Zooming in on common immune evasion mechanisms of pathogens in phagolysosomes: potential broad-spectrum therapeutic targets against infectious diseases

• Published in: FEMS microbiology reviews Vol. 47; no. 1; pp. 1 - 18
• Main Authors: Selvapandiyan, Angamuthu, Puri, Niti, Kumar, Pankaj, Alam, Anwar, Ehtesham, Nasreen Zafar, Griffin, George, Hasnain, Seyed Ehtesham
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2023
• Subjects: Acidification; Agonists; Antigen presentation; Antigens; Apoptosis; Autophagy; BCG; BCG vaccines; Communicable diseases; Communicable Diseases - metabolism; Cytosol; Development and progression; Drug development; Health aspects; Humans; Immune Evasion; Immune system; Infectious diseases; Inflammation; Inflammatory response; Intracellular; Lymphocytes T; Macrophages - metabolism; Macrophages - microbiology; Parasitic diseases; Pathogenic microorganisms; Pathogens; Phagocytosis; Phagolysosomes; Phagosomes; Phagosomes - metabolism; Phagosomes - microbiology; Reactive oxygen species; Therapeutic applications; Therapeutic targets; Zooming; India; apoptosis; agonist; phagosomes; antagonist; drug target; intracellular pathogens

Abstract The intracellular viral, bacterial, or parasitic pathogens evade the host immune challenges to propagate and cause fatal diseases. The microbes overpower host immunity at various levels including during entry into host cells, phagosome formation, phagosome maturation, phagosome–lysosome fus...