An LSC-based MRD assay to complement the traditional MFC method for prediction of AML relapse: a prospective study
Li et al delineate a novel technique for assessing measurable residual disease (MRD) by the assessment of isolated leukemia stem cells (LSCs). They report that assessment of MRD in LSCs provides a better prediction of outcome than standard multiparameter flow cytometry.
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| Published in | Blood Vol. 140; no. 5; pp. 516 - 520 |
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| Main Authors | , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
04.08.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0006-4971 1528-0020 1528-0020 |
| DOI | 10.1182/blood.2021014604 |
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| Abstract | Li et al delineate a novel technique for assessing measurable residual disease (MRD) by the assessment of isolated leukemia stem cells (LSCs). They report that assessment of MRD in LSCs provides a better prediction of outcome than standard multiparameter flow cytometry. |
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| AbstractList | Li et al delineate a novel technique for assessing measurable residual disease (MRD) by the assessment of isolated leukemia stem cells (LSCs). They report that assessment of MRD in LSCs provides a better prediction of outcome than standard multiparameter flow cytometry. [Display omitted] |
| Author | Wang, Yu Li, Si-Qi Wang, Feng-Rong Yan, Chen-Hua Han, Wei Sun, Yu-Qian Mo, Xiao-Dong Chang, Ying-Jun Zhang, Xiao-Hui Chen, Huan Xu, Lan-Ping Liu, Yan-Rong Chen, Yu-Hong Lv, Meng Liu, Kai-Yan Huang, Xiao-Jun Tang, Fei-Fei |
| Author_xml | – sequence: 1 givenname: Si-Qi surname: Li fullname: Li, Si-Qi organization: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Peking University People's Hospital & Peking University Institute of Hematology, Beijing, China – sequence: 2 givenname: Lan-Ping surname: Xu fullname: Xu, Lan-Ping organization: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Peking University People's Hospital & Peking University Institute of Hematology, Beijing, China – sequence: 3 givenname: Yu surname: Wang fullname: Wang, Yu organization: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Peking University People's Hospital & Peking University Institute of Hematology, Beijing, China – sequence: 4 givenname: Xiao-Hui orcidid: 0000-0003-0245-6792 surname: Zhang fullname: Zhang, Xiao-Hui organization: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Peking University People's Hospital & Peking University Institute of Hematology, Beijing, China – sequence: 5 givenname: Huan surname: Chen fullname: Chen, Huan organization: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Peking University People's Hospital & Peking University Institute of Hematology, Beijing, China – sequence: 6 givenname: Yu-Hong surname: Chen fullname: Chen, Yu-Hong organization: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Peking University People's Hospital & Peking University Institute of Hematology, Beijing, China – sequence: 7 givenname: Feng-Rong surname: Wang fullname: Wang, Feng-Rong organization: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Peking University People's Hospital & Peking University Institute of Hematology, Beijing, China – sequence: 8 givenname: Wei surname: Han fullname: Han, Wei organization: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Peking University People's Hospital & Peking University Institute of Hematology, Beijing, China – sequence: 9 givenname: Yu-Qian surname: Sun fullname: Sun, Yu-Qian organization: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Peking University People's Hospital & Peking University Institute of Hematology, Beijing, China – sequence: 10 givenname: Chen-Hua surname: Yan fullname: Yan, Chen-Hua organization: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, 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Beijing, China – sequence: 14 givenname: Yan-Rong surname: Liu fullname: Liu, Yan-Rong organization: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Peking University People's Hospital & Peking University Institute of Hematology, Beijing, China – sequence: 15 givenname: Kai-Yan surname: Liu fullname: Liu, Kai-Yan organization: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Peking University People's Hospital & Peking University Institute of Hematology, Beijing, China – sequence: 16 givenname: Ying-Jun orcidid: 0000-0002-6124-6050 surname: Chang fullname: Chang, Ying-Jun email: rmcyj@bjmu.edu.cn organization: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Peking University People's Hospital & Peking University Institute of Hematology, Beijing, China – sequence: 17 givenname: Xiao-Jun orcidid: 0000-0002-2145-6643 surname: Huang fullname: Huang, Xiao-Jun email: xjhrm@medmail.com.cn organization: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Peking University People's Hospital & Peking University Institute of Hematology, Beijing, China |
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| Cites_doi | 10.1172/JCI41495 10.1016/j.leukres.2021.106673 10.1038/s41409-018-0300-8 10.1182/hematology.2019000060 10.1038/leu.2015.252 10.1182/blood.2021013626 10.1182/blood-2002-10-3064 10.1186/s13045-017-0502-3 10.3324/haematol.2011.047894 10.1038/s41423-020-00597-1 10.1038/sj.leu.2404754 10.1038/leu.2014.327 10.1038/s41375-018-0326-3 10.1182/blood.2020005524 10.1111/bjh.13572 10.1182/blood-2017-09-801498 10.1007/s11427-019-1610-2 10.1111/bjh.14991 10.1111/bjh.16594 10.1182/blood-2012-02-408336 10.1002/ajh.24663 10.1182/blood.V97.11.3574 10.1371/journal.pone.0107587 10.1200/JCO.2013.49.1753 10.1002/cytob.21134 |
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| Snippet | [Display omitted] Li et al delineate a novel technique for assessing measurable residual disease (MRD) by the assessment of isolated leukemia stem cells (LSCs). They report that... |
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| SubjectTerms | Flow Cytometry - methods Humans Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - genetics Neoplasm Recurrence, Local Neoplasm, Residual - diagnosis Prognosis Prospective Studies Recurrence Transplantation, Homologous |
| Title | An LSC-based MRD assay to complement the traditional MFC method for prediction of AML relapse: a prospective study |
| URI | https://dx.doi.org/10.1182/blood.2021014604 https://www.ncbi.nlm.nih.gov/pubmed/35613411 https://www.proquest.com/docview/2670063569 |
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