Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B

• Published in: Journal of cerebral blood flow and metabolism Vol. 25; no. 11; pp. 1528 - 1547
• Main Authors: Price, Julie C, Klunk, William E, Lopresti, Brian J, Lu, Xueling, Hoge, Jessica A, Ziolko, Scott K, Holt, Daniel P, Meltzer, Carolyn C, DeKosky, Steven T, Mathis, Chester A
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.11.2005; Lippincott Williams & Wilkins; Sage Publications Ltd
• Subjects: Adult; Aged; Aged, 80 and over; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - metabolism; Amyloid - metabolism; Aniline Compounds - administration & dosage; Aniline Compounds - pharmacokinetics; Biological and medical sciences; Cerebellar Cortex - diagnostic imaging; Cerebellar Cortex - metabolism; Female; Humans; Image Processing, Computer-Assisted - methods; Investigative techniques, diagnostic techniques (general aspects); Kinetics; Male; Medical sciences; Memory Disorders - diagnostic imaging; Memory Disorders - metabolism; Middle Aged; Nervous system; Neurology; Positron-Emission Tomography - methods; Protein Binding; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Radiography; Thiazoles - administration & dosage; Thiazoles - pharmacokinetics; Ultrasonic investigative techniques; Vascular diseases and vascular malformations of the nervous system; mild cognitive impairment; amyloid beta-protein; Alzheimer's disease; PET; kinetic modeling; Human; Nervous system diseases; Alzheimer disease; Modeling; Cerebral disorder; Central nervous system disease; Degenerative disease; Positron emission tomography; Cerebrovascular disease; Positron; Emission tomography
• ISSN: 0271-678X; 1559-7016
• DOI: 10.1038/sj.jcbfm.9600146

A valid quantitative imaging method for the measurement of amyloid deposition in humans could improve Alzheimer's disease (AD) diagnosis and antiamyloid therapy assessment. Our group developed Pittsburgh Compound-B (PIB), an amyloid-binding radiotracer, for positron emission tomography (PET). T...