Sustainability of neutralising antibodies induced by bivalent or quadrivalent HPV vaccines and correlation with efficacy: a combined follow-up analysis of data from two randomised, double-blind, multicentre, phase 3 trials

• Published in: The Lancet infectious diseases Vol. 21; no. 10; pp. 1458 - 1468
• Main Authors: Mariz, Filipe Colaço, Gray, Penelope, Bender, Noemi, Eriksson, Tiina, Kann, Hanna, Apter, Dan, Paavonen, Jorma, Pajunen, Emma, Prager, Kristina M, Sehr, Peter, Surcel, Heljä-Marja, Waterboer, Tim, Müller, Martin, Pawlita, Michael, Lehtinen, Matti
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 01.10.2021; Elsevier Limited
• Subjects: Antibodies; Bispecific antibodies; Cancer; Combined vaccines; Data analysis; Double-blind studies; Human papillomavirus; Immunization; Immunogenicity; Infections; Infectious diseases; Medicin och hälsovetenskap; Pregnancy; Serology; Sustainability; Vaccine efficacy; Vaccines; Womens health; Finland

Quadrivalent and bivalent vaccines against oncogenic human papillomavirus (HPV) are used worldwide with different reported overall efficacies against HPV infections. Although protective concentrations of vaccine-induced antibodies are still not formally defined, we evaluated the sustainability of ne...