, have anti-inflammatory effects that are independent of their lipid-lowering properties. Despite suppressive antiretroviral therapy (ART), elevated levels of immune activation and inflammation often persist....